Agentic AI marks a major shift in how autonomous systems reason, plan, and execute multi-step tasks. Unlike traditional single model prompting, agentic workflows integrate multiple specialized agents with different Large Language Models(LLMs), tool-augmented capabilities, orchestration logic, and external system interactions to form dynamic pipelines capable of autonomous decision-making and action. As adoption accelerates across industry and research, organizations face a central challenge: how to design, engineer, and operate production-grade agentic AI workflows that are reliable, observable, maintainable, and aligned with safety and governance requirements. This paper provides a practical, end-to-end guide for design-Email addresses: cmedawer@odu.edu We introduce a structured engineering lifecycle encompassing workflow decomposition, multi-agent design patterns, Model Context Protocol(MCP), and tool integration, deterministic orchestration, Responsible-AI considerations, and environment-aware deployment strategies. We then present nine core best practices for engineering production-grade agentic AI workflows, including tool-first design over MCP, pure-function invocation, single-tool and single-responsibility agents, externalized prompt management, Responsible-AI-aligned model-consortium design, clean separation between workflow logic and MCP servers, containerized deployment for scalable operations, and adherence to the Keep it Simple, Stupid (KISS) principle to maintain simplicity and robustness. To demonstrate these principles in practice, we present a comprehensive case study: a multimodal news-analysis and media-generation workflow. By combining architectural guidance, operational patterns, and practical implementation insights, this paper offers a foundational reference to build robust, extensible, and production-ready agentic AI workflows. Introduction The rapid advancement of Large Language Models (LLMs) [1, 2], Vision-Language Models (VLMs) [3, 4, 5], and tool-augmented reasoning has laid the foundation for a new paradigm in automation: agentic AI [6, 7]. Traditional LLM interactions follow a simple pattern in which a human provides a prompt and the model generates a response (as illustrated in the top half of Figure 1).

Early graph prompt tuning approaches relied on task-specific designs for Graph Neural Networks (GNNs), limiting their adaptability across diverse pre-training strategies. In contrast, another promising line of research has investigated universal graph prompt tuning, which operates directly in the input graph's feature space and builds a theoretical foundation that universal graph prompt tuning can theoretically achieve an equivalent effect of any prompting function, eliminating dependence on specific pre-training strategies. Recent works propose selective node-based graph prompt tuning to pursue more ideal prompts. However, we argue that selective node-based graph prompt tuning inevitably compromises the theoretical foundation of universal graph prompt tuning. In this paper, we strengthen the theoretical foundation of universal graph prompt tuning by introducing stricter constraints, demonstrating that adding prompts to all nodes is a necessary condition for achieving the universality of graph prompts. To this end, we propose a novel model and paradigm, Learning and Editing Universal GrAph Prompt Tuning (LEAP), which preserves the theoretical foundation of universal graph prompt tuning while pursuing more ideal prompts. Specifically, we first build the basic universal graph prompts to preserve the theoretical foundation and then employ actor-critic reinforcement learning to select nodes and edit prompts. Extensive experiments on graph- and node-level tasks across various pre-training strategies in both full-shot and few-shot scenarios show that LEAP consistently outperforms fine-tuning and other prompt-based approaches.

Reconfigurable intelligent surface (RIS) and simultaneously transmitting and reflecting RIS (STAR-RIS) have emerged as key enablers for enhancing wireless coverage and capacity in next-generation networks. When mounted on unmanned aerial vehicles (UAVs), they benefit from flexible deployment and improved line-of-sight conditions. Despite their promising potential, a comprehensive performance comparison between aerial RIS and STAR-RIS architectures has not been thoroughly investigated. This letter presents a detailed performance comparison between aerial RIS and STAR-RIS in three-dimensional wireless environments. Accurate channel models incorporating directional radiation patterns are established, and the influence of deployment altitude and orientation is thoroughly examined. To optimize the system sum-rate, we formulate joint optimization problems for both architectures and propose an efficient solution based on the weighted minimum mean square error and block coordinate descent algorithms. Simulation results reveal that STAR-RIS outperforms RIS in low-altitude scenarios due to its full-space coverage capability, whereas RIS delivers better performance near the base station at higher altitudes. The findings provide practical insights for the deployment of aerial intelligent surfaces in future 6G communication systems.

