The Most Important Gain: New Knowledge 18 10 Problems of Knowledge Engineering 19 10.1 The Lack of Adequate and Appropriate Hardware 19 10.2 Lack of Cumulation of Al Methods and Techniques 19 10.3 Shortage of Trained Knowledge Engineers 20 10.4 The Problem of Knowledge Acquisition 21 10.5 The Development Gap 21 11 Acknowledgments 22 1 1 Introduction: Symbolic Computation and Inference This paper will discuss the applied artificial intelligence work that is sometimes called "knowledge engineering". The work is based on computer programs that do symbolic manipulations and symbolic inference, not calculation. The programs I will discuss do essentially no numerical calculation. They discover qualitative lines-of-reasoning leading to solutions to problems stated symbolically.

This paper briefly outlines the difference between Branching on the bas of response was the first step coward traditional instructional programs and MAI.

It is noted that no one method is best with a view to the potential role of automated decision for all applications. However, emphasis is given to the limitations of early work that have made artificial intelligence techniques and knowledge aids in that domain 1611.

Those of us involved In the creation of the Handbook of Artificial Intelligence, both writers and editors, have attempted to make the concepts, methods, tools, and main results of artificial Intelligence research accessible to a broad scientific and engineering audience. Currently, Al work Is familiar mainly to its practicing specialists and other interested computer scientists. Yet the field Is of growing interdisciplinary interest and practical Importance. With this book we are trying to build bridges that are easily crossed by engineers, scientists in other fields, and our own computer science colleagues. In the Handbook we Intend to cover the breadth and depth of Al, presenting general overviews of the scientific issues, as well as detailed discussions of particular to -hniques and Important Al systems.

These links are based on domain facts and relations (e g. that a topic is the name of a block of Step?: Discuss the final hypothesis for the goal

A clinical investigator graphical capabilities which can plot specific parameters for a keeping the records of his study patients on such a system can patient over time 1126]. However, it is in the analysis of stored use the program's statistical capabilities for data analysis.

These knowledge bases are generally built by interviewing human experts to extract the knowledge they use to solve problems in their area of expertise. However, it is not clear that the organization and level of abstraction of this performance knowledge is suitable for use in a tutorial program. We are exploring this problem in the GUIDON tutorial program, using the knowledge bases of MYCIN-like expert systems. MYCIN is a knowledge-based program that provides consultations about infectious disease diagnosis and therapy (Shortliffe, 1974). In MN CIN, domain relations and facts take the form of rules about what to do in a given circumstance. A principle feature of this formalism is the separation of the knowledge base from the interpreter for applying it. This makes the knowledge accessible for multiple uses, including application to particular problems (i.e. for "performance") and explanation of reasoning (Davis, 1976). We have most recently used the MYC1N knowledge base as the foundation of a tutorial system, called GUIDON.

Because of the recent - echnological advances in computer networks and communications, and because of the cost reduction of computer hardware, there has been a great interest in distributed data bases including some attempts at actual implementations. In this paper, we will first define what we mean by a distributed data base. Then we will give some of the reasons why people are so interested in this new field. After classifying the different types of distributed data bases, we will describe the current areas of research. Finally, we will give an annotated bibliography that lists the most important papers in thi:3 area.

Our understanding of any process can be measured by the extent to which a simulation we create mimics the real behavior of that process. Deviations of a simulation indicate either limitations or errors in our knowledge. In addition, these observed differences often suggest verifiable experimental hypotheses to extend our knowledge. The biochemical approach to understanding biological processes is essentially one of simulation. A biochemist typically prepares a cell-free extract that can mediate a well-described physiological process. The extract is then fractionated to purify the components that catalyze individual reactions.

Human scientists actively seek out information that bears on questions they have decided to pursue. They design experiments, explore the implications of the knowledge they have, refine their questions and test alternative ideas. Although many discoveries are the result of unexpected observations, these surprises take place in the context of an explicit pursuit of knowledge. Viewing scientific discovery as a kind of motivated action raises some basic issues common to goal-directed behavior generally: Where do desires (to know) come from? What are the actions that can be taken (to discover)? What are the resources those actions consume, and how are they allocated? How are decisions about selecting and combining actions made?