Current radiation therapy treatment planning is limited by suboptimal plan quality, inefficiency, and high costs. This perspective paper explores the complexity of treatment planning and introduces Human-Centric Intelligent Treatment Planning (HCITP), an AI-driven framework under human oversight, which integrates clinical guidelines, automates plan generation, and enables direct interactions with operators. We expect that HCITP will enhance efficiency, potentially reducing planning time to minutes, and will deliver personalized, high-quality plans. Challenges and potential solutions are discussed.

Precipitation nowcasting, which predicts rainfall up to a few hours ahead, is a critical tool for vulnerable communities in the Global South frequently exposed to intense, rapidly developing storms. Timely forecasts provide a crucial window to protect lives and livelihoods. Traditional numerical weather prediction (NWP) methods suffer from high latency, low spatial and temporal resolution, and significant gaps in accuracy across the world. Recent machine learning-based nowcasting methods, common in the Global North, cannot be extended to the Global South due to extremely sparse radar coverage. We present Global MetNet, an operational global machine learning nowcasting model. It leverages the Global Precipitation Mission's CORRA dataset, geostationary satellite data, and global NWP data to predict precipitation for the next 12 hours. The model operates at a high resolution of approximately 0.05° (~5km) spatially and 15 minutes temporally. Global MetNet significantly outperforms industry-standard hourly forecasts and achieves significantly higher skill, making forecasts useful over a much larger area of the world than previously available. Our model demonstrates better skill in data-sparse regions than even the best high-resolution NWP models achieve in the US. Validated using ground radar and satellite data, it shows significant improvements across key metrics like the critical success index and fractions skill score for all precipitation rates and lead times. Crucially, our model generates forecasts in under a minute, making it readily deployable for real-time applications. It is already deployed for millions of users on Google Search. This work represents a key step in reducing global disparities in forecast quality and integrating sparse, high-resolution satellite observations into weather forecasting.

Astronomical time-series analysis faces a critical limitation: the scarcity of labeled observational data. We present a pre-training approach that leverages simulations, significantly reducing the need for labeled examples from real observations. Our models, trained on simulated data from multiple astronomical surveys (ZTF and LSST), learn generalizable representations that transfer effectively to downstream tasks. Using classifier-based architectures enhanced with contrastive and adversarial objectives, we create domain-agnostic models that demonstrate substantial performance improvements over baseline methods in classification, redshift estimation, and anomaly detection when fine-tuned with minimal real data. Remarkably, our models exhibit effective zero-shot transfer capabilities, achieving comparable performance on future telescope (LSST) simulations when trained solely on existing telescope (ZTF) data. Furthermore, they generalize to very different astronomical phenomena (namely variable stars from NASA's \textit{Kepler} telescope) despite being trained on transient events, demonstrating cross-domain capabilities. Our approach provides a practical solution for building general models when labeled data is scarce, but domain knowledge can be encoded in simulations.

Standard benchmark datasets, such as MNIST, often fail to expose latent biases and multimodal feature complexities, limiting the trustworthiness of deep neural networks in high-stakes applications. We propose a novel multimodal Explainable AI (XAI) framework that unifies attention-augmented feature fusion, Grad-CAM++-based local explanations, and a Reveal-to-Revise feedback loop for bias detection and mitigation. Evaluated on multimodal extensions of MNIST, our approach achieves 93.2% classification accuracy, 91.6% F1-score, and 78.1% explanation fidelity (IoU-XAI), outperforming unimodal and non-explainable baselines. Ablation studies demonstrate that integrating interpretability with bias-aware learning enhances robustness and human alignment. Our work bridges the gap between performance, transparency, and fairness, highlighting a practical pathway for trustworthy AI in sensitive domains.

Large language models (LLMs) are now widely deployed in user-facing applications, reaching hundreds of millions worldwide. As they become integrated into everyday tasks, growing reliance on their outputs raises significant concerns. In particular, users may unknowingly be exposed to model-inherent biases that systematically disadvantage or stereotype certain groups. However, existing bias benchmarks continue to rely on templated prompts or restrictive multiple-choice questions that are suggestive, simplistic, and fail to capture the complexity of real-world user interactions. In this work, we address this gap by introducing a counterfactual bias evaluation framework that automatically generates realistic, open-ended questions over sensitive attributes such as sex, race, or religion. By iteratively mutating and selecting bias-inducing questions, our approach systematically explores areas where models are most susceptible to biased behavior. Beyond detecting harmful biases, we also capture distinct response dimensions that are increasingly relevant in user interactions, such as asymmetric refusals and explicit acknowledgment of bias. Leveraging our framework, we construct CAB, a human-verified benchmark spanning diverse topics, designed to enable cross-model comparisons. Using CAB, we analyze a range of LLMs across multiple bias dimensions, revealing nuanced insights into how different models manifest bias. For instance, while GPT-5 outperforms other models, it nonetheless exhibits persistent biases in specific scenarios. These findings underscore the need for continual improvements to ensure fair model behavior.

