Synthetic data generation--mitigating data scarcity, privacy concerns, and data quality challenges in biomedical fields--has been facilitated by rapid advances of large language models (LLMs). This scoping review follows PRISMA-ScR guidelines and synthesizes 59 studies, published between 2020 and 2025 and collected from PubMed, ACM, Web of Science, and Google Scholar. The review systematically examines biomedical research and application trends in synthetic data generation, emphasizing clinical applications, methodologies, and evaluations. Our analysis identifies data modalities of unstructured texts (78.0%), tabular data (13.6%), and multimodal sources (8.4%); generation methods of prompting (72.9%), fine-tuning (22.0%) LLMs and specialized model (5.1%); and heterogeneous evaluations of intrinsic metrics (27.1%), human-in-the-loop assessments (55.9%), and LLM-based evaluations (13.6%). The analysis addresses current limitations in what, where, and how health professionals can leverage synthetic data generation for biomedical domains. Our review also highlights challenges in adaption across clinical domains, resource and model accessibility, and evaluation standardizations.

We present a method to improve the detection limit for radionuclides using spectroscopic radiation detectors and the arrival time of each detected radiation quantum. We enable this method using a neural network with an attention mechanism. We illustrate the method on the detection of Cesium release from a nuclear facility during an upset, and our method shows $2\times$ improvement over the traditional spectroscopic method. We hypothesize that our method achieves this performance increase by modulating its detection probability by the overall rate of probable detections, specifically by adapting detection thresholds based on temporal event distributions and local spectral features, and show evidence to this effect. We believe this method is applicable broadly and may be more successful for radionuclides with more complicated decay chains than Cesium; we also note that our method can generalize beyond the addition of arrival time and could integrate other data about each detection event, such as pulse quality, location in detector, or even combining the energy and time from detections in different detectors.

This work has been submitted to the IEEE for possible publication. Abstract Face swapping manipulations in video streams represents an increasing threat in remote video communications, due to advances in automated and real-time tools. Recent literature proposes to characterize and exploit visual artifacts introduced in video frames by swapping algorithms when dealing with challenging physical scenes, such as face occlusions. This paper investigates the effectiveness of this approach by benchmarking CNN-based data-driven models on two data corpora (including a newly collected one) and analyzing generalization capabilities with respect to different acquisition sources and swapping algorithms. The results confirm excellent performance of general-purpose CNN architectures when operating within the same data source, but a significant difficulty in robustly characterizing occlusion-based visual cues across datasets. This highlights the need for specialized detection strategies to deal with such artifacts. The synthesis and manipulation of facial images and videos have achieved increasingly hyper-realistic results in recent years [4], leading to numerous research efforts for the automated identification of non-genuine visual data [25] [27].

This study investigates the integration of signal processing transformations -- Fast Fourier Transform (FFT), Walsh-Hadamard Transform (WHT), and Discrete Cosine Transform (DCT) -- within the ResNet50 convolutional neural network (CNN) model for image classification. The primary objective is to assess the trade-offs between computational efficiency, energy consumption, and classification accuracy during training and inference. Using the CIFAR-100 dataset (100 classes, 60,000 images), experiments demonstrated that incorporating WHT significantly reduced energy consumption while improving accuracy. Specifically, a baseline ResNet50 model achieved a testing accuracy of 66%, consuming an average of 25,606 kJ per model. In contrast, a modified ResNet50 incorporating WHT in the early convolutional layers achieved 74% accuracy, and an enhanced version with WHT applied to both early and late layers achieved 79% accuracy, with an average energy consumption of only 39 kJ per model. These results demonstrate the potential of WHT as a highly efficient and effective approach for energy-constrained CNN applications.

Visual Document Understanding (VDU) systems have achieved strong performance in information extraction by integrating textual, layout, and visual signals. However, their robustness under realistic adversarial perturbations remains insufficiently explored. We introduce the first unified framework for generating and evaluating multi-modal adversarial attacks on OCR-based VDU models. Our method covers six gradient-based layout attack scenarios, incorporating manipulations of OCR bounding boxes, pixels, and texts across both word and line granularities, with constraints on layout perturbation budget (e.g., IoU >= 0.6) to preserve plausibility. Experimental results across four datasets (FUNSD, CORD, SROIE, DocVQA) and six model families demonstrate that line-level attacks and compound perturbations (BBox + Pixel + Text) yield the most severe performance degradation. Projected Gradient Descent (PGD)-based BBox perturbations outperform random-shift baselines in all investigated models. Ablation studies further validate the impact of layout budget, text modification, and adversarial transferability.

