Foundation Models (FMs) are large-scale, pre-trained artificial intelligence (AI) systems that have revolutionized natural language processing and computer vision, and are now advancing geospatial analysis and Earth Observation (EO). They promise improved generalization across tasks, scalability, and efficient adaptation with minimal labeled data. However, despite the rapid proliferation of geospatial FMs, their real-world utility and alignment with global sustainability goals remain underexplored. We introduce SustainFM, a comprehensive benchmarking framework grounded in the 17 Sustainable Development Goals with extremely diverse tasks ranging from asset wealth prediction to environmental hazard detection. This study provides a rigorous, interdisciplinary assessment of geospatial FMs and offers critical insights into their role in attaining sustainability goals. Our findings show: (1) While not universally superior, FMs often outperform traditional approaches across diverse tasks and datasets. (2) Evaluating FMs should go beyond accuracy to include transferability, generalization, and energy efficiency as key criteria for their responsible use. (3) FMs enable scalable, SDG-grounded solutions, offering broad utility for tackling complex sustainability challenges. Critically, we advocate for a paradigm shift from model-centric development to impact-driven deployment, and emphasize metrics such as energy efficiency, robustness to domain shifts, and ethical considerations.

Plus: the FDA's drug regulator has resigned A West Coast biotech entrepreneur says he's secured $30 million to form a public-benefit company to study how to safely create genetically edited babies, marking the largest known investment into the taboo technology. The new company, called Preventive, is being formed to research so-called "heritable genome editing," in which the DNA of embryos would be modified by correcting harmful mutations or installing beneficial genes. The goal would be to prevent disease. Creating genetically edited humans remains controversial. The first scientist to do it, in China, was imprisoned for three years. The procedure remains illegal in many countries, including the US, and doubts surround its usefulness as a form of medicine.

Data for training structural health monitoring (SHM) systems are often expensive and/or impractical to obtain, particularly for labelled data. Population-based SHM (PBSHM) aims to address this limitation by leveraging data from multiple structures. However, data from different structures will follow distinct distributions, potentially leading to large generalisation errors for models learnt via conventional machine learning methods. To address this issue, transfer learning -- in the form of domain adaptation (DA) -- can be used to align the data distributions. Most previous approaches have only considered \emph{unsupervised} DA, where no labelled target data are available; they do not consider how to incorporate these technologies in an online framework -- updating as labels are obtained throughout the monitoring campaign. This paper proposes a Bayesian framework for DA in PBSHM, that can improve unsupervised DA mappings using a limited quantity of labelled target data. In addition, this model is integrated into an active sampling strategy to guide inspections to select the most informative observations to label -- leading to further reductions in the required labelled data to learn a target classifier. The effectiveness of this methodology is evaluated on a population of experimental bridges. Specifically, this population includes data corresponding to several damage states, as well as, a comprehensive set of environmental conditions. It is found that combining transfer learning and active learning can improve data efficiency when learning classification models in label-scarce scenarios. This result has implications for data-informed operation and maintenance of structures, suggesting a reduction in inspections over the operational lifetime of a structure -- and therefore a reduction in operational costs -- can be achieved.

Language models trained via outcome-based reinforcement learning (RL) to reason using chain-of-thought (CoT) have shown remarkable performance. Monitoring such a model's CoT may allow us to understand its intentions and detect potential malicious behavior. However, to be effective, this requires that CoTs are legible and faithful. We study CoT legibility across 14 reasoning models, finding that RL often causes reasoning to become illegible to both humans and AI monitors, with reasoning models (except Claude) generating illegible CoTs while returning to perfectly readable final answers. We show that models use illegible reasoning to reach correct answers (accuracy dropping by 53\% when forced to use only legible portions), yet find no correlation between legibility and performance when resampling - suggesting the relationship is more nuanced. We also find that legibility degrades on harder questions. We discuss potential hypotheses for these results, including steganography, training artifacts, and vestigial tokens. These results suggest that without explicit optimization for legibility, outcome-based RL naturally produces models with increasingly opaque reasoning processes, potentially undermining monitoring approaches.

We present Denario, an AI multi-agent system designed to serve as a scientific research assistant. Denario can perform many different tasks, such as generating ideas, checking the literature, developing research plans, writing and executing code, making plots, and drafting and reviewing a scientific paper. The system has a modular architecture, allowing it to handle specific tasks, such as generating an idea, or carrying out end-to-end scientific analysis using Cmbagent as a deep-research backend. In this work, we describe in detail Denario and its modules, and illustrate its capabilities by presenting multiple AI-generated papers generated by it in many different scientific disciplines such as astrophysics, biology, biophysics, biomedical informatics, chemistry, material science, mathematical physics, medicine, neuroscience and planetary science. Denario also excels at combining ideas from different disciplines, and we illustrate this by showing a paper that applies methods from quantum physics and machine learning to astrophysical data. We report the evaluations performed on these papers by domain experts, who provided both numerical scores and review-like feedback. We then highlight the strengths, weaknesses, and limitations of the current system. Finally, we discuss the ethical implications of AI-driven research and reflect on how such technology relates to the philosophy of science. We publicly release the code at https://github.com/AstroPilot-AI/Denario. A Denario demo can also be run directly on the web at https://huggingface.co/spaces/astropilot-ai/Denario, and the full app will be deployed on the cloud.

