Partial least squares (PLS) is a dimensionality reduction technique introduced in the field of chemometrics and successfully employed in many other areas. The PLS components are obtained by maximizing the covariance between linear combinations of the regressors and of the target variables. In this work, we focus on its application to scalar regression problems. PLS regression consists in finding the least squares predictor that is a linear combination of a subset of the PLS components. Alternatively, PLS regression can be formulated as a least squares problem restricted to a Krylov subspace. This equivalent formulation is employed to analyze the distance between ${\hat{\boldsymbol\beta}\;}_{\mathrm{PLS}}^{\scriptscriptstyle {(L)}}$, the PLS estimator of the vector of coefficients of the linear regression model based on $L$ PLS components, and $\hat{\boldsymbol \beta}_{\mathrm{OLS}}$, the one obtained by ordinary least squares (OLS), as a function of $L$. Specifically, ${\hat{\boldsymbol\beta}\;}_{\mathrm{PLS}}^{\scriptscriptstyle {(L)}}$ is the vector of coefficients in the aforementioned Krylov subspace that is closest to $\hat{\boldsymbol \beta}_{\mathrm{OLS}}$ in terms of the Mahalanobis distance with respect to the covariance matrix of the OLS estimate. We provide a bound on this distance that depends only on the distribution of the eigenvalues of the regressor covariance matrix. Numerical examples on synthetic and real-world data are used to illustrate how the distance between ${\hat{\boldsymbol\beta}\;}_{\mathrm{PLS}}^{\scriptscriptstyle {(L)}}$ and $\hat{\boldsymbol \beta}_{\mathrm{OLS}}$ depends on the number of clusters in which the eigenvalues of the regressor covariance matrix are grouped.

Wednesday will be a fateful day in Brussels, a faraway city of which post-Brexit Britain knows little and cares less. It's the day on which the EU's AI proposals enter the final stages of a tortuous lawmaking process. The bill is a landmark (first in the world) attempt to seriously regulate artificial intelligence (AI) based on its capacity to cause harm and will soon be in the final phase of the legislative process – so-called "trilogues" – where the EU parliament, commission and council decide what should be in the bill, and therefore become part of EU law. However, the bill is now hanging in the balance because of internal disagreement about some key aspects of the proposed legislation, especially those concerned with regulation of "foundation" AI models that are trained on massive datasets. In EU-speak these are "general-purpose AI" (GPAI) systems – ones capable of a range of general tasks (text synthesis, image manipulation, audio generation and so on) – such as GPT-4, Claude, Llama etc.

Brinkmanship escalated in the US Congress this week over strategies to reauthorize the government surveillance powers known as "Section 702," as civil rights groups sounded the alarm about the consequences of the program and its potential renewal. A WIRED investigation of more than 100 restricted Telegram channels indicated that the communication app's bans on extremist discourse aren't effective or adequate bans. And the identity management platform Okta admitted this week that a security breach previously thought to impact 1 percent of its customers actually affected 100 percent. Analysis indicates that OpenAI's custom chatbots, known as GPTs, can be manipulated to leak their training data and other private information. Funding for the US Centers for Disease Control and Prevention gun violence research is at risk as Republicans quietly work to strip support.

The fiercely competitive business environment and increasingly personalized customization needs are driving the digital transformation and upgrading of the manufacturing industry. IIoT intelligence, which can provide innovative and efficient solutions for various aspects of the manufacturing value chain, illuminates the path of transformation for the manufacturing industry. It is time to provide a systematic vision of IIoT intelligence. However, existing surveys often focus on specific areas of IIoT intelligence, leading researchers and readers to have biases in their understanding of IIoT intelligence, that is, believing that research in one direction is the most important for the development of IIoT intelligence, while ignoring contributions from other directions. Therefore, this paper provides a comprehensive overview of IIoT intelligence. We first conduct an in-depth analysis of the inevitability of manufacturing transformation and study the successful experiences from the practices of Chinese enterprises. Then we give our definition of IIoT intelligence and demonstrate the value of IIoT intelligence for industries in fucntions, operations, deployments, and application. Afterwards, we propose a hierarchical development architecture for IIoT intelligence, which consists of five layers. The practical values of technical upgrades at each layer are illustrated by a close look on lighthouse factories. Following that, we identify seven kinds of technologies that accelerate the transformation of manufacturing, and clarify their contributions. Finally, we explore the open challenges and development trends from four aspects to inspire future researches.