Frames capture aspects of an issue that are emphasized in a debate by interlocutors and can help us understand how political language conveys different perspectives and ultimately shapes people's opinions. The Media Frame Corpus (MFC) is the most commonly used framework with categories and detailed guidelines for operationalizing frames. It is, however, focused on a few salient U.S. news issues, making it unclear how well these frames can capture news issues in other cultural contexts. To explore this, we introduce FrameNews-PT, a dataset of Brazilian Portuguese news articles covering political and economic news and annotate it within the MFC framework. Through several annotation rounds, we evaluate the extent to which MFC frames generalize to the Brazilian debate issues. We further evaluate how fine-tuned and zero-shot models perform on out-of-domain data. Results show that the 15 MFC frames remain broadly applicable with minor revisions of the guidelines. However, some MFC frames are rarely used, and novel news issues are analyzed using general 'fall-back' frames. We conclude that cross-cultural frame use requires careful consideration.

Atmospheric sciences are crucial for understanding environmental phenomena ranging from air quality to extreme weather events, and climate change. Recent breakthroughs in sensing, communication, computing, and Artificial Intelligence (AI) have significantly advanced atmospheric sciences, enabling the generation of vast amounts of data through long-term Earth observations and providing powerful tools for analyzing atmospheric phenomena and predicting natural disasters. This paper contributes a critical interdisciplinary overview that bridges the fields of atmospheric science and computer science, highlighting the transformative potential of AI in atmospheric research. We identify key challenges associated with integrating AI into atmospheric research, including issues related to big data and infrastructure, and provide a detailed research roadmap that addresses both current and emerging challenges.

As large language models (LLMs) are deployed in safety-critical settings, it is essential to ensure that their responses comply with safety standards. Prior research has revealed that LLMs often fail to grasp the notion of safe behaviors, resulting in either unjustified refusals to harmless prompts or the generation of harmful content. While substantial efforts have been made to improve their robustness, existing defenses often rely on costly fine-tuning of model parameters or employ suboptimal heuristic techniques. In this work, we take a novel approach to safeguard LLMs by learning to adapt the system prompts in instruction-tuned LLMs. While LLMs are typically pre-trained to follow a fixed system prompt, we investigate the impact of tailoring the system prompt to each specific user input on the safety of the responses. To this end, we propose $\textbf{Sysformer}$, a trans$\textbf{former}$ model that updates an initial $\textbf{sys}$tem prompt to a more robust system prompt in the LLM input embedding space while attending to the user prompt. While keeping the LLM parameters frozen, the Sysformer is trained to refuse to respond to a set of harmful prompts while responding ideally to a set of safe ones. Through extensive experiments on $5$ LLMs from different families and $2$ recent benchmarks, we demonstrate that Sysformer can significantly enhance the robustness of LLMs, leading to upto $80\%$ gain in the refusal rate on harmful prompts while enhancing the compliance with the safe prompts by upto $90\%$. Results also generalize well to sophisticated jailbreaking attacks, making LLMs upto $100\%$ more robust against different attack strategies. We hope our findings lead to cheaper safeguarding of LLMs and motivate future investigations into designing variable system prompts.

This paper evaluates geopolitical biases in LLMs with respect to various countries though an analysis of their interpretation of historical events with conflicting national perspectives (USA, UK, USSR, and China). We introduce a novel dataset with neutral event descriptions and contrasting viewpoints from different countries. Our findings show significant geopolitical biases, with models favoring specific national narratives. Additionally, simple debiasing prompts had a limited effect in reducing these biases. Experiments with manipulated participant labels reveal models' sensitivity to attribution, sometimes amplifying biases or recognizing inconsistencies, especially with swapped labels. This work highlights national narrative biases in LLMs, challenges the effectiveness of simple debiasing methods, and offers a framework and dataset for future geopolitical bias research.

The remarkable growth in large language model (LLM) capabilities has spurred exploration into multi-agent systems, with debate frameworks emerging as a promising avenue for enhanced problem-solving. These multi-agent debate (MAD) approaches, where agents collaboratively present, critique, and refine arguments, potentially offer improved reasoning, robustness, and diverse perspectives over monolithic models. Despite prior studies leveraging MAD, a systematic understanding of its effectiveness compared to self-agent methods, particularly under varying conditions, remains elusive. This paper seeks to fill this gap by conceptualizing MAD as a test-time computational scaling technique, distinguished by collaborative refinement and diverse exploration capabilities. We conduct a comprehensive empirical investigation comparing MAD with strong self-agent test-time scaling baselines on mathematical reasoning and safety-related tasks. Our study systematically examines the influence of task difficulty, model scale, and agent diversity on MAD's performance. Key findings reveal that, for mathematical reasoning, MAD offers limited advantages over self-agent scaling but becomes more effective with increased problem difficulty and decreased model capability, while agent diversity shows little benefit. Conversely, for safety tasks, MAD's collaborative refinement can increase vulnerability, but incorporating diverse agent configurations facilitates a gradual reduction in attack success through the collaborative refinement process. We believe our findings provide critical guidance for the future development of more effective and strategically deployed MAD systems.