Options and structured products, as pivotal financial derivatives, provide contract holders with specific payoff structures based on the performance of underlying assets at predetermined times and conditions. They serve as effective tools for investment institutions to manage risk, hedge exposures, and optimize investment portfolios. With the continuous development of financial markets and the diversification of investor demands, financial institutions have invented a wide variety of exotic options based on the principles and experience of standard options. Exotic options can be further categorized according to their complexity: relatively simple exotic options such as Asian options, barrier options, lookback options, and ratchet options primarily add a single feature to standard options; while highly complex structured products like snowball products, phoenix notes, shark fin options, and cumulative products feature multiple path-dependent conditions and intricate payoff structures. These innovative financial instruments not only broaden investor choices but also provide powerful tools for more refined and personalized risk management and investment strategies[1]. Precisely because exotic options and structured products exhibit high levels of diversity, customization, and structural complexity, accurate pricing remains a core challenge for all market participants.

Fontan palliation for univentricular congenital heart disease progresses to hemodynamic failure with complex flow patterns poorly characterized by conventional 2D imaging. Current assessment relies on fluoroscopic angiography, providing limited 3D geometric information essential for computational fluid dynamics (CFD) analysis and surgical planning. A multi-step AI pipeline was developed utilizing Google's Gemini 2.5 Flash (2.5B parameters) for systematic, iterative processing of fluoroscopic angiograms through transformer-based neural architecture. The pipeline encompasses medical image preprocessing, vascular segmentation, contrast enhancement, artifact removal, and virtual hemodynamic flow visualization within 2D projections. Final views were processed through Tencent's Hunyuan3D-2mini (384M parameters) for stereolithography file generation. The pipeline successfully generated geometrically optimized 2D projections from single-view angiograms after 16 processing steps using a custom web interface. Initial iterations contained hallucinated vascular features requiring iterative refinement to achieve anatomically faithful representations. Final projections demonstrated accurate preservation of complex Fontan geometry with enhanced contrast suitable for 3D conversion. AI-generated virtual flow visualization identified stagnation zones in central connections and flow patterns in branch arteries. Complete processing required under 15 minutes with second-level API response times. This approach demonstrates clinical feasibility of generating CFD-suitable geometries from routine angiographic data, enabling 3D generation and rapid virtual flow visualization for cursory insights prior to full CFD simulation. While requiring refinement cycles for accuracy, this establishes foundation for democratizing advanced geometric and hemodynamic analysis using readily available imaging data.

Thermal energy storage (TES) is an effective method for load shifting and demand response in buildings. Optimal TES control and management are essential to improve the performance of the cooling system. Most existing TES systems operate on a fixed schedule, which cannot take full advantage of its load shifting capability, and requires extensive investigation and optimization. This study proposed a novel integrated load prediction and optimized control approach for ice-based TES in commercial buildings. A cooling load prediction model was developed and a mid-day modification mechanism was introduced into the prediction model to improve the accuracy. Based on the predictions, a rule-based control strategy was proposed according to the time-of-use tariff; the mid-day control adjustment mechanism was introduced in accordance with the mid-day prediction modifications. The proposed approach was applied in the ice-based TES system of a commercial complex in Beijing, and achieved a mean absolute error (MAE) of 389 kW and coefficient of variance of MAE of 12.5 %. The integrated prediction-based control strategy achieved an energy cost saving rate of 9.9 %. The proposed model was deployed in the realistic building automation system of the case building and significantly improved the efficiency and automation of the cooling system.

The increasing use of generative AI in scientific writing raises urgent questions about attribution and intellectual credit. When a researcher employs ChatGPT to draft a manuscript, the resulting text may echo ideas from sources the author has never encountered. If an AI system reproduces insights from, for example, an obscure 1975 paper without citation, does this constitute plagiarism? We argue that such cases exemplify the 'provenance problem': a systematic breakdown in the chain of scholarly credit. Unlike conventional plagiarism, this phenomenon does not involve intent to deceive (researchers may disclose AI use and act in good faith) yet still benefit from the uncredited intellectual contributions of others. This dynamic creates a novel category of attributional harm that current ethical and professional frameworks fail to address. As generative AI becomes embedded across disciplines, the risk that significant ideas will circulate without recognition threatens both the reputational economy of science and the demands of epistemic justice. This Perspective analyzes how AI challenges established norms of authorship, introduces conceptual tools for understanding the provenance problem, and proposes strategies to preserve integrity and fairness in scholarly communication.

Glioblastoma is the most prevalent primary brain malignancy, distinguished by its highly invasive behavior and exceptionally high rates of recurrence. Conventional radiation therapy, which employs uniform treatment margins, fails to account for patient-specific anatomical and biological factors that critically influence tumor cell migration. To address this limitation, numerous computational models of glioblastoma growth have been developed, enabling generation of tumor cell distribution maps extending beyond radiographically visible regions and thus informing more precise treatment strategies. However, despite encouraging preliminary findings, the clinical adoption of these growth models remains limited. To bridge this translational gap and accelerate both model development and clinical validation, we introduce PREDICT-GBM, a comprehensive integrated pipeline and dataset for modeling and evaluation. This platform enables systematic benchmarking of state-of-the-art tumor growth models using an expert-curated clinical dataset comprising 255 subjects with complete tumor segmentations and tissue characterization maps. Our analysis demonstrates that personalized radiation treatment plans derived from tumor growth predictions achieved superior recurrence coverage compared to conventional uniform margin approaches for two of the evaluated models. This work establishes a robust platform for advancing and systematically evaluating cutting-edge tumor growth modeling approaches, with the ultimate goal of facilitating clinical translation and improving patient outcomes.

