Secure monitoring and dynamic control in an IIoT environment are major requirements for current development goals. We believe that dynamic, secure monitoring of the IIoT environment can be achieved through integration with the Software-Defined Network (SDN) and Digital Twin (DT) paradigms. The current literature lacks implementation details for SDN-based DT and time-aware intelligent model training for short-term anomaly detection against IIoT threats. Therefore, we have proposed a novel framework for short-term anomaly detection that uses an SDN-based DT. Using a comprehensive dataset, time-aware labeling of features, and a comprehensive evaluation of various machine learning models, we propose a novel SD-TWIN-based anomaly detection algorithm. According to the performance of a new real-time SD-TWIN deployment, the GPU- accelerated LightGBM model is particularly effective, achieving a balance of high recall and strong classification performance.

Advances in genomic medicine accelerate the identi cation of mutations in disease-associated genes, but the pathogenicity of many mutations remains unknown, hindering their use in diagnostics and clinical decision-making. Predictive AI models are generated to combat this issue, but current tools display low accuracy when tested against functionally validated datasets. We show that integrating detailed conformational data extracted from molecular dynamics simulations (MDS) into advanced AI-based models increases their predictive power. We carry out an exhaustive mutational analysis of the disease gene PMM2 and subject structural models of each variant to MDS. AI models trained on this dataset outperform existing tools when predicting the known pathogenicity of mutations. Our best performing model, a neuronal networks model, also predicts the pathogenicity of several PMM2 mutations currently considered of unknown signi cance. We believe this model helps alleviate the burden of unknown variants in genomic medicine.

Pedestrian safety is a critical component of urban mobility and is strongly influenced by the interactions between pedestrian decision-making and driver yielding behavior at crosswalks. Modeling driver--pedestrian interactions at intersections requires accurately capturing the complexity of these behaviors. Traditional machine learning models often struggle to capture the nuanced and context-dependent reasoning required for these multifactorial interactions, due to their reliance on fixed feature representations and limited interpretability. In contrast, large language models (LLMs) are suited for extracting patterns from heterogeneous traffic data, enabling accurate modeling of driver-pedestrian interactions. Therefore, this paper leverages multimodal LLMs through a novel prompt design that incorporates domain-specific knowledge, structured reasoning, and few-shot prompting, enabling interpretable and context-aware inference of driver yielding behavior, as an example application of modeling pedestrian--driver interaction. We benchmarked state-of-the-art LLMs against traditional classifiers, finding that GPT-4o consistently achieves the highest accuracy and recall, while Deepseek-V3 excels in precision. These findings highlight the critical trade-offs between model performance and computational efficiency, offering practical guidance for deploying LLMs in real-world pedestrian safety systems.

Modern therapeutic antibody design often involves composing multi-part assemblages of individual functional domains, each of which may be derived from a different source or engineered independently. While these complex formats can expand disease applicability and improve safety, they present a significant engineering challenge: the function and stability of individual domains are not guaranteed in the novel format, and the entire molecule may no longer be synthesizable. To address these challenges, we develop a machine learning framework to predict "reformatting success" -- whether converting an antibody from one format to another will succeed or not. Our framework incorporates both antibody sequence and structural context, incorporating an evaluation protocol that reflects realistic deployment scenarios. In experiments on a real-world antibody reformatting dataset, we find the surprising result that large pretrained protein language models (PLMs) fail to outperform simple, domain-tailored, multimodal representations. This is particularly evident in the most difficult evaluation setting, where we test model generalization to a new starting antibody. In this challenging "new antibody, no data" scenario, our best multimodal model achieves high predictive accuracy, enabling prioritization of promising candidates and reducing wasted experimental effort.

This study examines credit default prediction by comparing three techniques, namely SMOTE, SMOTE-Tomek, and ADASYN, that are commonly used to address the class imbalance problem in credit default situations. Recognizing that credit default datasets are typically skewed, with defaulters comprising a much smaller proportion than non-defaulters, we began our analysis by evaluating machine learning (ML) models on the imbalanced data without any resampling to establish baseline performance. These baseline results provide a reference point for understanding the impact of subsequent balancing methods. In addition to traditional classifiers such as Naive Bayes and K-Nearest Neighbors (KNN), our study also explores the suitability of advanced ensemble boosting algorithms, including Extreme Gradient Boosting (XGBoost), AdaBoost, Gradient Boosting Machines (GBM), and Light GBM for credit default prediction using Boruta feature selection and DBSCAN-based outlier detection, both before and after resampling. A real-world credit default data set sourced from the University of Cleveland ML Repository was used to build ML classifiers, and their performances were tested. The criteria chosen to measure model performance are the area under the receiver operating characteristic curve (ROC-AUC), area under the precision-recall curve (PR-AUC), G-mean, and F1-scores. The results from this empirical study indicate that the Boruta+DBSCAN+SMOTE-Tomek+GBM classifier outperformed the other ML models (F1-score: 82.56%, G-mean: 82.98%, ROC-AUC: 90.90%, PR-AUC: 91.85%) in a credit default context. The findings establish a foundation for future progress in creating more resilient and adaptive credit default systems, which will be essential as credit-based transactions continue to rise worldwide.

