Introduction. We investigate the generalization ability of models built on datasets containing a small number of subjects, recorded in single study protocols. Next, we propose and evaluate methods combining these datasets into a single, large dataset. Finally, we propose and evaluate the use of ensemble techniques by combining gradient boosting with an artificial neural network to measure predictive power on new, unseen data. Methods. Sensor biomarker data from six public datasets were utilized in this study. To test model generalization, we developed a gradient boosting model trained on one dataset (SWELL), and tested its predictive power on two datasets previously used in other studies (WESAD, NEURO). Next, we merged four small datasets, i.e. (SWELL, NEURO, WESAD, UBFC-Phys), to provide a combined total of 99 subjects,. In addition, we utilized random sampling combined with another dataset (EXAM) to build a larger training dataset consisting of 200 synthesized subjects,. Finally, we developed an ensemble model that combines our gradient boosting model with an artificial neural network, and tested it on two additional, unseen publicly available stress datasets (WESAD and Toadstool). Results. Our method delivers a robust stress measurement system capable of achieving 85% predictive accuracy on new, unseen validation data, achieving a 25% performance improvement over single models trained on small datasets. Conclusion. Models trained on small, single study protocol datasets do not generalize well for use on new, unseen data and lack statistical power. Ma-chine learning models trained on a dataset containing a larger number of varied study subjects capture physiological variance better, resulting in more robust stress detection.

This paper proposes a weakly-supervised machine learning-based approach aiming at a tool to alert patients about possible respiratory diseases. Various types of pathologies may affect the respiratory system, potentially leading to severe diseases and, in certain cases, death. In general, effective prevention practices are considered as major actors towards the improvement of the patient's health condition. The proposed method strives to realize an easily accessible tool for the automatic diagnosis of respiratory diseases. Specifically, the method leverages Variational Autoencoder architectures permitting the usage of training pipelines of limited complexity and relatively small-sized datasets. Importantly, it offers an accuracy of 57 %, which is in line with the existing strongly-supervised approaches.

Background: Postoperative nausea and vomiting (PONV) is a frequently observed complication in patients undergoing surgery under general anesthesia. Moreover, it is a frequent cause of distress and dissatisfaction during the early postoperative period. The tools used for predicting PONV at present have not yielded satisfactory results. Therefore, prognostic tools for the prediction of early and delayed PONV were developed in this study with the aim of achieving satisfactory predictive performance. Methods: The retrospective data of adult patients admitted to the post-anesthesia care unit after undergoing surgical procedures under general anesthesia at the Sheba Medical Center, Israel, between September 1, 2018, and September 1, 2023, were used in this study. An ensemble model of machine learning algorithms trained on the data of 54848 patients was developed. The k-fold cross-validation method was used followed by splitting the data to train and test sets that optimally preserve the sociodemographic features of the patients, such as age, sex, and smoking habits, using the Bee Colony algorithm. Findings: Among the 54848 patients, early and delayed PONV were observed in 2706 (4.93%) and 8218 (14.98%) patients, respectively. The proposed PONV prediction tools could correctly predict early and delayed PONV in 84.0% and 77.3% of cases, respectively, outperforming the second-best PONV prediction tool (Koivuranta score) by 13.4% and 12.9%, respectively. Feature importance analysis revealed that the performance of the proposed prediction tools aligned with previous clinical knowledge, indicating their utility. Interpretation: The machine learning-based tools developed in this study enabled improved PONV prediction, thereby facilitating personalized care and improved patient outcomes.

Parkinson's disease (PD) is a prevalent neurodegenerative disorder known for its impact on motor neurons, causing symptoms like tremors, stiffness, and gait difficulties. This study explores the potential of vocal feature alterations in PD patients as a means of early disease prediction. This research aims to predict the onset of Parkinson's disease. Utilizing a variety of advanced machine-learning algorithms, including XGBoost, LightGBM, Bagging, AdaBoost, and Support Vector Machine, among others, the study evaluates the predictive performance of these models using metrics such as accuracy, area under the curve (AUC), sensitivity, and specificity. The findings of this comprehensive analysis highlight LightGBM as the most effective model, achieving an impressive accuracy rate of 96% alongside a matching AUC of 96%. LightGBM exhibited a remarkable sensitivity of 100% and specificity of 94.43%, surpassing other machine learning algorithms in accuracy and AUC scores. Given the complexities of Parkinson's disease and its challenges in early diagnosis, this study underscores the significance of leveraging vocal biomarkers coupled with advanced machine-learning techniques for precise and timely PD detection.

It has been observed that machine learning algorithms exhibit biased predictions against certain population groups. To mitigate such bias while achieving comparable accuracy, a promising approach is to introduce surrogate functions of the concerned fairness definition and solve a constrained optimization problem. However, it is intriguing in previous work that such fairness surrogate functions may yield unfair results and high instability. In this work, in order to deeply understand them, taking a widely used fairness definition--demographic parity as an example, we show that there is a surrogate-fairness gap between the fairness definition and the fairness surrogate function. Also, the theoretical analysis and experimental results about the "gap" motivate us that the fairness and stability will be affected by the points far from the decision boundary, which is the large margin points issue investigated in this paper. To address it, we propose the general sigmoid surrogate to simultaneously reduce both the surrogate-fairness gap and the variance, and offer a rigorous fairness and stability upper bound. Interestingly, the theory also provides insights into two important issues that deal with the large margin points as well as obtaining a more balanced dataset are beneficial to fairness and stability. Furthermore, we elaborate a novel and general algorithm called Balanced Surrogate, which iteratively reduces the "gap" to mitigate unfairness. Finally, we provide empirical evidence showing that our methods consistently improve fairness and stability while maintaining accuracy comparable to the baselines in three real-world datasets.

