The mortality related to cervical cancer can be substantially reduced through early detection and treatment. However, current detection techniques, such as Pap smear and colposcopy, fail to achieve a concurrently high sensitivity and specificity. In vivo fluorescence spectroscopy is a technique which quickly, noninvasively and quantitatively probes the biochemical and morphological changes that occur in precancerous tissue. RBF ensemble algorithms based on such spectra provide automated, and near realtime implementation of pre-cancer detection in the hands of nonexperts. The results are more reliable, direct and accurate than those achieved by either human experts or multivariate statistical algorithms. 1 Introduction Cervical carcinoma is the second most common cancer in women worldwide, exceeded only by breast cancer (Ramanujam et al., 1996). The mortality related to cervical cancer can be reduced if this disease is detected at the precancerous state, known as squamous intraepitheliallesion (SIL). Currently, a Pap smear is used to 982 K. Turner, N. Ramanujam, R. Richards-Kortum and J. Ghosh screen for cervical cancer {Kurman et al., 1994}. In a Pap test, a large number of cells obtained by scraping the cervical epithelium are smeared onto a slide which is then fixed and stained for cytologic examination.

Predictions oflifetimes of dynamically allocated objects can be used to improve time and space efficiency of dynamic memory management in computer programs. Barrett and Zorn [1993] used a simple lifetime predictor and demonstrated this improvement on a variety of computer programs. In this paper, we use decision trees to do lifetime prediction on the same programs and show significantly better prediction. Our method also has the advantage that during training we can use a large number of features and let the decision tree automatically choose the relevant subset.

The mortality related to cervical cancer can be substantially reduced through early detection and treatment. However, current detection techniques, such as Pap smear and colposcopy, fail to achieve a concurrently high sensitivity and specificity. In vivo fluorescence spectroscopy is a technique which quickly, noninvasively and quantitatively probes the biochemical and morphological changes that occur in precancerous tissue. RBF ensemble algorithms based on such spectra provide automated, and near realtime implementation of pre-cancer detection in the hands of nonexperts. The results are more reliable, direct and accurate than those achieved by either human experts or multivariate statistical algorithms. 1 Introduction Cervical carcinoma is the second most common cancer in women worldwide, exceeded only by breast cancer (Ramanujam et al., 1996). The mortality related to cervical cancer can be reduced if this disease is detected at the precancerous state, known as squamous intraepitheliallesion (SIL). Currently, a Pap smear is used to 982 K. Turner, N. Ramanujam, R. Richards-Kortum and J. Ghosh screen for cervical cancer {Kurman et al., 1994}. In a Pap test, a large number of cells obtained by scraping the cervical epithelium are smeared onto a slide which is then fixed and stained for cytologic examination.

Predictions oflifetimes of dynamically allocated objects can be used to improve time and space efficiency of dynamic memory management in computer programs. Barrett and Zorn [1993] used a simple lifetime predictor and demonstrated this improvement on a variety of computer programs. In this paper, we use decision trees to do lifetime prediction on the same programs and show significantly better prediction. Our method also has the advantage that during training we can use a large number of features and let the decision tree automatically choose the relevant subset.

The mortality related to cervical cancer can be substantially reduced throughearly detection and treatment. However, current detection techniques, such as Pap smear and colposcopy, fail to achieve a concurrently high sensitivity and specificity. In vivo fluorescence spectroscopy is a technique which quickly, noninvasively andquantitatively probes the biochemical and morphological changes that occur in precancerous tissue. RBF ensemble algorithms based on such spectra provide automated, and near realtime implementationof pre-cancer detection in the hands of nonexperts. Theresults are more reliable, direct and accurate than those achieved by either human experts or multivariate statistical algorithms. 1 Introduction Cervical carcinoma is the second most common cancer in women worldwide, exceeded onlyby breast cancer (Ramanujam et al., 1996). The mortality related to cervical cancer can be reduced if this disease is detected at the precancerous state, known as squamous intraepitheliallesion (SIL).

Predictions oflifetimes of dynamically allocated objects can be used to improve time and space efficiency of dynamic memory management incomputer programs. Barrett and Zorn [1993] used a simple lifetime predictor and demonstrated this improvement on a variety of computer programs. In this paper, we use decision trees to do lifetime prediction on the same programs and show significantly better prediction. Our method also has the advantage that during training we can use a large number of features and let the decision tree automatically choose the relevant subset.

This paper describes a new technique for object recognition based on learning appearance models. The image is decomposed into local regions which are described by a new texture representation called "Generalized Second Moments" thatare derived from the output of multiscale, multiorientation filter banks. Class-characteristic local texture features and their global composition is learned by a hierarchical mixture of experts architecture (Jordan & Jacobs). The technique is applied to a vehicle database consisting of 5 general car categories (Sedan, Van with backdoors, Van without backdoors, old Sedan, and Volkswagen Bug). This is a difficult problem with considerable in-class variation. The new technique has a 6.5% misclassification rate, compared to eigen-images which give 17.4% misclassification rate, and nearest neighbors which give 15 .7%

Machine-learning research has been making great progress in many directions. This article summarizes four of these directions and discusses some current open problems. The four directions are (1) the improvement of classification accuracy by learning ensembles of classifiers, (2) methods for scaling up supervised learning algorithms, (3) reinforcement learning, and (4) the learning of complex stochastic models.

Instance-based learning techniques typically handle continuous and linear input values well, but often do not handle nominal input attributes appropriately. The Value Difference Metric (VDM) was designed to find reasonable distance values between nominal attribute values, but it largely ignores continuous attributes, requiring discretization to map continuous values into nominal values. This paper proposes three new heterogeneous distance functions, called the Heterogeneous Value Difference Metric (HVDM), the Interpolated Value Difference Metric (IVDM), and the Windowed Value Difference Metric (WVDM). These new distance functions are designed to handle applications with nominal attributes, continuous attributes, or both. In experiments on 48 applications the new distance metrics achieve higher classification accuracy on average than three previous distance functions on those datasets that have both nominal and continuous attributes.

Most current methods for prediction of protein secondary structure use a small window of the protein sequence to predict the structure of the central amino acid. We describe a new method for prediction of the non-local structure called,8-sheet, which consists of two or more,8-strands that are connected by hydrogen bonds. Since,8-strands are often widely separated in the protein chain, a network with two windows is introduced. After training on a set of proteins the network predicts the sheets well, but there are many false positives. By using a global energy function the,8-sheet prediction is combined with a local prediction of the three secondary structures a-helix,,8-strand and coil.