Foundation vision encoders such as CLIP and DINOv2, trained on web-scale data, exhibit strong transfer performance across tasks and datasets. However, medical imaging foundation models remain constrained by smaller datasets, limiting our understanding of how data scale and pretraining paradigms affect performance in this setting. In this work, we systematically study continual pretraining of two vision encoders, MedImageInsight (MI2) and RAD-DINO representing the two major encoder paradigms CLIP and DINOv2, on up to 3.5M chest x-rays from a single institution, holding compute and evaluation protocols constant. We evaluate on classification (radiology findings, lines and tubes), segmentation (lines and tubes), and radiology report generation. While prior work has primarily focused on tasks related to radiology findings, we include lines and tubes tasks to counterbalance this bias and evaluate a model's ability to extract features that preserve continuity along elongated structures. Our experiments show that MI2 scales more effectively for finding-related tasks, while RAD-DINO is stronger on tube-related tasks. Surprisingly, continually pretraining MI2 with both reports and structured labels using UniCL improves performance, underscoring the value of structured supervision at scale. We further show that for some tasks, as few as 30k in-domain samples are sufficient to surpass open-weights foundation models. These results highlight the utility of center-specific continual pretraining, enabling medical institutions to derive significant performance gains by utilizing in-domain data.

There are many bottlenecks that decrease the flexibility of automotive systems, making their long-term maintenance, as well as updates and extensions in later lifecycle phases increasingly difficult, mainly due to long re-engineering, standardization, and compliance procedures, as well as heterogeneity and numerosity of devices and underlying software components involved. In this paper, we explore the potential of Large Language Models (LLMs) when it comes to the automation of tasks and processes that aim to increase the flexibility of automotive systems. Three case studies towards achieving this goal are considered as outcomes of early-stage research: 1) updates, hardware abstraction, and compliance, 2) interface compatibility checking, and 3) architecture modification suggestions. For proof-of-concept implementation, we rely on OpenAI's GPT-4o model.

Contrast-enhanced computed tomography (CECT) is the primary imaging technique that provides valuable spatial-temporal information about lesions, enabling the accurate diagnosis and subclassification of pancreatic tumors. However, the high heterogeneity and variability of pancreatic tumors still pose substantial challenges for precise subtyping diagnosis. Previous methods fail to effectively explore the contextual information across multiple CECT phases commonly used in radiologists' diagnostic workflows, thereby limiting their performance. In this paper, we introduce, for the first time, an automatic way to combine the multi-phase CECT data to discriminate between pancreatic tumor subtypes, among which the key is using Mamba with promising learnability and simplicity to encourage both temporal and spatial modeling from multi-phase CECT. Specifically, we propose a dual hierarchical contrast-enhanced-aware Mamba module incorporating two novel spatial and temporal sampling sequences to explore intra and inter-phase contrast variations of lesions. A similarity-guided refinement module is also imposed into the temporal scanning modeling to emphasize the learning on local tumor regions with more obvious temporal variations. Moreover, we design the space complementary integrator and multi-granularity fusion module to encode and aggregate the semantics across different scales, achieving more efficient learning for subtyping pancreatic tumors. The experimental results on an in-house dataset of 270 clinical cases achieve an accuracy of 97.4% and an AUC of 98.6% in distinguishing between pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine tumors (PNETs), demonstrating its potential as a more accurate and efficient tool.

Reliable uncertainty quantification (UQ) is essential in medical AI. Evidential Deep Learning (EDL) offers a computationally efficient way to quantify model uncertainty alongside predictions, unlike traditional methods such as Monte Carlo (MC) Dropout and Deep Ensembles (DE). However, all these methods often rely on a single expert's annotations as ground truth for model training, overlooking the inter-rater variability in healthcare. To address this issue, we propose MEGAN, a Multi-Expert Gating Network that aggregates uncertainty estimates and predictions from multiple AI experts via EDL models trained with diverse ground truths and modeling strategies. MEGAN's gating network optimally combines predictions and uncertainties from each EDL model, enhancing overall prediction confidence and calibration. We extensively benchmark MEGAN on endoscopy videos for Ulcerative colitis (UC) disease severity estimation, assessed by visual labeling of Mayo Endoscopic Subscore (MES), where inter-rater variability is prevalent. In large-scale prospective UC clinical trial, MEGAN achieved a 3.5% improvement in F1-score and a 30.5% reduction in Expected Calibration Error (ECE) compared to existing methods.

Retrieval-Augmented Generation (RAG) has emerged as a promising approach to address key limitations of Large Language Models (LLMs), such as hallucination, outdated knowledge, and lacking reference. However, current RAG frameworks often struggle with identifying whether retrieved documents meaningfully contribute to answer generation. This shortcoming makes it difficult to filter out irrelevant or even misleading content, which notably impacts the final performance. In this paper, we propose Document Information Gain (DIG), a novel metric designed to quantify the contribution of retrieved documents to correct answer generation. DIG measures a document's value by computing the difference of LLM's generation confidence with and without the document augmented. Further, we introduce InfoGain-RAG, a framework that leverages DIG scores to train a specialized reranker, which prioritizes each retrieved document from exact distinguishing and accurate sorting perspectives. This approach can effectively filter out irrelevant documents and select the most valuable ones for better answer generation. Extensive experiments across various models and benchmarks demonstrate that InfoGain-RAG can significantly outperform existing approaches, on both single and multiple retrievers paradigm. Specifically on NaturalQA, it achieves the improvements of 17.9%, 4.5%, 12.5% in exact match accuracy against naive RAG, self-reflective RAG and modern ranking-based RAG respectively, and even an average of 15.3% increment on advanced proprietary model GPT-4o across all datasets. These results demonstrate the feasibility of InfoGain-RAG as it can offer a reliable solution for RAG in multiple applications.

