Vertebral fracture grading classifies the severity of vertebral fractures, which is a challenging task in medical imaging and has recently attracted Deep Learning (DL) models. Only a few works attempted to make such models human-interpretable despite the need for transparency and trustworthiness in critical use cases like DL-assisted medical diagnosis. Moreover, such models either rely on post-hoc methods or additional annotations. In this work, we propose a novel interpretable-by-design method, ProtoVerse, to find relevant sub-parts of vertebral fractures (prototypes) that reliably explain the model's decision in a human-understandable way. Specifically, we introduce a novel diversity-promoting loss to mitigate prototype repetitions in small datasets with intricate semantics. We have experimented with the VerSe'19 dataset and outperformed the existing prototype-based method. Further, our model provides superior interpretability against the post-hoc method.

Deep learning applications for assessing medical images are limited because the datasets are often small and imbalanced. The use of synthetic data has been proposed in the literature, but neither a robust comparison of the different methods nor generalizability has been reported. Our approach integrates a retinal image quality assessment model and StyleGAN2 architecture to enhance Age-related Macular Degeneration (AMD) detection capabilities and improve generalizability. This work compares ten different Generative Adversarial Network (GAN) architectures to generate synthetic eye-fundus images with and without AMD. We combined subsets of three public databases (iChallenge-AMD, ODIR-2019, and RIADD) to form a single training and test set. We employed the STARE dataset for external validation, ensuring a comprehensive assessment of the proposed approach. The results show that StyleGAN2 reached the lowest Frechet Inception Distance (166.17), and clinicians could not accurately differentiate between real and synthetic images. ResNet-18 architecture obtained the best performance with 85% accuracy and outperformed the two human experts (80% and 75%) in detecting AMD fundus images. The accuracy rates were 82.8% for the test set and 81.3% for the STARE dataset, demonstrating the model's generalizability. The proposed methodology for synthetic medical image generation has been validated for robustness and accuracy, with free access to its code for further research and development in this field.

Abstract: By integrating survival analysis, machine learning algorithms, and economic interpretation, this research examines the temporal dynamics associated with attaining a 5 percent rise in purchasing power parity-adjusted GDP per capita over a period of 120 months (2013-2022). A comparative investigation reveals that DeepSurv is proficient at capturing non-linear interactions, although standard models exhibit comparable performance under certain circumstances. The weight matrix evaluates the economic ramifications of vulnerabilities, risks, and capacities. In order to meet the GDPpc objective, the findings emphasize the need of a balanced approach to risk-taking, strategic vulnerability reduction, and investment in governmental capacities and social cohesiveness. Policy guidelines promote individualized approaches that take into account the complex dynamics at play while making decisions. JEL: 04, C8, C5, O1 1. Introduction In contemporary economic research, the exploration of temporal dynamics in a nation's journey to achieve a specific level of GDP per capita gains paramount importance. This empirical investigation, conducted across 33 American countries, adopts a nuanced approach by incorporating a comprehensive dataset that includes countries with right-censored data (9 countries) and those reaching a 5% increase in GDP per capita at purchasing power parity (PIBpcPPP) within 120 months (24 countries). In addressing the central query, this research aims to unravel the intricate relationship of variables and risks influencing the time required for a country to achieve the specified 5% increase in GDP per capita. Leveraging advanced statistical techniques, particularly survival analysis, the study incorporates key variables such as Vul_Inherent, Vul_Fragility_Democracy, and Vul_Human Rights, offering a robust understanding of multifaceted vulnerabilities. This academic pursuit emphasizes rigorous methodologies, empirical analyses, and data-driven insights.

Continual learning, an important aspect of artificial intelligence and machine learning research, focuses on developing models that learn and adapt to new tasks while retaining previously acquired knowledge. Existing continual learning algorithms usually involve a small number of tasks with uniform sizes and may not accurately represent real-world learning scenarios. In this paper, we investigate the performance of continual learning algorithms with a large number of tasks drawn from a task distribution that is long-tail in terms of task sizes. We design one synthetic dataset and two real-world continual learning datasets to evaluate the performance of existing algorithms in such a setting. Moreover, we study an overlooked factor in continual learning, the optimizer states, e.g. first and second moments in the Adam optimizer, and investigate how it can be used to improve continual learning performance. We propose a method that reuses the optimizer states in Adam by maintaining a weighted average of the second moments from previous tasks. We demonstrate that our method, compatible with most existing continual learning algorithms, effectively reduces forgetting with only a small amount of additional computational or memory costs, and provides further improvements on existing continual learning algorithms, particularly in a long-tail task sequence.

Facts are subject to contingencies and can be true or false in different circumstances. One such contingency is time, wherein some facts mutate over a given period, e.g., the president of a country or the winner of a championship. Trustworthy language models ideally identify mutable facts as such and process them accordingly. We create MuLan, a benchmark for evaluating the ability of English language models to anticipate time-contingency, covering both 1:1 and 1:N relations. We hypothesize that mutable facts are encoded differently than immutable ones, hence being easier to update. In a detailed evaluation of six popular large language models, we consistently find differences in the LLMs' confidence, representations, and update behavior, depending on the mutability of a fact. Our findings should inform future work on the injection of and induction of time-contingent knowledge to/from LLMs.