Artificial intelligence (AI) has emerged as a powerful accelerator of materials discovery, yet most existing models remain problem-specific, requiring additional data collection and retraining for each new property. Here we introduce and validate GATE (Geometrically Aligned Transfer Encoder) -- a generalizable AI framework that jointly learns 34 physicochemical properties spanning thermal, electrical, mechanical, and optical domains. By aligning these properties within a shared geometric space, GATE captures cross-property correlations that reduce disjoint-property bias -- a key factor causing false positives in multi-criteria screening. To demonstrate its generalizable utility, GATE -- without any problem-specific model reconfiguration -- applied to the discovery of immersion cooling fluids for data centers, a stringent real-world challenge defined by the Open Compute Project (OCP). Screening billions of candidates, GATE identified 92,861 molecules as promising for practical deployment. Four were experimentally or literarily validated, showing strong agreement with wet-lab measurements and performance comparable to or exceeding a commercial coolant. These results establish GATE as a generalizable AI platform readily applicable across diverse materials discovery tasks.

Trustworthy evaluations of dangerous capabilities are increasingly crucial for determining whether an AI system is safe to deploy. One empirically demonstrated threat is sandbagging - the strategic underperformance on evaluations by AI models or their developers. A promising defense is to monitor a model's chain-of-thought (CoT) reasoning, as this could reveal its intentions and plans. In this work, we measure the ability of models to sandbag on dangerous capability evaluations against a CoT monitor by prompting them to sandbag while being either monitor-oblivious or monitor-aware. We show that both frontier models and small open-sourced models can covertly sandbag against CoT monitoring 0-shot without hints. However, they cannot yet do so reliably: they bypass the monitor 16-36% of the time when monitor-aware, conditioned on sandbagging successfully. We qualitatively analyzed the uncaught CoTs to understand why the monitor failed. We reveal a rich attack surface for CoT monitoring and contribute five covert sandbagging policies generated by models. These results inform potential failure modes of CoT monitoring and may help build more diverse sandbagging model organisms.

A vast majority of mass spectrometry data remains uncharacterized, leaving much of its biological and chemical information untapped. Recent advances in machine learning have begun to address this gap, particularly for tasks such as spectral identification in tandem mass spectrometry data. Here, we present the latest generation of LSM-MS2, a large-scale deep learning foundation model trained on millions of spectra to learn a semantic chemical space. LSM-MS2 achieves state-of-the-art performance in spectral identification, improving on existing methods by 30% in accuracy of identifying challenging isomeric compounds, yielding 42% more correct identifications in complex biological samples, and maintaining robustness under low-concentration conditions. Furthermore, LSM-MS2 produces rich spectral embeddings that enable direct biological interpretation from minimal downstream data, successfully differentiating disease states and predicting clinical outcomes across diverse translational applications.

We present a long-term deployment study of a machine vision-based anomaly detection system for failure prediction in a steel rolling mill. The system integrates industrial cameras to monitor equipment operation, alignment, and hot bar motion in real time along the process line. Live video streams are processed on a centralized video server using deep learning models, enabling early prediction of equipment failures and process interruptions, thereby reducing unplanned breakdown costs. Server-based inference minimizes the computational load on industrial process control systems (PLCs), supporting scalable deployment across production lines with minimal additional resources. By jointly analyzing sensor data from data acquisition systems and visual inputs, the system identifies the location and probable root causes of failures, providing actionable insights for proactive maintenance. This integrated approach enhances operational reliability, productivity, and profitability in industrial manufacturing environments.

Social media platforms generate massive volumes of heterogeneous data, capturing user behaviors, textual content, temporal dynamics, and network structures. Analyzing such data is crucial for understanding phenomena such as opinion dynamics, community formation, and information diffusion. However, discovering insights from this complex landscape is exploratory, conceptually challenging, and requires expertise in social media mining and visualization. Existing automated approaches, though increasingly leveraging large language models (LLMs), remain largely confined to structured tabular data and cannot adequately address the heterogeneity of social media analysis. We present SIA (Social Insight Agents), an LLM agent system that links heterogeneous multi-modal data -- including raw inputs (e.g., text, network, and behavioral data), intermediate outputs, mined analytical results, and visualization artifacts -- through coordinated agent flows. Guided by a bottom-up taxonomy that connects insight types with suitable mining and visualization techniques, SIA enables agents to plan and execute coherent analysis strategies. To ensure multi-modal integration, it incorporates a data coordinator that unifies tabular, textual, and network data into a consistent flow. Its interactive interface provides a transparent workflow where users can trace, validate, and refine the agent's reasoning, supporting both adaptability and trustworthiness. Through expert-centered case studies and quantitative evaluation, we show that SIA effectively discovers diverse and meaningful insights from social media while supporting human-agent collaboration in complex analytical tasks.