Abstract--Reliable, generalizable data foundations are critical for enabling large-scale models in computational lithography. However, essential tasks--mask generation, rule violation detection, and layout optimization--are often handled in isolation, hindered by scarce datasets and limited modeling approaches. T o address these challenges, we introduce Unitho, a unified multi-task large vision model built upon the Transformer architecture. Trained on a large-scale industrial lithography simulation dataset with hundreds of thousands of cases, Unitho supports end-to-end mask generation, lithography simulation, and rule violation detection. As process nodes continue to shrink, geometric distortions induced by photolithography, such as optical proximity effects (OPE), pose a growing challenge to device performance and manufacturing yield. To ensure that design layouts are transferred to the wafer with high fidelity, optical proximity correction (OPC) and subsequent lithography verification have become indispensable steps in the chip design workflow [1]. However, the industry-standard physics-based simulation, while accurate, is computationally intensive and time-consuming, as shown in Figure 1 This bottleneck is severely exacerbated during process window (PW) analysis, which requires validating design robustness under variations in focus and exposure dose. Since simulations must be repeated across the entire process matrix, the resulting computational overhead significantly prolongs design iteration cycles and severely impedes early-stage Design-Technology Co-Optimization (DTCO), as shown in Figure 1.

Recent progress in large language models (LLMs) has enabled understanding of both speech and non-speech audio, but exposing new safety risks emerging from complex audio inputs that are inadequately handled by current safeguards. We introduce SACRED-Bench (Speech-Audio Composition for RED-teaming) to evaluate the robustness of LLMs under complex audio-based attacks. Unlike existing perturbation-based methods that rely on noise optimization or white-box access, SACRED-Bench exploits speech-audio composition mechanisms. SACRED-Bench adopts three mechanisms: (a) speech overlap and multi-speaker dialogue, which embeds harmful prompts beneath or alongside benign speech; (b) speech-audio mixture, which imply unsafe intent via non-speech audio alongside benign speech or audio; and (c) diverse spoken instruction formats (open-ended QA, yes/no) that evade text-only filters. Experiments show that, even Gemini 2.5 Pro, the state-of-the-art proprietary LLM, still exhibits 66% attack success rate in SACRED-Bench test set, exposing vulnerabilities under cross-modal, speech-audio composition attacks. To bridge this gap, we propose SALMONN-Guard, a safeguard LLM that jointly inspects speech, audio, and text for safety judgments, reducing attack success down to 20%. Our results highlight the need for audio-aware defenses for the safety of multimodal LLMs. The benchmark and SALMONN-Guard checkpoints can be found at https://huggingface.co/datasets/tsinghua-ee/SACRED-Bench. Warning: this paper includes examples that may be offensive or harmful.

Abstract--The data-centric paradigm has emerged as a pivotal direction in artificial intelligence (AI), relying on high-quality training data. This shift is especially critical in the T ext-to-SQL task, where model performance is constrained by the scarcity, limited diversity, and structural simplicity of existing datasets. Our framework operates along six augmentation dimensions and integrates an end-to-end pipeline featuring SQL execution verification, natural language (NL) question generation, chain-of-thought (CoT) reasoning trace generation, and data classification. A modular Database Manager further ensures cross-database compatibility and scalability. This approach enables structure-aware example matching by modeling fine-grained alignments between NL questions and SQL queries. Our work establishes a scalable, data-centric foundation for advancing T ext-to-SQL systems and underscores the indispensable role of structured, high-fidelity data in modern AI development. Our code is available at https://github.com/T In recent years, the data-centric artificial intelligence (AI) paradigm has garnered increasing attention [1], [2]. Traditional algorithm-centric approaches primarily focus on expanding model architectures and optimizing learning algorithms. However, in many cutting-edge fields, the main bottleneck of development has gradually shifted from algorithmic complexity to the availability of high-quality data. Continuous optimization of algorithms is facing diminishing marginal returns, while vast amounts of data remain underutilized, containing immense potential value. Taking large language models (LLMs) as an example, their generalization ability and robustness highly depend on the breadth and quality of the training data. Similarly, in downstream tasks such as domain adaptation, high-quality data can serve both as reference material for generating answers and as guidance for solving problems [4].

