In today's data-sensitive landscape, distributed learning emerges as a vital tool, not only fortifying privacy measures but also streamlining computational operations. This becomes especially crucial within fully decentralized infrastructures where local processing is imperative due to the absence of centralized aggregation. Here, we introduce DYNAWEIGHT, a novel framework to information aggregation in multi-agent networks. DYNAWEIGHT offers substantial acceleration in decentralized learning with minimal additional communication and memory overhead. Unlike traditional static weight assignments, such as Metropolis weights, DYNAWEIGHT dynamically allocates weights to neighboring servers based on their relative losses on local datasets. Consequently, it favors servers possessing diverse information, particularly in scenarios of substantial data heterogeneity. Our experiments on various datasets MNIST, CIFAR10, and CIFAR100 incorporating various server counts and graph topologies, demonstrate notable enhancements in training speeds. Notably, DYNAWEIGHT functions as an aggregation scheme compatible with any underlying server-level optimization algorithm, underscoring its versatility and potential for widespread integration.

Chain-of-Thought (CoT) reasoning improves performance on complex tasks but introduces significant inference latency due to verbosity. We propose Multiround Adaptive Chain-of-Thought Compression (MACC), a framework that leverages the token elasticity phenomenon--where overly small token budgets can paradoxically increase output length--to progressively compress CoTs via multiround refinement. This adaptive strategy allows MACC to determine the optimal compression depth for each input. Our method achieves an average accuracy improvement of 5.6 percent over state-of-the-art baselines, while also reducing CoT length by an average of 47 tokens and significantly lowering latency. Furthermore, we show that test-time performance--accuracy and token length--can be reliably predicted using interpretable features like perplexity and compression rate on the training set. Evaluated across different models, our method enables efficient model selection and forecasting without repeated fine-tuning, demonstrating that CoT compression is both effective and predictable. Our code will be released in https://github.com/Leon221220/MACC.

Irregular sampling and high missingness are intrinsic challenges in modeling time series derived from electronic health records (EHRs), where clinical variables are measured at uneven intervals depending on workflow and intervention timing. To address this, we propose VITAL -- a variable-aware, large language model (LLM)-based framework tailored for learning from irregularly sampled physiological time series. VITAL differentiates between two distinct types of clinical variables: vital signs, which are frequently recorded and exhibit temporal patterns, and laboratory tests, which are measured sporadically and lack temporal structure. It reprograms vital signs into the language space, enabling the LLM to capture temporal context and reason over missing values through explicit encoding. In contrast, laboratory variables are embedded either using representative summary values or a learnable [Not measured] token, depending on their availability. Extensive evaluations on the benchmark datasets from the PhysioNet demonstrate that VITAL outperforms state-of-the-art methods designed for irregular time series. Furthermore, it maintains robust performance under high levels of missigness, which is prevalent in real-world clinical scenarios where key variables are often unavailable. Introduction Electronic Health Records (EHRs) digitally capture a wealth of patient data generated during routine clinical care. In particular, the Intensive Care Unit (ICU) is a data-rich environment due to the need for continuous, high-resolution patient monitoring. This has led to a surge of research in medical artificial intelligence (AI), with many studies leveraging publicly available EHR datasets in combination with machine learning techniques for tasks such as early warning, outcome prediction and patient stratification [1, 2, 3, 4, 5, 6, 7, 8, 9] A common approach in these studies is to model patient records as multivariate time series, capturing the temporal evolution of physiological and clinical variables. However, in practice, EHR time series are often irregularly sampled due to variations in clinical workflows, measurement protocols, and intervention timing.

Abstract--As a key technology for autonomous navigation and positioning in mobile robots, light detection and ranging (LiDAR) odometry is widely used in autonomous driving applications. The Iterative Closest Point (ICP)-based methods have become the core technique in LiDAR odometry due to their efficient and accurate point cloud registration capability. However, some existing ICP-based methods do not consider the reliability of the initial pose, which may cause the method to converge to a local optimum. Furthermore, the absence of an adaptive mechanism hinders the effective handling of complex dynamic environments, resulting in a significant degradation of registration accuracy. T o address these issues, this paper proposes an adaptive ICP-based LiDAR odometry method that relies on a reliable initial pose. First, distributed coarse registration based on density filtering is employed to obtain the initial pose estimation. The reliable initial pose is then selected by comparing it with the motion prediction pose, reducing the initial error between the source and target point clouds. Subsequently, by combining the current and historical errors, the adaptive threshold is dynamically adjusted to accommodate the real-time changes in the dynamic environment. Finally, based on the reliable initial pose and the adaptive threshold, point-to-plane adaptive ICP registration is performed from the current frame to the local map, achieving high-precision alignment of the source and target point clouds. Extensive experiments on the public KITTI dataset demonstrate that the proposed method outperforms existing approaches and significantly enhances the accuracy of LiDAR odometry.

Healthcare robotics requires robust multimodal perception and reasoning to ensure safety in dynamic clinical environments. Current Vision-Language Models (VLMs) demonstrate strong general-purpose capabilities but remain limited in temporal reasoning, uncertainty estimation, and structured outputs needed for robotic planning. We present a lightweight agentic multimodal framework for video-based scene understanding. Combining the Qwen2.5-VL-3B-Instruct model with a SmolAgent-based orchestration layer, it supports chain-of-thought reasoning, speech-vision fusion, and dynamic tool invocation. The framework generates structured scene graphs and leverages a hybrid retrieval module for interpretable and adaptive reasoning. Evaluations on the Video-MME benchmark and a custom clinical dataset show competitive accuracy and improved robustness compared to state-of-the-art VLMs, demonstrating its potential for applications in robot-assisted surgery, patient monitoring, and decision support.