Abstract-- This report presents a heterogeneous robotic system designed for remote primary triage in mass-casualty incidents (MCIs). The system employs a coordinated air-ground team of unmanned aerial vehicles (UA Vs) and unmanned ground vehicles (UGVs) to locate victims, assess their injuries, and prioritize medical assistance without risking the lives of first responders. The UA V identify and provide overhead views of casualties, while UGVs equipped with specialized sensors measure vital signs and detect and localize physical injuries. Unlike previous work that focused on exploration or limited medical evaluation, this system addresses the complete triage process: victim localization, vital sign measurement, injury severity classification, mental status assessment, and data consolidation for first responders. Developed as part of the DARPA Triage Challenge, this approach demonstrates how multi-robot systems can augment human capabilities in disaster response scenarios to maximize lives saved. I. INTRODUCTION Robotics has long sought to augment human capabilities in hazardous scenarios. Mass-casualty incidents (MCIs), such as those resulting from natural disasters, bombings, plane crashes, or industrial chemical spills, present an opportunity for robotic systems to assist first responders. The critical first step of providing medical assistance during MCIs is primary triage: the initial process of locating victims at the site of the MCI and assessing the severity of their injuries to prioritize treatment, which is essential to optimizing survival outcomes. Traditionally, primary triage relies on human responders who may face significant risk and information overload [1], underscoring the potential for automated systems to mitigate these challenges. While prior efforts have explored the use of air-ground robotic teams for search and exploration in disaster zones [2]-[5], few systems have focused specifically on rapid triage. Existing approaches typically solve parts of the problem in isolation without integrating comprehensive triage functions. For example, air-ground teams have also been developed to find and localize objects of interest [3], [6] Authors are with the GRASP Lab, School of Engineering and Applied Sciences, University of Pennsylvania. Authors are with the Perelman School of Medicine, University of Pennsylvania. This work was supported by the DARP A Triage Challenge under grant #HR001123S0011.

Currently, there exists a fundamental divide between the "cognitive black box" (implicit intuition) of human experts and the "computational black box" (untrustworthy decision-making) of artificial intelligence (AI). This paper proposes a new paradigm of "human-AI collaborative cognitive enhancement," aiming to transform the dual black boxes into a composable, auditable, and extensible "functional white-box" system through structured "meta-interaction." The core breakthrough lies in the "plug-and-play cognitive framework"--a computable knowledge package that can be extracted from expert dialogues and loaded into the Recursive Adversarial Meta-Thinking Network (RAMTN). This enables expert thinking, such as medical diagnostic logic and teaching intuition, to be converted into reusable and scalable public assets, realizing a paradigm shift from "AI as a tool" to "AI as a thinking partner." This work not only provides the first engineering proof for "cognitive equity" but also opens up a new path for AI governance: constructing a verifiable and intervenable governance paradigm through "transparency of interaction protocols" rather than prying into the internal mechanisms of models. The framework is open-sourced to promote technology for good and cognitive inclusion. This paper is an independent exploratory research conducted by the author. All content presented, including the theoretical framework (RAMTN), methodology (meta-interaction), system implementation, and case validation, constitutes the author's individual research achievements.

Automatic Sign Language Recognition (ASLR) has emerged as a vital field for bridging the gap between deaf and hearing communities. However, the problem of sign-to-sign retrieval or detecting a specific sign within a sequence of continuous signs remains largely unexplored. We define this novel task as Sign Language Spotting. In this paper, we present a first step toward sign language retrieval by addressing the challenge of detecting the presence or absence of a query sign video within a sentence-level gloss or sign video. Unlike conventional approaches that rely on intermediate gloss recognition or text-based matching, we propose an end-to-end model that directly operates on pose keypoints extracted from sign videos. Our architecture employs an encoder-only backbone with a binary classification head to determine whether the query sign appears within the target sequence. By focusing on pose representations instead of raw RGB frames, our method significantly reduces computational cost and mitigates visual noise. We evaluate our approach on the Word Presence Prediction dataset from the WSLP 2025 shared task, achieving 61.88\% accuracy and 60.00\% F1-score. These results demonstrate the effectiveness of our pose-based framework for Sign Language Spotting, establishing a strong foundation for future research in automatic sign language retrieval and verification. Code is available at https://github.com/EbimoJohnny/Pose-Based-Sign-Language-Spotting

The emerging "agentic web" envisions large populations of autonomous agents coordinating, transacting, and delegating across open networks. Yet many agent communication and commerce protocols treat agents as low-cost identities, despite the empirical reality that LLM agents remain unreliable, hallucinated, manipulable, and vulnerable to prompt-injection and tool-abuse. A natural response is "agents-at-stake": binding economically meaningful, slashable collateral to persistent identities and adjudicating misbehavior with verifiable evidence. However, heterogeneous tasks make universal verification brittle and centralization-prone, while traditional reputation struggles under rapid model drift and opaque internal states. We propose a protocol-native alternative: insured agents. Specialized insurer agents post stake on behalf of operational agents in exchange for premiums, and receive privileged, privacy-preserving audit access via TEEs to assess claims. A hierarchical insurer market calibrates stake through pricing, decentralizes verification via competitive underwriting, and yields incentive-compatible dispute resolution.

