As medical large language models (LLMs) become increasingly integrated into clinical workflows, concerns around alignment robustness, and safety are escalating. Prior work on model extraction has focused on classification models or memorization leakage, leaving the vulnerability of safety-aligned generative medical LLMs underexplored. We present a black-box distillation attack that replicates the domain-specific reasoning of safety-aligned medical LLMs using only output-level access. By issuing 48,000 instruction queries to Meditron-7B and collecting 25,000 benign instruction response pairs, we fine-tune a LLaMA3 8B surrogate via parameter efficient LoRA under a zero-alignment supervision setting, requiring no access to model weights, safety filters, or training data. With a cost of $12, the surrogate achieves strong fidelity on benign inputs while producing unsafe completions for 86% of adversarial prompts, far exceeding both Meditron-7B (66%) and the untuned base model (46%). This reveals a pronounced functional-ethical gap, task utility transfers, while alignment collapses. To analyze this collapse, we develop a dynamic adversarial evaluation framework combining Generative Query (GQ)-based harmful prompt generation, verifier filtering, category-wise failure analysis, and adaptive Random Search (RS) jailbreak attacks. We also propose a layered defense system, as a prototype detector for real-time alignment drift in black-box deployments. Our findings show that benign-only black-box distillation exposes a practical and under-recognized threat: adversaries can cheaply replicate medical LLM capabilities while stripping safety mechanisms, underscoring the need for extraction-aware safety monitoring.

Traffic prediction remains a key challenge in spatio-temporal data mining, despite progress in deep learning. Accurate forecasting is hindered by the complex influence of external factors such as traffic accidents and regulations, often overlooked by existing models due to limited data integration. To address these limitations, we present two enriched traffic datasets from Tokyo and California, incorporating traffic accident and regulation data. Leveraging these datasets, we propose ConFormer (Conditional Transformer), a novel framework that integrates graph propagation with guided normalization layer. This design dynamically adjusts spatial and temporal node relationships based on historical patterns, enhancing predictive accuracy. Our model surpasses the state-of-the-art STAEFormer in both predictive performance and efficiency, achieving lower computational costs and reduced parameter demands. Extensive evaluations demonstrate that ConFormer consistently outperforms mainstream spatio-temporal baselines across multiple metrics, underscoring its potential to advance traffic prediction research.

Background. Subdural hematoma (SDH) is a common neurosurgical emergency, with increasing incidence in aging populations. Rapid and accurate identification is essential to guide timely intervention, yet existing automated tools focus primarily on detection and provide limited interpretability or spatial localization. There remains a need for transparent, high-performing systems that integrate multimodal clinical and imaging information to support real-time decision-making. Methods. We developed a multimodal deep-learning framework that integrates structured clinical variables, a 3D convolutional neural network trained on CT volumes, and a transformer-enhanced 2D segmentation model for SDH detection and localization. Using 25,315 head CT studies from Hartford HealthCare (2015--2024), of which 3,774 (14.9\%) contained clinician-confirmed SDH, tabular models were trained on demographics, comorbidities, medications, and laboratory results. Imaging models were trained to detect SDH and generate voxel-level probability maps. A greedy ensemble strategy combined complementary predictors. Findings. Clinical variables alone provided modest discriminatory power (AUC 0.75). Convolutional models trained on CT volumes and segmentation-derived maps achieved substantially higher accuracy (AUCs 0.922 and 0.926). The multimodal ensemble integrating all components achieved the best overall performance (AUC 0.9407; 95\% CI, 0.930--0.951) and produced anatomically meaningful localization maps consistent with known SDH patterns. Interpretation. This multimodal, interpretable framework provides rapid and accurate SDH detection and localization, achieving high detection performance and offering transparent, anatomically grounded outputs. Integration into radiology workflows could streamline triage, reduce time to intervention, and improve consistency in SDH management.

Neural Radiance Fields (NeRF) have achieved remarkable results in novel view synthesis, typically using sRGB images for supervision. However, little attention has been paid to the color space in which the network is learning the radiance field representation. Inspired by the BiIlluminant Dichromatic Reflection (BIDR) model, which suggests that a logarithmic transformation simplifies the separation of illumination and reflectance, we hypothesize that log RGB space enables NeRF to learn a more compact and effective representation of scene appearance. To test this, we captured approximately 30 videos using a GoPro camera, ensuring linear data recovery through inverse encoding. We trained NeRF models under various color space interpretations linear, sRGB, GPLog, and log RGB by converting each network output to a common color space before rendering and loss computation, enforcing representation learning in different color spaces. Quantitative and qualitative evaluations demonstrate that using a log RGB color space consistently improves rendering quality, exhibits greater robustness across scenes, and performs particularly well in low light conditions while using the same bit-depth input images. Further analysis across different network sizes and NeRF variants confirms the generalization and stability of the log space advantage.

