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Constructing a Knowledge Base for Gene Regulatory Dynamics by Formal Concept Analysis Methods

arXiv.org Artificial Intelligence

Our aim is to build a set of rules, such that reasoning over temporal dependencies within gene regulatory networks is possible. The underlying transitions may be obtained by discretizing observed time series, or they are generated based on existing knowledge, e.g. by Boolean networks or their nondeterministic generalization. We use the mathematical discipline of formal concept analysis (FCA), which has been applied successfully in domains as knowledge representation, data mining or software engineering. By the attribute exploration algorithm, an expert or a supporting computer program is enabled to decide about the validity of a minimal set of implications and thus to construct a sound and complete knowledge base. From this all valid implications are derivable that relate to the selected properties of a set of genes. We present results of our method for the initiation of sporulation in Bacillus subtilis. However the formal structures are exhibited in a most general manner. Therefore the approach may be adapted to signal transduction or metabolic networks, as well as to discrete temporal transitions in many biological and nonbiological areas.


CPBVP: A Constraint-Programming Framework for Bounded Program Verification

arXiv.org Artificial Intelligence

This paper studies how to verify the conformity of a program with its specification and proposes a novel constraint-programming framework for bounded program verification (CPBPV). The CPBPV framework uses constraint stores to represent the specification and the program and explores execution paths nondeterministically. The input program is partially correct if each constraint store so produced implies the post-condition. CPBPV does not explore spurious execution paths as it incrementally prunes execution paths early by detecting that the constraint store is not consistent. CPBPV uses the rich language of constraint programming to express the constraint store. Finally, CPBPV is parametrized with a list of solvers which are tried in sequence, starting with the least expensive and less general. Experimental results often produce orders of magnitude improvements over earlier approaches, running times being often independent of the variable domains. Moreover, CPBPV was able to detect subtle errors in some programs while other frameworks based on model checking have failed.


Gaussian Processes and Limiting Linear Models

arXiv.org Machine Learning

Gaussian processes retain the linear model either as a special case, or in the limit. We show how this relationship can be exploited when the data are at least partially linear. However from the perspective of the Bayesian posterior, the Gaussian processes which encode the linear model either have probability of nearly zero or are otherwise unattainable without the explicit construction of a prior with the limiting linear model in mind. We develop such a prior, and show that its practical benefits extend well beyond the computational and conceptual simplicity of the linear model. For example, linearity can be extracted on a per-dimension basis, or can be combined with treed partition models to yield a highly efficient nonstationary model. Our approach is demonstrated on synthetic and real datasets of varying linearity and dimensionality.


Algorithm Selection as a Bandit Problem with Unbounded Losses

arXiv.org Artificial Intelligence

Algorithm selection is typically based on models of algorithm performance, learned during a separate offline training sequence, which can be prohibitively expensive. In recent work, we adopted an online approach, in which a performance model is iteratively updated and used to guide selection on a sequence of problem instances. The resulting exploration-exploitation trade-off was represented as a bandit problem with expert advice, using an existing solver for this game, but this required the setting of an arbitrary bound on algorithm runtimes, thus invalidating the optimal regret of the solver. In this paper, we propose a simpler framework for representing algorithm selection as a bandit problem, with partial information, and an unknown bound on losses. We adapt an existing solver to this game, proving a bound on its expected regret, which holds also for the resulting algorithm selection technique. We present preliminary experiments with a set of SAT solvers on a mixed SAT-UNSAT benchmark.


Action Programming Languages

Morgan & Claypool Publishers

Artificial systems that think and behave intelligently are one of the most exciting and challenging goals of Artificial Intelligence. Action Programming is the art and science of devising high-level control strategies for autonomous systems which employ a mental model of their environment and which reason about their actions as a means to achieve their goals. Applications of this programming paradigm include autonomous software agents, mobile robots with high-level reasoning capabilities, and General Game Playing. These lecture notes give an in-depth introduction to the current state-of-the-art in action programming. The main topics are knowledge representation for actions, procedural action programming, planning, agent logic programs, and reactive, behavior-based agents.


