Autism spectrum disorder (ASD) is a complex neurodevelopmental condition whose rising prevalence places increasing demands on a lengthy diagnostic process. Machine learning (ML) has shown promise in automating ASD diagnosis, but most existing models operate as black boxes and are typically trained on a single dataset, limiting their generalizability. In this study, we introduce a transparent and interpretable ML approach that leverages BioBERT, a state-of-the-art language model, to analyze unstructured clinical text. The model is trained to label descriptions of behaviors and map them to diagnostic criteria, which are then used to assign a final label (ASD or not). We evaluate transfer learning, the ability to transfer knowledge to new data, using two distinct real-world datasets. We trained on datasets sequentially and mixed together and compared the performance of the best models and their ability to transfer to new data. We also created a black-box approach and repeated this transfer process for comparison. Our transparent model demonstrated robust performance, with the mixed-data training strategy yielding the best results (97 % sensitivity, 98 % specificity). Sequential training across datasets led to a slight drop in performance, highlighting the importance of training data order. The black-box model performed worse (90 % sensitivity, 96 % specificity) when trained sequentially or with mixed data. Overall, our transparent approach outperformed the black-box approach. Mixing datasets during training resulted in slightly better performance and should be the preferred approach when practically possible. This work paves the way for more trustworthy, generalizable, and clinically actionable AI tools in neurodevelopmental diagnostics.

While commendable progress has been made in user-centric research on mobile assistive systems for blind and low-vision (BLV) individuals, references that directly inform robot navigation design remain rare. To bridge this gap, we conducted a comprehensive human study involving interviews with 26 guide dog handlers, four white cane users, nine guide dog trainers, and one O\&M trainer, along with 15+ hours of observing guide dog-assisted walking. After de-identification, we open-sourced the dataset to promote human-centered development and informed decision-making for assistive systems for BLV people. Building on insights from this formative study, we developed GuideNav, a vision-only, teach-and-repeat navigation system. Inspired by how guide dogs are trained and assist their handlers, GuideNav autonomously repeats a path demonstrated by a sighted person using a robot. Specifically, the system constructs a topological representation of the taught route, integrates visual place recognition with temporal filtering, and employs a relative pose estimator to compute navigation actions - all without relying on costly, heavy, power-hungry sensors such as LiDAR. In field tests, GuideNav consistently achieved kilometer-scale route following across five outdoor environments, maintaining reliability despite noticeable scene variations between teach and repeat runs. A user study with 3 guide dog handlers and 1 guide dog trainer further confirmed the system's feasibility, marking (to our knowledge) the first demonstration of a quadruped mobile system retrieving a path in a manner comparable to guide dogs.

Early forecasting of individual cognitive decline in Alzheimer's disease (AD) is central to disease evaluation and management. Despite advances, it is as of yet challenging for existing methodological frameworks to integrate multimodal data for longitudinal personalized forecasting while maintaining interpretability. To address this gap, we present the Neural Koopman Machine (NKM), a new machine learning architecture inspired by dynamical systems and attention mechanisms, designed to forecast multiple cognitive scores simultaneously using multimodal genetic, neuroimaging, proteomic, and demographic data. NKM integrates analytical ($α$) and biological ($β$) knowledge to guide feature grouping and control the hierarchical attention mechanisms to extract relevant patterns. By implementing Fusion Group-Aware Hierarchical Attention within the Koopman operator framework, NKM transforms complex nonlinear trajectories into interpretable linear representations. To demonstrate NKM's efficacy, we applied it to study the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. Our results suggest that NKM consistently outperforms both traditional machine learning methods and deep learning models in forecasting trajectories of cognitive decline. Specifically, NKM (1) forecasts changes of multiple cognitive scores simultaneously, (2) quantifies differential biomarker contributions to predicting distinctive cognitive scores, and (3) identifies brain regions most predictive of cognitive deterioration. Together, NKM advances personalized, interpretable forecasting of future cognitive decline in AD using past multimodal data through an explainable, explicit system and reveals potential multimodal biological underpinnings of AD progression.