Predicting molecule-protein interactions (MPIs) is a fundamental task in computational biology, with crucial applications in drug discovery and molecular function annotation. However, existing MPI models face two major challenges. First, the scarcity of labeled molecule-protein pairs significantly limits model performance, as available datasets capture only a small fraction of biological relevant interactions. Second, most methods rely solely on molecular and protein features, ignoring broader biological context such as genes, metabolic pathways, and functional annotations that could provide essential complementary information. To address these limitations, our framework first aggregates diverse biological datasets, including molecular, protein, genes and pathway-level interactions, and then develop an optimal transport-based approach to generate high-quality pseudo-labels for unlabeled molecule-protein pairs, leveraging the underlying distribution of known interactions to guide label assignment. By treating pseudo-labeling as a mechanism for bridging disparate biological modalities, our approach enables the effective use of heterogeneous data to enhance MPI prediction. We evaluate our framework on multiple MPI datasets including virtual screening tasks and protein retrieval tasks, demonstrating substantial improvements over state-of-the-art methods in prediction accuracies and zero shot ability across unseen interactions. Beyond MPI prediction, our approach provides a new paradigm for leveraging diverse biological data sources to tackle problems traditionally constrained by single- or bi-modal learning, paving the way for future advances in computational biology and drug discovery.

This study develops a forecasting framework t hat leverages the Construction Specifications Institute (CSI) MasterFormat as the target data structure, enabling predictions at the six - digit section level and supporting detailed cost projections across a wide spectrum of building materials. To enhance p redictive accuracy, the framework integrates explanatory variables such as raw material prices, commodity indexes, and macroeconomic indicators. Four time - series models, Long Short - Term Memory (LSTM), Autoregressive Integrated Moving Average (ARIMA), Vecto r Error Correction Model (VECM), and Chronos - Bolt, were evaluated under both baseline configurations (using CSI data only) and extended versions with explanatory variables. Results demonstrate that incorporating explanatory variables significantly improves predictive performance across all models. Among the tested approaches, the LSTM model consistently ach ieved the highest accuracy, with RMSE values as low as 1.390 and MAPE values of 0.957, representing improvements of up to 59 % over traditional statistical time - series model, ARIMA. Validation across multiple CSI divisions confirmed the framework's scalability, while Division 06 (Wood, Plastics, and Composites) is presented in detail as a demonstration case. This research offers a robust methodology that enables owners and contractors to improve budgeting practices and achieve more reliable cost estimation at the Definitive level. INTRODUCTION 1.1 Motivation The construction industry continues to demonstrate steady long - term growth, with global activity projected to reach US$9.8 trillion by 2026 [1] . Major upcoming programs in the United States, such as the Los Angeles 2028 Olympics and TSMC's fabrication facility in Arizona [2] [3], highlight the scale of high - value projects in the near future. However, volatility in construction material prices has emerged as a critical challenge, creating significant uncertainty for contractors in project planning, budgeting, and cost management. Price fluctuations, driven by raw material costs, macroeconomic conditions such as inflation and interest rates, and supply - demand imbalances, have amplified risks of cost overruns and delays [4] [5] [6] [7] [8] . Traditional econometric methods (i.e.,multiple regression analysis) and modern econometric methods (i.e., univariate, and multivariate time series methods) have faced limitations in effectively capturing the high - frequency volatility observed in constructi on material prices [9] . These models often struggle to handle the complexity of input data and exhibit limited predictive accuracy in real - world applications.

