Short text clustering is a known use case in the text analytics community. When the structure and content falls in the natural language domain e.g. Twitter posts or instant messages, then natural language techniques can be used, provided texts are of sufficient length to allow for use of (pre)trained models to extract meaningful information, such as part-of-speech or topic annotations. However, natural language models are not suitable for clustering transaction counterparties, as they are found in bank payment messaging systems, such as SWIFT. The manually typed tags are typically physical or legal entity details, which lack sentence structure, while containing all the variations and noise that manual entry introduces. This leaves a gap in an investigator or counter-fraud professional's toolset when looking to augment their knowledge of payment flow originator and beneficiary entities and trace funds and assets. A gap that vendors traditionally try to close with fuzzy matching tools. With these considerations in mind, we are proposing a hybrid string similarity, topic modelling, hierarchical clustering and rule-based pipeline to facilitate clustering of transaction counterparties, also catering for unknown number of expected clusters. We are also devising metrics to supplement the evaluation of the approach, based on the well-known measures of precision and recall. Testing on a real-life labelled dataset demonstrates significantly improved performance over a baseline rule-based ('keyword') approach. The approach retains most of the interpretability found in rule-based systems, as the former adds an additional level of cluster refinement to the latter. The resulting workflow reduces the need for manual review. When only a subset of the population needs to be investigated, such as in sanctions investigations, the approach allows for better control of the risks of missing entity variations.

Proteins perform nearly all cellular functions and constitute most drug targets, making their analysis fundamental to understanding human biology in health and disease. Tandem mass spectrometry (MS$^2$) is the major analytical technique in proteomics that identifies peptides by ionizing them, fragmenting them, and using the resulting mass spectra to identify and quantify proteins in biological samples. In MS$^2$ analysis, peptide fragment ion probability prediction plays a critical role, enhancing the accuracy of peptide identification from mass spectra as a complement to the intensity information. Current approaches rely on global statistics of fragmentation, which assumes that a fragment's probability is uniform across all peptides. Nevertheless, this assumption is oversimplified from a biochemical principle point of view and limits accurate prediction. To address this gap, we present Pep2Prob, the first comprehensive dataset and benchmark designed for peptide-specific fragment ion probability prediction. The proposed dataset contains fragment ion probability statistics for 608,780 unique precursors (each precursor is a pair of peptide sequence and charge state), summarized from more than 183 million high-quality, high-resolution, HCD MS$^2$ spectra with validated peptide assignments and fragmentation annotations. We establish baseline performance using simple statistical rules and learning-based methods, and find that models leveraging peptide-specific information significantly outperform previous methods using only global fragmentation statistics. Furthermore, performance across benchmark models with increasing capacities suggests that the peptide-fragmentation relationship exhibits complex nonlinearities requiring sophisticated machine learning approaches.

Accurate prediction of clinical outcomes using Electronic Health Records (EHRs) is critical for early intervention, efficient resource allocation, and improved patient care. EHRs contain multimodal data, including both structured data and unstructured clinical notes that provide rich, context-specific information. In this work, we introduce a unified framework that seamlessly integrates these diverse modalities, leveraging all relevant available information through a two-stage architecture for clinical risk prediction. In the first stage, a fine-tuned Large Language Model (LLM) extracts crucial, task-relevant information from clinical notes, which is enhanced by graph-based retrieval of external domain knowledge from sources such as a medical corpus like PubMed, grounding the LLM's understanding. The second stage combines both unstructured representations and features derived from the structured data to generate the final predictions. This approach supports a wide range of clinical tasks. Here, we demonstrate its effectiveness on 30-day readmission and in-hospital mortality prediction. Experimental results show that our framework achieves strong performance, with AUC scores of $0.84$ and $0.92$, respectively, despite these tasks involving severely imbalanced datasets, with positive rates ranging from approximately $4\%$ to $13\%$. Moreover, it outperforms all existing baselines and clinical practices, including established risk scoring systems. To the best of our knowledge, this is one of the first frameworks for healthcare prediction which enhances the power of an LLM-based graph-guided knowledge retrieval method by combining it with structured data for improved clinical outcome prediction.

This study proposes a generalizable encoding strategy that maps tactile sensor data to electrical stimulation patterns, enabling neural organoids to perform an open-loop artificial tactile Braille classification task. Human forebrain organoids cultured on a low-density microelectrode array (MEA) are systematically stimulated to characterize the relationship between electrical stimulation parameters (number of pulse, phase amplitude, phase duration, and trigger delay) and organoid responses, measured as spike activity and spatial displacement of the center of activity. Implemented on event-based tactile inputs recorded from the Evetac sensor, our system achieved an average Braille letter classification accuracy of 61 percent with a single organoid, which increased significantly to 83 percent when responses from a three-organoid ensemble were combined. Additionally, the multi-organoid configuration demonstrated enhanced robustness against various types of artificially introduced noise. This research demonstrates the potential of organoids as low-power, adaptive bio-hybrid computational elements and provides a foundational encoding framework for future scalable bio-hybrid computing architectures.

