Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung condition that causes airflow obstruction. The existing methods can only detect patients who already have COPD based on obvious features shown in the spirogram (In this article, the spirogram specifically involves measuring Volume-Flow curve time series). Early prediction of COPD risk is vital for monitoring COPD disease progression, slowing it down, or even preventing its onset. However, these methods fail to early predict an individual's probability of COPD in the future based on subtle features in the spirogram. To address this gap, for the first time, we propose DeepSpiro, a method based on deep learning for early prediction of future COPD risk. DeepSpiro consists of four parts. First, we construct Volume-Flow curves guided by Time-Volume instability smoothing (SpiroSmoother) to enhance the stability of the original Volume-Flow curves precisely. Second, we extract critical features from the evolution of varied-length key patches (SpiroEncoder) to capture the key temporal evolution from original high-dimensional dynamic sequences to a unified low-dimensional temporal representation. Third, we explain the model based on temporal attention and heterogeneous feature fusion (SpiroExplainer), which integrates information from heterogeneous data such as spirogram and demographic information. Fourth, we predict the risk of COPD based on the evolution of key patch concavity (SpiroPredictor), enabling accurate prediction of the risk of disease in high-risk patients who are not yet diagnosed, for up to 1, 2, 3, 4, 5 years, and beyond. We conduct experiments on the UK Biobank dataset. Results show that DeepSpiro achieves an AUC value of 0.8328 in the task of detecting COPD. In early prediction tasks, high-risk and low-risk groups show significant differences in the future, with a p-value of <0.001.

The widespread adoption of big data has ushered in a new era of data-driven decision-making, transforming numerous industries and sectors. However, the efficacy of these decisions hinges on the quality of the underlying data. Poor data quality can result in inaccurate analyses and deceptive conclusions. Managing the vast volume, velocity, and variety of data sources presents significant challenges, heightening the importance of addressing big data quality issues. While there has been increased attention from both academia and industry, current approaches often lack comprehensiveness and universality. They tend to focus on limited metrics, neglecting other dimensions of data quality. Moreover, existing methods are often context-specific, limiting their applicability across different domains. There is a clear need for intelligent, automated approaches leveraging artificial intelligence (AI) for advanced data quality corrections. To bridge these gaps, this Ph.D. thesis proposes a novel set of interconnected frameworks aimed at enhancing big data quality comprehensively. Firstly, we introduce new quality metrics and a weighted scoring system for precise data quality assessment. Secondly, we present a generic framework for detecting various quality anomalies using AI models. Thirdly, we propose an innovative framework for correcting detected anomalies through predictive modeling. Additionally, we address metadata quality enhancement within big data ecosystems. These frameworks are rigorously tested on diverse datasets, demonstrating their efficacy in improving big data quality. Finally, the thesis concludes with insights and suggestions for future research directions.

Data Shapley provides a principled approach to data valuation and plays a crucial role in data-centric machine learning (ML) research. Data selection is considered a standard application of Data Shapley. However, its data selection performance has shown to be inconsistent across settings in the literature. This study aims to deepen our understanding of this phenomenon. We introduce a hypothesis testing framework and show that Data Shapley's performance can be no better than random selection without specific constraints on utility functions. We identify a class of utility functions, monotonically transformed modular functions, within which Data Shapley optimally selects data. Based on this insight, we propose a heuristic for predicting Data Shapley's effectiveness in data selection tasks. Our experiments corroborate these findings, adding new insights into when Data Shapley may or may not succeed.

Anomaly detection, a critical facet in data analysis, involves identifying patterns that deviate from expected behavior. This research addresses the complexities inherent in anomaly detection, exploring challenges and adapting to sophisticated malicious activities. With applications spanning cybersecurity, healthcare, finance, and surveillance, anomalies often signify critical information or potential threats. Inspired by the success of Anomaly Generative Adversarial Network (AnoGAN) in image domains, our research extends its principles to tabular data. Our contributions include adapting AnoGAN's principles to a new domain and promising advancements in detecting previously undetectable anomalies. This paper delves into the multifaceted nature of anomaly detection, considering the dynamic evolution of normal behavior, context-dependent anomaly definitions, and data-related challenges like noise and imbalances.

Being able to successfully determine whether the testing samples has similar distribution as the training samples is a fundamental question to address before we can safely deploy most of the machine learning models into practice. In this paper, we propose TOOD detection, a simple yet effective tree-based out-of-distribution (TOOD) detection mechanism to determine if a set of unseen samples will have similar distribution as of the training samples. The TOOD detection mechanism is based on computing pairwise hamming distance of testing samples' tree embeddings, which are obtained by fitting a tree-based ensemble model through in-distribution training samples. Our approach is interpretable and robust for its tree-based nature. Furthermore, our approach is efficient, flexible to various machine learning tasks, and can be easily generalized to unsupervised setting. Extensive experiments are conducted to show the proposed method outperforms other state-of-the-art out-of-distribution detection methods in distinguishing the in-distribution from out-of-distribution on various tabular, image, and text data.

