Physics-Informed Machine Learning (PIML) has successfully integrated mechanistic understanding into machine learning, particularly in domains governed by well-known physical laws. This success has motivated efforts to apply PIML to biology, a field rich in dynamical systems but shaped by different constraints. Biological modeling, however, presents unique challenges: multi-faceted and uncertain prior knowledge, heterogeneous and noisy data, partial observability, and complex, high-dimensional networks. In this position paper, we argue that these challenges should not be seen as obstacles to PIML, but as catalysts for its evolution. We propose Biology-Informed Machine Learning (BIML): a principled extension of PIML that retains its structural grounding while adapting to the practical realities of biology. Rather than replacing PIML, BIML retools its methods to operate under softer, probabilistic forms of prior knowledge. We outline four foundational pillars as a roadmap for this transition: uncertainty quantification, contextualization, constrained latent structure inference, and scalability. Foundation Models and Large Language Models will be key enablers, bridging human expertise with computational modeling. We conclude with concrete recommendations to build the BIML ecosystem and channel PIML-inspired innovation toward challenges of high scientific and societal relevance.

Information cascade popularity prediction is a key problem in analyzing content diffusion in social networks. However, current related works suffer from three critical limitations: (1) temporal leakage in current evaluation--random cascade-based splits allow models to access future information, yielding unrealistic results; (2) feature-poor datasets that lack downstream conversion signals (e.g., likes, comments, or purchases), which limits more practical applications; (3) computational inefficiency of complex graph-based methods that require days of training for marginal gains. We systematically address these challenges from three perspectives: task setup, dataset construction, and model design. First, we propose a time-ordered splitting strategy that chronologically partitions data into consecutive windows, ensuring models are evaluated on genuine forecasting tasks without future information leakage. Second, we introduce Taoke, a large-scale e-commerce cascade dataset featuring rich promoter/product attributes and ground-truth purchase conversions--capturing the complete diffusion lifecycle from promotion to monetization. Third, we develop CasTemp, a lightweight framework that efficiently models cascade dynamics through temporal walks, Jaccard-based neighbor selection for inter-cascade dependencies, and GRU-based encoding with time-aware attention. Under leak-free evaluation, CasTemp achieves state-of-the-art performance across four datasets with orders-of-magnitude speedup. Notably, it excels at predicting second-stage popularity conversions--a practical task critical for real-world applications.

Abstract--Autonomous driving is an emerging technology that is expected to bring significant social, economic, and environmental benefits. However, these benefits come with rising energy consumption by computation engines, limiting the driving range of vehicles, especially electric ones. Perception computing is typically the most power-intensive component, as it relies on large-scale deep learning models to extract environmental features. Recently, numerous studies have employed model compression techniques, such as sparsification, quantization, and distillation, to reduce computational consumption. However, these methods often result in either a substantial model size or a significant drop in perception accuracy compared to high-computation models. T o address these challenges, we propose an energy-efficient autonomous driving framework, called EneAD, which includes an adaptive perception and a robust decision module. In the adaptive perception module, a perception optimization strategy is designed from the perspective of data management and tuning. Firstly, we manage multiple perception models with different computational consumption and adjust the execution framerate dynamically. Then, we define them as knobs and design a transferable tuning method based on Bayesian optimization to identify promising knob values that achieve low computation while maintaining desired accuracy. T o adaptively switch the knob values in various traffic scenarios, a lightweight classification model is proposed to distinguish the perception difficulty in different scenarios. In the robust decision module, we propose a decision model based on reinforcement learning and design a regularization term to enhance driving stability in the face of perturbed perception results. EneAD can reduce perception consumption by 1.9 to 3.5 and thus improve driving range by 3.9% to 8.5%. Autonomous driving has gained broad attention from the public during the last few years [1], [2]. With intelligence, the autonomous vehicle can have a more comprehensive perception of the surrounding traffic environment and make more reasonable driving decisions compared to human drivers. As a result, it is expected to bring society a large number of benefits, including improved mobility and a significant reduction in collisions. For example, the computing platform using the Nvidia AGX Orin SoC [4] has a Thermal Design Power (TDP) of 800W . These power demands can also increase the thermal demands on a vehicle's climate-control system.

