This study investigates the feasibility of automating clinical coding in Russian, a language with limited biomedical resources. We present a new dataset for ICD coding, which includes diagnosis fields from electronic health records (EHRs) annotated with over 10,000 entities and more than 1,500 unique ICD codes. This dataset serves as a benchmark for several state-of-the-art models, including BERT, LLaMA with LoRA, and RAG, with additional experiments examining transfer learning across domains (from PubMed abstracts to medical diagnosis) and terminologies (from UMLS concepts to ICD codes). We then apply the best-performing model to label an in-house EHR dataset containing patient histories from 2017 to 2021. Our experiments, conducted on a carefully curated test set, demonstrate that training with the automated predicted codes leads to a significant improvement in accuracy compared to manually annotated data from physicians. We believe our findings offer valuable insights into the potential for automating clinical coding in resource-limited languages like Russian, which could enhance clinical efficiency and data accuracy in these contexts.

Tuberculosis (TB) is the leading cause of death from an infectious disease globally, with the highest burden in low- and middle-income countries. In these regions, limited healthcare access and high patient-to-provider ratios impede effective patient support, communication, and treatment completion. To bridge this gap, we propose integrating a specialized Large Language Model into an efficacious digital adherence technology to augment interactive communication with treatment supporters. This AI-powered approach, operating within a human-in-the-loop framework, aims to enhance patient engagement and improve TB treatment outcomes.

Explainable AI (XAI) is concerned with how to make AI models more understandable to people. To date these explanations have predominantly been technocentric - mechanistic or productivity oriented. This paper introduces the Explainable AI for the Arts (XAIxArts) manifesto to provoke new ways of thinking about explainability and AI beyond technocentric discourses. Manifestos offer a means to communicate ideas, amplify unheard voices, and foster reflection on practice. To supports the co-creation and revision of the XAIxArts manifesto we combine a World Caf\'e style discussion format with a living manifesto to question four core themes: 1) Empowerment, Inclusion, and Fairness; 2) Valuing Artistic Practice; 3) Hacking and Glitches; and 4) Openness. Through our interactive living manifesto experience we invite participants to actively engage in shaping this XIAxArts vision within the CHI community and beyond.

Background: With the increasing availability of healthcare data, predictive modeling finds many applications in the biomedical domain, such as the evaluation of the level of risk for various conditions, which in turn can guide clinical decision making. However, it is unclear how knowledge graph data representations and their embedding, which are competitive in some settings, could be of interest in biomedical predictive modeling. Method: We simulated synthetic but realistic data of patients with intracranial aneurysm and experimented on the task of predicting their clinical outcome. We compared the performance of various classification approaches on tabular data versus a graph-based representation of the same data. Next, we investigated how the adopted schema for representing first individual data and second temporal data impacts predictive performances. Results: Our study illustrates that in our case, a graph representation and Graph Convolutional Network (GCN) embeddings reach the best performance for a predictive task from observational data. We emphasize the importance of the adopted schema and of the consideration of literal values in the representation of individual data.

Simulating prospective magnetic resonance imaging (MRI) scans from a given individual brain image is challenging, as it requires accounting for canonical changes in aging and/or disease progression while also considering the individual brain's current status and unique characteristics. While current deep generative models can produce high-resolution anatomically accurate templates for population-wide studies, their ability to predict future aging trajectories for individuals remains limited, particularly in capturing subject-specific neuroanatomical variations over time. In this study, we introduce Individualized Brain Synthesis (InBrainSyn), a framework for synthesizing high-resolution subject-specific longitudinal MRI scans that simulate neurodegeneration in both Alzheimer's disease (AD) and normal aging. InBrainSyn uses a parallel transport algorithm to adapt the population-level aging trajectories learned by a generative deep template network, enabling individualized aging synthesis. As InBrainSyn uses diffeomorphic transformations to simulate aging, the synthesized images are topologically consistent with the original anatomy by design. We evaluated InBrainSyn both quantitatively and qualitatively on AD and healthy control cohorts from the Open Access Series of Imaging Studies - version 3 dataset. Experimentally, InBrainSyn can also model neuroanatomical transitions between normal aging and AD. An evaluation of an external set supports its generalizability. Overall, with only a single baseline scan, InBrainSyn synthesizes realistic 3D spatiotemporal T1w MRI scans, producing personalized longitudinal aging trajectories. The code for InBrainSyn is available at: https://github.com/Fjr9516/InBrainSyn.

Multi-trait automated essay scoring (AES) systems provide a fine-grained evaluation of an essay's diverse aspects. While they excel in scoring, prior systems fail to explain why specific trait scores are assigned. This lack of transparency leaves instructors and learners unconvinced of the AES outputs, hindering their practical use. To address this, we propose a self-explainable Rationale-Driven Multi-trait automated Essay scoring (RaDME) framework. RaDME leverages the reasoning capabilities of large language models (LLMs) by distilling them into a smaller yet effective scorer. This more manageable student model is optimized to sequentially generate a trait score followed by the corresponding rationale, thereby inherently learning to select a more justifiable score by considering the subsequent rationale during training. Our findings indicate that while LLMs underperform in direct AES tasks, they excel in rationale generation when provided with precise numerical scores. Thus, RaDME integrates the superior reasoning capacities of LLMs into the robust scoring accuracy of an optimized smaller model. Extensive experiments demonstrate that RaDME achieves both accurate and adequate reasoning while supporting high-quality multi-trait scoring, significantly enhancing the transparency of AES.

