Recent research has explored LLMs as scalable tools for relevance labeling, but studies indicate they are susceptible to priming effects, where prior relevance judgments influence later ones. Although psychological theories link personality traits to such biases, it is unclear whether simulated personalities in LLMs exhibit similar effects. We investigate how Big Five personality profiles in LLMs influence priming in relevance labeling, using multiple LLMs on TREC 2021 and 2022 Deep Learning Track datasets. Our results show that certain profiles, such as High Openness and Low Neuroticism, consistently reduce priming susceptibility. Additionally, the most effective personality in mitigating priming may vary across models and task types. Based on these findings, we propose personality prompting as a method to mitigate threshold priming, connecting psychological evidence with LLM-based evaluation practices.

The constrained nature of synthesizable chemical space poses a significant challenge for sampling molecules that are both synthetically accessible and possess desired properties. In this work, we present PrexSyn, an efficient and programmable model for molecular discovery within synthesizable chemical space. PrexSyn is based on a decoder-only transformer trained on a billion-scale datastream of synthesizable pathways paired with molecular properties, enabled by a real-time, high-throughput C++-based data generation engine. The large-scale training data allows PrexSyn to reconstruct the synthesizable chemical space nearly perfectly at a high inference speed and learn the association between properties and synthesizable molecules. Based on its learned property-pathway mappings, PrexSyn can generate synthesizable molecules that satisfy not only single-property conditions but also composite property queries joined by logical operators, thereby allowing users to ``program'' generation objectives. Moreover, by exploiting this property-based querying capability, PrexSyn can efficiently optimize molecules against black-box oracle functions via iterative query refinement, achieving higher sampling efficiency than even synthesis-agnostic baselines, making PrexSyn a powerful general-purpose molecular optimization tool. Overall, PrexSyn pushes the frontier of synthesizable molecular design by setting a new state of the art in synthesizable chemical space coverage, molecular sampling efficiency, and inference speed.

Accurate prediction of enzyme kinetic parameters is crucial for drug discovery, metabolic engineering, and synthetic biology applications. Current computational approaches face limitations in capturing complex enzyme-substrate interactions and often focus on single parameters while neglecting the joint prediction of catalytic turnover numbers (Kcat) and Michaelis-Menten constants (Km). We present EnzyCLIP, a novel dual-encoder framework that leverages contrastive learning and cross-attention mechanisms to predict enzyme kinetic parameters from protein sequences and substrate molecular structures. Our approach integrates ESM-2 protein language model embeddings with ChemBERTa chemical representations through a CLIP-inspired architecture enhanced with bidirectional cross-attention for dynamic enzyme-substrate interaction modeling. EnzyCLIP combines InfoNCE contrastive loss with Huber regression loss to learn aligned multimodal representations while predicting log10-transformed kinetic parameters. The model is trained on the CatPred-DB database containing 23,151 Kcat and 41,174 Km experimentally validated measurements, and achieved competitive performance with R2 scores of 0.593 for Kcat and 0.607 for Km prediction. XGBoost ensemble methods applied to the learned embeddings further improved Km prediction (R2 = 0.61) while maintaining robust Kcat performance.

Protein language models (PLMs) have transformed sequence-based protein analysis, yet most applications rely only on final-layer embeddings, which may overlook biologically meaningful information encoded in earlier layers. We systematically evaluate all 33 layers of ESM-2 for kinase functional prediction using both unsupervised clustering and supervised classification. We show that mid-to-late transformer layers (layers 20-33) outperform the final layer by 32 percent in unsupervised Adjusted Rand Index and improve homology-aware supervised accuracy to 75.7 percent. Domain-level extraction, calibrated probability estimates, and a reproducible benchmarking pipeline further strengthen reliability. Our results demonstrate that transformer depth contains functionally distinct biological signals and that principled layer selection significantly improves kinase function prediction.

Large Language Models' (LLMs) programming capabilities enable their participation in open-source games: a game-theoretic setting in which players submit computer programs in lieu of actions. These programs offer numerous advantages, including interpretability, inter-agent transparency, and formal verifiability; additionally, they enable program equilibria, solutions that leverage the transparency of code and are inaccessible within normal-form settings. We evaluate the capabilities of leading open- and closed-weight LLMs to predict and classify program strategies and evaluate features of the approximate program equilibria reached by LLM agents in dyadic and evolutionary settings. We identify the emergence of payoff-maximizing, cooperative, and deceptive strategies, characterize the adaptation of mechanisms within these programs over repeated open-source games, and analyze their comparative evolutionary fitness. We find that open-source games serve as a viable environment to study and steer the emergence of cooperative strategy in multi-agent dilemmas.