The rapid advancement of Large Language Models (LLMs) has enabled them to generate complex, multi-step plans and itineraries. However, these generated plans often lack temporal and spatial consistency, particularly in scenarios involving physical travel constraints. This research aims to study the temporal performance of different LLMs and presents a validation framework that evaluates and improves the temporal consistency of LLM-generated travel itineraries. The system employs multiple state-of-the-art LLMs to generate travel plans and validates them against real-world flight duration constraints using the AeroDataBox API. This work contributes to the understanding of LLM capabilities in handling complex temporal reasoning tasks like itinerary generation and provides a framework to rectify any temporal inconsistencies like overlapping journeys or unrealistic transit times in the itineraries generated by LLMs before the itinerary is given to the user. Our experiments reveal that while current LLMs frequently produce temporally inconsistent itineraries, these can be systematically and reliably corrected using our framework, enabling their practical deployment in large-scale travel planning.

This study provides an in_depth analysis of the ethical and trustworthiness challenges emerging alongside the rapid advancement of generative artificial intelligence (AI) technologies and proposes a comprehensive framework for their systematic evaluation. While generative AI, such as ChatGPT, demonstrates remarkable innovative potential, it simultaneously raises ethical and social concerns, including bias, harmfulness, copyright infringement, privacy violations, and hallucination. Current AI evaluation methodologies, which mainly focus on performance and accuracy, are insufficient to address these multifaceted issues. Thus, this study emphasizes the need for new human_centered criteria that also reflect social impact. To this end, it identifies key dimensions for evaluating the ethics and trustworthiness of generative AI_fairness, transparency, accountability, safety, privacy, accuracy, consistency, robustness, explainability, copyright and intellectual property protection, and source traceability and develops detailed indicators and assessment methodologies for each. Moreover, it provides a comparative analysis of AI ethics policies and guidelines in South Korea, the United States, the European Union, and China, deriving key approaches and implications from each. The proposed framework applies across the AI lifecycle and integrates technical assessments with multidisciplinary perspectives, thereby offering practical means to identify and manage ethical risks in real_world contexts. Ultimately, the study establishes an academic foundation for the responsible advancement of generative AI and delivers actionable insights for policymakers, developers, users, and other stakeholders, supporting the positive societal contributions of AI technologies.

Abstract--Automating penetration testing is crucial for enhancing cybersecurity, yet current Large Language Models (LLMs) face significant limitations in this domain, including poor error handling, inefficient reasoning, and an inability to perform complex end-to-end tasks autonomously. T o address these challenges, we introduce Pentest-R1, a novel framework designed to optimize LLM reasoning capabilities for this task through a two-stage reinforcement learning pipeline. We first construct a dataset of over 500 real-world, multi-step walkthroughs, which Pentest-R1 leverages for offline reinforcement learning (RL) to instill foundational attack logic. Subsequently, the LLM is fine-tuned via online RL in an interactive Capture The Flag (CTF) environment, where it learns directly from environmental feedback to develop robust error self-correction and adaptive strategies. Our extensive experiments on the Cybench and AutoPenBench benchmarks demonstrate the framework's effectiveness. On AutoPenBench, Pentest-R1 achieves a 24.2% success rate, surpassing most state-of-the-art models and ranking second only to Gemini 2.5 Flash. Ablation studies confirm that the synergy of both training stages is critical to its success.

Video signals are vulnerable in multimedia communication and storage systems, as even slight bitstream-domain corruption can lead to significant pixel-domain degradation. To recover faithful spatio-temporal content from corrupted inputs, bitstream-corrupted video recovery has recently emerged as a challenging and understudied task. However, existing methods require time-consuming and labor-intensive annotation of corrupted regions for each corrupted video frame, resulting in a large workload in practice. In addition, high-quality recovery remains difficult as part of the local residual information in corrupted frames may mislead feature completion and successive content recovery. In this paper, we propose the first blind bitstream-corrupted video recovery framework that integrates visual foundation models with a recovery model, which is adapted to different types of corruption and bitstream-level prompts. Within the framework, the proposed Detect Any Corruption (DAC) model leverages the rich priors of the visual foundation model while incorporating bitstream and corruption knowledge to enhance corruption localization and blind recovery. Additionally, we introduce a novel Corruption-aware Feature Completion (CFC) module, which adaptively processes residual contributions based on high-level corruption understanding. With VFM-guided hierarchical feature augmentation and high-level coordination in a mixture-of-residual-experts (MoRE) structure, our method suppresses artifacts and enhances informative residuals. Comprehensive evaluations show that the proposed method achieves outstanding performance in bitstream-corrupted video recovery without requiring a manually labeled mask sequence. The demonstrated effectiveness will help to realize improved user experience, wider application scenarios, and more reliable multimedia communication and storage systems.