Learning from noisy labels is an important and long-standing problem in machine learning for real applications. One of the main research lines focuses on learning a label corrector to purify potential noisy labels. However, these methods typically rely on strict assumptions and are limited to certain types of label noise. In this paper, we reformulate the label-noise problem from a generative-model perspective, $\textit{i.e.}$, labels are generated by gradually refining an initial random guess. This new perspective immediately enables existing powerful diffusion models to seamlessly learn the stochastic generative process. Once the generative uncertainty is modeled, we can perform classification inference using maximum likelihood estimation of labels. To mitigate the impact of noisy labels, we propose the $\textbf{L}$abel-$\textbf{R}$etrieval-$\textbf{A}$ugmented (LRA) diffusion model, which leverages neighbor consistency to effectively construct pseudo-clean labels for diffusion training. Our model is flexible and general, allowing easy incorporation of different types of conditional information, $\textit{e.g.}$, use of pre-trained models, to further boost model performance. Extensive experiments are conducted for evaluation. Our model achieves new state-of-the-art (SOTA) results on all the standard real-world benchmark datasets. Remarkably, by incorporating conditional information from the powerful CLIP model, our method can boost the current SOTA accuracy by 10-20 absolute points in many cases.

Social media platforms such as Twitter (now known as X) have revolutionized how the public engage with important societal and political topics. Recently, climate change discussions on social media became a catalyst for political polarization and the spreading of misinformation. In this work, we aim to understand how real world events influence the opinions of individuals towards climate change related topics on social media. To this end, we extracted and analyzed a dataset of 13.6 millions tweets sent by 3.6 million users from 2006 to 2019. Then, we construct a temporal graph from the user-user mentions network and utilize the Louvain community detection algorithm to analyze the changes in community structure around Conference of the Parties on Climate Change~(COP) events. Next, we also apply tools from the Natural Language Processing literature to perform sentiment analysis and topic modeling on the tweets. Our work acts as a first step towards understanding the evolution of pro-climate change communities around COP events. Answering these questions helps us understand how to raise people's awareness towards climate change thus hopefully calling on more individuals to join the collaborative effort in slowing down climate change.

Fake news on social media has large, negative implications for society. However, little is known about what linguistic cues make people fall for fake news and, hence, how to design effective countermeasures for social media. In this study, we seek to understand which linguistic cues make people fall for fake news. Linguistic cues (e.g., adverbs, personal pronouns, positive emotion words, negative emotion words) are important characteristics of any text and also affect how people process real vs. fake news. Specifically, we compare the role of linguistic cues across both cognitive processing (related to careful thinking) and affective processing (related to unconscious automatic evaluations). To this end, we performed a within-subject experiment where we collected neurophysiological measurements of 42 subjects while these read a sample of 40 real and fake news articles. During our experiment, we measured cognitive processing through eye fixations, and affective processing in situ through heart rate variability. We find that users engage more in cognitive processing for longer fake news articles, while affective processing is more pronounced for fake news written in analytic words. To the best of our knowledge, this is the first work studying the role of linguistic cues in fake news processing. Altogether, our findings have important implications for designing online platforms that encourage users to engage in careful thinking and thus prevent them from falling for fake news.

Developing aerial robots that can both safely navigate and execute assigned mission without any human intervention - i.e., fully autonomous aerial mobility of passengers and goods - is the larger vision that guides the research, design, and development efforts in the aerial autonomy space. However, it is highly challenging to concurrently operationalize all types of aerial vehicles that are operating fully autonomously sharing the airspace. Full autonomy of the aerial transportation sector includes several aspects, such as design of the technology that powers the vehicles, operations of multi-agent fleets, and process of certification that meets stringent safety requirements of aviation sector. Thereby, Autonomous Advanced Aerial Mobility is still a vague term and its consequences for researchers and professionals are ambiguous. To address this gap, we present a comprehensive perspective on the emerging field of autonomous advanced aerial mobility, which involves the use of unmanned aerial vehicles (UAVs) and electric vertical takeoff and landing (eVTOL) aircraft for various applications, such as urban air mobility, package delivery, and surveillance. The article proposes a scalable and extensible autonomy framework consisting of four main blocks: sensing, perception, planning, and controls. Furthermore, the article discusses the challenges and opportunities in multi-agent fleet operations and management, as well as the testing, validation, and certification aspects of autonomous aerial systems. Finally, the article explores the potential of monolithic models for aerial autonomy and analyzes their advantages and limitations. The perspective aims to provide a holistic picture of the autonomous advanced aerial mobility field and its future directions.

