This study presents a comparative methodological analysis of six machine learning models for survival analysis (MLSA). Using data from nearly 45,000 colorectal cancer patients in the Hospital-Based Cancer Registries of São Paulo, we evaluated Random Survival Forest (RSF), Gradient Boosting for Survival Analysis (GBSA), Survival SVM (SSVM), XGBoost-Cox (XGB-Cox), XGBoost-AFT (XGB-AFT), and LightGBM (LGBM), capable of predicting survival considering censored data. Hyperparameter optimization was performed with different samplers, and model performance was assessed using the Concordance Index (C-Index), C-Index IPCW, time-dependent AUC, and Integrated Brier Score (IBS). Survival curves produced by the models were compared with predictions from classification algorithms, and predictor interpretation was conducted using SHAP and permutation importance. XGB-AFT achieved the best performance (C-Index = 0.7618; IPCW = 0.7532), followed by GBSA and RSF. The results highlight the potential and applicability of MLSA to improve survival prediction and support decision making.

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Hillsborough police report'may not give answers' Families of some of those killed in the Hillsborough disaster fear they may once again be denied full accountability as the long-delayed report into police conduct surrounding the stadium crush is due to be published on Tuesday. Several people who worked on the Independent Office for Police Conduct (IOPC) investigation - including a former director - have told the BBC they doubt the report will deliver all the answers survivors and bereaved relatives were promised. Some have warned that it may lead to accusations of another Hillsborough cover-up. Families have also criticised the length and cost of the investigation - the largest of its kind ever carried out in England and Wales. The police watchdog has spent more than 13 years examining the actions of South Yorkshire Police and other forces in the aftermath of the 1989 disaster in which 97 Liverpool supporters were killed during an FA Cup semi-final at Sheffield Wednesday's Hillsborough ground.

These are products we believe are worth purchasing year-round - the discount is just a bonus. These are products we believe are worth purchasing year-round - the discount is just a bonus. Our experts found the best deals and sales that are actually worth your money. The Guardian's journalism is independent. We will earn a commission if you buy something through an affiliate link. The Guardian's journalism is independent. We will earn a commission if you buy something through an affiliate link. We all have holiday traditions we look forward to each year: cooking your grandmother's classic stuffing recipe. With the influx of these so-called "doorbuster deals", it can be hard to know a true steal from a modest markdown. So we've asked shopping experts to curate the best Black Friday and Cyber Monday sales across five of the most-shopped for categories. Whether you're looking for a much-needed sleep upgrade or a cordless vacuum that'll stand the test of time, below is our list of the best Cyber Monday deals across streaming, home, kitchen, tech, travel and wellness products. These are items that normally add up fast but right now are going for prices you won't wince at. To put together our list of deals, we enlisted the help of Guardian contributors with years of experience testing products ranging from blenders to vacuums. Our recommendations are based on items tested and loved by our contributors and staff.

What is in the 28-point US plan for Ukraine? 'Ukraine is running out of men, money and time' Can the US get all sides to end the war? Why is Europe opposing Trump's peace plan? The Take How Ukraine turned into the world's drone testing lab The use of drones in the Russia-Ukraine war has revolutionised an industry of death and destruction. The rapid development of drone technology has changed how wars are fought.

Record cold for 235 million Americans starting in just HOURS as polar vortex brings'most extreme cold on Earth' Is this the END of Ozempic? Nashville neighbors can see what's REALLY going on with Nicole Kidman. Even I was once overweight. So trust me, this 30 DAY detox plan will get you thin WITHOUT Ozempic... but if you want to stay skinny, you'll have to make one major sacrifice: JILLIAN MICHAELS Mom who spent 10 years'gentle parenting' admits it was a mistake: 'My kids are anxious, insecure and entitled' Worrying side-effect of creatine you aren't being warned about: Cheap supplement is hailed as a'miracle' - but here's how to tell if YOUR brand is doing more harm than good Amazon warns 300 million shoppers of Cyber Monday scam... and how to avoid it'Murder for hire' housewife begs Bahamas judge to free her from GPS shackles so she can start a shocking new career Trump suffers fresh legal blow as Alina Habba's disqualification is upheld by appeals court Trump sparks fury as he frees $1.6 BILLION fraudster just days into seven-year-sentence I was drinking 130 units of alcohol a week and knew it was time to cut down. Then, I discovered this no-effort miracle solution.

Brit Award-winning singer Jorja Smith's record label has said it wants a share of the royalties for a song it claims was created using an artificial intelligence clone of the singer's voice. I Run by British dance act Haven went viral on TiKTok in October thanks, in part, to smooth soul vocals by an uncredited female singer. Although I Run has now been re-released with new vocals, Smith's label FAMM said it believes the track was made with AI trained on her work, and is seeking compensation. It's bigger than one artist or one song, FAMM wrote in a statement on Instagram . The label said it believes both versions of the track infringe on Jorja's rights and unfairly take advantage of the work of all the songwriters with whom she collaborates.

The question isn't whether the AI bubble will burst - but what the fallout will be Will the bubble ravage the economy when it bursts? What will it leave of value once it pops? The California Gold Rush left an outsized imprint on America. Some 300,000 people flocked there from 1848 to 1855, from as far away as the Ottoman Empire. Prospectors massacred Indigenous people to take the gold from their lands in the Sierra Nevada mountains. And they boosted the economies of nearby states and faraway countries from whence they bought their supplies.

'It's going much too fast': the inside story of the race to create the ultimate AI On the 8.49am train through Silicon Valley, the tables are packed with young people glued to laptops, earbuds in, rattling out code. As the northern California hills scroll past, instructions flash up on screens from bosses: fix this bug; add new script. There is no time to enjoy the view. These commuters are foot soldiers in the global race towards artificial general intelligence - when AI systems become as or more capable than highly qualified humans. Here in the Bay Area of San Francisco, some of the world's biggest companies are fighting it out to gain some kind of an advantage. And, in turn, they are competing with China. This race to seize control of a technology that could reshape the world is being fuelled by bets in the trillions of dollars by the US's most powerful capitalists. Passengers get off a train at Palo Alto station.

Drone video shows devastation from floods in Indonesia's Sumatra NewsFeed Drone video shows devastation from floods in Indonesia's Sumatra Drone video shows widespread destruction in part of Sumatra in Indonesia, where more than 440 people have died in flooding and landslides across the country. Hundreds of others are still missing. Pope Leo says two-state is'only solution' for Israel-Palestine Netanyahu requests Israel's president grant a pardon in corruption cases