Recent advancements in skin lesion classification models have significantly improved accuracy, with some models even surpassing dermatologists' diagnostic performance. However, in medical practice, distrust in AI models remains a challenge. Beyond high accuracy, trustworthy, explainable diagnoses are essential. Existing explainability methods have reliability issues, with LIME-based methods suffering from inconsistency, while CAM-based methods failing to consider all classes. To address these limitations, we propose Global Class Activation Probabilistic Map Evaluation, a method that analyses all classes' activation probability maps probabilistically and at a pixel level. By visualizing the diagnostic process in a unified manner, it helps reduce the risk of misdiagnosis. Furthermore, the application of SafeML enhances the detection of false diagnoses and issues warnings to doctors and patients as needed, improving diagnostic reliability and ultimately patient safety. We evaluated our method using the ISIC datasets with MobileNetV2 and Vision Transformers.

Rising mental health issues among youth have increased interest in automated approaches for detecting early signs of psychological distress in digital text. One key focus is the identification of cognitive distortions, irrational thought patterns that have a role in aggravating mental distress. Early detection of these distortions may enable timely, low-cost interventions. While prior work has focused on English clinical data, we present the first in-depth study of cross-lingual and cross-register generalization of cognitive distortion detection, analyzing forum posts written by Dutch adolescents. Our findings show that while changes in language and writing style can significantly affect model performance, domain adaptation methods show the most promise.

Speech-based Parkinson's disease (PD) detection has gained attention for its automated, cost-effective, and non-intrusive nature. As research studies usually rely on data from diagnostic-oriented speech tasks, this work explores the feasibility of diagnosing PD on the basis of speech data not originally intended for diagnostic purposes, using the Turn-Taking (TT) dataset. Our findings indicate that TT can be as useful as diagnostic-oriented PD datasets like PC-GIT A. We also investigate which specific dataset characteristics impact PD classification performance. The results show that concatenating audio recordings and balancing participants' gender and status distributions can be beneficial. Cross-dataset evaluation reveals that models trained on PC-GIT A generalize poorly to TT, whereas models trained on TT perform better on PC-GIT A. Furthermore, we provide insights into the high variability across folds, which is mainly due to large differences in individual speaker performance.

The development of many vision models mainly focuses on improving their performance using metrics such as accuracy, IoU, and mAP, with less attention to explainability due to the complexity of applying xAI methods to provide a meaningful explanation of trained models. Although many existing xAI methods aim to explain vision models sample-by-sample, methods explaining the general behavior of vision models, which can only be captured after running on a large dataset, are still underexplored. Furthermore, understanding the behavior of vision models on general images can be very important to prevent biased judgments and help identify the model's trends and patterns. With the application of Vision-Language Models, this paper proposes a pipeline to explain vision models at both the sample and dataset levels. The proposed pipeline can be used to discover failure cases and gain insights into vision models with minimal effort, thereby integrating vision model development with xAI analysis to advance image analysis.

Accurate sarcopenia diagnosis via ultrasound remains challenging due to subtle imaging cues, limited labeled data, and the absence of clinical context in most models. We propose MedVQA-TREE, a multimodal framework that integrates a hierarchical image interpretation module, a gated feature-level fusion mechanism, and a novel multi-hop, multi-query retrieval strategy. The vision module includes anatomical classification, region segmentation, and graph-based spatial reasoning to capture coarse, mid-level, and fine-grained structures. A gated fusion mechanism selectively integrates visual features with textual queries, while clinical knowledge is retrieved through a UMLS-guided pipeline accessing PubMed and a sarcopenia-specific external knowledge base. MedVQA-TREE was trained and evaluated on two public MedVQA datasets (VQA-RAD and PathVQA) and a custom sarcopenia ultrasound dataset. The model achieved up to 99% diagnostic accuracy and outperformed previous state-of-the-art methods by over 10%. These results underscore the benefit of combining structured visual understanding with guided knowledge retrieval for effective AI-assisted diagnosis in sarcopenia.

Foundation models have recently emerged as powerful feature extractors in computational pathology, yet they typically omit mechanisms for leveraging the global spatial structure of tissues and the local contextual relationships among diagnostically relevan t regions -- key elements for understanding the tumor microenvironment. Multiple instance learning (MIL) remains an essential next step following foundation model, designing a framework to aggregate patch - level features into slide - level predictions. We presen t EAGLE - Net, a structure - preserving, attention - guided MIL architecture designed to augment prediction and interpretability. EAGLE - Net integrates multi - scale absolute spatial encoding to capture global tissue architecture, a top - K neighborhood - aware loss to focus attention on local microenvironments, and background suppression loss to minimize false positives. We benchmarked EAGLE - Net on large pan - cancer datasets, including three cancer types for classification (10,260 slides) and seven cancer types for surv ival prediction (4,172 slides), using three distinct histology foundation backbones (REMEDIES, Uni - V1, Uni2 - h). Across tasks, EAGLE - Net achieved up to 3% higher classification accuracy and the top concordance indices in 6 of 7 cancer types, producing smoot h, biologically coherent attention maps that aligned with expert annotations and highlighted invasive fronts, necrosis, and immune infiltration. These results position EAGLE - Net as a generalizable, interpretable framework that complements foundation models, enabling improved biomarker discovery, prognostic modeling, and clinical decision support.