Discrete methodologies use the discrete language of finite state machines while continuous methodologies use the continuous modelling language of differential equations. The resulting need to interface discrete automata and continuous differential equations has made the theory of hybrid and cyberphysical systems a key component of control design. The advantages of separating the discrete and the continuous design are many. Yet, this separation has become a bottleneck in the design of scalable architectures that can control and regulate across a range of spatial and temporal scales [1, 2]. The divide between automation and regulation does not exist in animal machines. Nervous systems make decisions and regulate muscle activation with one and the same architecture that is event-based rather than continuous or discrete.

Large Language Models have advanced clinical text classification, but their opaque predictions remain a critical barrier to practical adoption in research and clinical settings where investigators and physicians need to understand which parts of a patient's record drive risk signals. To address this challenge, we introduce \textbf{CALM}, short for \textbf{Classification with Additive Large Language Models}, an interpretable framework for semi-structured text where inputs are composed of semantically meaningful components, such as sections of an admission note or question-answer fields from an intake form. CALM predicts outcomes as the additive sum of each component's contribution, making these contributions part of the forward computation itself and enabling faithful explanations at both the patient and population level. The additive structure also enables clear visualizations, such as component-level risk curves similar to those used in generalized additive models, making the learned relationships easier to inspect and communicate. Although CALM expects semi-structured inputs, many clinical documents already have this form, and similar structure can often be automatically extracted from free-text notes. CALM achieves performance comparable to conventional LLM classifiers while improving trust, supporting quality-assurance checks, and revealing clinically meaningful patterns during model development and auditing.

The AI conversation can be traced as far back as Alan Turing's milestone paper published in 1950, which considered the fundamental question "Can machines think?" [1]. In 1956, AI got its name and mission as a scientific field at the first AI conference held at Dartmouth College [2]. Following AI's foundational period in the 1950s ~ 1970s, AI has evolved from early rule-based systems (1970s ~ 1990s), through classical machine learning and deep learning with neural networks (1990s ~ 2020s), to today's generative and agentic AI systems (since 2010s). Correspondingly, as a vital requirement of these systems, the reliability concept and concerns are also evolving, particularly in the interpretation of "required function" (see Table 1 in Chapter 10), based on the definition in standards like ISO 8402 "The ability of an item to perform a required function, under given environmental and operational conditions and for a stated period of time ". While a conventional AI system is concerned with providing stable and accurate classifications, predictions, or optimizations, a reliable generative AI system focuses on producing outputs that are trustworthy, consistent, safe, and contextually appropriate [3]. Building on both, a reliable agentic AI system should additionally conduct functions of reasoning, goal alignment, planning, safe adaption and interaction in dynamic and collaborative multi-agent contexts. The expansion of reliability concepts has introduced new challenges and research opportunities, as exemplified in Figure 1. In the following sections, we shed lights on these challenges and opportunities in building reliable AI systems, particularly, agentic AI systems.

Graph machine learning has advanced rapidly in tasks such as link prediction, anomaly detection, and node classification. As models scale up, pretrained graph models have become valuable intellectual assets because they encode extensive computation and domain expertise. Building on these advances, Graph Foundation Models (GFMs) mark a major step forward by jointly pretraining graph and text encoders on massive and diverse data. This unifies structural and semantic understanding, enables zero-shot inference, and supports applications such as fraud detection and biomedical analysis. However, the high pretraining cost and broad cross-domain knowledge in GFMs also make them attractive targets for model extraction attacks (MEAs). Prior work has focused only on small graph neural networks trained on a single graph, leaving the security implications for large-scale and multimodal GFMs largely unexplored. This paper presents the first systematic study of MEAs against GFMs. We formalize a black-box threat model and define six practical attack scenarios covering domain-level and graph-specific extraction goals, architectural mismatch, limited query budgets, partial node access, and training data discrepancies. To instantiate these attacks, we introduce a lightweight extraction method that trains an attacker encoder using supervised regression of graph embeddings. Even without contrastive pretraining data, this method learns an encoder that stays aligned with the victim text encoder and preserves its zero-shot inference ability on unseen graphs. Experiments on seven datasets show that the attacker can approximate the victim model using only a tiny fraction of its original training cost, with almost no loss in accuracy. These findings reveal that GFMs greatly expand the MEA surface and highlight the need for deployment-aware security defenses in large-scale graph learning systems.