Spatiotemporal forecasting often relies on computationally intensive models to capture complex dynamics. Knowledge distillation (KD) has emerged as a key technique for creating lightweight student models, with recent advances like frequency-aware KD successfully preserving spectral properties (i.e., high-frequency details and low-frequency trends). However, these methods are fundamentally constrained by operating on pixel-level signals, leaving them blind to the rich semantic and causal context behind the visual patterns. To overcome this limitation, we introduce S^2-KD, a novel framework that unifies Semantic priors with Spectral representations for distillation. Our approach begins by training a privileged, multimodal teacher model. This teacher leverages textual narratives from a Large Multimodal Model (LMM) to reason about the underlying causes of events, while its architecture simultaneously decouples spectral components in its latent space. The core of our framework is a new distillation objective that transfers this unified semantic-spectral knowledge into a lightweight, vision-only student. Consequently, the student learns to make predictions that are not only spectrally accurate but also semantically coherent, without requiring any textual input or architectural overhead at inference. Extensive experiments on benchmarks like WeatherBench and TaxiBJ+ show that S^2-KD significantly boosts the performance of simple student models, enabling them to outperform state-of-the-art methods, particularly in long-horizon and complex non-stationary scenarios.

We study timestamped question answering over educational lecture videos under a single-GPU latency/memory budget. Given a natural-language query, the system retrieves relevant timestamped segments and synthesizes a grounded answer. We present CourseTimeQA (52.3 h, 902 queries across six courses) and a lightweight, latency-constrained cross-modal retriever (CrossFusion-RAG) that combines frozen encoders, a learned 512->768 vision projection, shallow query-agnostic cross-attention over ASR and frames with a temporal-consistency regularizer, and a small cross-attentive reranker. On CourseTimeQA, CrossFusion-RAG improves nDCG@10 by 0.10 and MRR by 0.08 over a strong BLIP-2 retriever while achieving approximately 1.55 s median end-to-end latency on a single A100. Closest comparators (zero-shot CLIP multi-frame pooling; CLIP + cross-encoder reranker + MMR; learned late-fusion gating; text-only hybrid with cross-encoder reranking and its MMR variant; caption-augmented text retrieval; non-learned temporal smoothing) are evaluated under matched hardware and indexing. We report robustness across ASR noise (WER quartiles), diagnostics for temporal localization, and full training/tuning details to support reproducible comparison.

We introduce MedCondDiff, a diffusion-based framework for multi-organ medical image segmentation that is efficient and anatomically grounded. The model conditions the denoising process on semantic priors extracted by a Pyramid Vision Transformer (PVT) backbone, yielding a semantically guided and lightweight diffusion architecture. This design improves robustness while reducing both inference time and VRAM usage compared to conventional diffusion models. Experiments on multi-organ, multi-modality datasets demonstrate that MedCondDiff delivers competitive performance across anatomical regions and imaging modalities, underscoring the potential of semantically guided diffusion models as an effective class of architectures for medical imaging tasks.

Are frontier AI systems becoming more capable? Certainly. Yet such progress is not an unalloyed blessing but rather a Trojan horse: behind their performance leaps lie more insidious and destructive safety risks, namely deception. Unlike hallucination, which arises from insufficient capability and leads to mistakes, deception represents a deeper threat in which models deliberately mislead users through complex reasoning and insincere responses. As system capabilities advance, deceptive behaviours have spread from textual to multimodal settings, amplifying their potential harm. First and foremost, how can we monitor these covert multimodal deceptive behaviors? Nevertheless, current research remains almost entirely confined to text, leaving the deceptive risks of multimodal large language models unexplored. In this work, we systematically reveal and quantify multimodal deception risks, introducing MM-DeceptionBench, the first benchmark explicitly designed to evaluate multimodal deception. Covering six categories of deception, MM-DeceptionBench characterizes how models strategically manipulate and mislead through combined visual and textual modalities. On the other hand, multimodal deception evaluation is almost a blind spot in existing methods. Its stealth, compounded by visual-semantic ambiguity and the complexity of cross-modal reasoning, renders action monitoring and chain-of-thought monitoring largely ineffective. To tackle this challenge, we propose debate with images, a novel multi-agent debate monitor framework. By compelling models to ground their claims in visual evidence, this method substantially improves the detectability of deceptive strategies. Experiments show that it consistently increases agreement with human judgements across all tested models, boosting Cohen's kappa by 1.5x and accuracy by 1.25x on GPT-4o.

The LLM field has spent a year perfecting RL for tasks machines already excel at, math, code, and deterministic reasoning, while completely sidestepping the domain that actually defines human intelligence: subjective, emotionally grounded, personality sensitive conversation. This space has often been regarded as inherently subjective and challenging to formalize, making it appear unsuitable for conventional RL pipelines. We show that it is not only possible and it is a solvable and transformative RL problem. We propose the first framework that infers user personality on the fly and optimizes model behavior toward personalized conversational preferences. Contrary to the widespread belief that RL collapses in non-verifiable settings, our method produces consistent, robust, and dramatic improvements in humanlike interaction quality. We also introduce the first dynamic emotional intelligence evaluation suite to quantify these gains. Our model, which is introduced as Echo-N1, behaves far above its base version and outperforming the proprietary Doubao 1.5 Character. This work establishes a new frontier for RL: optimizing models for the deeply subjective, deeply human dimensions of conversation.