This study investigates the effectiveness of unsupervised outlier detection methods in audit analytics, utilizing USA spending data from the U.S. Department of Health and Human Services (DHHS) as a case example. We employ and compare multiple outlier detection algorithms, including Histogram-based Outlier Score (HBOS), Robust Principal Component Analysis (PCA), Minimum Covariance Determinant (MCD), and K-Nearest Neighbors (KNN) to identify anomalies in federal spending patterns. The research addresses the growing need for efficient and accurate anomaly detection in large-scale governmental datasets, where traditional auditing methods may fall short. Our methodology involves data preparation, algorithm implementation, and performance evaluation using precision, recall, and F1 scores. Results indicate that a hybrid approach, combining multiple detection strategies, enhances the robustness and accuracy of outlier identification in complex financial data. This study contributes to the field of audit analytics by providing insights into the comparative effectiveness of various outlier detection models and demonstrating the potential of unsupervised learning techniques in improving audit quality and efficiency. The findings have implications for auditors, policymakers, and researchers seeking to leverage advanced analytics in governmental financial oversight and risk management.

Traditional document parsing architectures employ deterministic pipelines that sequentially combine optical character recognition (OCR), layout analysis, and rule-based table extraction to produce structured outputs. The evaluation of these systems has relied on well-established task-specific metrics including Character Error Rate (CER) and Word Error Rate (WER) [14, 20], Intersection-over-Union (IoU) [4, 16], and Tree Edit Distance-based Similarity (TEDS) [31]. These metrics operate under the assumption of unique ground truth representations, rewarding exact matches while systematically penalizing any structural deviations. The emergence of multi-modal generative document parsing systems has fundamentally transformed this landscape. Vision Language Models (VLMs) such as GPT-5 Mini, Gemini 2.5 Flash, and Claude Sonnet 3.7/4 [22, 6, 1, 2], generate holistic document interpretations that integrate visual, textual, and structural signals in an end-to-end manner. Unlike their deterministic predecessors, these systems frequently produce outputs that are semantically correct yet structurally divergent. Consider a table containing merged cells: one system may represent it as a flattened token sequence preserving reading order, while another generates hierarchical HTML markup with explicit structural relationships. Both interpretations faithfully capture the semantic content, yet traditional evaluation frameworks treat them as fundamentally incompatible, systematically misclassifying valid alternative interpretations as parsing errors. This mismatch of the evaluation paradigm has significant practical implications.

Electric vehicle (EV) charging loads identification from behind smart meter recordings is an indispensable aspect that enables effective decision-making for energy distributors to reach an informed and intelligent decision about the power grid's reliability. When EV charging happens behind the meter (BTM), the charging occurs on the customer side of the meter, which measures the overall electricity consumption. In other words, the charging of the EV is considered part of the customer's load and not separately measured by the Distribution Network Operators (DNOs). DNOs require complete knowledge about the EV presence in their network. Identifying the EV charging demand is essential to better plan and manage the distribution grid. Unlike supervised methods, this paper addresses the problem of EV charging load identification in a non-nonintrusive manner from low-frequency smart meter using an unsupervised learning approach based on anomaly detection technique. Our approach does not require prior knowledge of EV charging profiles. It only requires real power consumption data of non-EV users, which are abundant in practice. We propose a deep temporal convolution encoding decoding (TAE) network. The TAE is applied to power consumption from smart BTM from Victorian households in Australia, and the TAE shows superior performance in identifying households with EVs.

Detection of credit card fraud is an acute issue of financial security because transaction datasets are highly lopsided, with fraud cases being only a drop in the ocean. Balancing datasets using the most popular methods of traditional oversampling such as the Synthetic Minority Oversampling Technique (SMOTE) generally create simplistic synthetic samples that are not readily applicable to complex fraud patterns. Recent industry advances that include Conditional Tabular Generative Adversarial Networks (CTGAN) and Tabular Variational Autoencoders (TVAE) have demonstrated increased efficiency in tabular synthesis, yet all these models still exhibit issues with high-dimensional dependence modelling. Now we will present our hybrid approach where we use a Generative Adversarial Network (GAN) with a Transformer encoder block to produce realistic fraudulent transactions samples. The GAN architecture allows training realistic generators adversarial, and the Transformer allows the model to learn rich feature interactions by self-attention. Such a hybrid strategy overcomes the limitations of SMOTE, CTGAN, and TVAE by producing a variety of high-quality synthetic minority classes samples. We test our algorithm on the publicly-available Credit Card Fraud Detection dataset and compare it to conventional and generative resampling strategies with a variety of classifiers, such as Logistic Regression (LR), Random Forest (RF), Extreme Gradient Boosting (XGBoost), and Support Vector Machine (SVM). Findings indicate that our Transformer-based GAN shows substantial gains in Recall, F1-score and Area Under the Receiver Operating Characteristic Curve (AUC), which indicates that it is effective in overcoming the severe class imbalance inherent in the task of fraud detection.

This research investigates how Machine Learning (ML) algorithms can assist in workload allocation strategies by detecting tasks with node affinity operators (referred to as constraint operators), which constrain their execution to a limited number of nodes. Using real-world Google Cluster Data (GCD) workload traces and the AGOCS framework, the study extracts node attributes and task constraints, then analyses them to identify suitable node-task pairings. It focuses on tasks that can be executed on either a single node or fewer than a thousand out of 12.5k nodes in the analysed GCD cluster. Task constraint operators are compacted, pre-processed with one-hot encoding, and used as features in a training dataset. Various ML classifiers, including Artificial Neural Networks, K-Nearest Neighbours, Decision Trees, Naive Bayes, Ridge Regression, Adaptive Boosting, and Bagging, are fine-tuned and assessed for accuracy and F1-scores. The final ensemble voting classifier model achieved 98% accuracy and a 1.5-1.8% misclassification rate for tasks with a single suitable node.