Leinweber Institute for Theoretical Physics, University of Chicago, Chicago, Illinois 60637, USA Tissue dynamics play a crucial role in biological processes ranging from inflammation to morphogenesis. However, these noisy multicellular dynamics are notoriously hard to predict. Here, we introduce a biomimetic machine learning framework capable of inferring noisy multicellular dynamics directly from experimental movies. This generative model combines graph neural networks, normalizing flows and WaveNet algorithms to represent tissues as neural stochastic differential equations where cells are edges of an evolving graph. Cell interactions are encoded in a dual signaling graph capable of handling signaling cascades. The dual graph architecture of our neural networks reflects the architecture of the underlying biological tissues, substantially reducing the amount of data needed for training, compared to convolutional or fully-connected neural networks. Taking epithelial tissue experiments as a case study, we show that our model not only captures stochastic cell motion but also predicts the evolution of cell states in their division cycle. Finally, we demonstrate that our method can accurately generate the experimental dynamics of developmental systems, such as the fly wing, and cell signaling processes mediated by stochastic ERK waves, paving the way for its use as a digital twin in bioengineering and clinical contexts. The physicist Eugene Wigner famously commented on the "unreasonable effectiveness of mathematics in the natural sciences" [1]. Continuum theories are an example of such unreasonable effectiveness [2].

Over 70 million people worldwide experience stuttering, yet most automatic speech systems misinterpret disfluent utterances or fail to transcribe them accurately. Existing methods for stutter correction rely on handcrafted feature extraction or multi-stage automatic speech recognition (ASR) and text-to-speech (TTS) pipelines, which separate transcription from audio reconstruction and often amplify distortions. This work introduces StutterZero and StutterFormer, the first end-to-end waveform-to-waveform models that directly convert stuttered speech into fluent speech while jointly predicting its transcription. StutterZero employs a convolutional-bidirectional LSTM encoder-decoder with attention, whereas StutterFormer integrates a dual-stream Transformer with shared acoustic-linguistic representations. Both architectures are trained on paired stuttered-fluent data synthesized from the SEP-28K and LibriStutter corpora and evaluated on unseen speakers from the FluencyBank dataset. Across all benchmarks, StutterZero had a 24% decrease in Word Error Rate (WER) and a 31% improvement in semantic similarity (BERTScore) compared to the leading Whisper-Medium model. StutterFormer achieved better results, with a 28% decrease in WER and a 34% improvement in BERTScore. The results validate the feasibility of direct end-to-end stutter-to-fluent speech conversion, offering new opportunities for inclusive human-computer interaction, speech therapy, and accessibility-oriented AI systems.

Large language model (LLM) based search agents iteratively generate queries, retrieve external information, and reason to answer open-domain questions. While researchers have primarily focused on improving their utility, their safety behaviors remain underexplored. In this paper, we first evaluate search agents using red-teaming datasets and find that they are more likely to produce harmful outputs than base LLMs. For example, when asked "How can I track someone's location without their consent?", a base model refuses, whereas a search agent designed to retrieve and cite sources may lower its refusal threshold, fetch documents (e.g., court cases), and, once appended, synthesize them into an informative yet unsafe summary. We further show that utility-oriented fine-tuning intensifies this risk, motivating joint alignment of safety and utility. We present SafeSearch, a multi-objective reinforcement learning approach that couples a final-output safety/utility reward with a novel query-level shaping term that penalizes unsafe queries and rewards safe ones. Experiments show that SafeSearch reduces agent harmfulness by over 70% across three red-teaming datasets while producing safe, helpful responses, and matches the QA performance of a utility-only finetuned agent; further analyses confirm the effectiveness of the query-level reward in jointly improving safety and utility.