Catching Up Faster by Switching Sooner: A Prequential Solution to the AIC-BIC Dilemma

arXiv.org Machine Learning

Bayesian model averaging, model selection and its approximations such as BIC are generally statistically consistent, but sometimes achieve slower rates og convergence than other methods such as AIC and leave-one-out cross-validation. On the other hand, these other methods can br inconsistent. We identify the "catch-up phenomenon" as a novel explanation for the slow convergence of Bayesian methods. Based on this analysis we define the switch distribution, a modification of the Bayesian marginal distribution. We show that, under broad conditions,model selection and prediction based on the switch distribution is both consistent and achieves optimal convergence rates, thereby resolving the AIC-BIC dilemma. The method is practical; we give an efficient implementation. The switch distribution has a data compression interpretation, and can thus be viewed as a "prequential" or MDL method; yet it is different from the MDL methods that are usually considered in the literature. We compare the switch distribution to Bayes factor model selection and leave-one-out cross-validation.


Belief decision support and reject for textured images characterization

arXiv.org Artificial Intelligence

The textured images' classification assumes to consider the images in terms of area with the same texture. In uncertain environment, it could be better to take an imprecise decision or to reject the area corresponding to an unlearning class. Moreover, on the areas that are the classification units, we can have more than one texture. These considerations allows us to develop a belief decision model permitting to reject an area as unlearning and to decide on unions and intersections of learning classes. The proposed approach finds all its justification in an application of seabed characterization from sonar images, which contributes to an illustration.


Unveiling the mystery of visual information processing in human brain

arXiv.org Artificial Intelligence

It is generally accepted that human vision is an extremely powerful information processing system that facilitates our interaction with the surrounding world. However, despite extended and extensive research efforts, which encompass many exploration fields, the underlying fundamentals and operational principles of visual information processing in human brain remain unknown. We still are unable to figure out where and how along the path from eyes to the cortex the sensory input perceived by the retina is converted into a meaningful object representation, which can be consciously manipulated by the brain. Studying the vast literature considering the various aspects of brain information processing, I was surprised to learn that the respected scholarly discussion is totally indifferent to the basic keynote question: "What is information?" in general or "What is visual information?" in particular. In the old days, it was assumed that any scientific research approach has first to define its basic departure points. Why was it overlooked in brain information processing research remains a conundrum. In this paper, I am trying to find a remedy for this bizarre situation. I propose an uncommon definition of "information", which can be derived from Kolmogorov's Complexity Theory and Chaitin's notion of Algorithmic Information. Embracing this new definition leads to an inevitable revision of traditional dogmas that shape the state of the art of brain information processing research. I hope this revision would better serve the challenging goal of human visual information processing modeling.


A General Theory of Additive State Space Abstractions

Journal of Artificial Intelligence Research

Informally, a set of abstractions of a state space S is additive if the distance between any two states in S is always greater than or equal to the sum of the corresponding distances in the abstract spaces. The first known additive abstractions, called disjoint pattern databases, were experimentally demonstrated to produce state of the art performance on certain state spaces. However, previous applications were restricted to state spaces with special properties, which precludes disjoint pattern databases from being defined for several commonly used testbeds, such as Rubik's Cube, TopSpin and the Pancake puzzle. In this paper we give a general definition of additive abstractions that can be applied to any state space and prove that heuristics based on additive abstractions are consistent as well as admissible. We use this new definition to create additive abstractions for these testbeds and show experimentally that well chosen additive abstractions can reduce search time substantially for the (18,4)-TopSpin puzzle and by three orders of magnitude over state of the art methods for the 17-Pancake puzzle. We also derive a way of testing if the heuristic value returned by additive abstractions is provably too low and show that the use of this test can reduce search time for the 15-puzzle and TopSpin by roughly a factor of two.


A Unifying Framework for Structural Properties of CSPs: Definitions, Complexity, Tractability

Journal of Artificial Intelligence Research

Literature on Constraint Satisfaction exhibits the definition of several ``structural'' properties that can be possessed by CSPs, like (in)consistency, substitutability or interchangeability. Current tools for constraint solving typically detect such properties efficiently by means of incomplete yet effective algorithms, and use them to reduce the search space and boost search. In this paper, we provide a unifying framework encompassing most of the properties known so far, both in CSP and other fields' literature, and shed light on the semantical relationships among them. This gives a unified and comprehensive view of the topic, allows new, unknown, properties to emerge, and clarifies the computational complexity of the various detection problems. In particular, among the others, two new concepts, fixability and removability emerge, that come out to be the ideal characterisations of values that may be safely assigned or removed from a variable's domain, while preserving problem satisfiability. These two notions subsume a large number of known properties, including inconsistency, substitutability and others. Because of the computational intractability of all the property-detection problems, by following the CSP approach we then determine a number of relaxations which provide sufficient conditions for their tractability. In particular, we exploit forms of language restrictions and local reasoning.