Machine learning methods to aid defence systems in detecting malicious activity typically rely on labelled data. In some domains, such labelled data is unavailable or incomplete. In practice this can lead to low detection rates and high false positive rates, which characterise for example anti-money laundering systems. In fact, it is estimated that 1.7--4 trillion euros are laundered annually and go undetected. We propose The GANfather, a method to generate samples with properties of malicious activity, without label requirements. We propose to reward the generation of malicious samples by introducing an extra objective to the typical Generative Adversarial Networks (GANs) loss. Ultimately, our goal is to enhance the detection of illicit activity using the discriminator network as a novel and robust defence system. Optionally, we may encourage the generator to bypass pre-existing detection systems. This setup then reveals defensive weaknesses for the discriminator to correct. We evaluate our method in two real-world use cases, money laundering and recommendation systems. In the former, our method moves cumulative amounts close to 350 thousand dollars through a network of accounts without being detected by an existing system. In the latter, we recommend the target item to a broad user base with as few as 30 synthetic attackers. In both cases, we train a new defence system to capture the synthetic attacks.

Discovering causal relationships in complex socio-behavioral systems is challenging but essential for informed decision-making. We present Upload, PREprocess, Visualize, and Evaluate (UPREVE), a user-friendly web-based graphical user interface (GUI) designed to simplify the process of causal discovery. UPREVE allows users to run multiple algorithms simultaneously, visualize causal relationships, and evaluate the accuracy of learned causal graphs. With its accessible interface and customizable features, UPREVE empowers researchers and practitioners in social computing and behavioral-cultural modeling (among others) to explore and understand causal relationships effectively. Our proposed solution aims to make causal discovery more accessible and user-friendly, enabling users to gain valuable insights for better decision-making.

The development of Machine Learning is experiencing growing interest from the general public, and in recent years there have been numerous press articles questioning its objectivity: racism, sexism, \dots Driven by the growing attention of regulators on the ethical use of data in insurance, the actuarial community must rethink pricing and risk selection practices for fairer insurance. Equity is a philosophy concept that has many different definitions in every jurisdiction that influence each other without currently reaching consensus. In Europe, the Charter of Fundamental Rights defines guidelines on discrimination, and the use of sensitive personal data in algorithms is regulated. If the simple removal of the protected variables prevents any so-called `direct' discrimination, models are still able to `indirectly' discriminate between individuals thanks to latent interactions between variables, which bring better performance (and therefore a better quantification of risk, segmentation of prices, and so on). After introducing the key concepts related to discrimination, we illustrate the complexity of quantifying them. We then propose an innovative method, not yet met in the literature, to reduce the risks of indirect discrimination thanks to mathematical concepts of linear algebra. This technique is illustrated in a concrete case of risk selection in life insurance, demonstrating its simplicity of use and its promising performance.

Learning enabled components (LECs), while critical for decision making in autonomous vehicles (AVs), are likely to make incorrect decisions when presented with samples outside of their training distributions. Out-of-distribution (OOD) detectors have been proposed to detect such samples, thereby acting as a safety monitor, however, both OOD detectors and LECs require heavy utilization of embedded hardware typically found in AVs. For both components, there is a tradeoff between non-functional and functional performance, and both impact a vehicle's safety. For instance, giving an OOD detector a longer response time can increase its accuracy at the expense of the LEC. We consider an LEC with binary output like an autonomous emergency braking system (AEBS) and use risk, the combination of severity and occurrence of a failure, to model the effect of both components' design parameters on each other's functional and non-functional performance, as well as their impact on system safety. We formulate a co-design methodology that uses this risk model to find the design parameters for an OOD detector and LEC that decrease risk below that of the baseline system and demonstrate it on a vision based AEBS. Using our methodology, we achieve a 42.3% risk reduction while maintaining equivalent resource utilization.

This thesis work falls within the framework of question answering (QA) in the biomedical domain where several specific challenges are addressed, such as specialized lexicons and terminologies, the types of treated questions, and the characteristics of targeted documents. We are particularly interested in studying and improving methods that aim at finding accurate and short answers to biomedical natural language questions from a large scale of biomedical textual documents in English. QA aims at providing inquirers with direct, short and precise answers to their natural language questions. In this Ph.D. thesis, we propose four contributions to improve the performance of QA in the biomedical domain. In our first contribution, we propose a machine learning-based method for question type classification to determine the types of given questions which enable to a biomedical QA system to use the appropriate answer extraction method. We also propose an another machine learning-based method to assign one or more topics (e.g., pharmacological, test, treatment, etc.) to given questions in order to determine the semantic types of the expected answers which are very useful in generating specific answer retrieval strategies. In the second contribution, we first propose a document retrieval method to retrieve a set of relevant documents that are likely to contain the answers to biomedical questions from the MEDLINE database. We then present a passage retrieval method to retrieve a set of relevant passages to questions. In the third contribution, we propose specific answer extraction methods to generate both exact and ideal answers. Finally, in the fourth contribution, we develop a fully automated semantic biomedical QA system called SemBioNLQA which is able to deal with a variety of natural language questions and to generate appropriate answers by providing both exact and ideal answers.

