Despite significant medical advancements, cancer remains the second leading cause of death, with over 600,000 deaths per year in the US. One emerging field, pathway analysis, is promising but still relies on manually derived wet lab data, which is time-consuming to acquire. This work proposes an efficient, effective end-to-end framework for Artificial Intelligence (AI) based pathway analysis that predicts both cancer severity and mutation progression, thus recommending possible treatments. The proposed technique involves a novel combination of time-series machine learning models and pathway analysis. First, mutation sequences were isolated from The Cancer Genome Atlas (TCGA) Database. Then, a novel preprocessing algorithm was used to filter key mutations by mutation frequency. This data was fed into a Recurrent Neural Network (RNN) that predicted cancer severity. Then, the model probabilistically used the RNN predictions, information from the preprocessing algorithm, and multiple drug-target databases to predict future mutations and recommend possible treatments. This framework achieved robust results and Receiver Operating Characteristic (ROC) curves (a key statistical metric) with accuracies greater than 60%, similar to existing cancer diagnostics. In addition, preprocessing played an instrumental role in isolating important mutations, demonstrating that each cancer stage studied may contain on the order of a few-hundred key driver mutations, consistent with current research. Heatmaps based on predicted gene frequency were also generated, highlighting key mutations in each cancer. Overall, this work is the first to propose an efficient, cost-effective end-to-end framework for projecting cancer progression and providing possible treatments without relying on expensive, time-consuming wet lab work.

Temporal reasoning about historical events is a critical skill for NLP tasks like event extraction, historical entity linking, temporal question answering, timeline summarization, temporal event clustering and temporal natural language inference. Yet efforts on benchmarking temporal reasoning capabilities of large language models (LLMs) are rather limited. Existing temporal reasoning datasets are limited in scale, lack multilingual coverage and focus more on contemporary events. To address these limitations, we present HistoryBank, a multilingual database of 10M+ historical events extracted from Wikipedia timeline pages and article infoboxes. Our database provides unprecedented coverage in both historical depth and linguistic breadth with 10 languages. Additionally, we construct a comprehensive question answering benchmark for temporal reasoning across all languages. This benchmark covers a diverse set of 6 temporal QA reasoning tasks, and we evaluate a suite of popular language models (LLaMA-3-8B, Mistral-7B, Gemma-2-9b, Qwen3-8B, GPT4o) to assess their performance on these tasks. As expected GPT4o performs best across all answer types and languages; Gemma-2 outperforms the other small language models. Our work aims to provide a comprehensive resource for advancing multilingual and temporally-aware natural language understanding of historical events. To facilitate further research, we will make our code and datasets publicly available upon acceptance of this paper.

The volume of machine-generated content online has grown dramatically due to the widespread use of Large Language Models (LLMs), leading to new challenges for content moderation systems. Conventional content moderation classifiers, which are usually trained on text produced by humans, suffer from misclassifications due to LLM-generated text deviating from their training data and adversarial attacks that aim to avoid detection. Present-day defence tactics are reactive rather than proactive, since they rely on adversarial training or external detection models to identify attacks. In this work, we aim to identify the vulnerable components of toxicity classifiers that contribute to misclassification, proposing a novel strategy based on mechanistic interpretability techniques. Our study focuses on fine-tuned BERT and RoBERTa classifiers, testing on diverse datasets spanning a variety of minority groups. We use adversarial attacking techniques to identify vulnerable circuits. Finally, we suppress these vulnerable circuits, improving performance against adversarial attacks. We also provide demographic-level insights into these vulnerable circuits, exposing fairness and robustness gaps in model training. We find that models have distinct heads that are either crucial for performance or vulnerable to attack and suppressing the vulnerable heads improves performance on adversarial input. We also find that different heads are responsible for vulnerability across different demographic groups, which can inform more inclusive development of toxicity detection models.

The detection and grounding of manipulated content in multimodal data has emerged as a critical challenge in media forensics. While existing benchmarks demonstrate technical progress, they suffer from misalignment artifacts that poorly reflect real-world manipulation patterns: practical attacks typically maintain semantic consistency across modalities, whereas current datasets artificially disrupt cross-modal alignment, creating easily detectable anomalies. To bridge this gap, we pioneer the detection of semantically-coordinated manipulations where visual edits are systematically paired with semantically consistent textual descriptions. Our approach begins with constructing the first Semantic-Aligned Multimodal Manipulation (SAMM) dataset, generated through a two-stage pipeline: 1) applying state-of-the-art image manipulations, followed by 2) generation of contextually-plausible textual narratives that reinforce the visual deception. Building on this foundation, we propose a Retrieval-Augmented Manipulation Detection and Grounding (RamDG) framework. RamDG commences by harnessing external knowledge repositories to retrieve contextual evidence, which serves as the auxiliary texts and encoded together with the inputs through our image forgery grounding and deep manipulation detection modules to trace all manipulations. Extensive experiments demonstrate our framework significantly outperforms existing methods, achieving 2.06\% higher detection accuracy on SAMM compared to state-of-the-art approaches. The dataset and code are publicly available at https://github.com/shen8424/SAMM-RamDG-CAP.

