Late diagnosis and high costs are key factors that negatively impact the care of cancer patients worldwide. Although the availability of biological markers for the diagnosis of cancer type is increasing, costs and reliability of tests currently present a barrier to the adoption of their routine use. There is a pressing need for accurate methods that enable early diagnosis and cover a broad range of cancers. The use of machine learning and RNA-seq expression analysis has shown promise in the classification of cancer type. However, research is inconclusive about which type of machine learning models are optimal. The suitability of five algorithms were assessed for the classification of 17 different cancer types. Each algorithm was fine-tuned and trained on the full array of 18,015 genes per sample, for 4,221 samples (75 % of the dataset). They were then tested with 1,408 samples (25 % of the dataset) for which cancer types were withheld to determine the accuracy of prediction. The results show that ensemble algorithms achieve 100% accuracy in the classification of 14 out of 17 types of cancer. The clustering and classification models, while faster than the ensembles, performed poorly due to the high level of noise in the dataset. When the features were reduced to a list of 20 genes, the ensemble algorithms maintained an accuracy above 95% as opposed to the clustering and classification models.

Recently, many methods to reduce neural networks uncertainty have been proposed. However, most of the techniques used in these solutions usually present severe drawbacks. In this paper, we argue that neural networks low out-of-distribution detection performance is mainly due to the SoftMax loss anisotropy. Therefore, we built an isotropic loss to reduce neural networks uncertainty in a fast, scalable, turnkey, and native approach. Our experiments show that replacing SoftMax with the proposed loss does not affect classification accuracy. Moreover, our proposal overcomes ODIN typically by a large margin while producing usually competitive results against a state-of-the-art Mahalanobis method despite avoiding their limitations. Hence, neural networks uncertainty may be significantly reduced by a simple loss change without relying on special procedures such as data augmentation, adversarial training/validation, ensembles, or additional classification/regression models.

Class imbalance problem is commonly faced while developing machine learning models for real-life issues. Due to this problem, the fitted model tends to be biased towards the majority class data, which leads to lower precision, recall, AUC, F1, G-mean score. Several researches have been done to tackle this problem, most of which employed resampling, i.e. oversampling and undersampling techniques to bring the required balance in the data. In this paper, we propose neural network based algorithms for undersampling. Then we resampled several class imbalanced data using our algorithms and also some other popular resampling techniques. Afterwards we classified these undersampled data using some common classifier. We found out that our resampling approaches outperform most other resampling techniques in terms of both AUC, F1 and G-mean score.

--T oday's competition between the professional eSports teams is so strong that in-depth analysis of players' performance literally crucial for creating a powerful team. There are two main approaches to such an estimation: obtaining features and metrics directly from the in-game data or collecting detailed information about the player including data on his/her physical training. While the correlation between the player's skill and in-game data has already been covered in many papers, there are very few works related to analysis of eSports athlete's skill through his/her physical behavior . We propose the smart chair platform which is to collect data on the person's behavior on the chair using an integrated accelerometer, a gyroscope and a magnetometer . We extract the important game events to define the players' physical reactions to them. The obtained data are used for training machine learning models in order to distinguish between the low-skilled and high-skilled players. We extract and figure out the key features during the game and discuss the results. I NTRODUCTION Nowadays eSports is a rapidly growing industry with more than billion players involved worldwide.

While pump-and-dump schemes have attracted the attention of cryptocurrency observers and regulators alike, this paper represents the first detailed empirical query of pump-and-dump activities in cryptocurrency markets. We present a case study of a recent pump-and-dump event, investigate 412 pump-and-dump activities organized in Telegram channels from June 17, 2018 to February 26, 2019, and discover patterns in crypto-markets associated with pump-and-dump schemes. We then build a model that predicts the pump likelihood of all coins listed in a crypto-exchange prior to a pump. The model exhibits high precision as well as robustness, and can be used to create a simple, yet very effective trading strategy, which we empirically demonstrate can generate a return as high as 60% on small retail investments within a span of two and half months. The study provides a proof of concept for strategic crypto-trading and sheds light on the application of machine learning for crime detection.