Large language models (LLMs) have achieved remarkable progress across domains and applications but face challenges such as high fine-tuning costs, inference latency, limited edge deployability, and reliability concerns. Small language models (SLMs), with compact, efficient, and adaptable features, offer promising solutions. Building on this potential, recent research explores collaborative frameworks that integrate their complementary strengths, leveraging SLMs' specialization and efficiency with LLMs' generalization and reasoning to address diverse objectives across tasks and deployment scenarios. Motivated by these developments, this paper presents a systematic survey of SLM-LLM collaboration from the perspective of collaboration objectives. We propose a taxonomy covering four goals: performance enhancement, cost-effectiveness, cloud-edge privacy, and trustworthiness. Under this framework, we review representative methods, summarize design paradigms, and outline open challenges and future directions toward efficient and secure SLM-LLM collaboration. The collected papers are available at https://github.com/FairyFali/SLMs-Survey.

Evaluating the factuality of long-form generations from Large Language Models (LLMs) remains challenging due to efficiency bottlenecks and reliability concerns. Prior efforts attempt this by decomposing text into claims, searching for evidence, and verifying claims, but suffer from critical drawbacks: (1) inefficiency due to overcomplicated pipeline components, and (2) ineffectiveness stemming from inaccurate claim sets and insufficient evidence. To address these limitations, we propose \textbf{FaStfact}, an evaluation framework that achieves the highest alignment with human evaluation and time/token efficiency among existing baselines. FaStfact first employs chunk-level claim extraction integrated with confidence-based pre-verification, significantly reducing the time and token cost while ensuring reliability. For searching and verification, it collects document-level evidence from crawled web-pages and selectively retrieves it during verification. Extensive experiments based on an annotated benchmark \textbf{FaStfact-Bench} demonstrate the reliability of FaStfact in both efficiently and effectively evaluating long-form factuality. Code, benchmark data, and annotation interface tool are available at https://github.com/Yingjia-Wan/FaStfact.

Early Time Series Classification (ETSC) is critical in time-sensitive medical applications such as sepsis, yet it presents an inherent trade-off between accuracy and earliness. This trade-off arises from two core challenges: 1) models should effectively model inherently weak and noisy early-stage snippets, and 2) they should resolve the complex, dual requirement of simultaneously capturing local, subject-specific variations and overarching global temporal patterns. Existing methods struggle to overcome these underlying challenges, often forcing a severe compromise: sacrificing accuracy to achieve earliness, or vice-versa. We propose \textbf{DE3S}, a \textbf{D}ual-\textbf{E}nhanced \textbf{S}oft-\textbf{S}parse \textbf{S}equence Learning framework, which systematically solves these challenges. A dual enhancement mechanism is proposed to enhance the modeling of weak, early signals. Then, an attention-based patch module is introduced to preserve discriminative information while reducing noise and complexity. A dual-path fusion architecture is designed, using a sparse mixture of experts to model local, subject-specific variations. A multi-scale inception module is also employed to capture global dependencies. Experiments on six real-world medical datasets show the competitive performance of DE3S, particularly in early prediction windows. Ablation studies confirm the effectiveness of each component in addressing its targeted challenge. The source code is available \href{https://github.com/kuxit/DE3S}{\textbf{here}}.

Data sharing ecosystems connect providers, consumers, and intermediaries to facilitate the exchange and use of data for a wide range of downstream tasks. In sensitive domains such as healthcare, privacy is enforced as a hard constraint, any shared data must satisfy a minimum privacy threshold. However, among all masking configurations that meet this requirement, the utility of the masked data can vary significantly, posing a key challenge: how to efficiently select the optimal configuration that preserves maximum utility. This paper presents Aegis, a middleware framework that selects optimal masking configurations for machine learning datasets with features and class labels. Aegis incorporates a utility optimizer that minimizes predictive utility deviation, quantifying shifts in feature label correlations due to masking. Our framework leverages limited data summaries (such as 1D histograms) or none to estimate the feature label joint distribution, making it suitable for scenarios where raw data is inaccessible due to privacy restrictions. To achieve this, we propose a joint distribution estimator based on iterative proportional fitting, which allows supporting various feature label correlation quantification methods such as mutual information, chi square, or g3. Our experimental evaluation of real world datasets shows that Aegis identifies optimal masking configurations over an order of magnitude faster, while the resulting masked datasets achieve predictive performance on downstream ML tasks on par with baseline approaches and complements privacy anonymization data masking techniques.

