This white paper, developed through close collaboration between IBM Research and UIUC researchers within the IIDAI Institute, envisions transforming hybrid cloud systems to meet the growing complexity of AI workloads through innovative, full-stack co-design approaches, emphasizing usability, manageability, affordability, adaptability, efficiency, and scalability. By integrating cutting-edge technologies such as generative and agentic AI, cross-layer automation and optimization, unified control plane, and composable and adaptive system architecture, the proposed framework addresses critical challenges in energy efficiency, performance, and cost-effectiveness. Incorporating quantum computing as it matures will enable quantum-accelerated simulations for materials science, climate modeling, and other high-impact domains. Collaborative efforts between academia and industry are central to this vision, driving advancements in foundation models for material design and climate solutions, scalable multimodal data processing, and enhanced physics-based AI emulators for applications like weather forecasting and carbon sequestration. Research priorities include advancing AI agentic systems, LLM as an Abstraction (LLMaaA), AI model optimization and unified abstractions across heterogeneous infrastructure, end-to-end edge-cloud transformation, efficient programming model, middleware and platform, secure infrastructure, application-adaptive cloud systems, and new quantum-classical collaborative workflows. These ideas and solutions encompass both theoretical and practical research questions, requiring coordinated input and support from the research community. This joint initiative aims to establish hybrid clouds as secure, efficient, and sustainable platforms, fostering breakthroughs in AI-driven applications and scientific discovery across academia, industry, and society.

This paper presents the latest version of the Global AI Vibrancy Tool (GVT), an interactive suite of visualizations designed to facilitate the comparison of AI vibrancy across 36 countries, using 42 indicators organized into 8 pillars. The tool offers customizable features that allow users to conduct in-depth country-level comparisons and longitudinal analyses of AI-related metrics, all based on publicly available data. By providing a transparent assessment of national progress in AI, it serves the diverse needs of policymakers, industry leaders, researchers, and the general public. Using weights for indicators and pillars developed by AI Index's panel of experts and combined into an index, the Global AI Vibrancy Ranking for 2023 places the United States first by a significant margin, followed by China and the United Kingdom. The ranking also highlights the rise of smaller nations such as Singapore when evaluated on both absolute and per capita bases. The tool offers three sub-indices for evaluating Global AI Vibrancy along different dimensions: the Innovation Index, the Economic Competitiveness Index, and the Policy, Governance, and Public Engagement Index.

Antibodies safeguard our health through their precise and potent binding to specific antigens, demonstrating promising therapeutic efficacy in the treatment of numerous diseases, including COVID-19. Recent advancements in biomedical language models have shown the great potential to interpret complex biological structures and functions. However, existing antibody specific models have a notable limitation that they lack explicit consideration for antibody structural information, despite the fact that both 1D sequence and 3D structure carry unique and complementary insights into antibody behavior and functionality. This paper proposes Sequence-Structure multi-level pre-trained Antibody Language Model (S$^2$ALM), combining holistic sequential and structural information in one unified, generic antibody foundation model. We construct a hierarchical pre-training paradigm incorporated with two customized multi-level training objectives to facilitate the modeling of comprehensive antibody representations. S$^2$ALM's representation space uncovers inherent functional binding mechanisms, biological evolution properties and structural interaction patterns. Pre-trained over 75 million sequences and 11.7 million structures, S$^2$ALM can be adopted for diverse downstream tasks: accurately predicting antigen-antibody binding affinities, precisely distinguishing B cell maturation stages, identifying antibody crucial binding positions, and specifically designing novel coronavirus-binding antibodies. Remarkably, S$^2$ALM outperforms well-established and renowned baselines and sets new state-of-the-art performance across extensive antibody specific understanding and generation tasks. S$^2$ALM's ability to model comprehensive and generalized representations further positions its potential to advance real-world therapeutic antibody development, potentially addressing unmet academic, industrial, and clinical needs.

This study investigates gender bias in large language models (LLMs) by comparing their gender perception to that of human respondents, U.S. Bureau of Labor Statistics data, and a 50% no-bias benchmark. We created a new evaluation set using occupational data and role-specific sentences. Unlike common benchmarks included in LLM training data, our set is newly developed, preventing data leakage and test set contamination. Five LLMs were tested to predict the gender for each role using single-word answers. We used Kullback-Leibler (KL) divergence to compare model outputs with human perceptions, statistical data, and the 50% neutrality benchmark. All LLMs showed significant deviation from gender neutrality and aligned more with statistical data, still reflecting inherent biases.

The remarkable capabilities of Large Language Models (LLMs) make them increasingly compelling for adoption in real-world healthcare applications. However, the risks associated with using LLMs in medical applications have not been systematically characterized. We propose using five key principles for safe and trustworthy medical AI: Truthfulness, Resilience, Fairness, Robustness, and Privacy, along with ten specific aspects. Under this comprehensive framework, we introduce a novel MedGuard benchmark with 1,000 expert-verified questions. Our evaluation of 11 commonly used LLMs shows that the current language models, regardless of their safety alignment mechanisms, generally perform poorly on most of our benchmarks, particularly when compared to the high performance of human physicians. Despite recent reports indicate that advanced LLMs like ChatGPT can match or even exceed human performance in various medical tasks, this study underscores a significant safety gap, highlighting the crucial need for human oversight and the implementation of AI safety guardrails.

