The lack of well-calibrated confidence estimates makes neural networks inadequate in safety-critical domains such as autonomous driving or healthcare. In these settings, having the ability to abstain from making a prediction on out-of-distribution (OOD) data can be as important as correctly classifying in-distribution data. We introduce $p$-DkNN, a novel inference procedure that takes a trained deep neural network and analyzes the similarity structures of its intermediate hidden representations to compute $p$-values associated with the end-to-end model prediction. The intuition is that statistical tests performed on latent representations can serve not only as a classifier, but also offer a statistically well-founded estimation of uncertainty. $p$-DkNN is scalable and leverages the composition of representations learned by hidden layers, which makes deep representation learning successful. Our theoretical analysis builds on Neyman-Pearson classification and connects it to recent advances in selective classification (reject option). We demonstrate advantageous trade-offs between abstaining from predicting on OOD inputs and maintaining high accuracy on in-distribution inputs. We find that $p$-DkNN forces adaptive attackers crafting adversarial examples, a form of worst-case OOD inputs, to introduce semantically meaningful changes to the inputs.

The approval success rate of drug candidates is very low with the majority of failure due to safety and efficacy. Increasingly available high dimensional information on targets, drug molecules and indications provides an opportunity for ML methods to integrate multiple data modalities and better predict clinically promising drug targets. Notably, drug targets with human genetics evidence are shown to have better odds to succeed. However, a recent tensor factorization-based approach found that additional information on targets and indications might not necessarily improve the predictive accuracy. Here we revisit this approach by integrating different types of human genetics evidence collated from publicly available sources to support each target-indication pair. We use Bayesian tensor factorization to show that models incorporating all available human genetics evidence (rare disease, gene burden, common disease) modestly improves the clinical outcome prediction over models using single line of genetics evidence. We provide additional insight into the relative predictive power of different types of human genetics evidence for predicting the success of clinical outcomes.

This paper explores the effectiveness of data-driven models to predict voltage excursion events in power systems using simple categorical labels. By treating the prediction as a categorical classification task, the workflow is characterized by a low computational and data burden. A proof-of-concept case study on a real portion of the Italian 150 kV sub-transmission network, which hosts a significant amount of wind power generation, demonstrates the general validity of the proposal and offers insight into the strengths and weaknesses of several widely utilized prediction models for this application.

Neuroimaging studies are often limited by the number of subjects and cognitive processes that can be feasibly interrogated. However, a rapidly growing number of neuroscientific studies have collectively accumulated an extensive wealth of results. Digesting this growing literature and obtaining novel insights remains to be a major challenge, since existing meta-analytic tools are constrained to keyword queries. In this paper, we present Text2Brain, an easy to use tool for synthesizing brain activation maps from open-ended text queries. Text2Brain was built on a transformer-based neural network language model and a coordinate-based meta-analysis of neuroimaging studies. Text2Brain combines a transformer-based text encoder and a 3D image generator, and was trained on variable-length text snippets and their corresponding activation maps sampled from 13,000 published studies. In our experiments, we demonstrate that Text2Brain can synthesize meaningful neural activation patterns from various free-form textual descriptions. Text2Brain is available at https://braininterpreter.com as a web-based tool for efficiently searching through the vast neuroimaging literature and generating new hypotheses.

As machine learning has made its way into more and more areas of our lives, concerns about algorithmic bias have escalated. Machine learning models, which today facilitate decisions about everything from hiring and lending to medical diagnosis and criminal sentencing, may appear to be data-driven and impartial, at least to naïve users--but the typically opaque models are only as good the data they are trained on, and only as ethical as the value judgments embedded in the algorithms. The burgeoning field of algorithmic fairness, part of the much broader field of responsible computing, is aiming to remedy the situation. For several years now, along with philosophers, legal scholars, and experts in other fields, computer scientists have been tackling the issue. As Stanford University computer science professor Omer Reingold likes to put it, "We are part of the problem, and we should be part of the solution."

AI can be found throughout clinics and hospitals working alongside doctors, nurses, and specialists. Automated systems help flag risk factors, identify likely conditions, and assist medical professionals with other vital forms of diagnoses and treatment. Here are some common questions I get about AI in the medical field. Machine learning and deep learning can help on multiple fronts. If we talk about computer vision, a type of AI that processes images, there are already many applications. In medical departments such as radiology, ophthalmology, and neurology, doctors perform diagnoses based on MRI scans, CT scans, X-Rays, photographic images of tissue samples, and sometimes drawings of patients.

Whenever we come across such articles, we instinctively feel that something doesn't feel right. There are so many posts out there that it is nearly impossible to sort out the right from the wrong. Fake news can be claimed in two ways: First, an argument against the facts. The former can only be accomplished with automated query systems and substantial searches into the internet. The latter is possible through a natural language processing pipeline followed by a machine learning pipeline.

Fake news detection has become a major task to solve as there has been an increasing number of fake news on the internet in recent years. Although many classification models have been proposed based on statistical learning methods showing good results, reasoning behind the classification performances may not be enough. In the self-supervised learning studies, it has been highlighted that a quality of representation (embedding) space matters and directly affects a downstream task performance. In this study, a quality of the representation space is analyzed visually and analytically in terms of linear separability for different classes on a real and fake news dataset. To further add interpretability to a classification model, a modification of Class Activation Mapping (CAM) is proposed. The modified CAM provides a CAM score for each word token, where the CAM score on a word token denotes a level of focus on that word token to make the prediction. Finally, it is shown that the naive BERT model topped with a learnable linear layer is enough to achieve robust performance while being compatible with CAM.

Training and testing supervised object detection models require a large collection of images with ground truth labels. Labels define object classes in the image, as well as their locations, shape, and possibly other information such as pose. The labeling process has proven extremely time consuming, even with the presence of manpower. We introduce a novel labeling tool for 2D images as well as 3D triangular meshes: 3D Labeling Tool (3DLT). This is a standalone, feature-heavy and cross-platform software that does not require installation and can run on Windows, macOS and Linux-based distributions. Instead of labeling the same object on every image separately like current tools, we use depth information to reconstruct a triangular mesh from said images and label the object only once on the aforementioned mesh. We use registration to simplify 3D labeling, outlier detection to improve 2D bounding box calculation and surface reconstruction to expand labeling possibility to large point clouds. Our tool is tested against state of the art methods and it greatly surpasses them in terms of speed while preserving accuracy and ease of use.

Gravitational wave astronomy is a vibrant field that leverages both classic and modern data processing techniques for the understanding of the universe. Various approaches have been proposed for improving the efficiency of the detection scheme, with hierarchical matched filtering being an important strategy. Meanwhile, deep learning methods have recently demonstrated both consistency with matched filtering methods and remarkable statistical performance. In this work, we propose Hierarchical Detection Network (HDN), a novel approach to efficient detection that combines ideas from hierarchical matching and deep learning. The network is trained using a novel loss function, which encodes simultaneously the goals of statistical accuracy and efficiency. We discuss the source of complexity reduction of the proposed model, and describe a general recipe for initialization with each layer specializing in different regions. We demonstrate the performance of HDN with experiments using open LIGO data and synthetic injections, and observe with two-layer models a $79\%$ efficiency gain compared with matched filtering at an equal error rate of $0.2\%$. Furthermore, we show how training a three-layer HDN initialized using two-layer model can further boost both accuracy and efficiency, highlighting the power of multiple simple layers in efficient detection.