With the rapid development of artificial intelligence (AI), large language models (LLMs) have shown strong capabilities in natural language understanding, reasoning, and generation, attracting amounts of research interest in applying LLMs to health and medicine. Critical care medicine (CCM) provides diagnosis and treatment for critically ill patients who often require intensive monitoring and interventions in intensive care units (ICUs). Can LLMs be applied to CCM? Are LLMs just like stochastic parrots or ICU experts in assisting clinical decision-making? This scoping review aims to provide a panoramic portrait of the application of LLMs in CCM. Literature in seven databases, including PubMed, Embase, Scopus, Web of Science, CINAHL, IEEE Xplore, and ACM Digital Library, were searched from January 1, 2019, to June 10, 2024. Peer-reviewed journal and conference articles that discussed the application of LLMs in critical care settings were included. From an initial 619 articles, 24 were selected for final review. This review grouped applications of LLMs in CCM into three categories: clinical decision support, medical documentation and reporting, and medical education and doctor-patient communication. LLMs have advantages in handling unstructured data and do not require manual feature engineering. Meanwhile, applying LLMs to CCM faces challenges, including hallucinations, poor interpretability, bias and alignment challenges, and privacy and ethics issues. Future research should enhance model reliability and interpretability, integrate up-to-date medical knowledge, and strengthen privacy and ethical guidelines. As LLMs evolve, they could become key tools in CCM to help improve patient outcomes and optimize healthcare delivery. This study is the first review of LLMs in CCM, aiding researchers, clinicians, and policymakers to understand the current status and future potentials of LLMs in CCM.

Proteins govern most biological functions essential for life, but achieving controllable protein discovery and optimization remains challenging. Recently, machine learning-assisted protein editing (MLPE) has shown promise in accelerating optimization cycles and reducing experimental workloads. However, current methods struggle with the vast combinatorial space of potential protein edits and cannot explicitly conduct protein editing using biotext instructions, limiting their interactivity with human feedback. To fill these gaps, we propose a novel method called ProtET for efficient CLIP-informed protein editing through multi-modality learning. Our approach comprises two stages: in the pretraining stage, contrastive learning aligns protein-biotext representations encoded by two large language models (LLMs), respectively. Subsequently, during the protein editing stage, the fused features from editing instruction texts and original protein sequences serve as the final editing condition for generating target protein sequences. Comprehensive experiments demonstrated the superiority of ProtET in editing proteins to enhance human-expected functionality across multiple attribute domains, including enzyme catalytic activity, protein stability and antibody specific binding ability. And ProtET improves the state-of-the-art results by a large margin, leading to significant stability improvements of 16.67% and 16.90%. This capability positions ProtET to advance real-world artificial protein editing, potentially addressing unmet academic, industrial, and clinical needs.

The Canadian Olympic Committee has removed women's national soccer head coach Bev Priestman for the remainder of the Paris Games after staffers allegedly used a drone to spy on an opponent. Two Canadian team staffers, assistant coach Jasmine Mander and analyst Joseph Lombardi, were "sent home immediately" for allegedly using a drone to spy on a New Zealand practice. Canada beat New Zealand, 2-1, Thursday. Priestman, who has denied involvement, initially volunteered to step away from the club prior to the committee's decision. Canada Soccer CEO and General Secretary Kevin Blue said in a COC release that "additional information has come to our attention regarding previous drone use against opponents, predating the Paris 2024 Olympic Games."

Calls for engagement with the public in Artificial Intelligence (AI) research, development, and governance are increasing, leading to the use of surveys to capture people's values, perceptions, and experiences related to AI. In this paper, we critically examine the state of human participant surveys associated with these topics. Through both a reflexive analysis of a survey pilot spanning six countries and a systematic literature review of 44 papers featuring public surveys related to AI, we explore prominent perspectives and methodological nuances associated with surveys to date. We find that public surveys on AI topics are vulnerable to specific Western knowledge, values, and assumptions in their design, including in their positioning of ethical concepts and societal values, lack sufficient critical discourse surrounding deployment strategies, and demonstrate inconsistent forms of transparency in their reporting. Based on our findings, we distill provocations and heuristic questions for our community, to recognize the limitations of surveys for meeting the goals of engagement, and to cultivate shared principles to design, deploy, and interpret surveys cautiously and responsibly.

Deep learning (DL)-based channel state information (CSI) feedback has the potential to improve the recovery accuracy and reduce the feedback overhead in massive multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM) systems. However, the length of input CSI and the number of feedback bits should be adjustable in different scenarios, which can not be efficiently achieved by the existing CSI feedback models. Therefore, an adaptive bidirectional long short-term memory network (ABLNet) for CSI feedback is first designed to process various input CSI lengths, where the number of feedback bits is in proportion to the CSI length. Then, to realize a more flexible feedback bit number, a feedback bit control unit (FBCU) module is proposed to control the output length of feedback bits. Based on which, a target feedback performance can be adaptively achieved by a designed bit number adjusting (BNA) algorithm. Furthermore, a novel separate training approach is devised to solve the model protection problem that the UE and gNB are from different manufacturers. Experiments demonstrate that the proposed ABLNet with FBCU can fit for different input CSI lengths and feedback bit numbers; the CSI feedback performance can be stabilized by the BNA algorithm; and the proposed separate training approach can maintain the feedback performance and reduce the complexity of feedback model.