Semi-supervised anomaly detection methods leverage a few anomaly examples to yield drastically improved performance compared to unsupervised models. However, they still suffer from two limitations: 1) unlabeled anomalies (i.e., anomaly contamination) may mislead the learning process when all the unlabeled data are employed as inliers for model training; 2) only discrete supervision information (such as binary or ordinal data labels) is exploited, which leads to suboptimal learning of anomaly scores that essentially take on a continuous distribution. Therefore, this paper proposes a novel semi-supervised anomaly detection method, which devises \textit{contamination-resilient continuous supervisory signals}. Specifically, we propose a mass interpolation method to diffuse the abnormality of labeled anomalies, thereby creating new data samples labeled with continuous abnormal degrees. Meanwhile, the contaminated area can be covered by new data samples generated via combinations of data with correct labels. A feature learning-based objective is added to serve as an optimization constraint to regularize the network and further enhance the robustness w.r.t. anomaly contamination. Extensive experiments on 11 real-world datasets show that our approach significantly outperforms state-of-the-art competitors by 20%-30% in AUC-PR and obtains more robust and superior performance in settings with different anomaly contamination levels and varying numbers of labeled anomalies. The source code is available at https://github.com/xuhongzuo/rosas/.

The accelerated adoption of digital pathology and advances in deep learning have enabled the development of powerful models for various pathology tasks across a diverse array of diseases and patient cohorts. However, model training is often difficult due to label scarcity in the medical domain and the model's usage is limited by the specific task and disease for which it is trained. Additionally, most models in histopathology leverage only image data, a stark contrast to how humans teach each other and reason about histopathologic entities. We introduce CONtrastive learning from Captions for Histopathology (CONCH), a visual-language foundation model developed using diverse sources of histopathology images, biomedical text, and notably over 1.17 million image-caption pairs via task-agnostic pretraining. Evaluated on a suite of 13 diverse benchmarks, CONCH can be transferred to a wide range of downstream tasks involving either or both histopathology images and text, achieving state-of-the-art performance on histology image classification, segmentation, captioning, text-to-image and image-to-text retrieval. CONCH represents a substantial leap over concurrent visual-language pretrained systems for histopathology, with the potential to directly facilitate a wide array of machine learning-based workflows requiring minimal or no further supervised fine-tuning.

Most existing works on fairness assume the model has full access to demographic information. However, there exist scenarios where demographic information is partially available because a record was not maintained throughout data collection or due to privacy reasons. This setting is known as demographic scarce regime. Prior research have shown that training an attribute classifier to replace the missing sensitive attributes (proxy) can still improve fairness. However, the use of proxy-sensitive attributes worsens fairness-accuracy trade-offs compared to true sensitive attributes. To address this limitation, we propose a framework to build attribute classifiers that achieve better fairness-accuracy trade-offs. Our method introduces uncertainty awareness in the attribute classifier and enforces fairness on samples with demographic information inferred with the lowest uncertainty. We show empirically that enforcing fairness constraints on samples with uncertain sensitive attributes is detrimental to fairness and accuracy. Our experiments on two datasets showed that the proposed framework yields models with significantly better fairness-accuracy trade-offs compared to classic attribute classifiers. Surprisingly, our framework outperforms models trained with constraints on the true sensitive attributes.

Federated learning (FL) was originally regarded as a framework for collaborative learning among clients with data privacy protection through a coordinating server. In this paper, we propose a new active membership inference (AMI) attack carried out by a dishonest server in FL. In AMI attacks, the server crafts and embeds malicious parameters into global models to effectively infer whether a target data sample is included in a client's private training data or not. By exploiting the correlation among data features through a non-linear decision boundary, AMI attacks with a certified guarantee of success can achieve severely high success rates under rigorous local differential privacy (LDP) protection; thereby exposing clients' training data to significant privacy risk. Theoretical and experimental results on several benchmark datasets show that adding sufficient privacy-preserving noise to prevent our attack would significantly damage FL's model utility.

Context: Analyzing digital pathology images is necessary to draw diagnostic conclusions by investigating tissue patterns and cellular morphology. However, manual evaluation can be time-consuming, expensive, and prone to inter- and intra-observer variability. Objective: To assist pathologists using computerized solutions, automated tissue structure detection and segmentation must be proposed. Furthermore, generating pixel-level object annotations for histopathology images is expensive and time-consuming. As a result, detection models with bounding box labels may be a feasible solution. Design: This paper studies. YOLO-v4 (You-Only-Look-Once), a real-time object detector for microscopic images. YOLO uses a single neural network to predict several bounding boxes and class probabilities for objects of interest. YOLO can enhance detection performance by training on whole slide images. YOLO-v4 has been used in this paper. for glomeruli detection in human kidney images. Multiple experiments have been designed and conducted based on different training data of two public datasets and a private dataset from the University of Michigan for fine-tuning the model. The model was tested on the private dataset from the University of Michigan, serving as an external validation of two different stains, namely hematoxylin and eosin (H&E) and periodic acid-Schiff (PAS). Results: Average specificity and sensitivity for all experiments, and comparison of existing segmentation methods on the same datasets are discussed. Conclusions: Automated glomeruli detection in human kidney images is possible using modern AI models. The design and validation for different stains still depends on variability of public multi-stain datasets.