Large Language Models (LLMs) have exhibited strong reasoning capabilities and achieved remarkable performance in mathematical problem-solving tasks. Recently, distilling reasoning ability from long-form Chains-of-Thought (CoTs) has emerged as a promising approach for enhancing Small Language Models (SLMs). Existing studies typically treat SLMs as student models and use long-form CoTs as supervision signals for Supervised Fine-Tuning (SFT) to transfer reasoning ability. However, such long-form CoT teachers are usually unaware of the student model's capacity, which limits the effective utilization of the provided reasoning traces. To overcome this limitation, we propose errOr-aware self-ReflectION (ORION), a framework that refines teacher CoTs through an Error-Aware Reflection process. ORION enables the student model to construct more tailored teacher CoTs by refining teacher CoTs and incorporating its own reasoning errors. Experiments on multiple mathematical reasoning benchmarks demonstrate that ORION consistently improves performance by more than 2% over all baselines. Further analysis reveals that the CoTs constructed by ORION exhibit higher coherence and logical consistency, thereby serving as more effective supervision signals for SFT. All codes are available at https://github.com/NEUIR/ORION.git.

Large language models (LLMs) have demonstrated excellent capabilities in the field of biomedical question answering, but their application in real-world clinical consultations still faces core challenges. Single-round consultation systems require patients to describe all symptoms upfront, leading to vague diagnosis with unclear complaints. Traditional multi-turn dialogue models, constrained by static supervised learning, lack flexibility and fail to intelligently extract key clinical information. To address these limitations, we propose \Ours{}, a reinforcement learning (RL)-based multi-agent collaborative framework that models medical consultations as a dynamic decision-making process under uncertainty. The doctor agent continuously optimizes its questioning strategy within the RL framework through multi-turn interactions with the patient agent, dynamically adjusting its information-gathering path based on comprehensive rewards from the Consultation Evaluator. This RL fine-tuning mechanism enables LLMs to autonomously develop interaction strategies aligned with clinical reasoning logic, rather than superficially imitating patterns in existing dialogue data. Notably, we constructed MTMedDialog, the first English multi-turn medical consultation dataset capable of simulating patient interactions. Experiments demonstrate that \Ours{} outperforms existing models in both multi-turn reasoning capability and final diagnostic performance. This approach shows immense practical value by reducing misdiagnosis risks in time-pressured settings, freeing clinicians for complex cases, and pioneering a strategy to optimize medical resource allocation and alleviate workforce shortages. Code and data are available at https://github.com/JarvisUSTC/DoctorAgent-RL

Protein design is a fundamental challenge in biotechnology, aiming to design novel sequences with specific functions within the vast space of possible proteins. Recent advances in deep generative models have enabled function-based protein design from textual descriptions, yet struggle with structural plausibility. Inspired by classical protein design methods that leverage natural protein structures, we explore whether incorporating fragments from natural proteins can enhance foldability in generative models. Our empirical results show that even random incorporation of fragments improves foldability. Building on this insight, we introduce ProDVa, a novel protein design approach that integrates a text encoder for functional descriptions, a protein language model for designing proteins, and a fragment encoder to dynamically retrieve protein fragments based on textual functional descriptions. Experimental results demonstrate that our approach effectively designs protein sequences that are both functionally aligned and structurally plausible. Compared to state-of-the-art models, ProDVa achieves comparable function alignment using less than 0.04% of the training data, while designing significantly more well-folded proteins, with the proportion of proteins having pLDDT above 70 increasing by 7.38% and those with PAE below 10 increasing by 9.6%.

Human social interactions depend on the ability to infer others' unspoken intentions, emotions, and beliefs-a cognitive skill grounded in the psychological concept of Theory of Mind (ToM). While large language models (LLMs) excel in semantic understanding tasks, they struggle with the ambiguity and contextual nuance inherent in human communication. To bridge this gap, we introduce MetaMind, a multi-agent framework inspired by psychological theories of metacognition, designed to emulate human-like social reasoning. MetaMind decomposes social understanding into three collaborative stages: (1) a Theory-of-Mind Agent generates hypotheses about user mental states (e.g., intent, emotion), (2) a Moral Agent refines these hypotheses using cultural norms and ethical constraints, and (3) a Response Agent generates contextually appropriate responses while validating alignment with inferred intent. Our framework achieves state-of-the-art performance across three challenging benchmarks, with 35.7% improvement in real-world social scenarios and 6.2% gain in ToM reasoning. Notably, it enables LLMs to match human-level performance on key ToM tasks for the first time. Ablation studies confirm the necessity of all components, which showcase the framework's ability to balance contextual plausibility, social appropriateness, and user adaptation. This work advances AI systems toward human-like social intelligence, with applications in empathetic dialogue and culturally sensitive interactions. Code is available at https://github.com/XMZhangAI/MetaMind.

Artificial intelligence (AI) has recently seen transformative breakthroughs in the life sciences, expanding possibilities for researchers to interpret biological information at an unprecedented capacity, with novel applications and advances being made almost daily. In order to maximise return on the growing investments in AI-based life science research and accelerate this progress, it has become urgent to address the exacerbation of long-standing research challenges arising from the rapid adoption of AI methods. We review the increased erosion of trust in AI research outputs, driven by the issues of poor reusability and reproducibility, and highlight their consequent impact on environmental sustainability. Furthermore, we discuss the fragmented components of the AI ecosystem and lack of guiding pathways to best support Open and Sustainable AI (OSAI) model development. In response, this perspective introduces a practical set of OSAI recommendations directly mapped to over 300 components of the AI ecosystem and provides guiding implementation pathways. Our work connects researchers with relevant AI resources, facilitating the implementation of sustainable, reusable and reproducible AI. Built upon life science community consensus and aligned to existing efforts, the outputs of this perspective are designed to aid the future development of policy and additional structured pathways for guiding AI implementation.