Large language models (LLMs) have attracted huge interest in practical applications given their increasingly accurate responses and coherent reasoning abilities. Given their nature as black-boxes using complex reasoning processes on their inputs, it is inevitable that the demand for scalable and faithful explanations for LLMs' generated content will continue to grow. There have been major developments in the explainability of neural network models over the past decade. Among them, post-hoc explainability methods, especially Shapley values, have proven effective for interpreting deep learning models. However, there are major challenges in scaling up Shapley values for LLMs, particularly when dealing with long input contexts containing thousands of tokens and autoregressively generated output sequences. Furthermore, it is often unclear how to effectively utilize generated explanations to improve the performance of LLMs. In this paper, we introduce TextGenSHAP, an efficient post-hoc explanation method incorporating LM-specific techniques. We demonstrate that this leads to significant increases in speed compared to conventional Shapley value computations, reducing processing times from hours to minutes for token-level explanations, and to just seconds for document-level explanations. In addition, we demonstrate how real-time Shapley values can be utilized in two important scenarios, providing better understanding of long-document question answering by localizing important words and sentences; and improving existing document retrieval systems through enhancing the accuracy of selected passages and ultimately the final responses. Large language models (LLMs) continue to rapidly excel at different text generation tasks alongside the continued growth of resources dedicated to training text-based models (Brown et al., 2020; Chowdhery et al., 2022; Touvron et al., 2023). LLM's impressive capabilities have led to their widespread adoption throughout academic and commercial applications. Their capacity to reason cohesively on a wide range of natural language processing (NLP) tasks has prompted efforts to enable models to automatically ingest increasingly large contexts. These long-context models improve zero-shot, few-shot, and retrieval-augmented generation performance via in-context learning (Izacard et al., 2022b; Huang et al., 2023; Ram et al., 2023) and reduce the need for training task-specific models, empowering non-experts to readily use LLMs. Despite their remarkable text generation capabilities, LLMs which are trained primarily to model statistical correlations between tokens offer limited insight into their internal mechanisms. This characteristic has led LLMs to be widely considered black-box models which are acutely difficult to explain. Beyond their prediction performance, challenges regarding safety, security, truthfulness, and more have gained prominence, especially in the wake of widespread adoption amongst the general population.

The escalating drug addiction crisis in the United States underscores the urgent need for innovative therapeutic strategies. This study embarked on an innovative and rigorous strategy to unearth potential drug repurposing candidates for opioid and cocaine addiction treatment, bridging the gap between transcriptomic data analysis and drug discovery. We initiated our approach by conducting differential gene expression analysis on addiction-related transcriptomic data to identify key genes. We propose a novel topological differentiation to identify key genes from a protein-protein interaction (PPI) network derived from DEGs. This method utilizes persistent Laplacians to accurately single out pivotal nodes within the network, conducting this analysis in a multiscale manner to ensure high reliability. Through rigorous literature validation, pathway analysis, and data-availability scrutiny, we identified three pivotal molecular targets, mTOR, mGluR5, and NMDAR, for drug repurposing from DrugBank. We crafted machine learning models employing two natural language processing (NLP)-based embeddings and a traditional 2D fingerprint, which demonstrated robust predictive ability in gauging binding affinities of DrugBank compounds to selected targets. Furthermore, we elucidated the interactions of promising drugs with the targets and evaluated their drug-likeness. This study delineates a multi-faceted and comprehensive analytical framework, amalgamating bioinformatics, topological data analysis and machine learning, for drug repurposing in addiction treatment, setting the stage for subsequent experimental validation. The versatility of the methods we developed allows for applications across a range of diseases and transcriptomic datasets.