In the field of natural language processing (NLP), the capability to infer and reason about causality is increasingly recognized as a critical component of intelligent systems. Despite the recent advancement of large language models (LLMs) (Radford et al., 2019; Devlin et al., 2019; Brown et al., 2020; Zhang et al., 2022; OpenAI, 2023; Ignat et al., 2024, inter alia), a key question still remains: Can these models understand and reason about causality? This is a critical skill before we can trust AI agents to be integrated into decision-making systems. Moreover, even if LLMs succeed at some extent of reasoning, they still lack transparency of how their decisions are made, forming a strong need for interpretabil-ity (Luo and Specia, 2024; Räuker et al., 2023; Zou et al., 2023). T o bridge the gap, this thesis explores various facets of causal reasoning in LLMs. W e present a series of studies that collectively advance the knowledge of how well these models perform causal reasoning (Part I), how their decisions are made (Part II), how causality among learning variables influences NLP tasks (Part III), and how causality and NLP can together analyze social problems (Part IV). Below we introduce an overview of the four parts and their corresponding chapters.

Differentially private (DP) machine learning often relies on the availability of public data for tasks like privacy-utility trade-off estimation, hyperparameter tuning, and pretraining. While public data assumptions may be reasonable in text and image domains, they are less likely to hold for tabular data due to tabular data heterogeneity across domains. We propose leveraging powerful priors to address this limitation; specifically, we synthesize realistic tabular data directly from schema-level specifications - such as variable names, types, and permissible ranges - without ever accessing sensitive records. To that end, this work introduces the notion of "surrogate" public data - datasets generated independently of sensitive data, which consume no privacy loss budget and are constructed solely from publicly available schema or metadata. Surrogate public data are intended to encode plausible statistical assumptions (informed by publicly available information) into a dataset with many downstream uses in private mechanisms. We automate the process of generating surrogate public data with large language models (LLMs); in particular, we propose two methods: direct record generation as CSV files, and automated structural causal model (SCM) construction for sampling records. Through extensive experiments, we demonstrate that surrogate public tabular data can effectively replace traditional public data when pretraining differentially private tabular classifiers. To a lesser extent, surrogate public data are also useful for hyperparameter tuning of DP synthetic data generators, and for estimating the privacy-utility tradeoff.

Prompt learning is a popular fine-tuning method for vision-language models due to its efficiency. It requires a small number of additional learnable parameters while significantly enhancing performance on target tasks. However, most existing methods suffer from overfitting to fine-tuning data, yielding poor generalizability. To address this, we propose a new training objective function based on a Bayesian learning principle to balance adaptability and generalizability. We derive a prior over the logits, where the mean function is parameterized by the pre-trained model, while the posterior corresponds to the fine-tuned model. This objective establishes a balance by allowing the fine-tuned model to adapt to downstream tasks while remaining close to the pre-trained model.

Stroke remains the second - leading cause of death globally and the primary driver of long - term neurological disabilities, significantly impacting quality of life (Yüksel et al., 2023). It ranks among the top three contributors to disability - adjusted life ye ars (DALYs) lost worldwide, particularly within musculoskeletal and neurological disorders. Cerebrovascular diseases (CVDs), which manifest as strokes, are a major source of morbidity and mortality, affecting approximately 15 million individuals annually -- 5 million of whom face chronic paralysis (Organization, 2015; Polat et al., 2024). These conditions stem from disruptions in cerebral blood flow, leading to pathologies such as ischemic strokes, hemorrhages, and traumatic brain injuries due to vascular dama ge (Goni et al., 2022). Strokes are categorized into two distinct types: Ischemic Stroke: Caused by thrombotic or embolic blockages in cerebral arteries, resulting in hypoxic necrosis of brain tissue (Zhu et al., 2024).

Causal analysis plays a foundational role in scientific discovery and reliable decision-making, yet it remains largely inaccessible to domain experts due to its conceptual and algorithmic complexity. This disconnect between causal methodology and practical usability presents a dual challenge: domain experts are unable to leverage recent advances in causal learning, while causal researchers lack broad, real-world deployment to test and refine their methods. To address this, we introduce Causal-Copilot, an autonomous agent that operationalizes expert-level causal analysis within a large language model framework. Causal-Copilot automates the full pipeline of causal analysis for both tabular and time-series data -- including causal discovery, causal inference, algorithm selection, hyperparameter optimization, result interpretation, and generation of actionable insights. It supports interactive refinement through natural language, lowering the barrier for non-specialists while preserving methodological rigor. By integrating over 20 state-of-the-art causal analysis techniques, our system fosters a virtuous cycle -- expanding access to advanced causal methods for domain experts while generating rich, real-world applications that inform and advance causal theory. Empirical evaluations demonstrate that Causal-Copilot achieves superior performance compared to existing baselines, offering a reliable, scalable, and extensible solution that bridges the gap between theoretical sophistication and real-world applicability in causal analysis. A live interactive demo of Causal-Copilot is available at https://causalcopilot.com/.