LLMs have been found to memorize training textual sequences and regurgitate verbatim said sequences during text generation time. This fact is known to be the cause of privacy and related (e.g., copyright) problems. Unlearning in LLMs then takes the form of devising new algorithms that will properly deal with these side-effects of memorized data, while not hurting the model's utility. We offer a fresh perspective towards this goal, namely, that each textual sequence to be forgotten should be treated differently when being unlearned based on its degree of memorization within the LLM. We contribute a new metric for measuring unlearning quality, an adversarial attack showing that SOTA algorithms lacking this perspective fail for privacy, and two new unlearning methods based on Gradient Ascent and Task Arithmetic, respectively. A comprehensive performance evaluation across an extensive suite of NLP tasks then mapped the solution space, identifying the best solutions under different scales in model capacities and forget set sizes and quantified the gains of the new approaches.

This systematic review focuses on anomaly detection for connected and autonomous vehicles. The initial database search identified 2160 articles, of which 203 were included in this review after rigorous screening and assessment. This study revealed that the most commonly used Artificial Intelligence (AI) algorithms employed in anomaly detection are neural networks like LSTM, CNN, and autoencoders, alongside one-class SVM. Most anomaly-based models were trained using real-world operational vehicle data, although anomalies, such as attacks and faults, were often injected artificially into the datasets. These models were evaluated mostly using five key evaluation metrics: recall, accuracy, precision, F1-score, and false positive rate. The most frequently used selection of evaluation metrics used for anomaly detection models were accuracy, precision, recall, and F1-score. This systematic review presents several recommendations. First, there is a need to incorporate multiple evaluation metrics to provide a comprehensive assessment of the anomaly detection models. Second, only a small proportion of the studies have made their models open source, indicating a need to share models publicly to facilitate collaboration within the research community, and to validate and compare findings effectively. Third, there is a need for benchmarking datasets with predefined anomalies or cyberattacks to test and improve the effectiveness of the proposed anomaly-based detection models. Furthermore, there is a need for future research to investigate the deployment of anomaly detection to a vehicle to assess its performance on the road. There is a notable lack of research done on intrusion detection systems using different protocols to CAN, such as Ethernet and FlexRay.

In today's technologically driven world, the rapid spread of fake news, particularly during critical events like elections, poses a growing threat to the integrity of information. To tackle this challenge head-on, we introduce FakeWatch, a comprehensive framework carefully designed to detect fake news. Leveraging a newly curated dataset of North American election-related news articles, we construct robust classification models. Our framework integrates a model hub comprising of both traditional machine learning (ML) techniques, and state-of-the-art Language Models (LMs) to discern fake news effectively. Our objective is to provide the research community with adaptable and precise classification models adept at identifying fake news for the elections agenda. Quantitative evaluations of fake news classifiers on our dataset reveal that, while state-of-the-art LMs exhibit a slight edge over traditional ML models, classical models remain competitive due to their balance of accuracy and computational efficiency. Additionally, qualitative analyses shed light on patterns within fake news articles. We provide our labeled data at https://huggingface.co/datasets/newsmediabias/fake_news_elections_labelled_data and model https://huggingface.co/newsmediabias/FakeWatch for reproducibility and further research.

This thesis aims to study some of the mathematical challenges that arise in the analysis of statistical sequential decision-making algorithms for postoperative patients follow-up. Stochastic bandits (multiarmed, contextual) model the learning of a sequence of actions (policy) by an agent in an uncertain environment in order to maximise observed rewards. To learn optimal policies, bandit algorithms have to balance the exploitation of current knowledge and the exploration of uncertain actions. Such algorithms have largely been studied and deployed in industrial applications with large datasets, low-risk decisions and clear modelling assumptions, such as clickthrough rate maximisation in online advertising. By contrast, digital health recommendations call for a whole new paradigm of small samples, risk-averse agents and complex, nonparametric modelling. To this end, we developed new safe, anytime-valid concentration bounds, (Bregman, empirical Chernoff), introduced a new framework for risk-aware contextual bandits (with elicitable risk measures) and analysed a novel class of nonparametric bandit algorithms under weak assumptions (Dirichlet sampling). In addition to the theoretical guarantees, these results are supported by in-depth empirical evidence. Finally, as a first step towards personalised postoperative follow-up recommendations, we developed with medical doctors and surgeons an interpretable machine learning model to predict the long-term weight trajectories of patients after bariatric surgery.

PU learning refers to the classification problem in which only part of positive samples are labeled. Existing PU learning methods treat unlabeled samples equally. However, in many real tasks, from common sense or domain knowledge, some unlabeled samples are more likely to be positive than others. In this paper, we propose soft label PU learning, in which unlabeled data are assigned soft labels according to their probabilities of being positive. Considering that the ground truth of T PR, FPR, and AUC are unknown, we then design PU counterparts of these metrics to evaluate the performances of soft label PU learning methods within validation data. We show that these new designed PU metrics are good substitutes for the real metrics. After that, a method that optimizes such metrics is proposed. Experiments on public datasets and real datasets for anti-cheat services from Tencent games demonstrate the effectiveness of our proposed method.