Recently a variety of LSTM-based conditional language models (LM) have been applied across a range of language generation tasks. In this work we study various model architectures and different ways to represent and aggregate the source information in an end-to-end neural dialogue system framework. A method called snapshot learning is also proposed to facilitate learning from supervised sequential signals by applying a companion cross-entropy objective function to the conditioning vector. The experimental and analytical results demonstrate firstly that competition occurs between the conditioning vector and the LM, and the differing architectures provide different trade-offs between the two. Secondly, the discriminative power and transparency of the conditioning vector is key to providing both model interpretability and better performance. Thirdly, snapshot learning leads to consistent performance improvements independent of which architecture is used.

Cataloging the neuronal cell types that comprise circuitry of individual brain regions is a major goal of modern neuroscience and the BRAIN initiative. Single-cell RNA sequencing can now be used to measure the gene expression profiles of individual neurons and to categorize neurons based on their gene expression profiles. While the single-cell techniques are extremely powerful and hold great promise, they are currently still labor intensive, have a high cost per cell, and, most importantly, do not provide information on spatial distribution of cell types in specific regions of the brain. We propose a complementary approach that uses computational methods to infer the cell types and their gene expression profiles through analysis of brain-wide single-cell resolution in situ hybridization (ISH) imagery contained in the Allen Brain Atlas (ABA). We measure the spatial distribution of neurons labeled in the ISH image for each gene and model it as a spatial point process mixture, whose mixture weights are given by the cell types which express that gene. By fitting a point process mixture model jointly to the ISH images, we infer both the spatial point process distribution for each cell type and their gene expression profile. We validate our predictions of cell type-specific gene expression profiles using single cell RNA sequencing data, recently published for the mouse somatosensory cortex. Jointly with the gene expression profiles, cell features such as cell size, orientation, intensity and local density level are inferred per cell type.

One is going to give a historical overview about GoogleBrain and analyse the pattern, then we will conclude our finding about the current situation and future changes in search engine algorithm. Back in 2006 there were some interests in implementing artificial intelligence in Google search engine algorithm. A few years later in 2014, GoogleBrain was established after acquisition of DeepMind, a British artificial intelligence company which was founded in 2010. They worked on how to play video games based on machine learning and artificial neural networks (ANNs). The smart artificial intelligence revolution can recognize patterns in digital representations of sounds, images and data.

Dynamic functional connectivity (FC) has in recent years become a topic of interest in the neuroimaging community. Several models and methods exist for both functional magnetic resonance imaging (fMRI) and electroencephalography (EEG), and the results point towards the conclusion that FC exhibits dynamic changes. The existing approaches modeling dynamic connectivity have primarily been based on time-windowing the data and k-means clustering. We propose a non-parametric generative model for dynamic FC in fMRI that does not rely on specifying window lengths and number of dynamic states. Rooted in Bayesian statistical modeling we use the predictive likelihood to investigate if the model can discriminate between a motor task and rest both within and across subjects. We further investigate what drives dynamic states using the model on the entire data collated across subjects and task/rest. We find that the number of states extracted are driven by subject variability and preprocessing differences while the individual states are almost purely defined by either task or rest. This questions how we in general interpret dynamic FC and points to the need for more research on what drives dynamic FC.

A good clustering can help a data analyst to explore and understand a data set, but what constitutes a good clustering may depend on domain-specific and application-specific criteria. These criteria can be difficult to formalize, even when it is easy for an analyst to know a good clustering when she sees one. We present a new approach to interactive clustering for data exploration, called \ciif, based on a particularly simple feedback mechanism, in which an analyst can choose to reject individual clusters and request new ones. The new clusters should be different from previously rejected clusters while still fitting the data well. We formalize this interaction in a novel Bayesian prior elicitation framework. In each iteration, the prior is adapted to account for all the previous feedback, and a new clustering is then produced from the posterior distribution. To achieve the computational efficiency necessary for an interactive setting, we propose an incremental optimization method over data minibatches using Lagrangian relaxation. Experiments demonstrate that \ciif can produce accurate and diverse clusterings.

Bayesian inference has great promise for the privacy-preserving analysis of sensitive data, as posterior sampling automatically preserves differential privacy, an algorithmic notion of data privacy, under certain conditions (Dimitrakakis et al., 2014; Wang et al., 2015). While this one posterior sample (OPS) approach elegantly provides privacy "for free," it is data inefficient in the sense of asymptotic relative efficiency (ARE). We show that a simple alternative based on the Laplace mechanism, the workhorse of differential privacy, is as asymptotically efficient as non-private posterior inference, under general assumptions. This technique also has practical advantages including efficient use of the privacy budget for MCMC. We demonstrate the practicality of our approach on a time-series analysis of sensitive military records from the Afghanistan and Iraq wars disclosed by the Wikileaks organization.

Completely random measures (CRM) represent the key building block of a wide variety of popular stochastic models and play a pivotal role in modern Bayesian Nonparametrics. A popular representation of CRMs as a random series with decreasing jumps is due to Ferguson and Klass (1972). This can immediately be turned into an algorithm for sampling realizations of CRMs or more elaborate models involving transformed CRMs. However, concrete implementation requires to truncate the random series at some threshold resulting in an approximation error. The goal of this paper is to quantify the quality of the approximation by a moment-matching criterion, which consists in evaluating a measure of discrepancy between actual moments and moments based on the simulation output. Seen as a function of the truncation level, the methodology can be used to determine the truncation level needed to reach a certain level of precision. The resulting moment-matching \FK algorithm is then implemented and illustrated on several popular Bayesian nonparametric models.

The most common question asked by prospective data scientists is – "What is the best programming language for Machine Learning?" The answer to this question always results in a debate whether to choose R, Python or MATLAB for Machine Learning. Nobody can, in reality, answer the question as to whether Python or R is best language for Machine Learning. However, the programming language one should choose for machine learning directly depends on the requirements of a given data problem, the likes and preferences of the data scientist and the context of machine learning activities they want to perform. According to a survey on Kaggler's Favourite Tools, the open source R programming language turned out to be the favourite among 543 Kagglers of the 1714 Kaggler's listing their data science tools.

A graphical model is a statistical model that is associated to a graph whose nodes correspond to variables of interest. The edges of the graph reflect allowed conditional dependencies among the variables. Graphical models admit computationally convenient factorization properties and have long been a valuable tool for tractable modeling of multivariate distributions. More recently, applications such as reconstructing gene regulatory networks from gene expression data have driven major advances in structure learning, that is, estimating the graph underlying a model. We review some of these advances and discuss methods such as the graphical lasso and neighborhood selection for undirected graphical models (or Markov random fields), and the PC algorithm and score-based search methods for directed graphical models (or Bayesian networks). We further review extensions that account for effects of latent variables and heterogeneous data sources.

Markov random field (MRF) learning is intractable, and its approximation algorithms are computationally expensive. We target a small subset of MRF that is used frequently in computer vision. We characterize this subset with three concepts: Lattice, Homogeneity, and Inertia; and design a non-markov model as an alternative. Our goal is robust learning from small datasets. Our learning algorithm uses vector quantization and, at time complexity O(U log U) for a dataset of U pixels, is much faster than that of general-purpose MRF.