Patch robustness certification is an emerging kind of provable defense technique against adversarial patch attacks for deep learning systems. Certified detection ensures the detection of all patched harmful versions of certified samples, which mitigates the failures of empirical defense techniques that could (easily) be compromised. However, existing certified detection methods are ineffective in certifying samples that are misclassified or whose mutants are inconsistently pre icted to different labels. This paper proposes HiCert, a novel masking-based certified detection technique. By focusing on the problem of mutants predicted with a label different from the true label with our formal analysis, HiCert formulates a novel formal relation between harmful samples generated by identified loopholes and their benign counterparts. By checking the bound of the maximum confidence among these potentially harmful (i.e., inconsistent) mutants of each benign sample, HiCert ensures that each harmful sample either has the minimum confidence among mutants that are predicted the same as the harmful sample itself below this bound, or has at least one mutant predicted with a label different from the harmful sample itself, formulated after two novel insights. As such, HiCert systematically certifies those inconsistent samples and consistent samples to a large extent. To our knowledge, HiCert is the first work capable of providing such a comprehensive patch robustness certification for certified detection. Our experiments show the high effectiveness of HiCert with a new state-of the-art performance: It certifies significantly more benign samples, including those inconsistent and consistent, and achieves significantly higher accuracy on those samples without warnings and a significantly lower false silent ratio.

The Federal Highway Administration (FHWA) mandates that state Departments of Transportation (DOTs) collect reliable Annual Average Daily Traffic (AADT) data. However, many U.S. DOTs struggle to obtain accurate AADT, especially for unmonitored roads. While continuous count (CC) stations offer accurate traffic volume data, their implementation is expensive and difficult to deploy widely, compelling agencies to rely on short-duration traffic counts. This study proposes a machine learning framework, the first to our knowledge, to identify optimal representative days for conducting short count (SC) data collection to improve AADT prediction accuracy. Using 2022 and 2023 traffic volume data from the state of Texas, we compare two scenarios: an 'optimal day' approach that iteratively selects the most informative days for AADT estimation and a 'no optimal day' baseline reflecting current practice by most DOTs. To align with Texas DOT's traffic monitoring program, continuous count data were utilized to simulate the 24 hour short counts. The actual field short counts were used to enhance feature engineering through using a leave-one-out (LOO) technique to generate unbiased representative daily traffic features across similar road segments. Our proposed methodology outperforms the baseline across the top five days, with the best day (Day 186) achieving lower errors (RMSE: 7,871.15, MAE: 3,645.09, MAPE: 11.95%) and higher R^2 (0.9756) than the baseline (RMSE: 11,185.00, MAE: 5,118.57, MAPE: 14.42%, R^2: 0.9499). This research offers DOTs an alternative to conventional short-duration count practices, improving AADT estimation, supporting Highway Performance Monitoring System compliance, and reducing the operational costs of statewide traffic data collection.

What if users could meet their future selves today? AI-generated future selves simulate meaningful encounters with a digital twin decades in the future. As AI systems advance, combining cloned voices, age-progressed facial rendering, and autobiographical narratives, a central question emerges: Does the modality of these future selves alter their psychological and affective impact? How might a text-based chatbot, a voice-only system, or a photorealistic avatar shape present-day decisions and our feeling of connection to the future? We report a randomized controlled study (N=92) evaluating three modalities of AI-generated future selves (text, voice, avatar) against a neutral control condition. We also report a systematic model evaluation between Claude 4 and three other Large Language Models (LLMs), assessing Claude 4 across psychological and interaction dimensions and establishing conversational AI quality as a critical determinant of intervention effectiveness. All personalized modalities strengthened Future Self-Continuity (FSC), emotional well-being, and motivation compared to control, with avatar producing the largest vividness gains, yet with no significant differences between formats. Interaction quality metrics, particularly persuasiveness, realism, and user engagement, emerged as robust predictors of psychological and affective outcomes, indicating that how compelling the interaction feels matters more than the form it takes. Content analysis found thematic patterns: text emphasized career planning, while voice and avatar facilitated personal reflection. Claude 4 outperformed ChatGPT 3.5, Llama 4, and Qwen 3 in enhancing psychological, affective, and FSC outcomes.