Automated scoring plays a crucial role in education by reducing the reliance on human raters, offering scalable and immediate evaluation of student work. While large language models (LLMs) have shown strong potential in this task, their use as end-to-end raters faces challenges such as low accuracy, prompt sensitivity, limited interpretability, and rubric misalignment. These issues hinder the implementation of LLM-based automated scoring in assessment practice. To address the limitations, we propose AutoSCORE, a multi-agent LLM framework enhancing automated scoring via rubric-aligned Structured COmponent REcognition. With two agents, AutoSCORE first extracts rubric-relevant components from student responses and encodes them into a structured representation (i.e., Scoring Rubric Component Extraction Agent), which is then used to assign final scores (i.e., Scoring Agent). This design ensures that model reasoning follows a human-like grading process, enhancing interpretability and robustness. We evaluate AutoSCORE on four benchmark datasets from the ASAP benchmark, using both proprietary and open-source LLMs (GPT-4o, LLaMA-3.1-8B, and LLaMA-3.1-70B). Across diverse tasks and rubrics, AutoSCORE consistently improves scoring accuracy, human-machine agreement (QWK, correlations), and error metrics (MAE, RMSE) compared to single-agent baselines, with particularly strong benefits on complex, multi-dimensional rubrics, and especially large relative gains on smaller LLMs. These results demonstrate that structured component recognition combined with multi-agent design offers a scalable, reliable, and interpretable solution for automated scoring.

Reinforcement fine-tuning (RFT) often suffers from \emph{reward over-optimization}, where a policy model hacks the reward signals to achieve high scores while producing low-quality outputs. Our theoretical analysis shows that the key lies in reward misspecification at the high-reward tail: the inability to reliably distinguish Excellent responses from merely Great ones. This motivate us to focus on the high-reward region. However, such tail examples are scarce under the base LLM. While off-policy exemplars (e.g. from stronger models or rewrites) are easier to obtain, naively training on them yields a misspecified reward for the policy we aim to align. To address this, we study rubric-based rewards. By design, rubrics can leverage off-policy examples while remaining insensitive to their artifacts. To elicit rubrics that capture the high-reward tail, we highlight the importance of distinguishing among great and diverse responses, and introduce a workflow to implement this idea. We empirically demonstrate that rubric-based rewards substantially mitigate reward over-optimization and deliver effective LLM post-training improvements. Our code can be accessed at https://github.com/Jun-Kai-Zhang/rubrics.git .

Diabetes mellitus is a major global health challenge, affecting over half a billion adults worldwide with prevalence projected to rise. Although the American Diabetes Association (ADA) provides clear diagnostic thresholds, early recognition remains difficult due to vague symptoms, borderline laboratory values, gestational complexity, and the demands of long-term monitoring. Advances in large language models (LLMs) offer opportunities to enhance decision support through structured, interpretable, and patient-friendly outputs. This study evaluates GPT-5, the latest generative pre-trained transformer, using a simulation framework built entirely on synthetic cases aligned with ADA Standards of Care 2025 and inspired by public datasets including NHANES, Pima Indians, EyePACS, and MIMIC-IV. Five representative scenarios were tested: symptom recognition, laboratory interpretation, gestational diabetes screening, remote monitoring, and multimodal complication detection. For each, GPT-5 classified cases, generated clinical rationales, produced patient explanations, and output structured JSON summaries. Results showed strong alignment with ADA-defined criteria, suggesting GPT-5 may function as a dual-purpose tool for clinicians and patients, while underscoring the importance of reproducible evaluation frameworks for responsibly assessing LLMs in healthcare.

Current molecular generative models primarily focus on improving drug-target binding affinity and specificity, often neglecting the system-level phenotypic effects elicited by compounds. Transcriptional profiles, as molecule-level readouts of drug-induced phenotypic shifts, offer a powerful opportunity to guide molecular design in a phenotype-aware manner. We present PhenoMoler, a phenotype-guided molecular generation framework that integrates a chemistry large language model with expression profiles to enable biologically informed drug design. By conditioning the generation on drug-induced differential expression signatures, PhenoMoler explicitly links transcriptional responses to chemical structure. By selectively masking and reconstructing specific substructures-scaffolds, side chains, or linkers-PhenoMoler supports fine-grained, controllable molecular optimization. Extensive experiments demonstrate that PhenoMoler generates chemically valid, novel, and diverse molecules aligned with desired phenotypic profiles. Compared to FDA-approved drugs, the generated compounds exhibit comparable or enhanced drug-likeness (QED), optimized physicochemical properties, and superior binding affinity to key cancer targets. These findings highlight PhenoMoler's potential for phenotype-guided and structure-controllable molecular optimization.

Abstract--In this paper, we introduce ShipwreckFinder, an open-source QGIS plugin that detects shipwrecks from multi-beam sonar data. Shipwrecks are an important historical marker of maritime history, and can be discovered through manual inspection of bathymetric data. However, this is a time-consuming process and often requires expert analysis. Our proposed tool allows users to automatically preprocess bathymetry data, perform deep learning inference, threshold model outputs, and produce either pixel-wise segmentation masks or bounding boxes of predicted shipwrecks. The backbone of this open-source tool is a deep learning model, which is trained on a variety of shipwreck data from the Great Lakes and the coasts of Ireland. Additionally, we employ synthetic data generation in order to increase the size and diversity of our dataset. We demonstrate superior segmentation performance with our open-source tool and training pipeline as compared to a deep learning-based ArcGIS toolkit and a more classical inverse sinkhole detection method.