Recent advancements in language models (LMs) have marked a shift toward the growing importance of post-training. Yet, post-training approaches such as supervised fine-tuning (SFT) do not guarantee the effective use of knowledge acquired during pretraining. We therefore introduce InfoSteer, a lightweight method that encourages parametric information utilization in LMs during post-training. Specifically, InfoSteer treats the feed-forward network (FFN) layer as associate key-value memory and promotes the use of stored memory vectors via forward-pass interventions or regularization during backpropagation. This simple guidance during post-training phase yields consistent performance improvements across diverse model families -- including Qwen, Gemma and Llama -- spanning 15 downstream tasks in both in-distribution (ID) and out-of-distribution (OOD) evaluations. Beyond performance gains, we also find that steered LMs can adaptively allocate information by placing more emphasis on generating semantically meaningful tokens, while using fewer resources on simple transition ones (e.g., `\texttt{,}' or `\texttt{and}'). Our work underscores that vanilla post-training does not fully exploit the potential gained during pre-training, and that steering LMs in latent representation space offers a promising approach to enhance both performance and interpretability. The code is available at: https://github.com/chili-lab/InfoSteer.

Multimodal in-context learning (ICL) remains underexplored despite significant potential for domains such as medicine. Clinicians routinely encounter diverse, specialized tasks requiring adaptation from limited examples, such as drawing insights from a few relevant prior cases or considering a constrained set of differential diagnoses. While multimodal large language models (MLLMs) have shown advances in medical visual question answering (VQA), their ability to learn multimodal tasks from context is largely unknown. We introduce SMMILE, the first expert-driven multimodal ICL benchmark for medical tasks. Eleven medical experts curated problems, each including a multimodal query and multimodal in-context examples as task demonstrations. SMMILE encompasses 111 problems (517 question-image-answer triplets) covering 6 medical specialties and 13 imaging modalities. We further introduce SMMILE++, an augmented variant with 1038 permuted problems. A comprehensive evaluation of 15 MLLMs demonstrates that most models exhibit moderate to poor multimodal ICL ability in medical tasks. In open-ended evaluations, ICL contributes only an 8% average improvement over zero-shot on SMMILE and 9.4% on SMMILE++. We observe a susceptibility for irrelevant in-context examples: even a single noisy or irrelevant example can degrade performance by up to 9.5%. Moreover, we observe that MLLMs are affected by a recency bias, where placing the most relevant example last can lead to substantial performance improvements of up to 71%. Our findings highlight critical limitations and biases in current MLLMs when learning multimodal medical tasks from context. SMMILE is available at https://smmile-benchmark.github.io.

Computer use agents are LLM-based agents that can directly interact with a graphical user interface, by processing screenshots or accessibility trees. While these systems are gaining popularity, their safety has been largely overlooked, despite the fact that evaluating and understanding their potential for harmful behavior is essential for widespread adoption. To address this gap, we introduce OS-Harm, a new benchmark for measuring safety of computer use agents. OS-Harm is built on top of the OSWorld environment and aims to test models across three categories of harm: deliberate user misuse, prompt injection attacks, and model misbehavior. To cover these cases, we create 150 tasks that span several types of safety violations (harassment, copyright infringement, disinformation, data exfiltration, etc.) and require the agent to interact with a variety of OS applications (email client, code editor, browser, etc.). Moreover, we propose an automated judge to evaluate both accuracy and safety of agents that achieves high agreement with human annotations (0.76 and 0.79 F1 score). We evaluate computer use agents based on a range of frontier models - such as o4-mini, Claude 3.7 Sonnet, Gemini 2.5 Pro - and provide insights into their safety. In particular, all models tend to directly comply with many deliberate misuse queries, are relatively vulnerable to static prompt injections, and occasionally perform unsafe actions. The OS-Harm benchmark is available at https://github.com/tml-epfl/os-harm.