This paper investigates whether recent advances in Large Language Models (LLMs) can assist in translating human explanations into a format that can robustly support learning Linear Temporal Logic (LTL) from demonstrations. Both LLMs and optimization-based methods can extract LTL specifications from demonstrations; however, they have distinct limitations. LLMs can quickly generate solutions and incorporate human explanations, but their lack of consistency and reliability hampers their applicability in safety-critical domains. On the other hand, optimization-based methods do provide formal guarantees but cannot process natural language explanations and face scalability challenges. We present a principled approach to combining LLMs and optimization-based methods to faithfully translate human explanations and demonstrations into LTL specifications. We have implemented a tool called Janaka based on our approach. Our experiments demonstrate the effectiveness of combining explanations with demonstrations in learning LTL specifications through several case studies.

In the context of multi-view clustering, graph learning is recognized as a crucial technique, which generally involves constructing an adaptive neighbor graph based on probabilistic neighbors, and then learning a consensus graph to for clustering. However, they are confronted with two limitations. Firstly, they often rely on Euclidean distance to measure similarity when constructing the adaptive neighbor graph, which proves inadequate in capturing the intrinsic structure among data points in practice. Secondly, most of these methods focus solely on consensus graph, ignoring unique information from each view. Although a few graph-based studies have considered using specific information as well, the modelling approach employed does not exclude the noise impact from the specific component. To this end, we propose a novel tensor-based multi-view graph learning framework that simultaneously considers consistency and specificity, while effectively eliminating the influence of noise. Specifically, we calculate similarity distance on the Stiefel manifold to preserve the intrinsic properties of data. By making an assumption that the learned neighbor graph of each view comprises a consistent part, a specific part, and a noise part, we formulate a new tensor-based target graph learning paradigm for noise-free graph fusion. Owing to the benefits of tensor singular value decomposition (t-SVD) in uncovering high-order correlations, this model is capable of achieving a complete understanding of the target graph. Furthermore, we derive an algorithm to address the optimization problem. Experiments on six datasets have demonstrated the superiority of our method. We have released the source code on https://github.com/lshi91/CSTGL-Code.

Deep neural networks (DNNs) have revolutionized artificial intelligence but often lack performance when faced with out-of-distribution (OOD) data, a common scenario due to the inevitable domain shifts in real-world applications. This limitation stems from the common assumption that training and testing data share the same distribution-an assumption frequently violated in practice. Despite their effectiveness with large amounts of data and computational power, DNNs struggle with distributional shifts and limited labeled data, leading to overfitting and poor generalization across various tasks and domains. Meta-learning presents a promising approach by employing algorithms that acquire transferable knowledge across various tasks for fast adaptation, eliminating the need to learn each task from scratch. This survey paper delves into the realm of meta-learning with a focus on its contribution to domain generalization. We first clarify the concept of meta-learning for domain generalization and introduce a novel taxonomy based on the feature extraction strategy and the classifier learning methodology, offering a granular view of methodologies. Through an exhaustive review of existing methods and underlying theories, we map out the fundamentals of the field. Our survey provides practical insights and an informed discussion on promising research directions, paving the way for future innovation in meta-learning for domain generalization.

Recent advancements in Large Language Models (LLMs) have facilitated the development of Multimodal LLMs (MLLMs). Despite their impressive capabilities, MLLMs often suffer from an over-reliance on unimodal biases (e.g., language bias and vision bias), leading to incorrect answers in complex multimodal tasks. To investigate this issue, we propose a causal framework to interpret the biases in Visual Question Answering (VQA) problems. Within our framework, we devise a causal graph to elucidate the predictions of MLLMs on VQA problems, and assess the causal effect of biases through an in-depth causal analysis. Motivated by the causal graph, we introduce a novel MORE dataset, consisting of 12,000 VQA instances. This dataset is designed to challenge MLLMs' abilities, necessitating multi-hop reasoning and the surmounting of unimodal biases. Furthermore, we propose two strategies to mitigate unimodal biases and enhance MLLMs' reasoning capabilities, including a Decompose-Verify-Answer (DeVA) framework for limited-access MLLMs and the refinement of open-source MLLMs through fine-tuning. Extensive quantitative and qualitative experiments offer valuable insights for future research. Our project page is at https://opencausalab.github.io/MORE.

Large Language Models (LLMs) like ChatGPT and Llama2 have revolutionized natural language processing and search engine dynamics. However, these models incur exceptionally high computational costs. For instance, GPT-3 consists of 175 billion parameters where inference demands billions of floating-point operations. Caching is a natural solution to reduce LLM inference costs on repeated queries which constitute about 31% of the total queries. However, existing caching methods are incapable of finding semantic similarities among LLM queries, leading to unacceptable false hit-and-miss rates. This paper introduces MeanCache, a user-centric semantic cache for LLMs that identifies semantically similar queries to determine cache hit or miss. Using MeanCache, the response to a user's semantically similar query can be retrieved from a local cache rather than re-querying the LLM, thus reducing costs, service provider load, and environmental impact. Existing caching solutions for LLMs raise privacy and scalability concerns and perform wasteful query requests. MeanCache leverages Federated Learning (FL) to collaboratively train a query similarity model across LLM users without violating privacy. By placing a local cache in each user's device and using FL, MeanCache reduces the latency and costs and enhances model performance, resulting in lower false hit rates. MeanCache compresses the embedding dimensions to minimize cache storage and also finds the optimal cosine similarity threshold. Our experiments benchmarked against the state-of-the-art caching method, reveal that MeanCache attains an approximately 17% higher F-score and a 20% increase in precision during semantic cache hit-and-miss decisions. It also reduces the storage requirement by 83% and accelerates semantic cache hit-and-miss decisions by 11%.