Large Language Models (LLMs) promise to transform interactive games by enabling non-player characters (NPCs) to sustain unscripted dialogue. Yet it remains unclear whether constrained prompts actually improve player experience. We investigate this question through The Interview, a voice-based detective game powered by GPT-4o. A within-subjects usability study ($N=10$) compared high-constraint (HCP) and low-constraint (LCP) prompts, revealing no reliable experiential differences beyond sensitivity to technical breakdowns. Guided by these findings, we redesigned the HCP into a hybrid JSON+RAG scaffold and conducted a synthetic evaluation with an LLM judge, positioned as an early-stage complement to usability testing. Results uncovered a novel pattern: scaffolding effects were role-dependent: the Interviewer (quest-giver NPC) gained stability, while suspect NPCs lost improvisational believability. These findings overturn the assumption that tighter constraints inherently enhance play. Extending fuzzy-symbolic scaffolding, we introduce \textit{Symbolically Scaffolded Play}, a framework in which symbolic structures are expressed as fuzzy, numerical boundaries that stabilize coherence where needed while preserving improvisation where surprise sustains engagement.

The rapid rise of AI agents presents urgent challenges in authentication, authorization, and identity management. Current agent-centric protocols (like MCP) highlight the demand for clarified best practices in authentication and authorization. Looking ahead, ambitions for highly autonomous agents raise complex long-term questions regarding scalable access control, agent-centric identities, AI workload differentiation, and delegated authority. This OpenID Foundation whitepaper is for stakeholders at the intersection of AI agents and access management. It outlines the resources already available for securing today's agents and presents a strategic agenda to address the foundational authentication, authorization, and identity problems pivotal for tomorrow's widespread autonomous systems.

Post-training of Large Language Models (LLMs) is crucial for unlocking their task generalization potential and domain-specific capabilities. However, the current LLM post-training paradigm faces significant data challenges, including the high costs of manual annotation and diminishing marginal returns on data scales. Therefore, achieving data-efficient post-training has become a key research question. In this paper, we present the first systematic survey of data-efficient LLM post-training from a data-centric perspective. We propose a taxonomy of data-efficient LLM post-training methods, covering data selection, data quality enhancement, synthetic data generation, data distillation and compression, and self-evolving data ecosystems. We summarize representative approaches in each category and outline future research directions. By examining the challenges in data-efficient LLM post-training, we highlight open problems and propose potential research avenues. We hope our work inspires further exploration into maximizing the potential of data utilization in large-scale model training. Paper List: https://github.com/luo-junyu/Awesome-Data-Efficient-LLM

Electronic Health Records (EHR) store clinical documentation as base64 encoded attachments in FHIR DocumentReference resources, which makes semantic question answering difficult. Traditional vector database methods often miss nuanced clinical relationships. The Clinical Entity Augmented Retrieval (CLEAR) method, introduced by Lopez et al. 2025, uses entity aware retrieval and achieved improved performance with an F1 score of 0.90 versus 0.86 for embedding based retrieval, while using over 70 percent fewer tokens. We developed a Clinical Notes QA Evaluation Platform to validate CLEAR against zero shot large context inference and traditional chunk based retrieval augmented generation. The platform was tested on 12 clinical notes ranging from 10,000 to 65,000 tokens representing realistic EHR content. CLEAR achieved a 58.3 percent win rate, an average semantic similarity of 0.878, and used 78 percent fewer tokens than wide context processing. The largest performance gains occurred on long notes, with a 75 percent win rate for documents exceeding 65,000 tokens. These findings confirm that entity aware retrieval improves both efficiency and accuracy in clinical natural language processing. The evaluation framework provides a reusable and transparent benchmark for assessing clinical question answering systems where semantic precision and computational efficiency are critical.

Traditional non-biological storage media, such as hard drives, face limitations in both storage density and lifespan due to the rapid growth of data in the big data era. Mirror-image peptides composed of D-amino acids have emerged as a promising biological storage medium due to their high storage density, structural stability, and long lifespan. The sequencing of mirror-image peptides relies on \textit{de-novo} technology. However, its accuracy is limited by the scarcity of tandem mass spectrometry datasets and the challenges that current algorithms encounter when processing these peptides directly. This study is the first to propose improving sequencing accuracy indirectly by optimizing the design of mirror-image peptide sequences. In this work, we introduce DBond, a deep neural network based model that integrates sequence features, precursor ion properties, and mass spectrometry environmental factors for the prediction of mirror-image peptide bond cleavage. In this process, sequences with a high peptide bond cleavage ratio, which are easy to sequence, are selected. The main contributions of this study are as follows. First, we constructed MiPD513, a tandem mass spectrometry dataset containing 513 mirror-image peptides. Second, we developed the peptide bond cleavage labeling algorithm (PBCLA), which generated approximately 12.5 million labeled data based on MiPD513. Third, we proposed a dual prediction strategy that combines multi-label and single-label classification. On an independent test set, the single-label classification strategy outperformed other methods in both single and multiple peptide bond cleavage prediction tasks, offering a strong foundation for sequence optimization.