As large language models (LLMs) become increasingly embedded in products used by millions, their outputs may influence individual beliefs and, cumulatively, shape public opinion. If the behavior of LLMs can be intentionally steered toward specific ideological positions, such as political or religious views, then those who control these systems could gain disproportionate influence over public discourse. Although it remains an open question whether LLMs can reliably be guided toward coherent ideological stances and whether such steering can be effectively prevented, a crucial first step is to develop methods for detecting when such steering attempts occur. In this work, we adapt a previously proposed statistical method to the new context of ideological bias auditing. Our approach carries over the model-agnostic design of the original framework, which does not require access to the internals of the language model. Instead, it identifies potential ideological steering by analyzing distributional shifts in model outputs across prompts that are thematically related to a chosen topic. This design makes the method particularly suitable for auditing proprietary black-box systems. We validate our approach through a series of experiments, demonstrating its practical applicability and its potential to support independent post hoc audits of LLM behavior.

Training data attribution (TDA) plays a critical role in understanding the influence of individual training data points on model predictions. Gradient-based TDA methods, popularized by \textit{influence function} for their superior performance, have been widely applied in data selection, data cleaning, data economics, and fact tracing. However, in real-world scenarios where commercial models are not publicly accessible and computational resources are limited, existing TDA methods are often constrained by their reliance on full model access and high computational costs. This poses significant challenges to the broader adoption of TDA in practical applications. In this work, we present a systematic study of TDA methods under various access and resource constraints. We investigate the feasibility of performing TDA under varying levels of access constraints by leveraging appropriately designed solutions such as proxy models. Besides, we demonstrate that attribution scores obtained from models without prior training on the target dataset remain informative across a range of tasks, which is useful for scenarios where computational resources are limited. Our findings provide practical guidance for deploying TDA in real-world environments, aiming to improve feasibility and efficiency under limited access.

Roundabouts reduce severe crashes, yet risk patterns vary by conditions. This study analyzes 2017-2021 Ohio roundabout crashes using a two-step, explainable workflow. Cluster Correspondence Analysis (CCA) identifies co-occurring factors and yields four crash patterns. A tree-based severity model is then interpreted with SHAP to quantify drivers of injury within and across patterns. Results show higher severity when darkness, wet surfaces, and higher posted speeds coincide with fixed-object or angle events, and lower severity in clear, low-speed settings. Pattern-specific explanations highlight mechanisms at entries (fail-to-yield, gap acceptance), within multi-lane circulation (improper maneuvers), and during slow-downs (rear-end). The workflow links pattern discovery with case-level explanations, supporting site screening, countermeasure selection, and audit-ready reporting. The contribution to Information Systems is a practical template for usable XAI in public safety analytics.

Sample size calculations for power analysis are critical for clinical research and trial design, yet their complexity and reliance on statistical expertise create barriers for many researchers. We introduce PowerGPT, an AI-powered system integrating large language models (LLMs) with statistical engines to automate test selection and sample size estimation in trial design. In a randomized trial to evaluate its effectiveness, PowerGPT significantly improved task completion rates (99.3% vs. 88.9% for test selection, 99.3% vs. 77.8% for sample size calculation) and accuracy (94.1% vs. 55.4% in sample size estimation, p < 0.001), while reducing average completion time (4.0 vs. 9.3 minutes, p < 0.001). These gains were consistent across various statistical tests and benefited both statisticians and non-statisticians as well as bridging expertise gaps. Already under deployment across multiple institutions, PowerGPT represents a scalable AI-driven approach that enhances accessibility, efficiency, and accuracy in statistical power analysis for clinical research.

The Neural Tangent Kernel (NTK) framework has provided deep insights into the training dynamics of neural networks under gradient flow. However, it relies on the assumption that the network is differentiable with respect to its parameters, an assumption that breaks down when considering non-smooth target functions or parameterized models exhibiting non-differentiable behavior. In this work, we propose a Nonlocal Neural Tangent Kernel (NNTK) that replaces the local gradient with a nonlocal interaction-based approximation in parameter space. Nonlocal gradients are known to exist for a wider class of functions than the standard gradient. This allows NTK theory to be extended to nonsmooth functions, stochastic estimators, and broader families of models. We explore both fixed-kernel and attention-based formulations of this nonlocal operator. We illustrate the new formulation with numerical studies.

Recently, embedding resources, including models, benchmarks, and datasets, have been widely released to support a variety of languages. However, the Dutch language remains underrepresented, typically comprising only a small fraction of the published multilingual resources. To address this gap and encourage the further development of Dutch embeddings, we introduce new resources for their evaluation and generation. First, we introduce the Massive Text Embedding Benchmark for Dutch (MTEB-NL), which includes both existing Dutch datasets and newly created ones, covering a wide range of tasks. Second, we provide a training dataset compiled from available Dutch retrieval datasets, complemented with synthetic data generated by large language models to expand task coverage beyond retrieval. Finally, we release a series of E5-NL models compact yet efficient embedding models that demonstrate strong performance across multiple tasks. We make our resources publicly available through the Hugging Face Hub and the MTEB package.