Deep learning has demonstrated expert-level performance in melanoma classification, positioning it as a powerful tool in clinical dermatology. However, model opacity and the lack of interpretability remain critical barriers to clinical adoption, as clinicians often struggle to trust the decision-making processes of black-box models. To address this gap, we present a Cross-modal Explainable Framework for Melanoma (CEFM) that leverages contrastive learning as the core mechanism for achieving interpretability. Specifically, CEFM maps clinical criteria for melanoma diagnosis-namely Asymmetry, Border, and Color (ABC)-into the Vision Transformer embedding space using dual projection heads, thereby aligning clinical semantics with visual features. The aligned representations are subsequently translated into structured textual explanations via natural language generation, creating a transparent link between raw image data and clinical interpretation. Experiments on public datasets demonstrate 92.79% accuracy and an AUC of 0.961, along with significant improvements across multiple interpretability metrics. Qualitative analyses further show that the spatial arrangement of the learned embeddings aligns with clinicians' application of the ABC rule, effectively bridging the gap between high-performance classification and clinical trust.

Conventional wisdom in the age of LLMs dictates that solving IQ-test-like visual puzzles from the ARC-AGI-1 benchmark requires capabilities derived from massive pretraining. To counter this, we introduce CompressARC, a 76K parameter model without any pretraining that solves 20% of evaluation puzzles by minimizing the description length (MDL) of the target puzzle purely during inference time. The MDL endows CompressARC with extreme generalization abilities typically unheard of in deep learning. To our knowledge, CompressARC is the only deep learning method for ARC-AGI where training happens only on a single sample: the target inference puzzle itself, with the final solution information removed. Moreover, CompressARC does not train on the pre-provided ARC-AGI "training set". Under these extremely data-limited conditions, we do not ordinarily expect any puzzles to be solvable at all. Yet CompressARC still solves a diverse distribution of creative ARC-AGI puzzles, suggesting MDL to be an alternative feasible way to produce intelligence, besides conventional pretraining.

Artificial intelligence methods are increasingly being explored for managing wildfires and other natural hazards. In particular, reinforcement learning (RL) is a promising path towards improving outcomes in such uncertain decision-making scenarios and moving beyond reactive strategies. However, training RL agents requires many environment interactions, and the speed of existing wildfire simulators is a severely limiting factor. We introduce $\texttt{JaxWildfire}$, a simulator underpinned by a principled probabilistic fire spread model based on cellular automata. It is implemented in JAX and enables vectorized simulations using $\texttt{vmap}$, allowing high throughput of simulations on GPUs. We demonstrate that $\texttt{JaxWildfire}$ achieves 6-35x speedup over existing software and enables gradient-based optimization of simulator parameters. Furthermore, we show that $\texttt{JaxWildfire}$ can be used to train RL agents to learn wildfire suppression policies. Our work is an important step towards enabling the advancement of RL techniques for managing natural hazards.

Abstract--General-purpose large language models (LLMs) have demonstrated remarkable generative and reasoning capabilities but remain limited in healthcare and caregiving applications due to two key deficiencies: factual unreliability and a lack of empathetic communication. These shortcomings pose significant risks in sensitive contexts where users, particularly nonprofessionals and caregivers, seek medically relevant guidance or emotional reassurance. T o address these challenges, we introduce a Direct Preference Optimization (DPO)-based alignment framework designed to improve factual correctness, semantic coherence, and human-centric qualities such as empathy, politeness, and simplicity in caregiver-patient dialogues. Our approach fine-tunes domain-adapted Large Language Models (LLMs) using pairwise preference data, where preferred responses reflect supportive and accessible communication styles while rejected ones represent prescriptive or overly technical tones. Empirical evaluations across multiple open and proprietary LLMs show that our DPO-tuned models achieve higher semantic alignment, improved factual accuracy, and stronger human-centric evaluation scores compared to baseline and commercial alternatives such as Google's medical dialogue systems. These improvements demonstrate that preference-based alignment offers a scalable and transparent pathway toward developing trustworthy, empathetic, and clinically informed AI assistants for caregiver and healthcare communication. Caring for individuals with chronic or neuro-degenerative conditions such as Alzheimer's disease and dementia requires not only clinical coordination but also constant emotional resilience. Family caregivers and care partners often become the primary interpreters of medical information, navigating complex treatment decisions, behavioral changes, and communication challenges on a daily basis. LLMs have rapidly become integrated into everyday life. They can explain complex ideas in plain language, adjust to a user's tone, and offer a sense of understanding that static websites cannot. For caregivers seeking clear, kind, and quick answers, these systems can feel like an always-available companion in moments of doubt or stress.