Abstract-- The oscillations of the human heart rate are inherently complex and non-linear--they are best described by mathematical chaos, and they present a challenge when applied to the practical domain of cardiovascular health monitoring in everyday life. In this work, we study the non-linear chaotic behavior of heart rate through mutual information and introduce a novel approach for enhancing heart rate estimation in real-life conditions. Our proposed approach not only explains and handles the non-linear temporal complexity from a mathematical perspective but also improves the deep learning solutions when combined with them. We validate our proposed method on four established datasets from real-life scenarios and compare its performance with existing algorithms thoroughly with extensive ablation experiments. Our results demonstrate a substantial improvement, up to 40%, of the proposed approach in estimating heart rate compared to traditional methods and existing machine-learning techniques while reducing the reliance on multiple sensing modalities and eliminating the need for post-processing steps. Healthy biological systems exhibit complex patterns of variability that can be described by mathematical chaos [1], [2]. A healthy heart is not a metronome; instead, its complex and constantly changing oscillations enable the cardiovascular system to rapidly adjust to sudden physical and psychological challenges to homeostasis [2]. Therefore, measuring heart rate (HR) during daily life has significant importance in monitoring individuals' health.

Enterprise systems are crucial for enhancing productivity and decision-making among employees and customers. Integrating LLM based systems into enterprise systems enables intelligent automation, personalized experiences, and efficient information retrieval, driving operational efficiency and strategic growth. However, developing and evaluating such systems is challenging due to the inherent complexity of enterprise environments, where data is fragmented across multiple sources and governed by sophisticated access controls. We present EnterpriseBench, a comprehensive benchmark that simulates enterprise settings, featuring 500 diverse tasks across software engineering, HR, finance, and administrative domains. Our benchmark uniquely captures key enterprise characteristics including data source fragmentation, access control hierarchies, and cross-functional workflows. Additionally, we provide a novel data generation pipeline that creates internally consistent enterprise tasks from organizational metadata. Experiments with state-of-the-art LLM agents demonstrate that even the most capable models achieve only 41.8% task completion, highlighting significant opportunities for improvement in enterprise-focused AI systems.

Abstract--Accurate prediction of Drug-T arget Affinity (DT A) is crucial for reducing experimental costs and accelerating early screening in computational drug discovery. While sequence-based deep learning methods avoid reliance on costly 3D structures, they still overlook simultaneous modeling of global sequence semantic features and local topological structural features within drugs and proteins, and represent drugs as flat sequences without atomic-level, substructural-level, and molecular-level multi-scale features. We propose HiF-DT A, a hierarchical network that adopts a dual-pathway strategy to extract both global sequence semantic and local topological features from drug and protein sequences, and models drugs multi-scale to learn atomic, substructural, and molecular representations fused via a multi-scale bilinear attention module. Experiments on Davis, KIBA, and Metz datasets show HiF-DT A outperforms state-of-the-art baselines, with ablations confirming the importance of global-local extraction and multi-scale fusion. Accurate prediction of drug-target affinity (DT A) is essential for drug screening, immune modulation and precision medicine.

Drug recommendation (DR) systems aim to support healthcare professionals in selecting appropriate medications based on patients' medical conditions. State-of-the-art approaches utilize deep learning techniques for improving DR, but fall short in providing any insights on the derivation process of recommendations -- a critical limitation in such high-stake applications. We propose TraceDR, a novel DR system operating over a medical knowledge graph (MKG), which ensures access to large-scale and high-quality information. TraceDR simultaneously predicts drug recommendations and related evidence within a multi-task learning framework, enabling traceability of medication recommendations. For covering a more diverse set of diseases and drugs than existing works, we devise a framework for automatically constructing patient health records and release DrugRec, a new large-scale testbed for DR.

As large language models (LLMs) enter the medical domain, most benchmarks evaluate them on question answering or descriptive reasoning, overlooking quantitative reasoning critical to clinical decision-making. Existing datasets like MedCalc-Bench cover few calculation tasks and fail to reflect real-world computational scenarios. We introduce MedCalc-Eval, the largest benchmark for assessing LLMs' medical calculation abilities, comprising 700+ tasks across two types: equation-based (e.g., Cockcroft-Gault, BMI, BSA) and rule-based scoring systems (e.g., Apgar, Glasgow Coma Scale). These tasks span diverse specialties including internal medicine, surgery, pediatrics, and cardiology, offering a broader and more challenging evaluation setting. To improve performance, we further develop MedCalc-Env, a reinforcement learning environment built on the InternBootcamp framework, enabling multi-step clinical reasoning and planning. Fine-tuning a Qwen2.5-32B model within this environment achieves state-of-the-art results on MedCalc-Eval, with notable gains in numerical sensitivity, formula selection, and reasoning robustness. Remaining challenges include unit conversion, multi-condition logic, and contextual understanding. Code and datasets are available at https://github.com/maokangkun/MedCalc-Eval.

In medical imaging, vision-language models face a critical duality: pretrained networks offer broad robustness but lack subtle, modality-specific characteristics, while fine-tuned expert models achieve high in-distribution accuracy yet falter under modality shift. Existing model-merging techniques, designed for natural-image benchmarks, are simple and efficient but fail to deliver consistent gains across diverse medical modalities; their static interpolation limits reliability in varied clinical tasks. To address this, we introduce Test-Time Task adaptive merging (T^3), a backpropagation-free framework that computes per-sample interpolation coefficients via the Jensen-Shannon divergence between the two models' output distributions. T^3 dynamically preserves local precision when models agree and defers to generalist robustness under drift. To overcome the inference costs of sample-wise merging, we further propose a batch-wise extension, T^3_B, that computes a merging coefficient across a batch of samples, dramatically reducing computational bottleneck. Recognizing the lack of a standardized medical-merging benchmark, we present a rigorous cross-evaluation protocol spanning in-domain, base-to-novel, and corruptions across four modalities. Empirically, T^3 sets new state-of-the-art in Top-1 accuracy and error reduction, outperforming strong baselines while maintaining efficiency, paving the way for adaptive MVLM deployment in clinical settings. Our code is available at https://github.com/Razaimam45/TCube.

