Automatic medical discovery by AI is a dream of many. One step toward that goal is to create an AI model to understand clinical studies and synthesize clinical evidence from the literature. Clinical evidence synthesis currently relies on systematic reviews of clinical trials and retrospective analyses from medical literature. However, the rapid expansion of publications presents challenges in efficiently identifying, summarizing, and updating evidence. We introduce TrialMind, a generative AI-based pipeline for conducting medical systematic reviews, encompassing study search, screening, and data extraction phases. We utilize large language models (LLMs) to drive each pipeline component while incorporating human expert oversight to minimize errors. To facilitate evaluation, we also create a benchmark dataset TrialReviewBench, a custom dataset with 870 annotated clinical studies from 25 meta-analysis papers across various medical treatments. Our results demonstrate that TrialMind significantly improves the literature review process, achieving high recall rates (0.897-1.000) in study searching from over 20 million PubMed studies and outperforming traditional language model embeddings-based methods in screening (Recall@20 of 0.227-0.246 vs. 0.000-0.102). Furthermore, our approach surpasses direct GPT-4 performance in result extraction, with accuracy ranging from 0.65 to 0.84. We also support clinical evidence synthesis in forest plots, as validated by eight human annotators who preferred TrialMind over the GPT-4 baseline with a winning rate of 62.5%-100% across the involved reviews. Our findings suggest that an LLM-based clinical evidence synthesis approach, such as TrialMind, can enable reliable and high-quality clinical evidence synthesis to improve clinical research efficiency.

We present a comprehensive AI risk taxonomy derived from eight government policies from the European Union, United States, and China and 16 company policies worldwide, making a significant step towards establishing a unified language for generative AI safety evaluation. We identify 314 unique risk categories, organized into a four-tiered taxonomy. At the highest level, this taxonomy encompasses System & Operational Risks, Content Safety Risks, Societal Risks, and Legal & Rights Risks. The taxonomy establishes connections between various descriptions and approaches to risk, highlighting the overlaps and discrepancies between public and private sector conceptions of risk. By providing this unified framework, we aim to advance AI safety through information sharing across sectors and the promotion of best practices in risk mitigation for generative AI models and systems.

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No one else is able to do that," says Jack Saunders, a researcher at the University of Bath, who was not involved in Synthesia's work. The full-body avatars he previewed are very good, he says, despite small errors such as hands "slicing" into each other at times. But "chances are you're not really going to be looking that close to notice it," Saunders says. Synthesia launched its first version of hyperrealistic AI avatars, also known as deepfakes, in April. These avatars use large language models to match expressions and tone of voice to the sentiment of spoken text.

Artificial intelligence (AI) methods are poised to revolutionize intellectual work, with generative AI enabling automation of text analysis, text generation, and simple decision making or reasoning. The impact to science is only just beginning, but the opportunity is significant since scientific research relies fundamentally on extended chains of cognitive work. Here, we review the state of the art in agentic AI systems, and discuss how these methods could be extended to have even greater impact on science. We propose the development of an exocortex, a synthetic extension of a person's cognition. A science exocortex could be designed as a swarm of AI agents, with each agent individually streamlining specific researcher tasks, and whose inter-communication leads to emergent behavior that greatly extend the researcher's cognition and volition.

The rapid advancement of Text-to-Image(T2I) generative models has enabled the synthesis of high-quality images guided by textual descriptions. Despite this significant progress, these models are often susceptible in generating contents that contradict the input text, which poses a challenge to their reliability and practical deployment. To address this problem, we introduce a novel diffusion-based framework to significantly enhance the alignment of generated images with their corresponding descriptions, addressing the inconsistency between visual output and textual input. Our framework is built upon a comprehensive analysis of inconsistency phenomena, categorizing them based on their manifestation in the image. Leveraging a state-of-the-art large language module, we first extract objects and construct a knowledge graph to predict the locations of these objects in potentially generated images. We then integrate a state-of-the-art controllable image generation model with a visual text generation module to generate an image that is consistent with the original prompt, guided by the predicted object locations. Through extensive experiments on an advanced multimodal hallucination benchmark, we demonstrate the efficacy of our approach in accurately generating the images without the inconsistency with the original prompt.

Generative AI (GenAI) models have demonstrated remarkable capabilities in a wide variety of medical tasks. However, as these models are trained using generalist datasets with very limited human oversight, they can learn uses of medical products that have not been adequately evaluated for safety and efficacy, nor approved by regulatory agencies. Given the scale at which GenAI may reach users, unvetted recommendations pose a public health risk. In this work, we propose an approach to identify potentially harmful product recommendations, and demonstrate it using a recent multimodal large language model.

As telecommunications networks become increasingly complex, the integration of advanced technologies such as network digital twins and generative artificial intelligence (AI) emerges as a pivotal solution to enhance network operations and resilience. This paper explores the synergy between network digital twins, which provide a dynamic virtual representation of physical networks, and generative AI, particularly focusing on Generative Adversarial Networks (GANs) and Variational Autoencoders (VAEs). We propose a novel architectural framework that incorporates these technologies to significantly improve predictive maintenance, network scenario simulation, and real-time data-driven decision-making. Through extensive simulations, we demonstrate how generative AI can enhance the accuracy and operational efficiency of network digital twins, effectively handling real-world complexities such as unpredictable traffic loads and network failures. The findings suggest that this integration not only boosts the capability of digital twins in scenario forecasting and anomaly detection but also facilitates a more adaptive and intelligent network management system.

Foundation model-enabled generative artificial intelligence facilitates the development and implementation of agents, which can leverage distinguished reasoning and language processing capabilities to takes a proactive, autonomous role to pursue users' goals. Nevertheless, there is a lack of systematic knowledge to guide practitioners in designing the agents considering challenges of goal-seeking (including generating instrumental goals and plans), such as hallucinations inherent in foundation models, explainability of reasoning process, complex accountability, etc. To address this issue, we have performed a systematic literature review to understand the state-of-the-art foundation model-based agents and the broader ecosystem. In this paper, we present a pattern catalogue consisting of 17 architectural patterns with analyses of the context, forces, and trade-offs as the outcomes from the previous literature review. The proposed catalogue can provide holistic guidance for the effective use of patterns, and support the architecture design of foundation model-based agents by facilitating goal-seeking and plan generation.

This paper tackles the emerging challenge of training generative models within a self-consuming loop, wherein successive generations of models are recursively trained on mixtures of real and synthetic data from previous generations. We construct a theoretical framework to rigorously evaluate how this training procedure impacts the data distributions learned by future models, including parametric and non-parametric models. Specifically, we derive bounds on the total variation (TV) distance between the synthetic data distributions produced by future models and the original real data distribution under various mixed training scenarios for diffusion models with a one-hidden-layer neural network score function. Our analysis demonstrates that this distance can be effectively controlled under the condition that mixed training dataset sizes or proportions of real data are large enough. Interestingly, we further unveil a phase transition induced by expanding synthetic data amounts, proving theoretically that while the TV distance exhibits an initial ascent, it declines beyond a threshold point. Finally, we present results for kernel density estimation, delivering nuanced insights such as the impact of mixed data training on error propagation.