Data visualization is a fundamental tool in genomics research, enabling the exploration, interpretation, and communication of complex genomic features. While machine learning models show promise for transforming data into insightful visualizations, current models lack the training foundation for domain-specific tasks. In an effort to provide a foundational resource for genomics-focused model training, we present a framework for generating a dataset that pairs abstract, low-level questions about genomics data with corresponding visualizations. Building on prior work with statistical plots, our approach adapts to the complexity of genomics data and the specialized representations used to depict them. We further incorporate multiple linked queries and visualizations, along with justifications for design choices, figure captions, and image alt-texts for each item in the dataset. We use genomics data retrieved from three distinct genomics data repositories (4DN, ENCODE, Chromoscope) to produce GQVis: a dataset consisting of 1.14 million single-query data points, 628k query pairs, and 589k query chains. The GQVis dataset and generation code are available at https://huggingface.co/datasets/HIDIVE/GQVis and https://github.com/hms-dbmi/GQVis-Generation.

This paper discusses the potential for integrating Generative Artificial Intelligence (GenAI) into professional heritage practice with the aim of enhancing the accessibility of public-facing guidance documents. We developed HAZEL, a GenAI chatbot fine-tuned to assist with revising written guidance relating to heritage conservation and interpretation. Using quantitative assessments, we compare HAZEL's performance to that of ChatGPT (GPT-4) in a series of tasks related to the guidance writing process. The results of this comparison indicate a slightly better performance of HAZEL over ChatGPT, suggesting that the GenAI chatbot is more effective once the underlying large language model (LLM) has been fine-tuned. However, we also note significant limitations, particularly in areas requiring cultural sensitivity and more advanced technical expertise. These findings suggest that, while GenAI cannot replace human heritage professionals in technical authoring tasks, its potential to automate and expedite certain aspects of guidance writing could offer valuable benefits to heritage organisations, especially in resource-constrained contexts.

As Generative Artificial Intelligence is adopted across the financial services industry, a significant barrier to adoption and usage is measuring model performance. Historical machine learning metrics can oftentimes fail to generalize to GenAI workloads and are often supplemented using Subject Matter Expert (SME) Evaluation. Even in this combination, many projects fail to account for various unique risks present in choosing specific metrics. Additionally, many widespread benchmarks created by foundational research labs and educational institutions fail to generalize to industrial use. This paper explains these challenges and provides a Risk Assessment Framework to allow for better application of SME and machine learning Metrics

As the global reach of online higher education continues to grow, universities are increasingly accommodating students from diverse cultural backgrounds (Tereshko et al., 2024). This can present a number of challenges including linguistic barriers (Ullah et al., 2021), cultural differences in learning style (Omidvar & Tan, 2012), cultural sensitivity in course design (Nguyen, 2022) and perceived isolation when students feel their perspectives or experiences are not reflected or valued in the learning environment (Hansen-Brown et al., 2022). Ensuring active engagement and reasonable learning outcomes in such a environments requires distance educational systems that are not only adaptive but also culturally resonant (Dalle et al., 2024). Both embodied and virtual AI-Agents have great potential in this regard as they can facilitate personalized learning and adapt their interactions and content delivery to align with students' cultural context. In addition, Generative AI (GAI), such as, Large Language Models (LLMs) can amplify the potential for these culturally aware AI agents to address educational challenges due to their advanced capacity for understanding and generating contextually relevant content (Wang et al., 2024). This chapter reviews existing research and suggests the usage of culturally aware AI-Agents, powered by GAI, to foster engagement and improve learning outcomes in culturally diverse online higher education environments.

