Gene-gene interactions play a crucial role in the manifestation of complex human diseases. Uncovering significant gene-gene interactions is a challenging task. Here, we present an innovative approach utilizing data-driven computational tools, leveraging an advanced Transformer model, to unearth noteworthy gene-gene interactions. Despite the efficacy of Transformer models, their parameter intensity presents a bottleneck in data ingestion, hindering data efficiency. To mitigate this, we introduce a novel weighted diversified sampling algorithm. This algorithm computes the diversity score of each data sample in just two passes of the dataset, facilitating efficient subset generation for interaction discovery. Our extensive experimentation demonstrates that by sampling a mere 1\% of the single-cell dataset, we achieve performance comparable to that of utilizing the entire dataset.

The rapid advancement of Large Language Models (LLMs) (Achiam et al., 2023; Touvron et al., 2023b) has ushered in a new era of artificial intelligence, enabling the creation of sophisticated AI agents capable of tackling complex tasks across various domains (Nakajima, 2023; Torantulino, 2023). As these AI systems become more intricate, there is a growing need for effective collaboration mechanisms that allow multiple agents to work together. This collaborative approach, known as Multi-Agent Systems (MAS) (Han et al., 2024), has shown great promise in addressing challenges that are too complex or diverse for single-agent systems (Hong et al., 2024; Liu et al., 2023). While existing MAS implementations have shown promising results, they often rely on predefined roles (Li et al., 2023), centralized coordination (Guo et al., 2024; Chen et al., 2024), or rigid organizational structures (Wang et al., 2024b; Hong et al., 2024). These approaches limit cooperative resilience within MAS (Chacon-Chamorro et al., 2024), which focuses on robustness and adaptability in dynamic, unpredictable environments. Figure 1 presents two examples to illustrate the real-world challenges with details elaborated below: Example 1.1 (Domain shift). Domain shift refers to a change in the characteristics or requirements of a task as it progresses through different phases or contexts, presenting new challenges and requiring different skill sets. For instance, a scientific research project could begin with literature review, move to experiment design, and conclude with result analysis and paper writing. These transitions demand a flexible and adaptive multi-agent system that can seamlessly adjust its collaborative strategies and agent roles as the task progresses.

Adversarial training (AT) refers to integrating adversarial examples -- inputs altered with imperceptible perturbations that can significantly impact model predictions -- into the training process. Recent studies have demonstrated the effectiveness of AT in improving the robustness of deep neural networks against diverse adversarial attacks. However, a comprehensive overview of these developments is still missing. This survey addresses this gap by reviewing a broad range of recent and representative studies. Specifically, we first describe the implementation procedures and practical applications of AT, followed by a comprehensive review of AT techniques from three perspectives: data enhancement, network design, and training configurations. Lastly, we discuss common challenges in AT and propose several promising directions for future research.

In the rapidly evolving field of conversational AI, Ontology Expansion (OnExp) is crucial for enhancing the adaptability and robustness of conversational agents. Traditional models rely on static, predefined ontologies, limiting their ability to handle new and unforeseen user needs. This survey paper provides a comprehensive review of the state-of-the-art techniques in OnExp for conversational understanding. It categorizes the existing literature into three main areas: (1) New Intent Discovery, (2) New Slot-Value Discovery, and (3) Joint OnExp. By examining the methodologies, benchmarks, and challenges associated with these areas, we highlight several emerging frontiers in OnExp to improve agent performance in real-world scenarios and discuss their corresponding challenges. This survey aspires to be a foundational reference for researchers and practitioners, promoting further exploration and innovation in this crucial domain.

The importance of inducing bilingual dictionary components in many natural language processing (NLP) applications is indisputable. However, the dictionary compilation process requires extensive work and combines two disciplines, NLP and lexicography, while the former often omits the latter. In this paper, we present the most common approaches from NLP that endeavour to automatically induce one of the essential dictionary components, translation equivalents and focus on the neural-network-based methods using comparable data. We analyse them from a lexicographic perspective since their viewpoints are crucial for improving the described methods. Moreover, we identify the methods that integrate these viewpoints and can be further exploited in various applications that require them. This survey encourages a connection between the NLP and lexicography fields as the NLP field can benefit from lexicographic insights, and it serves as a helping and inspiring material for further research in the context of neural-network-based methods utilising comparable data.