We propose a new, training-free method, Graph Reasoning via Retrieval Augmented Framework (GRRAF), that harnesses retrieval-augmented generation (RAG) alongside the code-generation capabilities of large language models (LLMs) to address a wide range of graph reasoning tasks. In GRRAF, the target graph is stored in a graph database, and the LLM is prompted to generate executable code queries that retrieve the necessary information. This approach circumvents the limitations of existing methods that require extensive finetuning or depend on predefined algorithms, and it incorporates an error feedback loop with a time-out mechanism to ensure both correctness and efficiency. Experimental evaluations on the GraphInstruct dataset reveal that GRRAF achieves 100% accuracy on most graph reasoning tasks, including cycle detection, bipartite graph checks, shortest path computation, and maximum flow, while maintaining consistent token costs regardless of graph sizes. Imperfect but still very high performance is observed on subgraph matching. Notably, GRRAF scales effectively to large graphs with up to 10,000 nodes.

Deep Generative and Discriminative Digital Twin endowed with Variational Autoencoder for Unsupervised Predictive Thermal Condition Monitoring of Physical Robots in Industry 6.0 and Society 6.0 Department of Computer Science & Engineering, Frankfurt University of Applied Sciences, Frankfurt a.M., Germany (e-mail: kaigom@fra-uas.de).Abstract: Robots are unrelentingly used to achieve operational efficiency in Industry 4.0 along with symbiotic and sustainable assistance for the work-force in Industry 5.0. As resilience, robustness, and well-being are required in anti-fragile manufacturing and human-centric societal tasks, an autonomous anticipation and adaption to thermal saturation and burns due to motors overheating become instrumental for human safety and robot availability. Robots are thereby expected to self-sustain their performance and deliver user experience, in addition to communicating their capability to other agents in advance to ensure fully automated thermally feasible tasks, and prolong their lifetime without human intervention. However, the traditional robot shutdown, when facing an imminent thermal saturation, inhibits productivity in factories and comfort in the society, while cooling strategies are hard to implement after the robot acquisition. In this work, smart digital twins endowed with generative AI, i.e., variational autoencoders, are leveraged to manage thermally anomalous and generate uncritical robot states.

In this work, deep neural networks made up of multiple hidden Long Short-Term Memory (LSTM) and Feedforward layers are trained to predict the thermal behavior of the joint motors of robot manipulators. A model-free and scalable approach is adopted. It accommodates complexity and uncertainty challenges stemming from the derivation, identification, and validation of a large number of parameters of an approximation model that is hardly available. To this end, sensed joint torques are collected and processed to foresee the thermal behavior of joint motors. Promising prediction results of the machine learning based capture of the temperature dynamics of joint motors of a redundant robot with seven joints are presented.

Despite significant medical advancements, cancer remains the second leading cause of death, with over 600,000 deaths per year in the US. One emerging field, pathway analysis, is promising but still relies on manually derived wet lab data, which is time-consuming to acquire. This work proposes an efficient, effective end-to-end framework for Artificial Intelligence (AI) based pathway analysis that predicts both cancer severity and mutation progression, thus recommending possible treatments. The proposed technique involves a novel combination of time-series machine learning models and pathway analysis. First, mutation sequences were isolated from The Cancer Genome Atlas (TCGA) Database. Then, a novel preprocessing algorithm was used to filter key mutations by mutation frequency. This data was fed into a Recurrent Neural Network (RNN) that predicted cancer severity. Then, the model probabilistically used the RNN predictions, information from the preprocessing algorithm, and multiple drug-target databases to predict future mutations and recommend possible treatments. This framework achieved robust results and Receiver Operating Characteristic (ROC) curves (a key statistical metric) with accuracies greater than 60%, similar to existing cancer diagnostics. In addition, preprocessing played an instrumental role in isolating important mutations, demonstrating that each cancer stage studied may contain on the order of a few-hundred key driver mutations, consistent with current research. Heatmaps based on predicted gene frequency were also generated, highlighting key mutations in each cancer. Overall, this work is the first to propose an efficient, cost-effective end-to-end framework for projecting cancer progression and providing possible treatments without relying on expensive, time-consuming wet lab work.

Despite their superb capabilities, Vision-Language Models (VLMs) have been shown to be vulnerable to jailbreak attacks. While recent jailbreaks have achieved notable progress, their effectiveness and efficiency can still be improved. In this work, we reveal an interesting phenomenon: incorporating weak defense into the attack pipeline can significantly enhance both the effectiveness and the efficiency of jailbreaks on VLMs. Building on this insight, we propose Defense2Attack, a novel jailbreak method that bypasses the safety guardrails of VLMs by leveraging defensive patterns to guide jailbreak prompt design. Specifically, Defense2Attack consists of three key components: (1) a visual optimizer that embeds universal adversarial perturbations with affirmative and encouraging semantics; (2) a textual optimizer that refines the input using a defense-styled prompt; and (3) a red-team suffix generator that enhances the jailbreak through reinforcement fine-tuning. We empirically evaluate our method on four VLMs and four safety benchmarks. The results demonstrate that Defense2Attack achieves superior jailbreak performance in a single attempt, outperforming state-of-the-art attack methods that often require multiple tries. Our work offers a new perspective on jailbreaking VLMs.