Designing protein binders targeting specific sites, which requires to generate realistic and functional interaction patterns, is a fundamental challenge in drug discovery. Current structure-based generative models are limited in generating nterfaces with sufficient rationality and interpretability. In this paper, we propose Retrieval-Augmented Diffusion for Aligned interface (RADiAnce), a new framework that leverages known interfaces to guide the design of novel binders. By unifying retrieval and generation in a shared contrastive latent space, our model efficiently identifies relevant interfaces for a given binding site and seamlessly integrates them through a conditional latent diffusion generator, enabling cross-domain interface transfer. Extensive exeriments show that RADiAnce significantly outperforms baseline models across multiple metrics, including binding affinity and recovery of geometries and interactions. Additional experimental results validate cross-domain generalization, demonstrating that retrieving interfaces from diverse domains, such as peptides, antibodies, and protein fragments, enhances the generation performance of binders for other domains. Our work establishes a new paradigm for protein binder design that successfully bridges retrieval-based knowledge and generative AI, opening new possibilities for drug discovery.

This study examines the impact of Socratic Mind, a Generative Artificial Intelligence (GenAI) powered formative assessment tool that employs Socratic questioning to support student learning in a large, fully online undergraduate-level computing course. Employing a quasi-experimental, mixed-methods design, we investigated participants' engagement patterns, the influence of user experience on engagement, and impacts on both perceived and actual learning outcomes. Data were collected from the system logs, surveys on user experience and perceived engagement and learning gains, student reflections, and course performance data. Results indicated that participants consistently reported high levels of affective, behavioral, and cognitive engagement, and these were strongly linked to positive user experiences and perceived learning outcomes. Quantitative analysis further revealed that students who engaged with the GenAI tool experienced significant gains in their quiz scores compared to those who did not, particularly benefiting students with lower baseline achievement. Additionally, thematic analysis of qualitative feedback revealed substantial perceived improvements in higher-order thinking skills, including problem solving, critical thinking, and self-reflection. Our findings highlight the promise of AI-mediated dialogue in fostering deeper engagement and higher-order cognitive skills. As higher education institutions expand GenAI integration in curriculum, this dialogic, GenAI powered assessment tool can offer a scalable strategy to promote students' meaningful learning outcomes.

The eighteen plus symbol (18+) appears on a smartphone screen, and the OpenAI logo displays as the background on a laptop screen in this photo illustration in Athens, Greece, on October 16, 2025. The eighteen plus symbol (18+) appears on a smartphone screen, and the OpenAI logo displays as the background on a laptop screen in this photo illustration in Athens, Greece, on October 16, 2025. In August, OpenAI CEO Sam Altman said on a podcast that he was "proud" that his company had not gotten "distracted" by putting features like a "sexbot avatar" into ChatGPT. But on Tuesday, he announced that adult users will be able to access explicit interactive experiences, marking a major shift in the company's practices. "In December, as we roll out age-gating more fully and as part of our'treat adult users like adults' principle, we will allow even more, like erotica for verified adults," Altman said in a post on X.

For patients with inflammatory bowel disease, antibiotics can be a double-edged sword. The broad-spectrum drugs often prescribed for gut flare-ups can kill helpful microbes alongside harmful ones, sometimes worsening symptoms over time. When fighting gut inflammation, you don't always want to bring a sledgehammer to a knife fight. Researchers at MIT's Computer Science and Artificial Intelligence Laboratory (CSAIL) and McMaster University have identified a new compound that takes a more targeted approach. The molecule, called enterololin, suppresses a group of bacteria linked to Crohn's disease flare-ups while leaving the rest of the microbiome largely intact.

Tokyo police believe the man made about 20,000 sexually explicit images of 262 women, such as actors and idols, and amassed sales of ¥1.2 million between October last year and September this year. Tokyo police have arrested a 31-year-old man for allegedly creating fake sexual images of female celebrities with generative artificial intelligence technology and displaying them online, it was learned Thursday. It is the first time that police in Japan have cracked down on sexual deepfake images of celebrities created with generative AI. The suspect, Hiroya Yokoi of the city of Akita, has admitted he began making deepfakes to earn a small amount of money, which he used to cover living expenses and repay a student loan. Authorities believe Yokoi made a total of about 20,000 sexually explicit images of 262 women, such as actors, television personalities and idols, and amassed sales of ¥1.2 million between October last year and September this year.

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