Artificial intelligence (AI) has become a buzz word since Google's AlphaGo beat a world champion in 2017. In the past five years, machine learning as a subset of the broader category of AI has obtained considerable attention in the research community of granular materials. This work offers a detailed review of the recent advances in machine learning-aided studies of granular materials from the particle-particle interaction at the grain level to the macroscopic simulations of granular flow. This work will start with the application of machine learning in the microscopic particle-particle interaction and associated contact models. Then, different neural networks for learning the constitutive behaviour of granular materials will be reviewed and compared. Finally, the macroscopic simulations of practical engineering or boundary value problems based on the combination of neural networks and numerical methods are discussed. We hope readers will have a clear idea of the development of machine learning-aided modelling of granular materials via this comprehensive review work.

Client-Service Representatives (CSRs) are vital to organizations. Frequent interactions with disgruntled clients, however, disrupt their mental well-being. To help CSRs regulate their emotions while interacting with uncivil clients, we designed Pro-Pilot, an LLM-powered assistant, and evaluated its efficacy, perception, and use. Our comparative analyses between 665 human and Pro-Pilot-generated support messages demonstrate Pro-Pilot's ability to adapt to and demonstrate empathy in various incivility incidents. Additionally, 143 CSRs assessed Pro-Pilot's empathy as more sincere and actionable than human messages. Finally, we interviewed 20 CSRs who interacted with Pro-Pilot in a simulation exercise. They reported that Pro-Pilot helped them avoid negative thinking, recenter thoughts, and humanize clients; showing potential for bridging gaps in coworker support. Yet, they also noted deployment challenges and emphasized the irreplaceability of shared experiences. We discuss future designs and societal implications of AI-mediated emotional labor, underscoring empathy as a critical function for AI assistants in front-office roles.

The concept of diversity is widely used in various applications: from image or molecule generation to recommender systems. Thus, being able to properly measure diversity is important. This paper addresses the problem of quantifying diversity for a set of objects. First, we make a systematic review of existing diversity measures and explore their undesirable behavior in some cases. Based on this review, we formulate three desirable properties (axioms) of a reliable diversity measure: monotonicity, uniqueness, and continuity. We show that none of the existing measures has all three properties and thus these measures are not suitable for quantifying diversity. Then, we construct two examples of measures that have all the desirable properties, thus proving that the list of axioms is not self-contradicting. Unfortunately, the constructed examples are too computationally complex for practical use, thus we pose an open problem of constructing a diversity measure that has all the listed properties and can be computed in practice.

Deep generative models are becoming increasingly used as tools for financial analysis. However, it is unclear how these models will influence financial markets, especially when they infer financial value in a semi-autonomous way. In this work, we explore the interplay between deep generative models and market dynamics. We develop a form of virtual traders that use deep generative models to make buy/sell decisions, which we term neuro-symbolic traders, and expose them to a virtual market. Under our framework, neuro-symbolic traders are agents that use vision-language models to discover a model of the fundamental value of an asset. Agents develop this model as a stochastic differential equation, calibrated to market data using gradient descent. We test our neuro-symbolic traders on both synthetic data and real financial time series, including an equity stock, commodity, and a foreign exchange pair. We then expose several groups of neuro-symbolic traders to a virtual market environment. This market environment allows for feedback between the traders belief of the underlying value to the observed price dynamics. We find that this leads to price suppression compared to the historical data, highlighting a future risk to market stability. Our work is a first step towards quantifying the effect of deep generative agents on markets dynamics and sets out some of the potential risks and benefits of this approach in the future.

This paper has proposed a Digital Twin (DT) framework for real-time motion and pose control of soft robotic grippers. The developed DT is based on an industrial robot workstation, integrated with our newly proposed approach for soft gripper control, primarily based on computer vision, for setting the driving pressure for desired gripper status in real-time. Knowing the gripper motion, the gripper parameters (e.g. curvatures and bending angles, etc.) are simulated by kinematics modelling in Unity 3D, which is based on four-piecewise constant curvature kinematics. The mapping in between the driving pressure and gripper parameters is achieved by implementing OpenCV based image processing algorithms and data fitting. Results show that our DT-based approach can achieve satisfactory performance in real-time control of soft gripper manipulation, which can satisfy a wide range of industrial applications.