This full research-to-practice paper explores approaches for developing course chatbots by comparing low-code platforms and custom-coded solutions in educational contexts. With the rise of Large Language Models (LLMs) like GPT-4 and LLaMA, LLM-based chatbots are being integrated into teaching workflows to automate tasks, provide assistance, and offer scalable support. However, selecting the optimal development strategy requires balancing ease of use, customization, data privacy, and scalability. This study compares two development approaches: low-code platforms like AnythingLLM and Botpress, with custom-coded solutions using LangChain, FAISS, and FastAPI. The research uses Prompt engineering, Retrieval-augmented generation (RAG), and personalization to evaluate chatbot prototypes across technical performance, scalability, and user experience. Findings indicate that while low-code platforms enable rapid prototyping, they face limitations in customization and scaling, while custom-coded systems offer more control but require significant technical expertise. Both approaches successfully implement key research principles such as adaptive feedback loops and conversational continuity. The study provides a framework for selecting the appropriate development strategy based on institutional goals and resources. Future work will focus on hybrid solutions that combine low-code accessibility with modular customization and incorporate multimodal input for intelligent tutoring systems.

Uncertainty quantification (UQ) is vital for trustworthy deep learning, yet existing methods are either computationally intensive, such as Bayesian or ensemble methods, or provide only partial, task-specific estimates, such as single-forward-pass techniques. In this paper, we propose a post-hoc single-forward-pass framework that jointly captures aleatoric and epistemic uncertainty without modifying or retraining pretrained models. Our method applies \emph{Split-Point Analysis} (SPA) to decompose predictive residuals into upper and lower subsets, computing \emph{Mean Absolute Residuals} (MARs) on each side. We prove that, under ideal conditions, the total MAR equals the harmonic mean of subset MARs; deviations define a novel \emph{Self-consistency Discrepancy Score} (SDS) for fine-grained epistemic estimation across regression and classification. For regression, side-specific quantile regression yields prediction intervals with improved empirical coverage, which are further calibrated via SDS. For classification, when calibration data are available, we apply SPA-based calibration identities to adjust the softmax outputs and then compute predictive entropy on these calibrated probabilities. Extensive experiments on diverse regression and classification benchmarks demonstrate that our framework matches or exceeds several state-of-the-art UQ methods while incurring minimal overhead. Our source code is available at https://github.com/zzz0527/SPC-UQ.

Understanding humor is a core aspect of social intelligence, yet it remains a significant challenge for Large Multimodal Models (LMMs). We introduce PixelHumor, a benchmark dataset of 2,800 annotated multi-panel comics designed to evaluate LMMs' ability to interpret multimodal humor and recognize narrative sequences. Experiments with state-of-the-art LMMs reveal substantial gaps: for instance, top models achieve only 61% accuracy in panel sequencing, far below human performance. This underscores critical limitations in current models' integration of visual and textual cues for coherent narrative and humor understanding. By providing a rigorous framework for evaluating multimodal contextual and narrative reasoning, PixelHumor aims to drive the development of LMMs that better engage in natural, socially aware interactions.

The rapid progress of large language models (LLMs) has opened new opportunities for education. While learners can interact with academic papers through LLM-powered dialogue, limitations still exist: absence of structured organization and high text reliance can impede systematic understanding and engagement with complex concepts. To address these challenges, we propose Auto-Slides, an LLM-driven system that converts research papers into pedagogically structured, multimodal slides (e.g., diagrams and tables). Drawing on cognitive science, it creates a presentation-oriented narrative and allows iterative refinement via an interactive editor, in order to match learners' knowledge level and goals. Auto-Slides further incorporates verification and knowledge retrieval mechanisms to ensure accuracy and contextual completeness. Through extensive user studies, Auto-Slides enhances learners' comprehension and engagement compared to conventional LLM-based reading. Our contributions lie in designing a multi-agent framework for transforming academic papers into pedagogically optimized slides and introducing interactive customization for personalized learning.

Generating regulatorily compliant Suspicious Activity Report (SAR) remains a high-cost, low-scalability bottleneck in Anti-Money Laundering (AML) workflows. While large language models (LLMs) offer promising fluency, they suffer from factual hallucination, limited crime typology alignment, and poor explainability -- posing unacceptable risks in compliance-critical domains. This paper introduces Co-Investigator AI, an agentic framework optimized to produce Suspicious Activity Reports (SARs) significantly faster and with greater accuracy than traditional methods. Drawing inspiration from recent advances in autonomous agent architectures, such as the AI Co-Scientist, our approach integrates specialized agents for planning, crime type detection, external intelligence gathering, and compliance validation. The system features dynamic memory management, an AI-Privacy Guard layer for sensitive data handling, and a real-time validation agent employing the Agent-as-a-Judge paradigm to ensure continuous narrative quality assurance. Human investigators remain firmly in the loop, empowered to review and refine drafts in a collaborative workflow that blends AI efficiency with domain expertise. We demonstrate the versatility of Co-Investigator AI across a range of complex financial crime scenarios, highlighting its ability to streamline SAR drafting, align narratives with regulatory expectations, and enable compliance teams to focus on higher-order analytical work. This approach marks the beginning of a new era in compliance reporting -- bringing the transformative benefits of AI agents to the core of regulatory processes and paving the way for scalable, reliable, and transparent SAR generation.