Alzheimer's disease and related dementias (ADRD) ranks as the sixth leading cause of death in the US, underlining the importance of accurate ADRD risk prediction. While recent advancement in ADRD risk prediction have primarily relied on imaging analysis, yet not all patients undergo medical imaging before an ADRD diagnosis. Merging machine learning with claims data can reveal additional risk factors and uncover interconnections among diverse medical codes. Our goal is to utilize Graph Neural Networks (GNNs) with claims data for ADRD risk prediction. Addressing the lack of human-interpretable reasons behind these predictions, we introduce an innovative method to evaluate relationship importance and its influence on ADRD risk prediction, ensuring comprehensive interpretation. We employed Variationally Regularized Encoder-decoder Graph Neural Network (VGNN) for estimating ADRD likelihood. We created three scenarios to assess the model's efficiency, using Random Forest and Light Gradient Boost Machine as baselines. We further used our relation importance method to clarify the key relationships for ADRD risk prediction. VGNN surpassed other baseline models by 10% in the area under the receiver operating characteristic. The integration of the GNN model and relation importance interpretation could potentially play an essential role in providing valuable insight into factors that may contribute to or delay ADRD progression. Employing a GNN approach with claims data enhances ADRD risk prediction and provides insights into the impact of interconnected medical code relationships. This methodology not only enables ADRD risk modeling but also shows potential for other image analysis predictions using claims data.

Privacy policies serve as the primary conduit through which online service providers inform users about their data collection and usage procedures. However, in a bid to be comprehensive and mitigate legal risks, these policy documents are often quite verbose. In practical use, users tend to click the Agree button directly rather than reading them carefully. This practice exposes users to risks of privacy leakage and legal issues. Recently, the advent of Large Language Models (LLM) such as ChatGPT and GPT-4 has opened new possibilities for text analysis, especially for lengthy documents like privacy policies. In this study, we investigate a privacy policy text analysis framework PolicyGPT based on the LLM. This framework was tested using two datasets. The first dataset comprises of privacy policies from 115 websites, which were meticulously annotated by legal experts, categorizing each segment into one of 10 classes. The second dataset consists of privacy policies from 304 popular mobile applications, with each sentence manually annotated and classified into one of another 10 categories. Under zero-shot learning conditions, PolicyGPT demonstrated robust performance. For the first dataset, it achieved an accuracy rate of 97%, while for the second dataset, it attained an 87% accuracy rate, surpassing that of the baseline machine learning and neural network models.

Two prevalent types of distributional shifts in machine learning are the covariate shift (as observed across different domains) and the semantic shift (as seen across different classes). Traditional OOD detection techniques typically address only one of these shifts. However, real-world testing environments often present a combination of both covariate and semantic shifts. In this study, we introduce a novel problem, semantic OOD detection across domains, which simultaneously addresses both distributional shifts. To this end, we introduce two regularization strategies: domain generalization regularization, which ensures semantic invariance across domains to counteract the covariate shift, and OOD detection regularization, designed to enhance OOD detection capabilities against the semantic shift through energy bounding. Through rigorous testing on three standard domain generalization benchmarks, our proposed framework showcases its superiority over conventional domain generalization approaches in terms of OOD detection performance. Moreover, it holds its ground by maintaining comparable InD classification accuracy.

High-quality human transcription is essential for training and improving Automatic Speech Recognition (ASR) models. Recent study~\cite{libricrowd} has found that every 1% worse transcription Word Error Rate (WER) increases approximately 2% ASR WER by using the transcriptions to train ASR models. Transcription errors are inevitable for even highly-trained annotators. However, few studies have explored human transcription correction. Error correction methods for other problems, such as ASR error correction and grammatical error correction, do not perform sufficiently for this problem. Therefore, we propose HTEC for Human Transcription Error Correction. HTEC consists of two stages: Trans-Checker, an error detection model that predicts and masks erroneous words, and Trans-Filler, a sequence-to-sequence generative model that fills masked positions. We propose a holistic list of correction operations, including four novel operations handling deletion errors. We further propose a variant of embeddings that incorporates phoneme information into the input of the transformer. HTEC outperforms other methods by a large margin and surpasses human annotators by 2.2% to 4.5% in WER. Finally, we deployed HTEC to assist human annotators and showed HTEC is particularly effective as a co-pilot, which improves transcription quality by 15.1% without sacrificing transcription velocity.

Data augmentation is a common practice to help generalization in the procedure of deep model training. In the context of physiological time series classification, previous research has primarily focused on label-invariant data augmentation methods. However, another class of augmentation techniques (\textit{i.e., Mixup}) that emerged in the computer vision field has yet to be fully explored in the time series domain. In this study, we systematically review the mix-based augmentations, including mixup, cutmix, and manifold mixup, on six physiological datasets, evaluating their performance across different sensory data and classification tasks. Our results demonstrate that the three mix-based augmentations can consistently improve the performance on the six datasets. More importantly, the improvement does not rely on expert knowledge or extensive parameter tuning. Lastly, we provide an overview of the unique properties of the mix-based augmentation methods and highlight the potential benefits of using the mix-based augmentation in physiological time series data.