Medical imaging and multi-modal clinical settings often face the challange of missing modality in their diagnostic pipelines. Existing imputation methods either lack representational capacity or are computationally expensive. We propose PI-NAIM, a novel dual-path architecture that dynamically routes samples to optimized imputation approaches based on missingness complexity. Our framework integrates: (1) intelligent path routing that directs low missingness samples to efficient statistical imputation (MICE) and complex patterns to powerful neural networks (GAIN with temporal analysis); (2) cross-path attention fusion that leverages missingness-aware embeddings to intelligently combine both branches; and (3) end-to-end joint optimization of imputation accuracy and downstream task performance. Extensive experiments on MIMIC-III and multimodal benchmarks demonstrate state-of-the-art performance, achieving RMSE of 0.108 (vs. baselines' 0.119-0.152) and substantial gains in downstream tasks with an AUROC of 0.812 for mortality prediction. PI-NAIM's modular design enables seamless integration into vision pipelines handling incomplete sensor measurements, missing modalities, or corrupted inputs, providing a unified solution for real-world scenario. The code is publicly available at https://github.com/AfifaKhaled/PI-NAIM-Path-Integrated-Neural-Adaptive-Imputation-Model

Fine-grained analysis of intraoperative behavior and its impact on patient outcomes remain a longstanding challenge. We present Frame-to-Outcome (F2O), an end-to-end system that translates tissue dissection videos into gesture sequences and uncovers patterns associated with postoperative outcomes. Leveraging transformer-based spatial and temporal modeling and frame-wise classification, F2O robustly detects consecutive short (~2 seconds) gestures in the nerve-sparing step of robot-assisted radical prostatectomy (AUC: 0.80 frame-level; 0.81 video-level). F2O-derived features (gesture frequency, duration, and transitions) predicted postoperative outcomes with accuracy comparable to human annotations (0.79 vs. 0.75; overlapping 95% CI). Across 25 shared features, effect size directions were concordant with small differences (~ 0.07), and strong correlation (r = 0.96, p < 1e-14). F2O also captured key patterns linked to erectile function recovery, including prolonged tissue peeling and reduced energy use. By enabling automatic interpretable assessment, F2O establishes a foundation for data-driven surgical feedback and prospective clinical decision support.

Vision-language foundation models (VLMs) show promise for diverse imaging tasks but often underperform on medical benchmarks. Prior efforts to improve performance include model finetuning, which requires large domain-specific datasets and significant compute, or manual prompt engineering, which is hard to generalize and often inaccessible to medical institutions seeking to deploy these tools. These challenges motivate interest in approaches that draw on a model's embedded knowledge while abstracting away dependence on human-designed prompts to enable scalable, weight-agnostic performance improvements. To explore this, we adapt the Declarative Self-improving Python (DSPy) framework for structured automated prompt optimization in medical vision-language systems through a comprehensive, formal evaluation. We implement prompting pipelines for five medical imaging tasks across radiology, gastroenterology, and dermatology, evaluating 10 open-source VLMs with four prompt optimization techniques. Optimized pipelines achieved a median relative improvement of 53% over zero-shot prompting baselines, with the largest gains ranging from 300% to 3,400% on tasks where zero-shot performance is low. These results highlight the substantial potential of applying automated prompt optimization to medical AI systems, demonstrating significant gains for vision-based applications requiring accurate clinical image interpretation. By reducing dependence on prompt design to elicit intended outputs, these techniques allow clinicians to focus on patient care and clinical decision-making. Furthermore, our experiments offer scalability and preserve data privacy, demonstrating performance improvement on open-source VLMs. We publicly release our evaluation pipelines to support reproducible research on specialized medical tasks, available at https://github.com/DaneshjouLab/prompt-triage-lab.

