The presence of interictal epileptiform discharges (IEDs) in electroencephalogram (EEG) recordings is a critical biomarker of epilepsy. Even trained neurologists find detecting IEDs difficult, leading many practitioners to turn to machine learning for help. While existing machine learning algorithms can achieve strong accuracy on this task, most models are uninterpretable and cannot justify their conclusions. Absent the ability to understand model reasoning, doctors cannot leverage their expertise to identify incorrect model predictions and intervene accordingly. To improve the human-model interaction, we introduce ProtoEEG-kNN, an inherently interpretable model that follows a simple case-based reasoning process. ProtoEEG-kNN reasons by comparing an EEG to similar EEGs from the training set and visually demonstrates its reasoning both in terms of IED morphology (shape) and spatial distribution (location). We show that ProtoEEG-kNN can achieve state-of-the-art accuracy in IED detection while providing explanations that experts prefer over existing approaches.

This study introduces a human-in-the-loop pipeline that converts unscaled, hand-drawn floor plan sketches into semantically consistent 3D BIM models. The workflow leverages multimodal large language models (MLLMs) within a multi-agent framework, combining perceptual extraction, human feedback, schema validation, and automated BIM scripting. Initially, sketches are iteratively refined into a structured JSON layout of walls, doors, and windows. Later, these layouts are transformed into executable scripts that generate 3D BIM models. Experiments on ten diverse floor plans demonstrate strong convergence: openings (doors, windows) are captured with high reliability in the initial pass, while wall detection begins around 83% and achieves near-perfect alignment after a few feedback iterations. Across all categories, precision, recall, and F1 scores remain above 0.83, and geometric errors (RMSE, MAE) progressively decrease to zero through feedback corrections. This study demonstrates how MLLM-driven multi-agent reasoning can make BIM creation accessible to both experts and non-experts using only freehand sketches.

Understanding how patterns of interaction between neural populations reorganize with behavior is central to systems neuroscience and to applications that decode or modulate brain activity. These interactions are often framed under the umbrella of brain connectivity, distinguished as structural (anatomical pathways), functional (statistical dependencies), and effective (directed influence)--complementary lenses on how distributed circuits communicate and adapt to task demands [1, 2]. Reviews emphasize both the promise and the challenges of connectivity-centric approaches, particularly the need to capture short-timescale dynamics while maintaining interpretability [3, 4]. Graph-based formulations make this agenda concrete: representing brain regions as nodes and their relationships as edges enables quantitative analysis of modularity, hubs, and task-dependent reconfiguration [5, 6]. Such network perspectives motivate methods that go beyond static, correlation-only descriptions toward dynamic, directed estimates that better align with mechanistic questions. We focus on intracranial local field potentials (LFPs), a high-temporal-resolution measure of population activity recorded simultaneously from multiple deep-brain regions [7, 8, 9, 10]. Multi-region LFP imposes unique modeling requirements: (i) many micro-contacts per region must be consolidated into coherent region-level trajectories; (ii) neural activity reconfigures across well-defined behavioral phases; and (iii) the spatial layout of contacts is high-dimensional and non-Euclidean [11]. Existing pipelines often average across behavior with a single correlation-based graph [2] or impose hard-coded anatomical connectivity [12, 13], limiting their ability to capture phase-specific, directed interactions. Recent machine learning advances in graph learning from neural time series highlight the opportunity but do not yet fill this gap.

Drug combinations offer therapeutic benefits but also carry the risk of adverse drug-drug interactions (DDIs), especially under complex molecular structures. Accurate DDI event prediction requires capturing fine-grained inter-drug relationships, which are critical for modeling metabolic mechanisms such as enzyme-mediated competition. However, existing approaches typically rely on isolated drug representations and fail to explicitly model atom-level cross-molecular interactions, limiting their effectiveness across diverse molecular complexities and DDI type distributions. To address these limitations, we propose MolBridge, a novel atom-level joint graph refinement framework for robust DDI event prediction. MolBridge constructs a joint graph that integrates atomic structures of drug pairs, enabling direct modeling of inter-drug associations. A central challenge in such joint graph settings is the potential loss of information caused by over-smoothing when modeling long-range atomic dependencies. To overcome this, we introduce a structure consistency module that iteratively refines node features while preserving the global structural context. This joint design allows MolBridge to effectively learn both local and global interaction outperforms state-of-the-art baselines, achieving superior performance across long-tail and inductive scenarios. patterns, yielding robust representations across both frequent and rare DDI types. Extensive experiments on two benchmark datasets show that MolBridge consistently. These results demonstrate the advantages of fine-grained graph refinement in improving the accuracy, robustness, and mechanistic interpretability of DDI event prediction.This work contributes to Web Mining and Content Analysis by developing graph-based methods for mining and analyzing drug-drug interaction networks.

Marked Temporal Point Process (MTPP) has been well studied to model the event distribution in marked event streams, which can be used to predict the mark and arrival time of the next event. However, existing studies overlook that the distribution of event marks is highly imbalanced in many real-world applications, with some marks being frequent but others rare. The imbalance poses a significant challenge to the performance of the next event prediction, especially for events of rare marks. To address this issue, we propose a thresholding method, which learns thresholds to tune the mark probability normalized by the mark's prior probability to optimize mark prediction, rather than predicting the mark directly based on the mark probability as in existing studies. In conjunction with this method, we predict the mark first and then the time. In particular, we develop a novel neural MTPP model to support effective time sampling and estimation of mark probability without computationally expensive numerical improper integration. Extensive experiments on real-world datasets demonstrate the superior performance of our solution against various baselines for the next event mark and time prediction. The code is available at https://github.com/undes1red/IFNMTPP.

