[PhD thesis of FCP.] Nowadays, genetics studies large amounts of very diverse variables. Mathematical statistics has evolved in parallel to its applications, with much recent interest high-dimensional settings. In the genetics of human common disease, a number of relevant problems can be formulated as tests of independence. We show how defining adequate premetric structures on the support spaces of the genetic data allows for novel approaches to such testing. This yields a solid theoretical framework, which reflects the underlying biology, and allows for computationally-efficient implementations. For each problem, we provide mathematical results, simulations and the application to real data.

This paper presents a natural language processing (NLP) approach to the problem of thoroughly comprehending song lyrics, with particular attention on genre classification, view-based success prediction, and approximate release year. Our tests provide promising results with 65\% accuracy in genre classification and 79\% accuracy in success prediction, leveraging a DistilBERT model for genre classification and BERT embeddings for release year prediction. Support Vector Machines outperformed other models in predicting the release year, achieving the lowest root mean squared error (RMSE) of 14.18. Our study offers insights that have the potential to revolutionize our relationship with music by addressing the shortcomings of current approaches in properly understanding the emotional intricacies of song lyrics.

To address the challenges of similarity between lesions and surrounding tissues, overlapping appearances of partially benign and malignant nodules, and difficulty in classification, a deep learning network that integrates CNN and Transformer is proposed for the classification of benign and malignant breast lesions in ultrasound images. This network adopts a dual-branch architecture for local-global feature extraction, making full use of the advantages of CNN in extracting local features and the ability of ViT to extract global features to enhance the network's feature extraction capabilities for breast nodules. The local feature extraction branch employs a residual network with multiple attention-guided modules, which can effectively capture the local details and texture features of breast nodules, enhance sensitivity to subtle changes within the nodules, and thus can aid in accurate classification of their benign and malignancy. The global feature extraction branch utilizes the multi-head self-attention ViT network, which can capture the overall shape, boundary, and relationship with surrounding tissues, and thereby enhancing the understanding and modeling of both nodule and global image features. Experimental results on a public ultrasound breast nodule data set show that the proposed method is better than other comparison networks, This indicates that the fusion of CNN and Transformer networks can effectively improve the performance of the classification model and provide a powerful solution for the benign-malignant classification of ultrasound breast.

Personalized Federated Learning (FL) algorithms collaboratively train customized models for each client, enhancing the accuracy of the learned models on the client's local data (e.g., by clustering similar clients, or by fine-tuning models locally). In this paper, we investigate the impact of such personalization techniques on the group fairness of the learned models, and show that personalization can also lead to improved (local) fairness as an unintended benefit. We begin by illustrating these benefits of personalization through numerical experiments comparing two classes of personalized FL algorithms (clustering and fine-tuning) against a baseline FedAvg algorithm, elaborating on the reasons behind improved fairness using personalized FL, and then providing analytical support. Motivated by these, we further propose a new, Fairness-aware Federated Clustering Algorithm, Fair-FCA, in which clients can be clustered to obtain a (tuneable) fairness-accuracy tradeoff. Through numerical experiments, we demonstrate the ability of Fair-FCA to strike a balance between accuracy and fairness at the client level.

This paper develops an approach to classify instances of product failure in a complex textiles manufacturing dataset using explainable techniques. The dataset used in this study was obtained from a New Zealand manufacturer of woollen carpets and rugs. In investigating the trade-off between accuracy and explainability, three different tree-based classification algorithms were evaluated: a Decision Tree and two ensemble methods, Random Forest and XGBoost. Additionally, three feature selection methods were also evaluated: the SelectKBest method, using chi-squared as the scoring function, the Pearson Correlation Coefficient, and the Boruta algorithm. Not surprisingly, the ensemble methods typically produced better results than the Decision Tree model. The Random Forest model yielded the best results overall when combined with the Boruta feature selection technique. Finally, a tree ensemble explaining technique was used to extract rule lists to capture necessary and sufficient conditions for classification by a trained model that could be easily interpreted by a human. Notably, several features that were in the extracted rule lists were statistical features and calculated features that were added to the original dataset. This demonstrates the influence that bringing in additional information during the data preprocessing stages can have on the ultimate model performance.

Applying differential privacy (DP) by means of the DP-SGD algorithm to protect individual data points during training is becoming increasingly popular in NLP. However, the choice of granularity at which DP is applied is often neglected. For example, neural machine translation (NMT) typically operates on the sentence-level granularity. From the perspective of DP, this setup assumes that each sentence belongs to a single person and any two sentences in the training dataset are independent. This assumption is however violated in many real-world NMT datasets, e.g. those including dialogues. For proper application of DP we thus must shift from sentences to entire documents. In this paper, we investigate NMT at both the sentence and document levels, analyzing the privacy/utility trade-off for both scenarios, and evaluating the risks of not using the appropriate privacy granularity in terms of leaking personally identifiable information (PII). Our findings indicate that the document-level NMT system is more resistant to membership inference attacks, emphasizing the significance of using the appropriate granularity when working with DP.