End-to-end autonomous driving frameworks face persistent challenges in generalization, training efficiency, and interpretability. While recent methods leverage Vision-Language Models (VLMs) through supervised learning on large-scale datasets to improve reasoning, they often lack robustness in novel scenarios. Conversely, reinforcement learning (RL)-based approaches enhance adaptability but remain data-inefficient and lack transparent decision-making. % contribution To address these limitations, we propose COVLM-RL, a novel end-to-end driving framework that integrates Critical Object-oriented (CO) reasoning with VLM-guided RL. Specifically, we design a Chain-of-Thought (CoT) prompting strategy that enables the VLM to reason over critical traffic elements and generate high-level semantic decisions, effectively transforming multi-view visual inputs into structured semantic decision priors. These priors reduce the input dimensionality and inject task-relevant knowledge into the RL loop, accelerating training and improving policy interpretability. However, bridging high-level semantic guidance with continuous low-level control remains non-trivial. To this end, we introduce a consistency loss that encourages alignment between the VLM's semantic plans and the RL agent's control outputs, enhancing interpretability and training stability. Experiments conducted in the CARLA simulator demonstrate that COVLM-RL significantly improves the success rate by 30\% in trained driving environments and by 50\% in previously unseen environments, highlighting its strong generalization capability.

Supervised fine-tuning (SFT) is a standard approach for adapting large language models to specialized domains, yet its application to protein sequence modeling and protein language models (PLMs) remains ad hoc. This is in part because high-quality annotated data are far more difficult to obtain for proteins than for natural language. We present a simple and general recipe for fast SFT of PLMs, designed to improve the fidelity, reliability, and novelty of generated protein sequences. Unlike existing approaches that require costly precompiled experimental datasets for SFT, our method leverages the PLM itself, integrating a lightweight curation pipeline with domain-specific filters to construct high-quality training data. These filters can independently refine a PLM's output and identify candidates for in vitro evaluation; when combined with SFT, they enable PLMs to generate more stable and functional enzymes, while expanding exploration into protein sequence space beyond natural variants. Although our approach is agnostic to both the choice of protein language model (PLM) and the protein system, we demonstrate its effectiveness with a genome-scale PLM (GenSLM) applied to the tryptophan synthase enzyme family. The supervised fine-tuned model generates sequences that are not only more novel but also display improved characteristics across both targeted design constraints and emergent protein property measures.

The meteoric rise in text generation capability has been accompanied by parallel growth in interest in machine-generated text detection: the capability to identify whether a given text was generated using a model or written by a person. While detection models show strong performance, they have the capacity to cause significant negative impacts. We explore potential biases in English machine-generated text detection systems. We curate a dataset of student essays and assess 16 different detection systems for bias across four attributes: gender, race/ethnicity, English-language learner (ELL) status, and economic status. We evaluate these attributes using regression-based models to determine the significance and power of the effects, as well as performing subgroup analysis. We find that while biases are generally inconsistent across systems, there are several key issues: several models tend to classify disadvantaged groups as machine-generated, ELL essays are more likely to be classified as machine-generated, economically disadvantaged students' essays are less likely to be classified as machine-generated, and non-White ELL essays are disproportionately classified as machine-generated relative to their White counterparts. Finally, we perform human annotation and find that while humans perform generally poorly at the detection task, they show no significant biases on the studied attributes.

Glacial lake monitoring bears great significance in mitigating the anticipated risk of Glacial Lake Outburst Floods. However, existing segmentation methods based on convolutional neural networks (CNNs) and Vision Transformers (ViTs), remain constrained to pixel-level predictions, lacking high-level global scene semantics and human-interpretable reasoning. To address this, we introduce GLACIA (\textbf{G}lacial \textbf{LA}ke segmentation with \textbf{C}ontextual \textbf{I}nstance \textbf{A}wareness), the first framework that integrates large language models with segmentation capabilities to produce both accurate segmentation masks and corresponding spatial reasoning outputs. We construct the Glacial Lake Position Reasoning (GLake-Pos) dataset pipeline, which provides diverse, spatially grounded question-answer pairs designed to overcome the lack of instance-aware positional reasoning data in remote sensing. Comparative evaluation demonstrate that GLACIA (mIoU: 87.30) surpasses state-of-the-art method based on CNNs (mIoU: 78.55 - 79.01), ViTs (mIoU: 69.27 - 81.75), Geo-foundation models (mIoU: 76.37 - 87.10), and reasoning based segmentation methods (mIoU: 60.12 - 75.66). Our approach enables intuitive disaster preparedness and informed policy-making in the context of rapidly changing glacial environments by facilitating natural language interaction, thereby supporting more efficient and interpretable decision-making. The code is released on https://github.com/lalitmaurya47/GLACIA