Large language models (LLMs) have shown great promise in the medical domain, achieving strong performance on several benchmarks. However, they continue to underperform in real-world medical scenarios, which often demand stronger context-awareness, i.e., the ability to recognize missing or critical details (e.g., user identity, medical history, risk factors) and provide safe, helpful, and contextually appropriate responses. To address this issue, we propose Multifaceted Self-Refinement (MuSeR), a data-driven approach that enhances LLMs' context-awareness along three key facets (decision-making, communication, and safety) through self-evaluation and refinement. Specifically, we first design a attribute-conditioned query generator that simulates diverse real-world user contexts by varying attributes such as role, geographic region, intent, and degree of information ambiguity. An LLM then responds to these queries, self-evaluates its answers along three key facets, and refines its responses to better align with the requirements of each facet. Finally, the queries and refined responses are used for supervised fine-tuning to reinforce the model's context-awareness ability. Evaluation results on the latest HealthBench dataset demonstrate that our method significantly improves LLM performance across multiple aspects, with particularly notable gains in the context-awareness axis. Furthermore, by incorporating knowledge distillation with the proposed method, the performance of a smaller backbone LLM (e.g., Qwen3-32B) surpasses its teacher model, achieving a new SOTA across all open-source LLMs on HealthBench (63.8%) and its hard subset (43.1%). Code and dataset will be released at https://muser-llm.github.io.

Large Language Models (LLMs) have demonstrated remarkable capabilities in understanding and generating human-like content. This has revolutionized various sectors such as healthcare, software development, and education. In education, LLMs offer potential for personalized and interactive learning experiences, especially in regions with limited teaching resources. However, adapting these models effectively to curriculum-specific content, such as the National Council of Educational Research and Training (NCERT) syllabus in India, presents unique challenges in terms of accuracy, alignment, and pedagogical relevance. In this paper, we present the framework "PustakAI"\footnote{Pustak means `book' in many Indian languages.} for the design and evaluation of a novel question-answering dataset "NCERT-QA" aligned with the NCERT curriculum for English and Science subjects of grades 6 to 8. We classify the curated QA pairs as Factoid, Inferential, and Others (evaluative and reasoning). We evaluate the dataset with various prompting techniques, such as meta-prompt, few-shot, and CoT-style prompting, using diverse evaluation metrics to understand which approach aligns more efficiently with the structure and demands of the curriculum. Along with the usability of the dataset, we analyze the strengths and limitations of current open-source LLMs (Gemma3:1b, Llama3.2:3b, and Nemotron-mini:4b) and high-end LLMs (Llama-4-Scout-17B and Deepseek-r1-70B) as AI-based learning tools in formal education systems.

The opioid crisis represents a significant moment in public health that reveals systemic shortcomings across regulatory systems, healthcare practices, corporate governance, and public policy. Analyzing how these interconnected systems simultaneously failed to protect public health requires innovative analytic approaches for exploring the vast amounts of data and documents disclosed in the UCSF-JHU Opioid Industry Documents Archive (OIDA). The complexity, multimodal nature, and specialized characteristics of these healthcare-related legal and corporate documents necessitate more advanced methods and models tailored to specific data types and detailed annotations, ensuring the precision and professionalism in the analysis. In this paper, we tackle this challenge by organizing the original dataset according to document attributes and constructing a benchmark with 400k training documents and 10k for testing. From each document, we extract rich multimodal information-including textual content, visual elements, and layout structures-to capture a comprehensive range of features. Using multiple AI models, we then generate a large-scale dataset comprising 360k training QA pairs and 10k testing QA pairs. Building on this foundation, we develop domain-specific multimodal Large Language Models (LLMs) and explore the impact of multimodal inputs on task performance. To further enhance response accuracy, we incorporate historical QA pairs as contextual grounding for answering current queries. Additionally, we incorporate page references within the answers and introduce an importance-based page classifier, further improving the precision and relevance of the information provided. Preliminary results indicate the improvements with our AI assistant in document information extraction and question-answering tasks. The dataset is available at: https://huggingface.co/datasets/opioidarchive/oida-qa