The goal of Computer Adaptive Testing (CAT) is to reliably estimate an individual's ability as modeled by an item response theory (IRT) instrument using only a subset of the instrument's items. A secondary goal is to vary the items presented across different testing sessions so that the sequence of items does not become overly stereotypical -- we want all items to have an exposure rate sufficiently far from zero. We formulate the optimization problem for CAT in terms of Bayesian information theory, where one chooses the item at each step based on the criterion of the ability model discrepancy -- the statistical distance between the ability estimate at the next step and the full-test ability estimate. This viewpoint of CAT naturally motivates a stochastic selection procedure that equates choosing the next item to sampling from a model-averaging ensemble ability model. Using the NIH Work Disability Functional Assessment Battery (WD-FAB), we evaluate our new methods in comparison to pre-existing methods found in the literature. We find that our stochastic selector has superior properties in terms of both item exposure and test accuracy/efficiency.

Bayesian Federated Learning (BFL) enables uncertainty quantification and robust adaptation in distributed learning. In contrast to the frequentist approach, it estimates the posterior distribution of a global model, offering insights into model reliability. However, current BFL methods neglect continual learning challenges in dynamic environments where data distributions shift over time. We propose a continual BFL framework applied to human sensing with radar data collected over several days. Using Stochastic Gradient Langevin Dynamics (SGLD), our approach sequentially updates the model, leveraging past posteriors to construct the prior for the new tasks. We assess the accuracy, the expected calibration error (ECE) and the convergence speed of our approach against several baselines. Results highlight the effectiveness of continual Bayesian updates in preserving knowledge and adapting to evolving data.

This work aligns deep learning (DL) with human reasoning capabilities and needs to enable more efficient, interpretable, and robust image classification. We approach this from three perspectives: explainability, causality, and biological vision. Introduction and background open this work before diving into operative chapters. First, we assess neural networks' visualization techniques for medical images and validate an explainable-by-design method for breast mass classification. A comprehensive review at the intersection of XAI and causality follows, where we introduce a general scaffold to organize past and future research, laying the groundwork for our second perspective. In the causality direction, we propose novel modules that exploit feature co-occurrence in medical images, leading to more effective and explainable predictions. We further introduce CROCODILE, a general framework that integrates causal concepts, contrastive learning, feature disentanglement, and prior knowledge to enhance generalization. Lastly, we explore biological vision, examining how humans recognize objects, and propose CoCoReco, a connectivity-inspired network with context-aware attention mechanisms. Overall, our key findings include: (i) simple activation maximization lacks insight for medical imaging DL models; (ii) prototypical-part learning is effective and radiologically aligned; (iii) XAI and causal ML are deeply connected; (iv) weak causal signals can be leveraged without a priori information to improve performance and interpretability; (v) our framework generalizes across medical domains and out-of-distribution data; (vi) incorporating biological circuit motifs improves human-aligned recognition. This work contributes toward human-aligned DL and highlights pathways to bridge the gap between research and clinical adoption, with implications for improved trust, diagnostic accuracy, and safe deployment.

Biological synapses effortlessly balance memory retention and flexibility, yet artificial neural networks still struggle with the extremes of catastrophic forgetting and catastrophic remembering. Here, we introduce Metaplasticity from Synaptic Uncertainty (MESU), a Bayesian framework that updates network parameters according their uncertainty. This approach allows a principled combination of learning and forgetting that ensures that critical knowledge is preserved while unused or outdated information is gradually released. Unlike standard Bayesian approaches -- which risk becoming overly constrained, and popular continual-learning methods that rely on explicit task boundaries, MESU seamlessly adapts to streaming data. It further provides reliable epistemic uncertainty estimates, allowing out-of-distribution detection, the only computational cost being to sample the weights multiple times to provide proper output statistics. Experiments on image-classification benchmarks demonstrate that MESU mitigates catastrophic forgetting, while maintaining plasticity for new tasks. When training 200 sequential permuted MNIST tasks, MESU outperforms established continual learning techniques in terms of accuracy, capability to learn additional tasks, and out-of-distribution data detection. Additionally, due to its non-reliance on task boundaries, MESU outperforms conventional learning techniques on the incremental training of CIFAR-100 tasks consistently in a wide range of scenarios. Our results unify ideas from metaplasticity, Bayesian inference, and Hessian-based regularization, offering a biologically-inspired pathway to robust, perpetual learning.

This review is focused on the data-driven approaches applied in different applications of Acoustic-to-Articulatory Inversion (AAI) of speech. This review paper considered the relevant works published in the last ten years (2011-2021). The selection criteria includes (a) type of AAI - Speaker Dependent and Speaker Independent AAI, (b) objectives of the work - Articulatory approximation, Articulatory Feature space selection and Automatic Speech Recognition (ASR), explore the correlation between acoustic and articulatory features, and framework for Computer-assisted language training, (c) Corpus - Simultaneously recorded speech (wav) and medical imaging models such as ElectroMagnetic Articulography (EMA), Electropalatography (EPG), Laryngography, Electroglottography (EGG), X-ray Cineradiography, Ultrasound, and real-time Magnetic Resonance Imaging (rtMRI), (d) Methods or models - recent works are considered, and therefore all the works are based on machine learning, (e) Evaluation - as AAI is a non-linear regression problem, the performance evaluation is mostly done by Correlation Coefficient (CC), Root Mean Square Error (RMSE), and also considered Mean Square Error (MSE), and Mean Format Error (MFE). The practical application of the AAI model can provide a better and user-friendly interpretable image feedback system of articulatory positions, especially tongue movement. Such trajectory feedback system can be used to provide phonetic, language, and speech therapy for pathological subjects.