It is an effective tool to sequence. Our model can learn network dynamics from packet improve the efficiency and security of the Internet of Things traces, and the obtained results from the experiments are (IoT) ecosystem. The ability to classify IoT traffic accurately promising: ITCT demonstrates a remarkable ability to generalize empowers Internet Service Providers (ISPs) to furnish highquality across various prediction tasks and environments. Having services to network users, thereby ensuring optimal been evaluated with generic datasets, the model employs performance, security, and resource allocation [1]. Transformers to learn contextual embeddings of categorical Conventional traffic classification techniques, which distinguish features effectively. We have pre-trained this model using an various network services based on basic traffic characteristics MQTT-based IoT traffic dataset [14], enabling others to further like communication protocol and port number, are fine-tune it with their own data, regardless of the dataset's increasingly inadequate due to the complexity and changeability size. The results indicate the ITCT transformer's potential to of contemporary traffic [2], [3]. To overcome this achieve commendable evaluation metrics. For example, one of challenge, numerous studies have employed machine learning our proposed models attained an overall accuracy of 82%, a (ML) algorithms for traffic classification using statistical similar performance to other classifiers tested.

This paper studies gender bias in machine translation through the lens of Large Language Models (LLMs). Four widely-used test sets are employed to benchmark various base LLMs, comparing their translation quality and gender bias against state-of-the-art Neural Machine Translation (NMT) models for English to Catalan (En $\rightarrow$ Ca) and English to Spanish (En $\rightarrow$ Es) translation directions. Our findings reveal pervasive gender bias across all models, with base LLMs exhibiting a higher degree of bias compared to NMT models. To combat this bias, we explore prompting engineering techniques applied to an instruction-tuned LLM. We identify a prompt structure that significantly reduces gender bias by up to 12% on the WinoMT evaluation dataset compared to more straightforward prompts. These results significantly reduce the gender bias accuracy gap between LLMs and traditional NMT systems.

In modern healthcare, addressing the complexities of accurate disease prediction and personalized recommendations is both crucial and challenging. This research introduces MLtoGAI, which integrates Semantic Web technology with Machine Learning (ML) to enhance disease prediction and offer user-friendly explanations through ChatGPT. The system comprises three key components: a reusable disease ontology that incorporates detailed knowledge about various diseases, a diagnostic classification model that uses patient symptoms to detect specific diseases accurately, and the integration of Semantic Web Rule Language (SWRL) with ontology and ChatGPT to generate clear, personalized health advice. This approach significantly improves prediction accuracy and ensures results that are easy to understand, addressing the complexity of diseases and diverse symptoms. The MLtoGAI system demonstrates substantial advancements in accuracy and user satisfaction, contributing to developing more intelligent and accessible healthcare solutions. This innovative approach combines the strengths of ML algorithms with the ability to provide transparent, human-understandable explanations through ChatGPT, achieving significant improvements in prediction accuracy and user comprehension. By leveraging semantic technology and explainable AI, the system enhances the accuracy of disease prediction and ensures that the recommendations are relevant and easily understood by individual patients. Our research highlights the potential of integrating advanced technologies to overcome existing challenges in medical diagnostics, paving the way for future developments in intelligent healthcare systems. Additionally, the system is validated using 200 synthetic patient data records, ensuring robust performance and reliability.

Applying differential privacy (DP) by means of the DP-SGD algorithm to protect individual data points during training is becoming increasingly popular in NLP. However, the choice of granularity at which DP is applied is often neglected. For example, neural machine translation (NMT) typically operates on the sentence-level granularity. From the perspective of DP, this setup assumes that each sentence belongs to a single person and any two sentences in the training dataset are independent. This assumption is however violated in many real-world NMT datasets, e.g. those including dialogues. For proper application of DP we thus must shift from sentences to entire documents. In this paper, we investigate NMT at both the sentence and document levels, analyzing the privacy/utility trade-off for both scenarios, and evaluating the risks of not using the appropriate privacy granularity in terms of leaking personally identifiable information (PII). Our findings indicate that the document-level NMT system is more resistant to membership inference attacks, emphasizing the significance of using the appropriate granularity when working with DP.

Reinforcement learning from human feedback (RLHF) aligns Large Language Models (LLMs) with human preferences. However, these preferences can often change over time due to external factors (e.g. environment change and societal influence). Consequently, what was wrong then might be right now. Current preference optimization algorithms do not account for temporal preference drift in their modeling, which can lead to severe misalignment. To address this limitation, we use a Dynamic Bradley-Terry model that models preferences via time-dependent reward functions, and propose Non-Stationary Direct Preference Optimisation (NS-DPO). By introducing a discount parameter in the loss function, NS-DPO applies exponential weighting, which proportionally focuses learning on more time-relevant datapoints. We theoretically analyse the convergence of NS-DPO in the offline setting, providing upper bounds on the estimation error caused by non-stationary preferences. Finally, we demonstrate the effectiveness of NS-DPO1 for fine-tuning LLMs in scenarios with drifting preferences. By simulating preference drift using renowned reward models and modifying popular LLM datasets accordingly, we show that NS-DPO fine-tuned LLMs remain robust under non-stationarity, significantly outperforming baseline algorithms that ignore temporal preference changes, without sacrificing performance in stationary cases.