We initiate the study of differentially private learning in the proportional dimensionality regime, in which the number of data samples $n$ and problem dimension $d$ approach infinity at rates proportional to one another, meaning that $d / n \to \delta$ as $n \to \infty$ for an arbitrary, given constant $\delta \in (0, \infty)$. This setting is significantly more challenging than that of all prior theoretical work in high-dimensional differentially private learning, which, despite the name, has assumed that $\delta = 0$ or is sufficiently small for problems of sample complexity $O(d)$, a regime typically considered "low-dimensional" or "classical" by modern standards in high-dimensional statistics. We provide sharp theoretical estimates of the error of several well-studied differentially private algorithms for robust linear regression and logistic regression, including output perturbation, objective perturbation, and noisy stochastic gradient descent, in the proportional dimensionality regime. The $1 + o(1)$ factor precision of our error estimates enables a far more nuanced understanding of the price of privacy of these algorithms than that afforded by existing, coarser analyses, which are essentially vacuous in the regime we consider. We incorporate several probabilistic tools that have not previously been used to analyze differentially private learning algorithms, such as a modern Gaussian comparison inequality and recent universality laws with origins in statistical physics.

Language-conditioned robotic learning has significantly enhanced robot adaptability by enabling a single model to execute diverse tasks in response to verbal commands. Despite these advancements, security vulnerabilities within this domain remain largely unexplored. This paper addresses this gap by proposing a novel adversarial prompt attack tailored to language-conditioned robotic models. Our approach involves crafting a universal adversarial prefix that induces the model to perform unintended actions when added to any original prompt. We demonstrate that existing adversarial techniques exhibit limited effectiveness when directly transferred to the robotic domain due to the inherent robustness of discretized robotic action spaces. To overcome this challenge, we propose to optimize adversarial prefixes based on continuous action representations, circumventing the discretization process. Additionally, we identify the beneficial impact of intermediate features on adversarial attacks and leverage the negative gradient of intermediate self-attention features to further enhance attack efficacy. Extensive experiments on VIMA models across 13 robot manipulation tasks validate the superiority of our method over existing approaches and demonstrate its transferability across different model variants.

In autonomous driving, the combination of AI and vehicular technology offers great potential. However, this amalgamation comes with vulnerabilities to adversarial attacks. This survey focuses on the intersection of Adversarial Machine Learning (AML) and autonomous systems, with a specific focus on LiDAR-based systems. We comprehensively explore the threat landscape, encompassing cyber-attacks on sensors and adversarial perturbations. Additionally, we investigate defensive strategies employed in countering these threats. This paper endeavors to present a concise overview of the challenges and advances in securing autonomous driving systems against adversarial threats, emphasizing the need for robust defenses to ensure safety and security.

The paper considers the controller synthesis problem for general MIMO systems with unknown dynamics, aiming to fulfill the temporal reach-avoid-stay task, where the unsafe regions are time-dependent, and the target must be reached within a specified time frame. The primary aim of the paper is to construct the spatiotemporal tube (STT) using a sampling-based approach and thereby devise a closed-form approximation-free control strategy to ensure that system trajectory reaches the target set while avoiding time-dependent unsafe sets. The proposed scheme utilizes a novel method involving STTs to provide controllers that guarantee both system safety and reachability. In our sampling-based framework, we translate the requirements of STTs into a Robust optimization program (ROP). To address the infeasibility of ROP caused by infinite constraints, we utilize the sampling-based Scenario optimization program (SOP). Subsequently, we solve the SOP to generate the tube and closed-form controller for an unknown system, ensuring the temporal reach-avoid-stay specification. Finally, the effectiveness of the proposed approach is demonstrated through three case studies: an omnidirectional robot, a SCARA manipulator, and a magnetic levitation system.

Large Language Models (LLMs) have demonstrated impressive capabilities in generating coherent text but often struggle with grounding language and strategic dialogue. To address this gap, we focus on journalistic interviews, a domain rich in grounding communication and abundant in data. We curate a dataset of 40,000 two-person informational interviews from NPR and CNN, and reveal that LLMs are significantly less likely than human interviewers to use acknowledgements and to pivot to higher-level questions. Realizing that a fundamental deficit exists in multi-turn planning and strategic thinking, we develop a realistic simulated environment, incorporating source personas and persuasive elements, in order to facilitate the development of agents with longer-horizon rewards. Our experiments show that while source LLMs mimic human behavior in information sharing, interviewer LLMs struggle with recognizing when questions are answered and engaging persuasively, leading to suboptimal information extraction across model size and capability. These findings underscore the need for enhancing LLMs' strategic dialogue capabilities.