The Brain-Heart Interconnectome (BHI) combines neurology and cardiology but is hindered by inefficiencies in evidence synthesis, poor adherence to quality standards, and research waste. To address these challenges, we developed an AI-driven system to enhance systematic reviews in the BHI domain. The system integrates automated detection of Population, Intervention, Comparator, Outcome, and Study design (PICOS), semantic search using vector embeddings, graph-based querying, and topic modeling to identify redundancies and underexplored areas. Core components include a Bi-LSTM model achieving 87% accuracy for PICOS compliance, a study design classifier with 95.7% accuracy, and Retrieval-Augmented Generation (RAG) with GPT-3.5, which outperformed GPT-4 for graph-based and topic-driven queries. The system provides real-time updates, reducing research waste through a living database and offering an interactive interface with dashboards and conversational AI. While initially developed for BHI, the system's adaptable architecture enables its application across various biomedical fields, supporting rigorous evidence synthesis, efficient resource allocation, and informed clinical decision-making.

Most conference papers present new results, but this paper will focus more on opportunities for the audience to make their own contributions. This paper is intended to challenge the community to think more broadly about what we can do with comparable corpora. We will start with a review of the history, and then suggest new directions for future research. This was a keynote at BUCC-2025, a workshop associated with Coling-2025.

In transportation systems and autonomous vehicles, intelligent agents must understand the future motion of traffic participants to effectively plan motion trajectories. At the same time, the motion of traffic participants is inherently uncertain. In this paper, we propose TrajFlow, a generative framework for estimating the occupancy density of traffic participants. Our framework utilizes a causal encoder to extract semantically meaningful embeddings of the observed trajectory, as well as a normalizing flow to decode these embeddings and determine the most likely future location of traffic participants at some time point in the future. Our formulation differs from existing approaches because we model the marginal distribution of spatial locations instead of the joint distribution of unobserved trajectories. The advantages of a marginal formulation are numerous. First, we demonstrate that the marginal formulation produces higher accuracy on challenging trajectory forecasting benchmarks. Second, the marginal formulation allows for a fully continuous sampling of future locations. Finally, marginal densities are better suited for downstream tasks as they allow for the computation of per-agent motion trajectories and occupancy grids, the two most commonly used representations for motion forecasting. We present a novel architecture based entirely on neural differential equations as an implementation of this framework and provide ablations to demonstrate the advantages of a continuous implementation over a more traditional discrete neural network based approach. The code is available at https://github.com/kosieram21/TrajFlow .

Autonomous Driving Systems (ADSs) are safety-critical, as real-world safety violations can result in significant losses. Rigorous testing is essential before deployment, with simulation testing playing a key role. However, ADSs are typically complex, consisting of multiple modules such as perception and planning, or well-trained end-to-end autonomous driving systems. Offline methods, such as the Genetic Algorithm (GA), can only generate predefined trajectories for dynamics, which struggle to cause safety violations for ADSs rapidly and efficiently in different scenarios due to their evolutionary nature. Online methods, such as single-agent reinforcement learning (RL), can quickly adjust the dynamics' trajectory online to adapt to different scenarios, but they struggle to capture complex corner cases of ADS arising from the intricate interplay among multiple vehicles. Multi-agent reinforcement learning (MARL) has a strong ability in cooperative tasks. On the other hand, it faces its own challenges, particularly with convergence. This paper introduces MARL-OT, a scalable framework that leverages MARL to detect safety violations of ADS resulting from surrounding vehicles' cooperation. MARL-OT employs MARL for high-level guidance, triggering various dangerous scenarios for the rule-based online fuzzer to explore potential safety violations of ADS, thereby generating dynamic, realistic safety violation scenarios. Our approach improves the detected safety violation rate by up to 136.2% compared to the state-of-the-art (SOTA) testing technique.

Spectral clustering is a powerful technique for clustering high-dimensional data, utilizing graph-based representations to detect complex, non-linear structures and non-convex clusters. The construction of a similarity graph is essential for ensuring accurate and effective clustering, making graph structure learning (GSL) central for enhancing spectral clustering performance in response to the growing demand for scalable solutions. Despite advancements in GSL, there is a lack of comprehensive surveys specifically addressing its role within spectral clustering. To bridge this gap, this survey presents a comprehensive review of spectral clustering methods, emphasizing on the critical role of GSL. We explore various graph construction techniques, including pairwise, anchor, and hypergraph-based methods, in both fixed and adaptive settings. Additionally, we categorize spectral clustering approaches into single-view and multi-view frameworks, examining their applications within one-step and two-step clustering processes. We also discuss multi-view information fusion techniques and their impact on clustering data. By addressing current challenges and proposing future research directions, this survey provides valuable insights for advancing spectral clustering methodologies and highlights the pivotal role of GSL in tackling large-scale and high-dimensional data clustering tasks.