Current deep learning-based solutions for image analysis tasks are commonly incapable of handling problems to which multiple different plausible solutions exist. In response, posterior-based methods such as conditional Diffusion Models and Invertible Neural Networks have emerged; however, their translation is hampered by a lack of research on adequate validation. In other words, the way progress is measured often does not reflect the needs of the driving practical application. Closing this gap in the literature, we present the first systematic framework for the application-driven validation of posterior-based methods in inverse problems. As a methodological novelty, it adopts key principles from the field of object detection validation, which has a long history of addressing the question of how to locate and match multiple object instances in an image. Treating modes as instances enables us to perform mode-centric validation, using well-interpretable metrics from the application perspective. We demonstrate the value of our framework through instantiations for a synthetic toy example and two medical vision use cases: pose estimation in surgery and imaging-based quantification of functional tissue parameters for diagnostics. Our framework offers key advantages over common approaches to posterior validation in all three examples and could thus revolutionize performance assessment in inverse problems.

In the current ML field models are getting larger and more complex, and data used for model training are also getting larger in quantity and higher in dimensions. Therefore, in order to train better models, and save training time and computational resources, a good Feature Selection (FS) method in the preprocessing stage is necessary. Feature importance (FI) is of great importance since it is the basis of feature selection. Therefore, this paper creatively introduces the calculation of PN (the probability of Necessity), PN (the probability of Sufficiency), and PNS (the probability of Necessity and Sufficiency) of Causality into quantifying feature importance and creates 3 new FI measuring methods---- PN-FI, which means how much importance a feature has in image recognition tasks, PS-FI that means how much importance a feature has in image generating tasks, and PNS-FI which measures both. The main body of this paper is three RCTs, with whose results we show how PS-FI, PN-FI, and PNS-FI of 3 features----dog nose, dog eyes, and dog mouth are calculated. The experiments show that firstly, FI values are intervals with tight upper and lower bounds. Secondly, the feature dog eyes has the most importance while the other two have almost the same. Thirdly, the bounds of PNS and PN are tighter than that of PS's.

Several artificial neural networks (ANNs) have been developed recently to predict the prognosis of different types of cancer based on the tumor transcriptome. However, they have not demonstrated significantly better performance than the regularized Cox proportional hazards regression model. Training an ANN is challenging with a limited number of data samples and a high-dimensional feature space. Recent advancements in image classification have shown that contrastive learning (CL) can facilitate further learning tasks by learning good feature representation from a limited number of data samples. In this paper, we applied supervised CL to tumor gene expression and clinical data to learn feature representations in a low-dimensional space. We then used these learned features to train a Cox model for predicting cancer prognosis. Using data from The Cancer Genome Atlas (TCGA), we demonstrated that our CL-based Cox model (CLCox) significantly outperformed existing methods in predicting the prognosis of 19 types of cancer considered. We also developed CL-based classifiers to classify tumors into different risk groups and showed that CL can significantly improve classification accuracy. Specifically, our CL-based classifiers achieved an area under the receiver operating characteristic curve (AUC) of greater than 0.8 for 14 types of cancer and and an AUC of greater than 0.9 for 2 types of cancer. CLCox models and CL-based classifiers trained with TCGA lung cancer and prostate cancer data were validated with the data of two independent cohorts.

Early warning systems (EWS) are predictive tools at the center of recent efforts to improve graduation rates in public schools across the United States. These systems assist in targeting interventions to individual students by predicting which students are at risk of dropping out. Despite significant investments in their widespread adoption, there remain large gaps in our understanding of the efficacy of EWS, and the role of statistical risk scores in education. In this work, we draw on nearly a decade's worth of data from a system used throughout Wisconsin to provide the first large-scale evaluation of the long-term impact of EWS on graduation outcomes. We present empirical evidence that the prediction system accurately sorts students by their dropout risk. We also find that it may have caused a single-digit percentage increase in graduation rates, though our empirical analyses cannot reliably rule out that there has been no positive treatment effect. Going beyond a retrospective evaluation of DEWS, we draw attention to a central question at the heart of the use of EWS: Are individual risk scores necessary for effectively targeting interventions? We propose a simple mechanism that only uses information about students' environments -- such as their schools, and districts -- and argue that this mechanism can target interventions just as efficiently as the individual risk score-based mechanism. Our argument holds even if individual predictions are highly accurate and effective interventions exist. In addition to motivating this simple targeting mechanism, our work provides a novel empirical backbone for the robust qualitative understanding among education researchers that dropout is structurally determined. Combined, our insights call into question the marginal value of individual predictions in settings where outcomes are driven by high levels of inequality.

We studied the capability of automated machine translation in the online video education space by automatically translating Khan Academy videos with state-of-the-art translation models and applying text-to-speech synthesis and audio/video synchronization to build engaging videos in target languages. We also analyzed and established two reliable translation confidence estimators based on round-trip translations in order to efficiently manage translation quality and reduce human translation effort. Finally, we developed a deployable system to deliver translated videos to end users and collect user corrections for iterative improvement.