We present a novel framework for Industry 5.0 that simplifies the deployment of AI models on edge devices in various industrial settings. The design reduces latency and avoids external data transfer by enabling local inference and real-time processing. Our implementation is agent-based, which means that individual agents, whether human, algorithmic, or collaborative, are responsible for well-defined tasks, enabling flexibility and simplifying integration. Moreover, our framework supports modular integration and maintains low resource requirements. Preliminary evaluations concerning the food industry in real scenarios indicate improved deployment time and system adaptability performance. The source code is publicly available at https://github.com/

Detecting anomalous nodes in attributed networks, where each node is associated with both structural connections and descriptive attributes, is essential for identifying fraud, misinformation, and suspicious behavior in domains such as social networks, academic citation graphs, and e-commerce platforms. We propose Flex-GAD, a novel unsupervised framework for graph anomaly detection at the node level. Flex-GAD integrates two encoders to capture complementary aspects of graph data. The framework incorporates a novel community-based GCN encoder to model intra-community and inter-community information into node embeddings, thereby ensuring structural consistency, along with a standard attribute encoder. These diverse representations are fused using a self-attention-based representation fusion module, which enables adaptive weighting and effective integration of the encoded information. This fusion mechanism allows automatic emphasis of the most relevant node representation across different encoders. We evaluate Flex-GAD on seven real-world attributed graphs with varying sizes, node degrees, and attribute homogeneity. Flex-GAD achieves an average AUC improvement of 7.98% over the previously best-performing method, GAD-NR, demonstrating its effectiveness and flexibility across diverse graph structures. Moreover, it significantly reduces training time, running 102x faster per epoch than Anomaly DAE and 3x faster per epoch than GAD-NR on average across seven benchmark datasets.

Large language models (LLMs) have achieved remarkable success across diverse domains, due to their strong instruction-following capabilities. This has led to increasing interest in optimizing instructions for black-box LLMs, whose internal parameters are inaccessible but widely used due to their strong performance. To optimize instructions for black-box LLMs, recent methods employ white-box LLMs to generate candidate instructions from optimized soft prompts. However, white-box LLMs often map different soft prompts to the same instruction, leading to redundant queries. While previous studies regarded this many-to-one mapping as a structure that hinders optimization efficiency, we reinterpret it as a useful prior knowledge that can accelerate the optimization. To this end, we introduce PREimage-informed inSTruction Optimization (PRESTO), a novel framework that leverages the preimage structure of soft prompts for efficient optimization. PRESTO consists of three key components: (1) score sharing, which shares the evaluation score with all soft prompts in a preimage; (2) preimage-based initialization, which selects initial data points that maximize search space coverage using preimage information; and (3) score consistency regularization, which enforces prediction consistency within each preimage. By leveraging preimages, PRESTO achieves the effect of effectively obtaining 14 times more scored data under the same query budget, resulting in more efficient optimization. Experimental results on 33 instruction optimization tasks demonstrate the superior performance of PRESTO. Code is available at https://github.com/mlvlab/PRESTO

Single-cell RNA-seq foundation models achieve strong performance on downstream tasks but remain black boxes, limiting their utility for biological discovery. Recent work has shown that sparse dictionary learning can extract concepts from deep learning models, with promising applications in biomedical imaging and protein models. However, interpreting biological concepts remains challenging, as biological sequences are not inherently human-interpretable. We introduce a novel concept-based interpretability framework for single-cell RNA-seq models with a focus on concept interpretation and evaluation. We propose an attribution method with counterfactual perturbations that identifies genes that influence concept activation, moving beyond correlational approaches like differential expression analysis. We then provide two complementary interpretation approaches: an expert-driven analysis facilitated by an interactive interface and an ontology-driven method with attribution-based biological pathway enrichment. Applying our framework to two well-known single-cell RNA-seq models from the literature, we interpret concepts extracted by Top-K Sparse Auto-Encoders trained on two immune cell datasets. With a domain expert in immunology, we show that concepts improve interpretability compared to individual neurons while preserving the richness and informativeness of the latent representations. This work provides a principled framework for interpreting what biological knowledge foundation models have encoded, paving the way for their use for hypothesis generation and discovery.

Large language models (LLMs) are increasingly used in content moderation systems, where ensuring fairness and neutrality is essential. In this study, we examine how persona adoption influences the consistency and fairness of harmful content classification across different LLM architectures, model sizes, and content modalities (language vs. vision). At first glance, headline performance metrics suggest that personas have little impact on overall classification accuracy. However, a closer analysis reveals important behavioral shifts. Personas with different ideological leanings display distinct propensities to label content as harmful, showing that the lens through which a model "views" input can subtly shape its judgments. Further agreement analyses highlight that models, particularly larger ones, tend to align more closely with personas from the same political ideology, strengthening within-ideology consistency while widening divergence across ideological groups. To show this effect more directly, we conducted an additional study on a politically targeted task, which confirmed that personas not only behave more coherently within their own ideology but also exhibit a tendency to defend their perspective while downplaying harmfulness in opposing views. Together, these findings highlight how persona conditioning can introduce subtle ideological biases into LLM outputs, raising concerns about the use of AI systems that may reinforce partisan perspectives under the guise of neutrality.