Computational humor is a frontier for creating advanced and engaging natural language processing (NLP) applications, such as sophisticated dialogue systems. While previous studies have benchmarked the humor capabilities of Large Language Models (LLMs), they have often relied on single-dimensional evaluations, such as judging whether something is simply ``funny.'' This paper argues that a multifaceted understanding of humor is necessary and addresses this gap by systematically evaluating LLMs through the lens of Oogiri, a form of Japanese improvisational comedy games. To achieve this, we expanded upon existing Oogiri datasets with data from new sources and then augmented the collection with Oogiri responses generated by LLMs. We then manually annotated this expanded collection with 5-point absolute ratings across six dimensions: Novelty, Clarity, Relevance, Intelligence, Empathy, and Overall Funniness. Using this dataset, we assessed the capabilities of state-of-the-art LLMs on two core tasks: their ability to generate creative Oogiri responses and their ability to evaluate the funniness of responses using a six-dimensional evaluation. Our results show that while LLMs can generate responses at a level between low- and mid-tier human performance, they exhibit a notable lack of Empathy. This deficit in Empathy helps explain their failure to replicate human humor assessment. Correlation analyses of human and model evaluation data further reveal a fundamental divergence in evaluation criteria: LLMs prioritize Novelty, whereas humans prioritize Empathy. We release our annotated corpus to the community to pave the way for the development of more emotionally intelligent and sophisticated conversational agents.

Joint Senior Corresponding Author: Michael Nercessian Email: michael.nercessian@berkeley.edu Abstract Randomized controlled trials (RCTs) are indispensable for establishing the clinical value of medical artificial-intelligence (AI) tools, yet their high cost and long timelines hinder timely validation as new models emerge rapidly. Here, we propose BRIDGE, a data-reuse RCT design for AI-based risk models. AI risk models support a broad range of interventions, including screening, treatment selection, and clinical alerts. BRIDGE trials recycle participant-level data from completed trials of AI models when legacy and updated models make concordant predictions, thereby reducing the enrollment requirement for subsequent trials. We provide a practical checklist for investigators to assess whether reusing data from previous trials allows for valid causal inference and preserves type I error. Using real-world datasets across breast cancer, cardiovascular disease, and sepsis, we demonstrate concordance between successive AI models, with up to 64.8% overlap in top 5% high-risk cohorts. We then simulate a series of breast cancer screening studies, where our design reduced required enrollment by 46.6%--saving over US$2.8 million--while maintaining 80% power. By transforming trials into adaptive, modular studies, our proposed design makes Level I evidence generation feasible for every model iteration, thereby accelerating cost-effective translation of AI into routine care . Introduction Artificial intelligence (AI) models have the potential to transform patient care by identifying high-risk individuals using high-dimensional data--such as imaging, electronic health records, or time-series data--to personalize screening, prevention, and treatment decisions across a range of diseases, including cancer and heart disease.

Grassmannian manifold offers a powerful carrier for geometric representation learning by modelling high-dimensional data as low-dimensional subspaces. However, existing approaches predominantly rely on static single-subspace representations, neglecting the dynamic interplay between multiple subspaces critical for capturing complex geometric structures. To address this limitation, we propose a topology-driven multi-subspace fusion framework that enables adaptive subspace collaboration on the Grassmannian. Our solution introduces two key innovations: (1) Inspired by the Kolmogorov-Arnold representation theorem, an adaptive multi-subspace modelling mechanism is proposed that dynamically selects and weights task-relevant subspaces via topological convergence analysis, and (2) a multi-subspace interaction block that fuses heterogeneous geometric representations through Fr echet mean optimisation on the manifold. Theoretically, we establish the convergence guarantees of adaptive subspaces under a projection metric topology, ensuring stable gradient-based optimisation. Practically, we integrate Riemannian batch normalisation and mutual information regularisation to enhance discriminability and robustness. Extensive experiments on 3D action recognition (HDM05, FPHA), EEG classification (MAMEM-SSVEPII), and graph tasks demonstrate state-of-the-art performance. Our work not only advances geometric deep learning but also successfully adapts the proven multi-channel interaction philosophy of Euclidean networks to non-Euclidean domains, achieving superior discriminability and interpretability.

Interpretability is essential in Whole Slide Image (WSI) analysis for computational pathology, where understanding model predictions helps build trust in AI-assisted diagnostics. While Integrated Gradients (IG) and related attribution methods have shown promise, applying them directly to WSIs introduces challenges due to their high-resolution nature. These methods capture model decision patterns but may overlook class-discriminative signals that are crucial for distinguishing between tumor subtypes. In this work, we introduce Contrastive Integrated Gradients (CIG), a novel attribution method that enhances interpretability by computing contrastive gradients in logit space. First, CIG highlights class-discriminative regions by comparing feature importance relative to a reference class, offering sharper differentiation between tumor and non-tumor areas. Second, CIG satisfies the axioms of integrated attribution, ensuring consistency and theoretical soundness. Third, we propose two attribution quality metrics, MIL-AIC and MIL-SIC, which measure how predictive information and model confidence evolve with access to salient regions, particularly under weak supervision.