Large language models have simplified the production of personalized translations reflecting predefined stylistic constraints. However, these systems still struggle when stylistic requirements are implicitly represented by a set of examples, such as texts produced by a specific human translator. In this work, we explore various strategies for personalizing automatically generated translations when few examples are available, with a focus on the challenging domain of literary translation. We begin by determining the feasibility of the task and how style information is encoded within model representations. Then, we evaluate various prompting strategies and inference-time interventions for steering model generations towards a personalized style, with a particular focus on contrastive steering with sparse autoencoder (SAE) latents to identify salient personalization properties. We demonstrate that contrastive SAE steering yields robust style conditioning and translation quality, resulting in higher inference-time computational efficiency than prompting approaches. We further examine the impact of steering on model activations, finding that layers encoding personalization properties are impacted similarly by prompting and SAE steering, suggesting a similar mechanism at play.

While an image is worth more than a thousand words, only a few provide crucial information for a given task and thus should be focused on. In light of this, ideal text-to-image (T2I) retrievers should prioritize specific visual attributes relevant to queries. To evaluate current retrievers on handling attribute-focused queries, we build COCO-Facet, a COCO-based benchmark with 9,112 queries about diverse attributes of interest. We find that CLIP-like retrievers, which are widely adopted due to their efficiency and zero-shot ability, have poor and imbalanced performance, possibly because their image embeddings focus on global semantics and subjects while leaving out other details. Notably, we reveal that even recent Multimodal Large Language Model (MLLM)-based, stronger retrievers with a larger output dimension struggle with this limitation. Hence, we hypothesize that retrieving with general image embeddings is suboptimal for performing such queries. As a solution, we propose to use promptable image embeddings enabled by these multimodal retrievers, which boost performance by highlighting required attributes. Our pipeline for deriving such embeddings generalizes across query types, image pools, and base retriever architectures. To enhance real-world applicability, we offer two acceleration strategies: Pre-processing promptable embeddings and using linear approximations. We show that the former yields a 15% improvement in Recall@5 when prompts are predefined, while the latter achieves an 8% improvement when prompts are only available during inference.

The [CLS] token in BERT is commonly used as a fixed-length representation for classification tasks, yet prior work has shown that both other tokens and intermediate layers encode valuable contextual information. In this work, we study lightweight extensions to BERT that refine the [CLS] representation by aggregating information across layers and tokens. Specifically, we explore three modifications: (i) max-pooling the [CLS] token across multiple layers, (ii) enabling the [CLS] token to attend over the entire final layer using an additional multi-head attention (MHA) layer, and (iii) combining max-pooling across the full sequence with MHA. Our approach, called MaxPoolBERT, enhances BERT's classification accuracy (especially on low-resource tasks) without requiring new pre-training or significantly increasing model size. Experiments on the GLUE benchmark show that MaxPoolBERT consistently achieves a better performance than the standard BERT base model on low resource tasks of the GLUE benchmark.

Whole-body audio-driven avatar pose and expression generation is a critical task for creating lifelike digital humans and enhancing the capabilities of interactive virtual agents, with wide-ranging applications in virtual reality, digital entertainment, and remote communication. Existing approaches often generate audio-driven facial expressions and gestures independently, which introduces a significant limitation: the lack of seamless coordination between facial and gestural elements, resulting in less natural and cohesive animations. To address this limitation, we propose AsynFusion, a novel framework that leverages diffusion transformers to achieve harmonious expression and gesture synthesis. The proposed method is built upon a dual-branch DiT architecture, which enables the parallel generation of facial expressions and gestures. Within the model, we introduce a Cooperative Synchronization Module to facilitate bidirectional feature interaction between the two modalities, and an Asynchronous LCM Sampling strategy to reduce computational overhead while maintaining high-quality outputs. Extensive experiments demonstrate that AsynFusion achieves state-of-the-art performance in generating real-time, synchronized whole-body animations, consistently outperforming existing methods in both quantitative and qualitative evaluations.

Large Language Models (LLMs) have demonstrated notable capabilities across financial tasks, including financial report summarization, earnings call transcript analysis, and asset classification. However, their real-world effectiveness in managing complex fund investment remains inadequately assessed. A fundamental limitation of existing benchmarks for evaluating LLM-driven trading strategies is their reliance on historical back-testing, inadvertently enabling LLMs to "time travel"-leveraging future information embedded in their training corpora, thus resulting in possible information leakage and overly optimistic performance estimates. To address this issue, we introduce DeepFund, a live fund benchmark tool designed to rigorously evaluate LLM in real-time market conditions. Utilizing a multi-agent architecture, DeepFund connects directly with real-time stock market data-specifically data published after each model pretraining cutoff-to ensure fair and leakage-free evaluations. Empirical tests on nine flagship LLMs from leading global institutions across multiple investment dimensions-including ticker-level analysis, investment decision-making, portfolio management, and risk control-reveal significant practical challenges. Notably, even cutting-edge models such as DeepSeek-V3 and Claude-3.7-Sonnet incur net trading losses within DeepFund real-time evaluation environment, underscoring the present limitations of LLMs for active fund management. Our code is available at https://github.com/HKUSTDial/DeepFund.