Generative models of 3D cardiovascular anatomy can synthesize informative structures for clinical research and medical device evaluation, but face a trade-off between geometric controllability and realism. We propose CardioComposer: a programmable, inference-time framework for generating multi-class anatomical label maps based on interpretable ellipsoidal primitives. These primitives represent geometric attributes such as the size, shape, and position of discrete substructures. We specifically develop differentiable measurement functions based on voxel-wise geometric moments, enabling loss-based gradient guidance during diffusion model sampling. We demonstrate that these losses can constrain individual geometric attributes in a disentangled manner and provide compositional control over multiple substructures. Finally, we show that our method is compatible with a wide array of anatomical systems containing non-convex substructures, spanning cardiac, vascular, and skeletal organs.

Rigorous evaluation of commercial Augmented Reality (AR) hardware is crucial, yet public benchmarks for tool tracking on modern Head-Mounted Displays (HMDs) are limited. This paper addresses this gap by systematically assessing the Magic Leap 2 (ML2) controllers tracking performance. Using a robotic arm for repeatable motion (EN ISO 9283) and an optical tracking system as ground truth, our protocol evaluates static and dynamic performance under various conditions, including realistic paths from a hydrogen leak inspection use case. The results provide a quantitative baseline of the ML2 controller's accuracy and repeatability and present a robust, transferable evaluation methodology. The findings provide a basis to assess the controllers suitability for the inspection use case and similar industrial sensor-based AR guidance tasks.

Drug shortages pose critical risks to patient care and healthcare systems worldwide, yet the effectiveness of regulatory interventions remains poorly understood due to information asymmetries in pharmaceutical supply chains. We propose \textbf{ShortageSim}, addresses this challenge by providing the first simulation framework that evaluates the impact of regulatory interventions on competition dynamics under information asymmetry. Using Large Language Model (LLM)-based agents, the framework models the strategic decisions of drug manufacturers and institutional buyers, in response to shortage alerts given by the regulatory agency. Unlike traditional game theory models that assume perfect rationality and complete information, ShortageSim simulates heterogeneous interpretations on regulatory announcements and the resulting decisions. Experiments on self-processed dataset of historical shortage events show that ShortageSim reduces the resolution lag for production disruption cases by up to 84\%, achieving closer alignment to real-world trajectories than the zero-shot baseline. Our framework confirms the effect of regulatory alert in addressing shortages and introduces a new method for understanding competition in multi-stage environments under uncertainty. We open-source ShortageSim and a dataset of 2,925 FDA shortage events, providing a novel framework for future research on policy design and testing in supply chains under information asymmetry.

Do neural networks build their representations through smooth, gradual refinement, or via more complex computational processes? We investigate this by extending the logit lens to analyze the policy network of Leela Chess Zero, a superhuman chess engine. Although playing strength and puzzle-solving ability improve consistently across layers, capability progression occurs in distinct computational phases with move preferences undergoing continuous reevaluation--move rankings remain poorly correlated with final outputs until late, and correct puzzle solutions found in middle layers are sometimes overridden. This late-layer reversal is accompanied by concept preference analyses showing final layers prioritize safety over aggression, suggesting a mechanism by which heuristic priors can override tactical solutions.

Large Language Models (LLMs) are increasingly deployed in high-stakes domains such as science, law, and healthcare, where accurate expressions of uncertainty are essential for reliability and trust. However, current LLMs are often observed to generate incorrect answers with high confidence, a phenomenon known as "overconfidence". Recent efforts have focused on calibrating LLMs' verbalized confidence: i.e., their expressions of confidence in text form, such as "I am 80% confident that...". Existing approaches either rely on prompt engineering or fine-tuning with heuristically generated uncertainty estimates, both of which have limited effectiveness and generalizability. Motivated by the notion of proper scoring rules for calibration in classical machine learning models, we introduce ConfTuner, a simple and efficient fine-tuning method that introduces minimal overhead and does not require ground-truth confidence scores or proxy confidence estimates. ConfTuner relies on a new loss function, tokenized Brier score, which we theoretically prove to be a proper scoring rule, intuitively meaning that it "correctly incentivizes the model to report its true probability of being correct". ConfTuner improves calibration across diverse reasoning tasks and generalizes to black-box models such as GPT-4o. Our results further show that better-calibrated confidence enables downstream gains in self-correction and model cascade, advancing the development of trustworthy LLM systems. The code is available at https://github.com/liushiliushi/ConfTuner.

Bold claims about AI's role in science-from "AGI will cure all diseases" to promises of radically accelerated discovery-raise a central epistemic question: do large language models (LLMs) truly generate new knowledge, or do they merely remix memorized fragments? We propose unlearning-as-ablation as a falsifiable probe of constructive scientific discovery. The idea is to systematically remove a target result together with its forget-closure (supporting lemmas, paraphrases, and multi-hop entailments) and then evaluate whether the model can re-derive the result from only permitted axioms and tools. Success would indicate generative capability beyond recall; failure would expose current limits. Unlike prevailing motivations for unlearning-privacy, copyright, or safety-our framing repositions it as an epistemic probe for AI-for-Science. We outline a minimal pilot in mathematics and algorithms to illustrate feasibility, and sketch how the same approach could later be extended to domains such as physics or chemistry. This is a position paper: our contribution is conceptual and methodological, not empirical. We aim to stimulate discussion on how principled ablation tests could help distinguish models that reconstruct knowledge from those that merely retrieve it, and how such probes might guide the next generation of AI-for-Science benchmarks.