We propose VEXIR2Vec, a code embedding framework for finding similar functions in binaries. Our representations rely on VEX IR, the intermediate representation used by binary analysis tools like Valgrind and angr. Our proposed embeddings encode both syntactic and semantic information to represent a function, and is both application and architecture independent. We also propose POV, a custom Peephole Optimization engine that normalizes the VEX IR for effective similarity analysis. We design several optimizations like copy/constant propagation, constant folding, common subexpression elimination and load-store elimination in POV. We evaluate our framework on two experiments -- diffing and searching -- involving binaries targeting different architectures, compiled using different compilers and versions, optimization sequences, and obfuscations. We show results on several standard projects and on real-world vulnerabilities. Our results show that VEXIR2Vec achieves superior precision and recall values compared to the state-of-the-art works. Our framework is highly scalable and is built as a multi-threaded, parallel library by only using open-source tools. VEXIR2Vec achieves about $3.2 \times$ speedup on the closest competitor, and orders-of-magnitude speedup on other tools.

Additive friction stir deposition (AFSD) is a novel solid-state additive manufacturing technique that circumvents issues of porosity, cracking, and properties anisotropy that plague traditional powder bed fusion and directed energy deposition approaches. However, correlations between process parameters, thermal profiles, and resulting microstructure in AFSD remain poorly understood. This hinders process optimization for properties. This work employs a framework combining supervised machine learning (SML) and physics-informed neural networks (PINNs) to predict peak temperature distribution in AFSD from process parameters. Eight regression algorithms were implemented for SML modeling, while four PINNs leveraged governing equations for transport, wave propagation, heat transfer, and quantum mechanics. Across multiple statistical measures, ensemble techniques like gradient boosting proved superior for SML, with lowest MSE of 165.78. The integrated ML approach was also applied to classify deposition quality from process factors, with logistic regression delivering robust accuracy. By fusing data-driven learning and fundamental physics, this dual methodology provides comprehensive insights into tailoring microstructure through thermal management in AFSD. The work demonstrates the power of bridging statistical and physics-based modeling for elucidating AM process-property relationships.

Multi-domain fake news detection aims to identify whether various news from different domains is real or fake and has become urgent and important. However, existing methods are dedicated to improving the overall performance of fake news detection, ignoring the fact that unbalanced data leads to disparate treatment for different domains, i.e., the domain bias problem. To solve this problem, we propose the Dual-Teacher De-biasing Distillation framework (DTDBD) to mitigate bias across different domains. Following the knowledge distillation methods, DTDBD adopts a teacher-student structure, where pre-trained large teachers instruct a student model. In particular, the DTDBD consists of an unbiased teacher and a clean teacher that jointly guide the student model in mitigating domain bias and maintaining performance. For the unbiased teacher, we introduce an adversarial de-biasing distillation loss to instruct the student model in learning unbiased domain knowledge. For the clean teacher, we design domain knowledge distillation loss, which effectively incentivizes the student model to focus on representing domain features while maintaining performance. Moreover, we present a momentum-based dynamic adjustment algorithm to trade off the effects of two teachers. Extensive experiments on Chinese and English datasets show that the proposed method substantially outperforms the state-of-the-art baseline methods in terms of bias metrics while guaranteeing competitive performance.

Normative models in neuroimaging learn the brain patterns of healthy population distribution and estimate how disease subjects like Alzheimer's Disease (AD) deviate from the norm. Existing variational autoencoder (VAE)-based normative models using multimodal neuroimaging data aggregate information from multiple modalities by estimating product or averaging of unimodal latent posteriors. This can often lead to uninformative joint latent distributions which affects the estimation of subject-level deviations. In this work, we addressed the prior limitations by adopting the Mixture-of-Product-of-Experts (MoPoE) technique which allows better modelling of the joint latent posterior. Our model labelled subjects as outliers by calculating deviations from the multimodal latent space. Further, we identified which latent dimensions and brain regions were associated with abnormal deviations due to AD pathology.

The recent COVID-19 pandemic underscores the significance of early-stage non-pharmacological intervention strategies. The widespread use of masks and the systematic implementation of contact tracing strategies provide a potentially equally effective and socially less impactful alternative to more conventional approaches, such as large-scale mobility restrictions. However, manual contact tracing faces strong limitations in accessing the network of contacts, and the scalability of currently implemented protocols for smartphone-based digital contact tracing becomes impractical during the rapid expansion phases of the outbreaks, due to the surge in exposure notifications and associated tests. A substantial improvement in digital contact tracing can be obtained through the integration of probabilistic techniques for risk assessment that can more effectively guide the allocation of new diagnostic tests. In this study, we first quantitatively analyze the diagnostic and social costs associated with these containment measures based on contact tracing, employing three state-of-the-art models of SARS-CoV-2 spreading. Our results suggest that probabilistic techniques allow for more effective mitigation at a lower cost. Secondly, our findings reveal a remarkable efficacy of probabilistic contact-tracing techniques in capturing backward propagations and super-spreading events, relevant features of the diffusion of many pathogens, including SARS-CoV-2.