Text-conditioned molecular generation aims to translate natural-language descriptions into chemical structures, enabling scientists to specify functional groups, scaffolds, and physicochemical constraints without handcrafted rules. Diffusion-based models, particularly latent diffusion models (LDMs), have recently shown promise by performing stochastic search in a continuous latent space that compactly captures molecular semantics. Yet existing methods rely on one-shot conditioning, where the entire prompt is encoded once and applied throughout diffusion, making it hard to satisfy all the requirements in the prompt. We discuss three outstanding challenges of one-shot conditioning generation, including the poor interpretability of the generated components, the failure to generate all substructures, and the overambition in considering all requirements simultaneously. We then propose three principles to address those challenges, motivated by which we propose Chain-of-Generation (CoG), a training-free multi-stage latent diffusion framework. CoG decomposes each prompt into curriculum-ordered semantic segments and progressively incorporates them as intermediate goals, guiding the denoising trajectory toward molecules that satisfy increasingly rich linguistic constraints. To reinforce semantic guidance, we further introduce a post-alignment learning phase that strengthens the correspondence between textual and molecular latent spaces. Extensive experiments on benchmark and real-world tasks demonstrate that CoG yields higher semantic alignment, diversity, and controllability than one-shot baselines, producing molecules that more faithfully reflect complex, compositional prompts while offering transparent insight into the generation process.

Smart cities and pervasive IoT deployments have generated interest in IoT data analysis across transportation and urban planning. At the same time, Large Language Models offer a new interface for exploring IoT data - particularly through natural language. Users today face two key challenges when working with IoT data using LLMs: (1) data collection infrastructure is expensive, producing terabytes of low-level sensor readings that are too granular for direct use, and (2) data analysis is slow, requiring iterative effort and technical expertise. Directly feeding all IoT telemetry to LLMs is impractical due to finite context windows, prohibitive token costs at scale, and non-interactive latencies. What is missing is a system that first parses a user's query to identify the analytical task, then selects the relevant data slices, and finally chooses the right representation before invoking an LLM. We present Flash-Fusion, an end-to-end edge-cloud system that reduces the IoT data collection and analysis burden on users. Two principles guide its design: (1) edge-based statistical summarization (achieving 73.5% data reduction) to address data volume, and (2) cloud-based query planning that clusters behavioral data and assembles context-rich prompts to address data interpretation. We deploy Flash-Fusion on a university bus fleet and evaluate it against a baseline that feeds raw data to a state-of-the-art LLM. Flash-Fusion achieves a 95% latency reduction and 98% decrease in token usage and cost while maintaining high-quality responses. It enables personas across disciplines - safety officers, urban planners, fleet managers, and data scientists - to efficiently iterate over IoT data without the burden of manual query authoring or preprocessing.

Mental health illness represents a substantial global socioeconomic burden, with COVID - 19 further exacerbating accessibility challenges and driving increased demand for telehealth mental health support. While large language models ( L LMs) offer promising solutions through 24/7 availability and non - judgmental interactions, pre - trained models often lack the contextual and emotional awareness necessary for appropriate therapeutic responses. This paper investigated the application of supervised fine - tu ning (SFT) and reinforcement learning (RL) techniques to enhance GPT - 2's capacity for therapeutic dialogue generation. The methodology restructured input formats to enable simultaneous processing of contextual information and emotional states alongside user input, employing a multi - component reward function that aligned model outputs with professional therapist responses and annotated emotions. Results demonstrated improvements through reinforcement learning over baseline GPT - 2 across multiple evaluation me trics: BLEU (0.0111), ROUGE - 1 (0.1397), ROUGE - 2 (0.0213), ROUGE - L (0.1317), and METEOR (0.0581). LLM evaluation confirmed high contextual relevance and professionalism, while reinforcement learning achieved 99.34% emotion accuracy compared to 66.96% for baseline GPT - 2. These findings demonstrate reinforcement learning's effectiveness in developing therap eutic dialogue systems that can serve as valuable assistive tools for therapists while maintaining essential human clinical oversight. The code and a ppendic es are publicly available at: https://github.com/ez