In practical data analysis under noisy environment, it is common to first use robust methods to identify outliers, and then to conduct further analysis after removing the outliers. In this paper, we consider statistical inference of the model estimated after outliers are removed, which can be interpreted as a selective inference (SI) problem. To use conditional SI framework, it is necessary to characterize the events of how the robust method identifies outliers. Unfortunately, the existing methods cannot be directly used here because they are applicable to the case where the selection events can be represented by linear/quadratic constraints. In this paper, we propose a conditional SI method for popular robust regressions by using homotopy method. We show that the proposed conditional SI method is applicable to a wide class of robust regression and outlier detection methods and has good empirical performance on both synthetic data and real data experiments.

Rules embody a set of if-then statements which include one or more conditions to classify a subset of samples in a dataset. In various applications such classification rules are considered to be interpretable by the decision makers. We introduce two new algorithms for interpretability and learning. Both algorithms take advantage of linear programming, and hence, they are scalable to large data sets. The first algorithm extracts rules for interpretation of trained models that are based on tree/rule ensembles. The second algorithm generates a set of classification rules through a column generation approach. The proposed algorithms return a set of rules along with their optimal weights indicating the importance of each rule for classification. Moreover, our algorithms allow assigning cost coefficients, which could relate to different attributes of the rules, such as; rule lengths, estimator weights, number of false negatives, and so on. Thus, the decision makers can adjust these coefficients to divert the training process and obtain a set of rules that are more appealing for their needs. We have tested the performances of both algorithms on a collection of datasets and presented a case study to elaborate on optimal rule weights. Our results show that a good compromise between interpretability and accuracy can be obtained by the proposed algorithms.

As a highly data-driven application, recommender systems could be affected by data bias, resulting in unfair results for different data groups, which could be a reason that affects the system performance. Therefore, it is important to identify and solve the unfairness issues in recommendation scenarios. In this paper, we address the unfairness problem in recommender systems from the user perspective. We group users into advantaged and disadvantaged groups according to their level of activity, and conduct experiments to show that current recommender systems will behave unfairly between two groups of users. Specifically, the advantaged users (active) who only account for a small proportion in data enjoy much higher recommendation quality than those disadvantaged users (inactive). Such bias can also affect the overall performance since the disadvantaged users are the majority. To solve this problem, we provide a re-ranking approach to mitigate this unfairness problem by adding constraints over evaluation metrics. The experiments we conducted on several real-world datasets with various recommendation algorithms show that our approach can not only improve group fairness of users in recommender systems, but also achieve better overall recommendation performance.

Data poisoning is one of the most relevant security threats against machine learning and data-driven technologies. Since many applications rely on untrusted training data, an attacker can easily craft malicious samples and inject them into the training dataset to degrade the performance of machine learning models. As recent work has shown, such Denial-of-Service (DoS) data poisoning attacks are highly effective. To mitigate this threat, we propose a new approach of detecting DoS poisoned instances. In comparison to related work, we deviate from clustering and anomaly detection based approaches, which often suffer from the curse of dimensionality and arbitrary anomaly threshold selection. Rather, our defence is based on extracting information from the training data in such a generalized manner that we can identify poisoned samples based on the information present in the unpoisoned portion of the data. We evaluate our defence against two DoS poisoning attacks and seven datasets, and find that it reliably identifies poisoned instances. In comparison to related work, our defence improves false positive / false negative rates by at least 50%, often more.

Chest radiography is the most common radiographic examination performed in daily clinical practice for the detection of various heart and lung abnormalities. The large amount of data to be read and reported, with more than 100 studies per day for a single radiologist, poses a challenge in consistently maintaining high interpretation accuracy. The introduction of large-scale public datasets has led to a series of novel systems for automated abnormality classification. However, the labels of these datasets were obtained using natural language processed medical reports, yielding a large degree of label noise that can impact the performance. In this study, we propose novel training strategies that handle label noise from such suboptimal data. Prior label probabilities were measured on a subset of training data re-read by 4 board-certified radiologists and were used during training to increase the robustness of the training model to the label noise. Furthermore, we exploit the high comorbidity of abnormalities observed in chest radiography and incorporate this information to further reduce the impact of label noise. Additionally, anatomical knowledge is incorporated by training the system to predict lung and heart segmentation, as well as spatial knowledge labels. To deal with multiple datasets and images derived from various scanners that apply different post-processing techniques, we introduce a novel image normalization strategy. Experiments were performed on an extensive collection of 297,541 chest radiographs from 86,876 patients, leading to a state-of-the-art performance level for 17 abnormalities from 2 datasets. With an average AUC score of 0.880 across all abnormalities, our proposed training strategies can be used to significantly improve performance scores.