Operational disruptions can significantly impact companies performance. Ford, with its 37 plants globally, uses 17 billion parts annually to manufacture six million cars and trucks. With up to ten tiers of suppliers between the company and raw materials, any extended disruption in this supply chain can cause substantial financial losses. Therefore, the ability to forecast and identify such disruptions early is crucial for maintaining seamless operations. In this study, we demonstrate how we construct a dataset consisting of many multivariate time series to forecast first-tier supply chain disruptions, utilizing features related to capacity, inventory, utilization, and processing, as outlined in the classical Factory Physics framework. This dataset is technically challenging due to its vast scale of over five hundred thousand time series. Furthermore, these time series, while exhibiting certain similarities, also display heterogeneity within specific subgroups. To address these challenges, we propose a novel methodology that integrates an enhanced Attention Sequence to Sequence Deep Learning architecture, using Neural Network Embeddings to model group effects, with a Survival Analysis model. This model is designed to learn intricate heterogeneous data patterns related to operational disruptions. Our model has demonstrated a strong performance, achieving 0.85 precision and 0.8 recall during the Quality Assurance (QA) phase across Ford's five North American plants. Additionally, to address the common criticism of Machine Learning models as black boxes, we show how the SHAP framework can be used to generate feature importance from the model predictions. It offers valuable insights that can lead to actionable strategies and highlights the potential of advanced machine learning for managing and mitigating supply chain risks in the automotive industry.

Investigating the genetic architecture of complex diseases is challenging due to the highly polygenic and interactive landscape of genetic and environmental factors. Although genome-wide association studies (GWAS) have identified thousands of variants for multiple complex phenotypes, conventional statistical approaches can be limited by simplified assumptions such as linearity and lack of epistasis models. In this work, we trained artificial neural networks for predicting complex traits using both simulated and real genotype/phenotype datasets. We extracted feature importance scores via different post hoc interpretability methods to identify potentially associated loci (PAL) for the target phenotype. Simulations we performed with various parameters demonstrated that associated loci can be detected with good precision using strict selection criteria, but downstream analyses are required for fine-mapping the exact variants due to linkage disequilibrium, similarly to conventional GWAS. By applying our approach to the schizophrenia cohort in the Estonian Biobank, we were able to detect multiple PAL related to this highly polygenic and heritable disorder. We also performed enrichment analyses with PAL in genic regions, which predominantly identified terms associated with brain morphology. With further improvements in model optimization and confidence measures, artificial neural networks can enhance the identification of genomic loci associated with complex diseases, providing a more comprehensive approach for GWAS and serving as initial screening tools for subsequent functional studies.

The integration of Artificial Intelligence (AI) into education has transformative potential, providing tailored learning experiences and creative instructional approaches. However, the inherent biases in AI algorithms hinder this improvement by unintentionally perpetuating prejudice against specific demographics, especially in human-centered applications like education. This survey delves deeply into the developing topic of algorithmic fairness in educational contexts, providing a comprehensive evaluation of the diverse literature on fairness, bias, and ethics in AI-driven educational applications. It identifies the common forms of biases, such as data-related, algorithmic, and user-interaction, that fundamentally undermine the accomplishment of fairness in AI teaching aids. By outlining existing techniques for mitigating these biases, ranging from varied data gathering to algorithmic fairness interventions, the survey emphasizes the critical role of ethical considerations and legal frameworks in shaping a more equitable educational environment. Furthermore, it guides readers through the complexities of fairness measurements, methods, and datasets, shedding light on the way to bias reduction. Despite these gains, this survey highlights long-standing issues, such as achieving a balance between fairness and accuracy, as well as the need for diverse datasets. Overcoming these challenges and ensuring the ethical and fair use of AI's promise in education call for a collaborative, interdisciplinary approach.

This paper explores the use of TTS synthesized training data for KWS (keyword spotting) task while minimizing development cost and time. Keyword spotting models require a huge amount of training data to be accurate, and obtaining such training data can be costly. In the current state of the art, TTS models can generate large amounts of natural-sounding data, which can help reducing cost and time for KWS model development. Still, TTS generated data can be lacking diversity compared to real data. To pursue maximizing KWS model accuracy under the constraint of limited resources and current TTS capability, we explored various strategies to mix TTS data and real human speech data, with a focus on minimizing real data use and maximizing diversity of TTS output. Our experimental results indicate that relatively small amounts of real audio data with speaker diversity (100 speakers, 2k utterances) and large amounts of TTS synthesized data can achieve reasonably high accuracy (within 3x error rate of baseline), compared to the baseline (trained with 3.8M real positive utterances).