A good feature representation is a determinant factor to achieve high performance for many machine learning algorithms in terms of classification. This is especially true for techniques that do not build complex internal representations of data (e.g. decision trees, in contrast to deep neural networks). To transform the feature space, feature construction techniques build new high-level features from the original ones. Among these techniques, Genetic Programming is a good candidate to provide interpretable features required for data analysis in high energy physics. Classically, original features or higher-level features based on physics first principles are used as inputs for training. However, physicists would benefit from an automatic and interpretable feature construction for the classification of particle collision events. Our main contribution consists in combining different aspects of Genetic Programming and applying them to feature construction for experimental physics. In particular, to be applicable to physics, dimensional consistency is enforced using grammars. Results of experiments on three physics datasets show that the constructed features can bring a significant gain to the classification accuracy. To the best of our knowledge, it is the first time a method is proposed for interpretable feature construction with units of measurement, and that experts in high-energy physics validate the overall approach as well as the interpretability of the built features.

Breast cancer is the leading cause of cancer-related death among women, and it is difficult to diagnose. Nearly 1 in 10 cancers is misdiagnosed as not cancerous; on the other hand, the more mammograms a woman has, the greater the chance she will see a false positive result and face an unnecessary invasive procedure--most likely a biopsy. More accurate diagnostic techniques are emerging. But what if instead we relied on the guidance of an algorithm? Assad Oberai, Hughes Professor in the Aerospace and Mechanical Engineering Department at the USC Viterbi School of Engineering, asked this exact question in a recent paper published in ScienceDirect.

In this paper, we propose a new method to build fair Neural-Network classifiers by using a constraint based on the Wasserstein distance. More specifically, we detail how to efficiently compute the gradients of Wasserstein-2 regularizers for Neural-Networks. The proposed strategy is then used to train Neural-Networks decision rules which favor fair predictions. Our method fully takes into account two specificities of Neural-Networks training: (1) The network parameters are indirectly learned based on automatic differentiation and on the loss gradients, and (2) batch training is the gold standard to approximate the parameter gradients, as it requires a reasonable amount of computations and it can efficiently explore the parameters space. Results are shown on synthetic data, as well as on the UCI Adult Income Dataset. Our method is shown to perform well compared with 'ZafarICWWW17' and linear-regression with Wasserstein-1 regularization, as in 'JiangUAI19', in particular when non-linear decision rules are required for accurate predictions.

We are increasingly turning to machine learning systems to support human decisions. While decision makers may be subject to many forms of prejudice and bias, the promise and hope is that machines would be able to make more equitable decisions. Unfortunately, whether because they are fitted on already biased data or otherwise, there are concerns that some of these data driven recommendation systems treat members of different classes differently, perpetrating biases, providing different degrees of utilities, and inducing disparities. The examples that have emerged are quite varied: 1. Criminal justice: courts in the United States use COMP AS--a commercially available algorithm to assess a criminal defendant's likelihood of becoming a recidivist--to help them decide who should receive parole, based on records collected through the criminal justice system. In 2016 ProPublica analyzed COMP AS and "found that black defendants were far more likely than white defendants to be incorrectly judged to be at a higher risk of recidivism, while white defendants were more likely than black defendants to be incorrectly flagged as low risk" [1].

--Effective representation learning of electronic health records is a challenging task and is becoming more important as the availability of such data is becoming pervasive. The data contained in these records are irregular and contain multiple modalities such as notes, and medical codes. They are preempted by medical conditions the patient may have, and are typically recorded by medical staff. Accompanying codes are notes containing valuable information about patients beyond the structured information contained in electronic health records. We use transformer networks and the recently proposed BERT language model to embed these data streams into a unified vector representation. The presented approach effectively encodes a patient's visit data into a single distributed representation, which can be used for downstream tasks. Our model demonstrates superior performance and generalization on mortality, readmission and length of stay tasks using the publicly available MIMIC-III ICU dataset. LECTRONIC health records (EHR) are commonly adopted in hospitals to improve patient care. In an intensive care unit (ICU), various data sources are collected on a daily basis as preempted by medical staff as the patient undergoes care in the unit. The collected data consists of data from different modalities: medical codes such as diagnosis which are standardized by well-organized ontology's like the International Classification of Disease (ICD) Additionally, lab tests and bedside monitoring devices are used to collect signals each of which are collected at varying frequencies for a quantitative measure of the patient care.