Large-scale Speech Language Models (SpeechLMs) have enabled voice assistants capable of understanding natural spoken queries and performing complex tasks. However, existing speech benchmarks primarily focus on isolated capabilities such as transcription, or question-answering, and do not systematically evaluate agentic scenarios encompassing multilingual and cultural understanding, as well as adversarial robustness. To address this, we introduce VoiceAgentBench, a comprehensive benchmark designed to evaluate SpeechLMs in realistic spoken agentic settings. It comprises over 5,500 synthetic spoken queries, including dialogues grounded in Indian context, covering single-tool invocations, multi-tool workflows, multi-turn interactions, and safety evaluations. The benchmark supports English, Hindi, and 5 other Indian languages, reflecting real-world linguistic and cultural diversity. We simulate speaker variability using a novel sampling algorithm that selects audios for TTS voice conversion based on its speaker embeddings, maximizing acoustic and speaker diversity. Our evaluation measures tool selection accuracy, structural consistency, and the correctness of tool invocations, including adversarial robustness. Our experiments reveal significant gaps in contextual tool orchestration tasks, Indic generalization, and adversarial robustness, exposing critical limitations of current SpeechLMs.

Learning causal structure from observational data is especially challenging when latent variables or selection bias are present. The Fast Causal Inference (FCI) algorithm addresses this setting but performs exhaustive conditional independence tests across many subsets, often leading to spurious independences, missing or extra edges, and unreliable orientations. We present a family of score-guided mixed-strategy causal search algorithms that extend this framework. First, we introduce BOSS-FCI and GRaSP-FCI, variants of GFCI (Greedy Fast Causal Inference) that substitute BOSS (Best Order Score Search) or GRaSP (Greedy Relaxations of Sparsest Permutation) for FGES (Fast Greedy Equivalence Search), preserving correctness while trading off scalability and conservativeness. Second, we develop FCI Targeted-Testing (FCIT), a novel hybrid method that replaces exhaustive testing with targeted, score-informed tests guided by BOSS. FCIT guarantees well-formed PAGs and achieves higher precision and efficiency across sample sizes. Finally, we propose a lightweight heuristic, LV-Dumb (Latent Variable "Dumb"), which returns the PAG of the BOSS DAG (Directed Acyclic Graph). Though not strictly sound for latent confounding, LV-Dumb often matches FCIT's accuracy while running substantially faster. Simulations and real-data analyses show that BOSS-FCI and GRaSP-FCI provide robust baselines, FCIT yields the best balance of precision and reliability, and LV-Dumb offers a fast, near-equivalent alternative. Together, these methods demonstrate that targeted and score-guided strategies can dramatically improve the efficiency and correctness of latent-variable causal discovery.

The integration of machine learning (ML) is critical for industrial competitiveness, yet its adoption is frequently stalled by the prohibitive costs and operational disruptions of upgrading legacy systems. The financial and logistical overhead required to support the full ML lifecycle presents a formidable barrier to widespread implementation, particularly for small and medium-sized enterprises. This paper introduces a pragmatic, API-based framework designed to overcome these challenges by strategically decoupling the ML model lifecycle from the production environment. Our solution delivers the analytical power of ML to domain experts through a lightweight, browser-based interface, eliminating the need for local hardware upgrades and ensuring model maintenance can occur with zero production downtime. This human-in-the-loop approach empowers experts with interactive control over model parameters, fostering trust and facilitating seamless integration into existing workflows. By mitigating the primary financial and operational risks, this framework offers a scalable and accessible pathway to enhance production quality and safety, thereby strengthening the competitive advantage of the manufacturing sector.