Recently, there has been gradually more attention paid to Out-of-Distribution (OOD) performance prediction, whose goal is to predict the performance of trained models on unlabeled OOD test datasets, so that we could better leverage and deploy off-the-shelf trained models in risk-sensitive scenarios. Although progress has been made in this area, evaluation protocols in previous literature are inconsistent, and most works cover only a limited number of real-world OOD datasets and types of distribution shifts. T o provide convenient and fair comparisons for various algorithms, we propose Out-of-Distribution Performance Prediction Benchmark (ODP-Bench), a comprehensive benchmark that includes most commonly used OOD datasets and existing practical performance prediction algorithms. W e provide our trained models as a testbench for future researchers, thus guaranteeing the consistency of comparison and avoiding the burden of repeating the model training process. Furthermore, we also conduct in-depth experimental analyses to better understand their capability boundary.

Vision-Language Models (VLMs) excel in diverse multimodal tasks. However, user requirements vary across scenarios, which can be categorized into fast response, high-quality output, and low energy consumption. Relying solely on large models deployed in the cloud for all queries often leads to high latency and energy cost, while small models deployed on edge devices are capable of handling simpler tasks with low latency and energy cost. To fully leverage the strengths of both large and small models, we propose ECVL-ROUTER, the first scenario-aware routing framework for VLMs. Our approach introduces a new routing strategy and evaluation metrics that dynamically select the appropriate model for each query based on user requirements, maximizing overall utility. We also construct a multimodal response-quality dataset tailored for router training and validate the approach through extensive experiments. Results show that our approach successfully routes over 80% of queries to the small model while incurring less than 10% drop in problem solving probability. Vision-Language Models (VLMs), which integrate visual and textual understanding, have become crucial components in a wide range of AI applications, from robotics control to user interface navigation (Zhang et al., 2024; Shinde et al., 2025; Li et al., 2024). Moreover, a one-size-fits-all deployment strategy is suboptimal, as users increasingly expect systems that not only deliver high-quality responses but also adapt to diverse real-world scenarios with varying demands for latency, cost, and privacy. To effectively integrate the strengths of both L VLMs and SVLMs, edge-cloud collaborative routing(Y uan et al., 2025; Hao et al., 2024) is a natural fits. At its core is a lightweight model router (Ding et al., 2024; Ong et al., 2024) that inspects each query and selects an appropriate VLM. However, a general router is insufficient, routing must be scenario-aware: behaviors vary across diverse application contexts and can be configured by users or automatically inferred by scenario detection algorithms (Fifty et al., 2023; Someki et al., 2025). Existing routers are often text-centric and optimize a fixed trade-off between cost and quality, failing to adapt to multimodal, scenario-aware user needs. For example, real-time games interaction prioritizes low latency, medical diagnostics emphasizes answer quality, and mobile assistants require low energy use and strong privacy (Asgari et al., 2025).

Brain-to-speech (BTS) systems represent a groundbreaking approach to human communication by enabling the direct transformation of neural activity into linguistic expressions. While recent non-invasive BTS studies have largely focused on decoding predefined words or sentences, achieving open-vocabulary neural communication comparable to natural human interaction requires decoding unconstrained speech. Additionally, effectively integrating diverse signals derived from speech is crucial for developing personalized and adaptive neural communication and rehabilitation solutions for patients. This study investigates the potential of speech synthesis for previously unseen sentences across various speech modes by leveraging phoneme-level information extracted from high-density electroencephalography (EEG) signals, both independently and in conjunction with electromyography (EMG) signals. Furthermore, we examine the properties affecting phoneme decoding accuracy during sentence reconstruction and offer neurophysiological insights to further enhance EEG decoding for more effective neural communication solutions. Our findings underscore the feasibility of biosignal-based sentence-level speech synthesis for reconstructing unseen sentences, highlighting a significant step toward developing open-vocabulary neural communication systems adapted to diverse patient needs and conditions. Additionally, this study provides meaningful insights into the development of communication and rehabilitation solutions utilizing EEG-based decoding technologies.

Evaluating the abilities of large language models (LLMs) for tasks that require long-term memory and thus long-context reasoning, for example in conversational settings, is hampered by the existing benchmarks, which often lack narrative coherence, cover narrow domains, and only test simple recall-oriented tasks. This paper introduces a comprehensive solution to these challenges. First, we present a novel framework for automatically generating long (up to 10M tokens), coherent, and topically diverse conversations, accompanied by probing questions targeting a wide range of memory abilities. From this, we construct BEAM, a new benchmark comprising 100 conversations and 2,000 validated questions. Second, to enhance model performance, we propose LIGHT-a framework inspired by human cognition that equips LLMs with three complementary memory systems: a long-term episodic memory, a short-term working memory, and a scratchpad for accumulating salient facts. Our experiments on BEAM reveal that even LLMs with 1M token context windows (with and without retrieval-augmentation) struggle as dialogues lengthen. In contrast, LIGHT consistently improves performance across various models, achieving an average improvement of 3.5%-12.69% over the strongest baselines, depending on the backbone LLM. An ablation study further confirms the contribution of each memory component.