Existing deepfake detection methods heavily rely on static labeled datasets. However, with the proliferation of generative models, real-world scenarios are flooded with massive amounts of unlabeled fake face data from unknown sources. This presents a critical dilemma: detectors relying solely on existing data face generalization failure, while manual labeling for this new stream is infeasible due to the high realism of fakes. A more fundamental challenge is that, unlike typical unsupervised learning tasks where categories are clearly defined, real and fake faces share the same semantics, which leads to a decline in the performance of traditional unsupervised strategies. Therefore, there is an urgent need for a new paradigm designed specifically for this scenario to effectively utilize these unlabeled data. Accordingly, this paper proposes a dual-path guided network (DPGNet) to address two key challenges: (1) bridging the domain differences between faces generated by different generative models; and (2) utilizing unlabeled image samples. The method comprises two core modules: text-guided cross-domain alignment, which uses learnable cues to unify visual and textual embeddings into a domain-invariant feature space; and curriculum-driven pseudo-label generation, which dynamically utilizes unlabeled samples. Extensive experiments on multiple mainstream datasets show that DPGNet significantly outperforms existing techniques,, highlighting its effectiveness in addressing the challenges posed by the deepfakes using unlabeled data.

Federated Learning (FL) is an established paradigm for training deep learning models on decentralized data. However, as the size of the models grows, conventional FL approaches often require significant computational resources on client devices, which may not be feasible. We introduce FedPromo, a novel framework that enables efficient adaptation of large-scale foundation models stored on a central server to new domains encountered only by remote clients. Instead of directly training the large model on client devices, FedPromo optimizes lightweight proxy models via FL, significantly reducing computational overhead while maintaining privacy. Our method follows a two-stage process: first, server-side knowledge distillation aligns the representations of a large-scale foundation model (e.g., a transformer) with those of a compact counterpart (e.g., a CNN). Then, the compact model encoder is deployed to client devices, where trainable classifiers are learned locally. These classifiers are subsequently aggregated and seamlessly transferred back to the foundation model, facilitating personalized adaptation without requiring direct access to user data. Through novel regularization strategies, our framework enables decentralized multi-domain learning, balancing performance, privacy, and resource efficiency. Extensive experiments on five image classification benchmarks demonstrate that FedPromo outperforms existing methods while assuming limited-resource clients.

Aneurysmal subarachnoid hemorrhage (SAH) is a life-threatening neurological emergency with mortality rates exceeding 30%. Transfer learning from related hematoma types represents a potentially valuable but underexplored approach. Although Unet architectures remain the gold standard for medical image segmentation due to their effectiveness on limited datasets, Low-Rank Adaptation (LoRA) methods for parameter-efficient transfer learning have been rarely applied to convolutional neural networks in medical imaging contexts. We implemented a Unet architecture pre-trained on computed tomography scans from 124 traumatic brain injury patients across multiple institutions, then fine-tuned on 30 aneurysmal SAH patients from the University of Michigan Health System using 3-fold cross-validation. We developed a novel CP-LoRA method based on tensor CP-decomposition and introduced DoRA variants (DoRA-C, convDoRA, CP-DoRA) that decompose weight matrices into magnitude and directional components. We compared these approaches against existing LoRA methods (LoRA-C, convLoRA) and standard fine-tuning strategies across different modules on a multi-view Unet model. LoRA-based methods consistently outperformed standard Unet fine-tuning. Performance varied by hemorrhage volume, with all methods showing improved accuracy for larger volumes. CP-LoRA achieved comparable performance to existing methods while using significantly fewer parameters. Over-parameterization with higher ranks consistently yielded better performance than strictly low-rank adaptations. This study demonstrates that transfer learning between hematoma types is feasible and that LoRA-based methods significantly outperform conventional Unet fine-tuning for aneurysmal SAH segmentation.

Advances in 3D reconstruction and novel view synthesis have enabled efficient and photorealistic rendering. However, images for reconstruction are still either largely manual or constrained by simple preplanned trajectories. To address this issue, recent works propose generalizable next-best-view planners that do not require online learning. Nevertheless, robustness and performance remain limited across various shapes. Hence, this study introduces Voxel-Face-Aware Hierarchical Next-Best-View Acquisition for Efficient 3D Reconstruction (Hestia), which addresses the shortcomings of the reinforcement learning-based generalizable approaches for five-degree-of-freedom viewpoint prediction. Hestia systematically improves the planners through four components: a more diverse dataset to promote robustness, a hierarchical structure to manage the high-dimensional continuous action search space, a close-greedy strategy to mitigate spurious correlations, and a face-aware design to avoid overlooking geometry. Experimental results show that Hestia achieves non-marginal improvements, with at least a 4% gain in coverage ratio, while reducing Chamfer Distance by 50% and maintaining real-time inference. In addition, Hestia outperforms prior methods by at least 12% in coverage ratio with a 5-image budget and remains robust to object placement variations. Finally, we demonstrate that Hestia, as a next-best-view planner, is feasible for the real-world application. Our project page is https://johnnylu305.github.io/hestia web.