The level of tumour-infiltrating lymphocytes (TILs) is a prognostic factor for patients with (triple-negative) breast cancer (BC). Computational TIL assessment (CTA) has the potential to assist pathologists in this labour-intensive task, but current CTA models rely heavily on many detailed annotations. We propose and validate a fundamentally simpler deep learning based CTA that can be trained in only ten minutes on hundredfold fewer pathologist annotations. We collected whole slide images (WSIs) with TILs scores and clinical data of 2,340 patients with BC from six cohorts including three randomised clinical trials. Morphological features were extracted from whole slide images (WSIs) using a pathology foundation model. Our label-efficient Computational stromal TIL assessment model (ECTIL) directly regresses the TILs score from these features. ECTIL trained on only a few hundred samples (ECTIL-TCGA) showed concordance with the pathologist over five heterogeneous external cohorts (r=0.54-0.74, AUROC=0.80-0.94). Training on all slides of five cohorts (ECTIL-combined) improved results on a held-out test set (r=0.69, AUROC=0.85). Multivariable Cox regression analyses indicated that every 10% increase of ECTIL scores was associated with improved overall survival independent of clinicopathological variables (HR 0.86, p<0.01), similar to the pathologist score (HR 0.87, p<0.001). We demonstrate that ECTIL is highly concordant with an expert pathologist and obtains a similar hazard ratio. ECTIL has a fundamentally simpler design than existing methods and can be trained on orders of magnitude fewer annotations. Such a CTA may be used to pre-screen patients for, e.g., immunotherapy clinical trial inclusion, or as a tool to assist clinicians in the diagnostic work-up of patients with BC. Our model is available under an open source licence (https://github.com/nki-ai/ectil).

Large language models (LLMs) are expected to offer structured Markdown responses for the sake of readability in web chatbots (e.g., ChatGPT). Although there are a myriad of metrics to evaluate LLMs, they fail to evaluate the readability from the view of output content structure. To this end, we focus on an overlooked yet important metric -- Markdown Awareness, which directly impacts the readability and structure of the content generated by these language models. In this paper, we introduce MDEval, a comprehensive benchmark to assess Markdown Awareness for LLMs, by constructing a dataset with 20K instances covering 10 subjects in English and Chinese. Unlike traditional model-based evaluations, MDEval provides excellent interpretability by combining model-based generation tasks and statistical methods. Our results demonstrate that MDEval achieves a Spearman correlation of 0.791 and an accuracy of 84.1% with human, outperforming existing methods by a large margin. Extensive experimental results also show that through fine-tuning over our proposed dataset, less performant open-source models are able to achieve comparable performance to GPT-4o in terms of Markdown Awareness. To ensure reproducibility and transparency, MDEval is open sourced at https://github.com/SWUFE-DB-Group/MDEval-Benchmark.

Cross-lingual transfer is a popular approach to increase the amount of training data for NLP tasks in a low-resource context. However, the best strategy to decide which cross-lingual data to include is unclear. Prior research often focuses on a small set of languages from a few language families and/or a single task. It is still an open question how these findings extend to a wider variety of languages and tasks. In this work, we analyze cross-lingual transfer for 266 languages from a wide variety of language families. Moreover, we include three popular NLP tasks: POS tagging, dependency parsing, and topic classification. Our findings indicate that the effect of linguistic similarity on transfer performance depends on a range of factors: the NLP task, the (mono- or multilingual) input representations, and the definition of linguistic similarity.

Existing score-based methods for directed acyclic graph (DAG) learning from observational data struggle to recover the causal graph accurately and sample-efficiently. To overcome this, in this study, we propose DrBO (DAG recovery via Bayesian Optimization)-a novel DAG learning framework leveraging Bayesian optimization (BO) to find high-scoring DAGs. We show that, by sophisticatedly choosing the promising DAGs to explore, we can find higher-scoring ones much more efficiently. To address the scalability issues of conventional BO in DAG learning, we replace Gaussian Processes commonly employed in BO with dropout neural networks, trained in a continual manner, which allows for (i) flexibly modeling the DAG scores without overfitting, (ii) incorporation of uncertainty into the estimated scores, and (iii) scaling with the number of evaluations. As a result, DrBO is computationally efficient and can find the accurate DAG in fewer trials and less time than existing state-of-the-art methods. This is demonstrated through an extensive set of empirical evaluations on many challenging settings with both synthetic and real data. Our implementation is available at https://github.com/baosws/DrBO.

Extractive summarization involves selecting the most relevant sentences from a text. Recently, researchers have focused on advancing methods to improve state-of-the-art results in low-resource settings. Motivated by these advancements, we propose the MPoincareSum method. This method applies the Mamba state space model to generate the semantics of reviews and sentences, which are then concatenated. A Poincare compression is used to select the most meaningful features, followed by the application of a linear layer to predict sentence relevance based on the corresponding review. Finally, we paraphrase the relevant sentences to create the final summary. To evaluate the effectiveness of MPoincareSum, we conducted extensive experiments using the Amazon review dataset. The performance of the method was assessed using ROUGE scores. The experimental results demonstrate that MPoincareSum outperforms several existing approaches in the literature