In this chapter we illustrate the use of some Machine Learning techniques in the context of omics data. More precisely, we review and evaluate the use of Random Forest and Penalized Multinomial Logistic Regression for integrative analysis of genomics and immunomics in pancreatic cancer. Furthermore, we propose the use of association rules with predictive purposes to overcome the low predictive power of the previously mentioned models. Finally, we apply the reviewed methods to a real data set from TCGA made of 107 tumoral pancreatic samples and 117,486 germline SNPs, showing the good performance of the proposed methods to predict the immunological infiltration in pancreatic cancer.

Social networks are vital for information sharing, especially in the health sector for discussing diseases and treatments. These platforms, however, often feature posts as brief texts, posing challenges for Artificial Intelligence (AI) in understanding context. We introduce a novel hybrid approach combining community-maintained knowledge graphs (like Wikidata) with deep learning to enhance the categorization of social media posts. This method uses advanced entity recognizers and linkers (like Falcon 2.0) to connect short post entities to knowledge graphs. Knowledge graph embeddings (KGEs) and contextualized word embeddings (like BERT) are then employed to create rich, context-based representations of these posts. Our focus is on the health domain, particularly in identifying posts related to eating disorders (e.g., anorexia, bulimia) to aid healthcare providers in early diagnosis. We tested our approach on a dataset of 2,000 tweets about eating disorders, finding that merging word embeddings with knowledge graph information enhances the predictive models' reliability. This methodology aims to assist health experts in spotting patterns indicative of mental disorders, thereby improving early detection and accurate diagnosis for personalized medicine.

In this work, we investigate to use Large Language Models (LLMs) for rumor detection on social media. However, it is challenging for LLMs to reason over the entire propagation information on social media, which contains news contents and numerous comments, due to LLMs may not concentrate on key clues in the complex propagation information, and have trouble in reasoning when facing massive and redundant information. Accordingly, we propose an LLM-empowered Rumor Detection (LeRuD) approach, in which we design prompts to teach LLMs to reason over important clues in news and comments, and divide the entire propagation information into a Chain-of-Propagation for reducing LLMs' burden. We conduct extensive experiments on the Twitter and Weibo datasets, and LeRuD outperforms several state-of-the-art rumor detection models by 3.2% to 7.7%. Meanwhile, by applying LLMs, LeRuD requires no data for training, and thus shows more promising rumor detection ability in few-shot or zero-shot scenarios.

Ancient rock carvings have been uncovered near the Amazon River amid drought conditions in Brazil. A set of ancient texts burned by the volcanic eruption on Mount Vesuvius in 79 A.D. have been deciphered thanks to a team of researchers using AI. The nearly 2,000-year-old texts were unreadable after being charred in a villa in Herculaneum, a Roman town near Pompeii. The texts were discovered in an ancient villa in the town of Herculaneum. Believed to have been owned by the father-in-law of Julius Caesar, the texts were carbonized by the heat of the volcanic debris.

This paper investigates the tracking problem of a smooth coordinate-invariant trajectory using dual quaternion algebra. The proposed architecture consists of a cascade structure in which the outer-loop MPC performs real-time smoothing of the manipulator's end-effector twist while an inner-loop kinematic controller ensures tracking of the instantaneous desired end-effector pose. Experiments on a $7$-DoF Franka Emika Panda robotic manipulator validate the proposed method demonstrating its application to constraint the robot twists, accelerations and jerks within prescribed bounds.

Classic Delphi and Fuzzy Delphi methods are used to test content validity of a data collection tools such as questionnaires. Fuzzy Delphi takes the opinion issued by judges from a linguistic perspective reducing ambiguity in opinions by using fuzzy numbers. We propose an extension named 2-Tuple Fuzzy Linguistic Delphi method to deal with scenarios in which judges show different expertise degrees by using fuzzy multigranular semantics of the linguistic terms and to obtain intermediate and final results expressed by 2-tuple linguistic values. The key idea of our proposal is to validate the full questionnaire by means of the evaluation of its parts, defining the validity of each item as a Decision Making problem. Taking the opinion of experts, we measure the degree of consensus, the degree of consistency, and the linguistic score of each item, in order to detect those items that affect, positively or negatively, the quality of the instrument. Considering the real need to evaluate a b-learning educational experience with a consensual questionnaire, we present a Decision Making model for questionnaire validation that solve it. Additionally, we contribute to this consensus reaching problem by developing an online tool under GPL v3 license. The software visualizes the collective valuations for each iteration and assists to determine which parts of the questionnaire should be modified to reach a consensual solution.

This work presents the early development of a model of image captioning for the Brazilian Portuguese language. We used the GRIT (Grid - and Region-based Image captioning Transformer) model to accomplish this work. GRIT is a Transformer-only neural architecture that effectively utilizes two visual features to generate better captions. The GRIT method emerged as a proposal to be a more efficient way to generate image captioning. In this work, we adapt the GRIT model to be trained in a Brazilian Portuguese dataset to have an image captioning method for the Brazilian Portuguese Language.

We apply a state-of-the-art membership inference attack (MIA) to systematically test the practical privacy vulnerability of fine-tuning large image classification models.We focus on understanding the properties of data sets and samples that make them vulnerable to membership inference. In terms of data set properties, we find a strong power law dependence between the number of examples per class in the data and the MIA vulnerability, as measured by true positive rate of the attack at a low false positive rate. For an individual sample, large gradients at the end of training are strongly correlated with MIA vulnerability.

An open scientific challenge is how to classify events with reliable measures of uncertainty, when we have a mechanistic model of the data-generating process but the distribution over both labels and latent nuisance parameters is different between train and target data. We refer to this type of distributional shift as generalized label shift (GLS). Direct classification using observed data $\mathbf{X}$ as covariates leads to biased predictions and invalid uncertainty estimates of labels $Y$. We overcome these biases by proposing a new method for robust uncertainty quantification that casts classification as a hypothesis testing problem under nuisance parameters. The key idea is to estimate the classifier's receiver operating characteristic (ROC) across the entire nuisance parameter space, which allows us to devise cutoffs that are invariant under GLS. Our method effectively endows a pre-trained classifier with domain adaptation capabilities and returns valid prediction sets while maintaining high power. We demonstrate its performance on two challenging scientific problems in biology and astroparticle physics with data from realistic mechanistic models.

Symbolic regression holds great potential for uncovering underlying mathematical and physical relationships from empirical data. While existing transformer-based models have recently achieved significant success in this domain, they face challenges in terms of generalizability and adaptability. Typically, in cases where the output expressions do not adequately fit experimental data, the models lack efficient mechanisms to adapt or modify the expression. This inflexibility hinders their application in real-world scenarios, particularly in discovering unknown physical or biological relationships. Inspired by how human experts refine and adapt expressions, we introduce Symbolic Q-network (Sym-Q), a novel reinforcement learning-based model that redefines symbolic regression as a sequential decision-making task. Sym-Q leverages supervised demonstrations and refines expressions based on reward signals indicating the quality of fitting precision. Its distinctive ability to manage the complexity of expression trees and perform precise step-wise updates significantly enhances flexibility and efficiency. Our results demonstrate that Sym-Q excels not only in recovering underlying mathematical structures but also uniquely learns to efficiently refine the output expression based on reward signals, thereby discovering underlying expressions. Sym-Q paves the way for more intuitive and impactful discoveries in physical science, marking a substantial advancement in the field of symbolic regression.