Skin color has historically been a focal point of discrimination, yet fairness research in machine learning for medical imaging often relies on coarse subgroup categories, overlooking individual-level variations. Such group-based approaches risk obscuring biases faced by outliers within subgroups. This study introduces a distribution-based framework for evaluating and mitigating individual fairness in skin lesion classification. We treat skin tone as a continuous attribute rather than a categorical label, and employ kernel density estimation (KDE) to model its distribution. We further compare twelve statistical distance metrics to quantify disparities between skin tone distributions and propose a distance-based reweighting (DRW) loss function to correct underrepresentation in minority tones. Experiments across CNN and Transformer models demonstrate: (i) the limitations of categorical reweighting in capturing individual-level disparities, and (ii) the superior performance of distribution-based reweighting, particularly with Fidelity Similarity (FS), Wasserstein Distance (WD), Hellinger Metric (HM), and Harmonic Mean Similarity (HS). These findings establish a robust methodology for advancing fairness at individual level in dermatological AI systems, and highlight broader implications for sensitive continuous attributes in medical image analysis.

The advancement of human healthspan and bioengineering relies heavily on predicting the behavior of complex biological systems. While high-throughput multiomics data is becoming increasingly abundant, converting this data into actionable predictive models remains a bottleneck. High-capacity, datadriven simulation systems are critical in this landscape; unlike classical mechanistic models restricted by prior knowledge, these architectures can infer latent interactions directly from observational data, allowing for the simulation of temporal trajectories and the anticipation of downstream intervention effects in personalized medicine and synthetic biology. To address this challenge, we introduce Neural Ordinary Differential Equations (NODEs) as a dynamic framework for learning the complex interplay between the proteome and metabolome. We applied this framework to time-series data derived from engineered Escherichia coli strains, modeling the continuous dynamics of metabolic pathways. The proposed NODE architecture demonstrates superior performance in capturing system dynamics compared to traditional machine learning pipelines. Our results show a greater than 90% improvement in root mean squared error over baselines across both Limonene (up to 94.38% improvement) and Isopentenol (up to 97.65% improvement) pathway datasets. Furthermore, the NODE models demonstrated a 1000x acceleration in inference time, establishing them as a scalable, high-fidelity tool for the next generation of metabolic engineering and biological discovery.

Text-to-image (TTI) diffusion models have achieved remarkable visual quality, yet they have been repeatedly shown to exhibit social biases across sensitive attributes such as gender, race and age. To mitigate these biases, existing approaches frequently depend on curated prompt datasets - either manually constructed or generated with large language models (LLMs) - as part of their training and/or evaluation procedures. Beside the curation cost, this also risks overlooking unanticipated, less obvious prompts that trigger biased generation, even in models that have undergone debiasing. In this work, we introduce Bias-Guided Prompt Search (BGPS), a framework that automatically generates prompts that aim to maximize the presence of biases in the resulting images. BGPS comprises two components: (1) an LLM instructed to produce attribute-neutral prompts and (2) attribute classifiers acting on the TTI's internal representations that steer the decoding process of the LLM toward regions of the prompt space that amplify the image attributes of interest. We conduct extensive experiments on Stable Diffusion 1.5 and a state-of-the-art debiased model and discover an array of subtle and previously undocumented biases that severely deteriorate fairness metrics. Crucially, the discovered prompts are interpretable, i.e they may be entered by a typical user, quantitatively improving the perplexity metric compared to a prominent hard prompt optimization counterpart. Our findings uncover TTI vulnerabilities, while BGPS expands the bias search space and can act as a new evaluation tool for bias mitigation. Despite significant advances in text-to-image generation, diffusion models (DMs) (Ho et al., 2020; Rombach et al., 2022) perpetuate and amplify social biases, such as gender, race/ethnicity, culture and age (Seshadri et al., 2024; Bianchi et al., 2023), that prove remarkably persistent across various models like Stable Diffusion (Luccioni et al., 2023), DALL E (Cho et al., 2023) and Midjourney. These patterns reveal how descriptive modifiers and contextual cues encode biases throughout the prompt space - regions that current debiasing techniques, despite reporting success on curated datasets, leave entirely unexplored. Manual or LLM-assisted prompt curation yields realistic test cases but explores only a limited fraction of the prompt space. On the other end, gradient-based prompt optimization discovers high-bias regions but produces unreadable text, e.g. "nurse kerala matplotlib tbody" (see section 4.3), unsuitable for practical auditing or understanding bias mechanisms.