Neuromorphic engineering aims to advance computing by mimicking the brain's efficient processing, where data is encoded as asynchronous temporal events. This eliminates the need for a synchronisation clock and minimises power consumption when no data is present. However, many benchmarks for neuromorphic algorithms primarily focus on spatial features, neglecting the temporal dynamics that are inherent to most sequence-based tasks. This gap may lead to evaluations that fail to fully capture the unique strengths and characteristics of neuromorphic systems. In this paper, we present NeuroMorse, a temporally structured dataset designed for benchmarking neuromorphic learning systems. NeuroMorse converts the top 50 words in the English language into temporal Morse code spike sequences. Despite using only two input spike channels for Morse dots and dashes, complex information is encoded through temporal patterns in the data. The proposed benchmark contains feature hierarchy at multiple temporal scales that test the capacity of neuromorphic algorithms to decompose input patterns into spatial and temporal hierarchies. We demonstrate that our training set is challenging to categorise using a linear classifier and that identifying keywords in the test set is difficult using conventional methods.

Generating realistic synthetic electronic health records (EHRs) holds tremendous promise for accelerating healthcare research, facilitating AI model development and enhancing patient privacy. However, existing generative methods typically treat EHRs as flat sequences of discrete medical codes. This approach overlooks two critical aspects: the inherent hierarchical organization of clinical coding systems and the rich semantic context provided by code descriptions. Consequently, synthetic patient sequences often lack high clinical fidelity and have limited utility in downstream clinical tasks. In this paper, we propose the Hierarchy- and Semantics-Guided Transformer (HiSGT), a novel framework that leverages both hierarchical and semantic information for the generative process. HiSGT constructs a hierarchical graph to encode parent-child and sibling relationships among clinical codes and employs a graph neural network to derive hierarchy-aware embeddings. These are then fused with semantic embeddings extracted from a pre-trained clinical language model (e.g., ClinicalBERT), enabling the Transformer-based generator to more accurately model the nuanced clinical patterns inherent in real EHRs. Extensive experiments on the MIMIC-III and MIMIC-IV datasets demonstrate that HiSGT significantly improves the statistical alignment of synthetic data with real patient records, as well as supports robust downstream applications such as chronic disease classification. By addressing the limitations of conventional raw code-based generative models, HiSGT represents a significant step toward clinically high-fidelity synthetic data generation and a general paradigm suitable for interpretable medical code representation, offering valuable applications in data augmentation and privacy-preserving healthcare analytics.

Deploying digital pathology models across medical centers is challenging due to distribution shifts. Recent advances in domain generalization improve model transferability in terms of aggregated performance measured by the Area Under Curve (AUC). However, clinical regulations often require to control the transferability of other metrics, such as prescribed sensitivity levels. We introduce a novel approach to control the sensitivity of whole slide image (WSI) classification models, based on optimal transport and Multiple Instance Learning (MIL). Validated across multiple cohorts and tasks, our method enables robust sensitivity control with only a handful of calibration samples, providing a practical solution for reliable deployment of computational pathology systems.

Accurate regional climate forecast calls for high-resolution downscaling of Global Climate Models (GCMs). This work presents a deep-learning-based multi-model evaluation and downscaling framework ranking 32 Coupled Model Intercomparison Project Phase 6 (CMIP6) models using a Deep Learning-TOPSIS (DL-TOPSIS) mechanism and so refines outputs using advanced deep-learning models. Using nine performance criteria, five K\"oppen-Geiger climate zones -- Tropical, Arid, Temperate, Continental, and Polar -- are investigated over four seasons. While TaiESM1 and CMCC-CM2-SR5 show notable biases, ranking results show that NorESM2-LM, GISS-E2-1-G, and HadGEM3-GC31-LL outperform other models. Four models contribute to downscaling the top-ranked GCMs to 0.1$^{\circ}$ resolution: Vision Transformer (ViT), Geospatial Spatiotemporal Transformer with Attention and Imbalance-Aware Network (GeoSTANet), CNN-LSTM, and CNN-Long Short-Term Memory (ConvLSTM). Effectively capturing temperature extremes (TXx, TNn), GeoSTANet achieves the highest accuracy (Root Mean Square Error (RMSE) = 1.57$^{\circ}$C, Kling-Gupta Efficiency (KGE) = 0.89, Nash-Sutcliffe Efficiency (NSE) = 0.85, Correlation ($r$) = 0.92), so reducing RMSE by 20% over ConvLSTM. CNN-LSTM and ConvLSTM do well in Continental and Temperate zones; ViT finds fine-scale temperature fluctuations difficult. These results confirm that multi-criteria ranking improves GCM selection for regional climate studies and transformer-based downscaling exceeds conventional deep-learning methods. This framework offers a scalable method to enhance high-resolution climate projections, benefiting impact assessments and adaptation plans.