Archaeologists say they located a Black Death burial site containing some of a village's 12,000 dead. Breakthroughs, discoveries, and DIY tips sent six days a week. The Black Death () killed as much as half of Europe's total population between 1346 and 1353, so there are a of bodies buried across the continent. For example, contemporary accounts from Thuringia--a state in central Germany--report that about 12,000 plague victims died around Erfurt amid the city's outbreak in 1350. But despite multiple accounts attesting to this devastation, none of the 11 mass graves could be pinpointed for centuries.

High-resolution climate projections are essential for local decision-making. However, available climate projections have low spatial resolution (e.g. 12.5 km), which limits their usability. We address this limitation by leveraging single-image super-resolution models to statistically downscale climate projections to 1-km resolution. Since high-resolution climate projections are unavailable, we train models on a high-resolution observational gridded data set and apply them to low-resolution climate projections. We cannot evaluate downscaled climate projections with common metrics (e.g. pixel-wise root-mean-square error) because we lack ground-truth high-resolution climate projections. Therefore, we evaluate climate indicators computed at weather station locations. Experiments on daily mean temperature demonstrate that single-image super-resolution models can downscale climate projections without increasing the error of climate indicators compared to low-resolution climate projections.

Despite decades of progress in machine learning applications for predicting molecular structures from MS/MS spectra, the development of new methods is severely hindered by the lack of standard datasets and evaluation protocols. To address this problem, we propose MassSpecGym - the first comprehensive benchmark for the discovery and identification of molecules from MS/MS data.

Lightweight deep learning models offer substantial reductions in computational cost and environmental impact, making them crucial for scientific applications. We present a lightweight CycleGAN for modality transfer in fluorescence microscopy (confocal to super-resolution STED/deconvolved STED), addressing the common challenge of unpaired datasets. By replacing the traditional channel-doubling strategy in the U-Net-based generator with a fixed channel approach, we drastically reduce trainable parameters from 41.8 million to approximately nine thousand, achieving superior performance with faster training and lower memory usage. We also introduce the GAN as a diagnostic tool for experimental and labeling quality. When trained on high-quality images, the GAN learns the characteristics of optimal imaging; deviations between its generated outputs and new experimental images can reveal issues such as photobleaching, artifacts, or inaccurate labeling. This establishes the model as a practical tool for validating experimental accuracy and image fidelity in microscopy workflows.

The Hessian of a differentiable convex function is positive semidefinite.

The COVID-19 pandemic has highlighted the need for quantitative modeling and analysis to understand real-world disease dynamics. In particular, post hoc analyses using compartmental models offer valuable insights into the effectiveness of public health interventions, such as vaccination strategies and containment policies. However, such compartmental models like SIR (Susceptible-Infectious-Recovered) often face limitations in directly incorporating noisy observational data. In this work, we employ Physics-Informed Neural Networks (PINNs) to solve the inverse problem of the SIR model using infection data from the Robert Koch Institute (RKI). Our main contribution is a fine-grained, spatio-temporal analysis of COVID-19 dynamics across all German federal states over a three-year period. We estimate state-specific transmission and recovery parameters and time-varying reproduction number (R_t) to track the pandemic progression. The results highlight strong variations in transmission behavior across regions, revealing correlations with vaccination uptake and temporal patterns associated with major pandemic phases. Our findings demonstrate the utility of PINNs in localized, long-term epidemiological modeling.

W in V, W is independent of V\ ( Descendants(W) Parents( W)) given Parents (W) . As expected we see that the number of detected causes by Granger is multiple times more than those of SyPI; in most cases Granger detects as causes all the candidate states. On the other hand, SyPI does not suffer from such problems even when there are latent confounders. Finally, in the third column, we report the detected distant causes. Strict thresholds (the default of SyPI method) are used for the analysis.