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A state-space model of cross-region dynamic connectivity in MEG/EEG
Cross-region dynamic connectivity, which describes spatio-temporal dependence of neural activity among multiple brain regions of interest (ROIs), can provide important information for understanding cognition. For estimating such connectivity, magnetoencephalography (MEG) and electroencephalography (EEG) are well-suited tools because of their millisecond temporal resolution. However, localizing source activity in the brain requires solving an under-determined linear problem. In typical two-step approaches, researchers first solve the linear problem with general priors assuming independence across ROIs, and secondly quantify cross-region connectivity. In this work, we propose a one-step state-space model to improve estimation of dynamic connectivity. The model treats the mean activity in individual ROIs as the state variable, and describes non-stationary dynamic dependence across ROIs using time-varying auto-regression. Compared with a two-step method, which first obtains the commonly used minimum-norm estimates of source activity, and then fits the auto-regressive model, our state-space model yielded smaller estimation errors on simulated data where the model assumptions held. When applied on empirical MEG data from one participant in a scene-processing experiment, our state-space model also demonstrated intriguing preliminary results, indicating leading and lagged linear dependence between the early visual cortex and a higher-level scene-sensitive region, which could reflect feed-forward and feedback information flow within the visual cortex during scene processing.
Hypothesis Testing in Unsupervised Domain Adaptation with Applications in Alzheimer's Disease
We only observe their transformed versions $h(\mathbf{x_s^i})$ and $g(\mathbf{x_t^i})$, for some known function class $h(\cdot)$ and $g(\cdot)$. Our goal is to perform a statistical test checking if $P_{\rm source}$ = $P_{\rm target}$ while removing the distortions induced by the transformations. This problem is closely related to concepts underlying numerous domain adaptation algorithms, and in our case, is motivated by the need to combine clinical and imaging based biomarkers from multiple sites and/or batches, where this problem is fairly common and an impediment in the conduct of analyses with much larger sample sizes. We develop a framework that addresses this problem using ideas from hypothesis testing on the transformed measurements, where in the distortions need to be estimated {\it in tandem} with the testing. We derive a simple algorithm and study its convergence and consistency properties in detail, and we also provide lower-bound strategies based on recent work in continuous optimization. On a dataset of individuals at risk for neurological disease, our results are competitive with alternative procedures that are twice as expensive and in some cases operationally infeasible to implement.
Adaptive Skills Adaptive Partitions (ASAP)
We introduce the Adaptive Skills, Adaptive Partitions (ASAP) framework that (1) learns skills (i.e., temporally extended actions or options) as well as (2) where to apply them. We believe that both (1) and (2) are necessary for a truly general skill learning framework, which is a key building block needed to scale up to lifelong learning agents. The ASAP framework is also able to solve related new tasks simply by adapting where it applies its existing learned skills. We prove that ASAP converges to a local optimum under natural conditions. Finally, our experimental results, which include a RoboCup domain, demonstrate the ability of ASAP to learn where to reuse skills as well as solve multiple tasks with considerably less experience than solving each task from scratch.
Threshold Learning for Optimal Decision Making
Decision making under uncertainty is commonly modelled as a process of competitive stochastic evidence accumulation to threshold (the drift-diffusion model). However, it is unknown how animals learn these decision thresholds. We examine threshold learning by constructing a reward function that averages over many trials to Wald's cost function that defines decision optimality. These rewards are highly stochastic and hence challenging to optimize, which we address in two ways: first, a simple two-factor reward-modulated learning rule derived from Williams' REINFORCE method for neural networks; and second, Bayesian optimization of the reward function with a Gaussian process. Bayesian optimization converges in fewer trials than REINFORCE but is slower computationally with greater variance. The REINFORCE method is also a better model of acquisition behaviour in animals and a similar learning rule has been proposed for modelling basal ganglia function.
Two Literal Crypto Bros Built a Real Estate Empire. Then the Homes Started to Fall Apart
Two Literal Crypto Bros Built a Real Estate Empire. In 2019, two Canadian brothers blew into Detroit with an irresistible pitch: For $50, almost anyone could become a property owner. When houses decayed and the city intervened, the blame games began. A fire broke out at 10410 Cadieux in March 2025, burning a hole in the roof. The smell hit me first: damp brick, stagnant water, mold, and bleach. I was partway down a flight of wooden stairs that led to the basement of a 1920s duplex in east Detroit, Michigan. Leading the way was Cornell Dorris, a tenant in the building for nearly a decade. Dorris is in his early forties, has two daughters who visit on weekends, and makes a living smoking meat and cooking for events. As my eyes adjusted, I made out rodent droppings and a black puddle that spread across the basement floor. "Anytime it rains, the water comes down," Dorris said. The air was unnaturally heavy, and I felt a nagging urge to leave. Dorris doesn't have a typical landlord. Almost four years ago, his building was acquired by a startup called RealToken, or RealT.
Should You Leave Your Phone Charging Overnight?
Should You Leave Your Phone Charging Overnight? It used to be common wisdom that leaving your phone charging overnight degrades the battery. But handset design has evolved to mitigate the harm caused by constant charging. You may have heard that leaving your smartphone charging overnight--either plugged in or atop a wireless charger --can damage your battery. But is it actually harmful or dangerous to do that?
Preference Completion from Partial Rankings
We propose a novel and efficient algorithm for the collaborative preference completion problem, which involves jointly estimating individualized rankings for a set of entities over a shared set of items, based on a limited number of observed affinity values. Our approach exploits the observation that while preferences are often recorded as numerical scores, the predictive quantity of interest is the underlying rankings. Thus, attempts to closely match the recorded scores may lead to overfitting and impair generalization performance. Instead, we propose an estimator that directly fits the underlying preference order, combined with nuclear norm constraints to encourage low--rank parameters. Besides (approximate) correctness of the ranking order, the proposed estimator makes no generative assumption on the numerical scores of the observations. One consequence is that the proposed estimator can fit any consistent partial ranking over a subset of the items represented as a directed acyclic graph (DAG), generalizing standard techniques that can only fit preference scores. Despite this generality, for supervision representing total or blockwise total orders, the computational complexity of our algorithm is within a $\log$ factor of the standard algorithms for nuclear norm regularization based estimates for matrix completion.
Generalized Correspondence-LDA Models (GC-LDA) for Identifying Functional Regions in the Brain
This paper presents Generalized Correspondence-LDA (GC-LDA), a generalization of the Correspondence-LDA model that allows for variable spatial representations to be associated with topics, and increased flexibility in terms of the strength of the correspondence between data types induced by the model. We present three variants of GC-LDA, each of which associates topics with a different spatial representation, and apply them to a corpus of neuroimaging data. In the context of this dataset, each topic corresponds to a functional brain region, where the region's spatial extent is captured by a probability distribution over neural activity, and the region's cognitive function is captured by a probability distribution over linguistic terms. We illustrate the qualitative improvements offered by GC-LDA in terms of the types of topics extracted with alternative spatial representations, as well as the model's ability to incorporate a-priori knowledge from the neuroimaging literature. We furthermore demonstrate that the novel features of GC-LDA improve predictions for missing data.