Since the advent of various pre-trained large language models, extracting structured knowledge from scientific text has experienced a revolutionary change compared with traditional machine learning or natural language processing techniques. Despite these advances, accessible automated tools that allow users to construct, validate, and visualise datasets from scientific literature extraction remain scarce. We therefore developed ComProScanner, an autonomous multi-agent platform that facilitates the extraction, validation, classification, and visualisation of machine-readable chemical compositions and properties, integrated with synthesis data from journal articles for comprehensive database creation. We evaluated our framework using 100 journal articles against 10 different LLMs, including both open-source and proprietary models, to extract highly complex compositions associated with ceramic piezoelectric materials and corresponding piezoelectric strain coefficients (d33), motivated by the lack of a large dataset for such materials. DeepSeek-V3-0324 outperformed all models with a significant overall accuracy of 0.82. This framework provides a simple, user-friendly, readily-usable package for extracting highly complex experimental data buried in the literature to build machine learning or deep learning datasets.

W.J.T. Mitchell's influential essay 'What do pictures want?' shifts the theoretical focus away from the interpretative act of understanding pictures and from the motivations of the humans who create them to the possibility that the picture itself is an entity with agency and wants. In this article, I reframe Mitchell's question in light of contemporary AI image generation tools to ask: what do AI-generated images want? Drawing from art historical discourse on the nature of abstraction, I argue that AI-generated images want specificity and concreteness because they are fundamentally abstract. Multimodal text-to-image models, which are the primary subject of this article, are based on the premise that text and image are interchangeable or exchangeable tokens and that there is a commensurability between them, at least as represented mathematically in data. The user pipeline that sees textual input become visual output, however, obscures this representational regress and makes it seem like one form transforms into the other -- as if by magic.

As large language models (LLMs) advance, the ultimate vision for their role in science is emerging: we could build an AI collaborator to effectively assist human beings throughout the entire scientific research process. We refer to this envisioned system as ResearchGPT. Given that scientific research progresses through multiple interdependent phases, achieving this vision requires rigorous benchmarks that evaluate the end-to-end workflow rather than isolated sub-tasks. To this end, we contribute CS-54k, a high-quality corpus of scientific Q&A pairs in computer science, built from 14k CC-licensed papers. It is constructed through a scalable, paper-grounded pipeline that combines retrieval-augmented generation (RAG) with multi-stage quality control to ensure factual grounding. From this unified corpus, we derive two complementary subsets: CS-4k, a carefully curated benchmark for evaluating AI's ability to assist scientific research, and CS-50k, a large-scale training dataset. Extensive experiments demonstrate that CS-4k stratifies state-of-the-art LLMs into distinct capability tiers. Open models trained on CS-50k with supervised training and reinforcement learning demonstrate substantial improvements. Even 7B-scale models, when properly trained, outperform many larger proprietary systems, such as GPT-4.1, GPT-4o, and Gemini 2.5 Pro. This indicates that making AI models better research assistants relies more on domain-aligned training with high-quality data than on pretraining scale or general benchmark performance. We release CS-4k and CS-50k in the hope of fostering AI systems as reliable collaborators in CS research.

The advancement of natural language processing for morphologically rich and moderately-resourced languages like Modern Greek has been hindered by architectural stagnation, data scarcity, and limited context processing capabilities, particularly in specialized domains such as law. In this work, we propose the Greek Embedding Models (GEMs), a new family of transformer-based language models, specifically developed to address these limitations through architectural diversity and enhanced data curation. The proposed family of models are trained on several large-scale, meticulously curated corpora, encompassing both comprehensive general-domain datasets and specialized legal collections, addressing the persistent data scarcity that has impeded Greek language modeling advancement. The proposed quality-based corpus curation methodology incorporates extensive preprocessing pipelines, sophisticated deduplication strategies and targeted repetition of high-quality legal sub-corpora to enhance domain adaptation. The GEMs family comprises both established architectures (RoBERTa and Longformer) and advanced models not previously applied to Greek (ELECTRA, ConvBERT, and ModernBERT), providing comprehensive coverage of modern transformer designs. Additionally, we introduce the first bilingual Greek-English embedding models tailored for cross-lingual legal applications. Comprehensive evaluation across three core natural language understanding benchmarks demonstrates that the proposed GEM-RoBERTa and GEM-ConvBERT achieve statistically significant performance improvements over established state-of-the-art models, with accuracy gains of up to 3.6\% while conducted statistical analysis using Friedman Aligned-Ranks and Finner post-hoc tests confirms the superiority of our approach across multiple evaluation metrics.

Building agents that generalize across web, desktop, and mobile environments remains an open challenge, as prior systems rely on environment-specific interfaces that limit cross-platform deployment. We introduce Surfer 2, a unified architecture operating purely from visual observations that achieves state-of-the-art performance across all three environments. Surfer 2 integrates hierarchical context management, decoupled planning and execution, and self-verification with adaptive recovery, enabling reliable operation over long task horizons. Our system achieves 97.1% accuracy on WebVoyager, 69.6% on WebArena, 60.1% on OSWorld, and 87.1% on AndroidWorld, outperforming all prior systems without task-specific fine-tuning. With multiple attempts, Surfer 2 exceeds human performance on all benchmarks. These results demonstrate that systematic orchestration amplifies foundation model capabilities and enables general-purpose computer control through visual interaction alone, while calling for a next-generation vision language model to achieve Pareto-optimal cost-efficiency.