We present ACADATA, a high-quality parallel dataset for academic translation, that consists of two subsets: ACAD-TRAIN, which contains approximately 1.5 million author-generated paragraph pairs across 96 language directions and ACAD-BENCH, a curated evaluation set of almost 6,000 translations covering 12 directions. To validate its utility, we fine-tune two Large Language Models (LLMs) on ACAD-TRAIN and benchmark them on ACAD-BENCH against specialized machine-translation systems, general-purpose, open-weight LLMs, and several large-scale proprietary models. Experimental results demonstrate that fine-tuning on ACAD-TRAIN leads to improvements in academic translation quality by +6.1 and +12.4 d-BLEU points on average for 7B and 2B models respectively, while also improving long-context translation in a general domain by up to 24.9% when translating out of English. The fine-tuned top-performing model surpasses the best propietary and open-weight models on academic translation domain. By releasing ACAD-TRAIN, ACAD-BENCH and the fine-tuned models, we provide the community with a valuable resource to advance research in academic domain and long-context translation.

Retrieval-augmented generation (RAG) systems enhance large language models (LLMs) with external knowledge but are vulnerable to corpus poisoning and contamination attacks, which can compromise output integrity. Existing defenses often apply aggressive filtering, leading to unnecessary loss of valuable information and reduced reliability in generation. To address this problem, we propose a two-stage semantic filtering and conflict-free framework for trustworthy RAG. In the first stage, we perform a joint filter with semantic and cluster-based filtering which is guided by the Entity-intent-relation extractor (EIRE). EIRE extracts entities, latent objectives, and entity relations from both the user query and filtered documents, scores their semantic relevance, and selectively adds valuable documents into the clean retrieval database. In the second stage, we proposed an EIRE-guided conflict-aware filtering module, which analyzes semantic consistency between the query, candidate answers, and retrieved knowledge before final answer generation, filtering out internal and external contradictions that could mislead the model. Through this two-stage process, SeCon-RAG effectively preserves useful knowledge while mitigating conflict contamination, achieving significant improvements in both generation robustness and output trustworthiness. Extensive experiments across various LLMs and datasets demonstrate that the proposed SeCon-RAG markedly outperforms state-of-the-art defense methods.

This paper presents a comprehensive overview of the Ultralytics YOLO(You Only Look Once) family of object detectors, focusing the architectural evolution, benchmarking, deployment perspectives, and future challenges. The review begins with the most recent release, YOLO26 (or YOLOv26), which introduces key innovations including Distribution Focal Loss (DFL) removal, native NMS-free inference, Progressive Loss Balancing (ProgLoss), Small-Target-Aware Label Assignment (STAL), and the MuSGD optimizer for stable training. The progression is then traced through YOLO11, with its hybrid task assignment and efficiency-focused modules; YOLOv8, which advanced with a decoupled detection head and anchor-free predictions; and YOLOv5, which established the modular PyTorch foundation that enabled modern YOLO development. Benchmarking on the MS COCO dataset provides a detailed quantitative comparison of YOLOv5, YOLOv8, YOLO11, and YOLO26 (YOLOv26), alongside cross-comparisons with YOLOv12, YOLOv13, RT-DETR, and DEIM(DETR with Improved Matching). Metrics including precision, recall, F1 score, mean Average Precision, and inference speed are analyzed to highlight trade-offs between accuracy and efficiency. Deployment and application perspectives are further discussed, covering export formats, quantization strategies, and real-world use in robotics, agriculture, surveillance, and manufacturing. Finally, the paper identifies challenges and future directions, including dense-scene limitations, hybrid CNN-Transformer integration, open-vocabulary detection, and edge-aware training approaches. (Object Detection, YOLOv26, YOLO)

Large Language Models (LLMs) are widely used for temporal prediction, but their reliance on pretraining data raises contamination concerns, as accurate predictions on pre-cutoff test data may reflect memorization rather than reasoning, leading to an overestimation of their generalization capability. With the recent emergence of prompting-based unlearning techniques, a natural question arises: Can LLMs be prompted to simulate an earlier knowledge cutoff? In this work, we investigate the capability of prompting to simulate earlier knowledge cutoff in LLMs. We construct three evaluation datasets to assess the extent to which LLMs can forget (1) direct factual knowledge, (2) semantic shifts, and (3) causally related knowledge. Results demonstrate that while prompt-based simulated knowledge cutoffs show effectiveness when directly queried with the information after that date, they struggle to induce forgetting when the forgotten content is not directly asked but causally related to the query. These findings highlight the need for more rigorous evaluation settings when applying LLMs for temporal prediction tasks. The full dataset and evaluation code are available at https://github.com/gxx27/time_unlearn.

Extracting individual sentences from a document as evidence or reasoning steps is commonly done in many NLP tasks. However, extracted sentences often lack context necessary to make them understood, e.g., coreference and background information. To this end, we propose a content selection and planning framework for zero-shot decontextualisation, which determines what content should be mentioned and in what order for a sentence to be understood out of context. Specifically, given a potentially ambiguous sentence and its context, we first segment it into basic semantically-independent units. We then identify potentially ambiguous units from the given sentence, and extract relevant units from the context based on their discourse relations. Finally, we generate a content plan to rewrite the sentence by enriching each ambiguous unit with its relevant units. Experimental results demonstrate that our approach is competitive for sentence decontextualisation, producing sentences that exhibit better semantic integrity and discourse coherence, outperforming existing methods.