Machine learning, artificial intelligence, and other modern statistical methods are providing new opportunities to operationalise previously untapped and rapidly growing sources of data for patient benefit. Despite much promising research currently being undertaken, particularly in imaging, the literature as a whole lacks transparency, clear reporting to facilitate replicability, exploration for potential ethical concerns, and clear demonstrations of effectiveness. Among the many reasons why these problems exist, one of the most important (for which we provide a preliminary solution here) is the current lack of best practice guidance specific to machine learning and artificial intelligence. However, we believe that interdisciplinary groups pursuing research and impact projects involving machine learning and artificial intelligence for health would benefit from explicitly addressing a series of questions concerning transparency, reproducibility, ethics, and effectiveness (TREE). The 20 critical questions proposed here provide a framework for research groups to inform the design, conduct, and reporting; for editors and peer reviewers to evaluate contributions to the literature; and for patients, clinicians and policy makers to critically appraise where new findings may deliver patient benefit. Machine learning (ML), artificial intelligence (AI), and other modern statistical methods are providing new opportunities to operationalise previously untapped and rapidly growing sources of data for patient benefit. The potential uses include improving diagnostic accuracy,1 more reliably predicting prognosis,2 targeting treatments,3 and increasing the operational efficiency of health systems.4 Examples of potentially disruptive technology with early promise include image based diagnostic applications of ML/AI, which have shown the most early clinical promise (eg, deep learning based algorithms improving accuracy in diagnosing retinal pathology compared with that of specialist physicians5), or natural language processing used as a tool to extract information from structured and unstructured (that is, free) text embedded in electronic health records.2 Although we are only just …

Gravitational-wave detection strategies are based on a signal analysis technique known as matched filtering. Despite the success of matched filtering, due to its computational cost, there has been recent interest in developing deep convolutional neural networks (CNNs) for signal detection. Designing these networks remains a challenge as most procedures adopt a trial and error strategy to set the hyperparameter values. We propose a new method for hyperparameter optimization based on genetic algorithms (GAs). We compare six different GA variants and explore different choices for the GA-optimized fitness score. We show that the GA can discover high-quality architectures when the initial hyperparameter seed values are far from a good solution as well as refining already good networks. For example, when starting from the architecture proposed by George and Huerta, the network optimized over the 20-dimensional hyperparameter space has 78% fewer trainable parameters while obtaining an 11% increase in accuracy for our test problem. Using genetic algorithm optimization to refine an existing network should be especially useful if the problem context (e.g. statistical properties of the noise, signal model, etc) changes and one needs to rebuild a network. In all of our experiments, we find the GA discovers significantly less complicated networks as compared to the seed network, suggesting it can be used to prune wasteful network structures. While we have restricted our attention to CNN classifiers, our GA hyperparameter optimization strategy can be applied within other machine learning settings.

Subset selection is a valuable tool for interpretable learning, scientific discovery, and data compression. However, classical subset selection is often eschewed due to selection instability, computational bottlenecks, and lack of post-selection inference. We address these challenges from a Bayesian perspective. Given any Bayesian predictive model $\mathcal{M}$, we elicit predictively-competitive subsets using linear decision analysis. The approach is customizable for (local) prediction or classification and provides interpretable summaries of $\mathcal{M}$. A key quantity is the acceptable family of subsets, which leverages the predictive distribution from $\mathcal{M}$ to identify subsets that offer nearly-optimal prediction. The acceptable family spawns new (co-) variable importance metrics based on whether variables (co-) appear in all, some, or no acceptable subsets. Crucially, the linear coefficients for any subset inherit regularization and predictive uncertainty quantification via $\mathcal{M}$. The proposed approach exhibits excellent prediction, interval estimation, and variable selection for simulated data, including $p=400 > n$. These tools are applied to a large education dataset with highly correlated covariates, where the acceptable family is especially useful. Our analysis provides unique insights into the combination of environmental, socioeconomic, and demographic factors that predict educational outcomes, and features highly competitive prediction with remarkable stability.

Cardiovascular diseases and heart failures in particular are the main cause of non-communicable disease mortality in the world. Constant patient monitoring enables better medical treatment as it allows practitioners to react on time and provide the appropriate treatment. Telemedicine can provide constant remote monitoring so patients can stay in their homes, only requiring medical sensing equipment and network connections. A limiting factor for telemedical centers is the amount of patients that can be monitored simultaneously. We aim to increase this amount by implementing a decision support system. This paper investigates a machine learning model to estimate a risk score based on patient vital parameters that allows sorting all cases every day to help practitioners focus their limited capacities on the most severe cases. The model we propose reaches an AUCROC of 0.84, whereas the baseline rule-based model reaches an AUCROC of 0.73. Our results indicate that the usage of deep learning to improve the efficiency of telemedical centers is feasible. This way more patients could benefit from better health-care through remote monitoring.

Due to its relevance in intelligent transportation systems, anomaly detection in traffic videos has recently received much interest. It remains a difficult problem due to a variety of factors influencing the video quality of a real-time traffic feed, such as temperature, perspective, lighting conditions, and so on. Even though state-of-the-art methods perform well on the available benchmark datasets, they need a large amount of external training data as well as substantial computational resources. In this paper, we propose an efficient approach for a video anomaly detection system which is capable of running at the edge devices, e.g., on a roadside camera. The proposed approach comprises a pre-processing module that detects changes in the scene and removes the corrupted frames, a two-stage background modelling module and a two-stage object detector. Finally, a backtracking anomaly detection algorithm computes a similarity statistic and decides on the onset time of the anomaly. We also propose a sequential change detection algorithm that can quickly adapt to a new scene and detect changes in the similarity statistic. Experimental results on the Track 4 test set of the 2021 AI City Challenge show the efficacy of the proposed framework as we achieve an F1-score of 0.9157 along with 8.4027 root mean square error (RMSE) and are ranked fourth in the competition.