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Doctor-in-the-Loop: An Explainable, Multi-View Deep Learning Framework for Predicting Pathological Response in Non-Small Cell Lung Cancer

arXiv.org Artificial Intelligence

Non-small cell lung cancer (NSCLC) remains a major global health challenge, with high post-surgical recurrence rates underscoring the need for accurate pathological response predictions to guide personalized treatments. Although artificial intelligence models show promise in this domain, their clinical adoption is limited by the lack of medically grounded guidance during training, often resulting in non-explainable intrinsic predictions. To address this, we propose Doctor-in-the-Loop, a novel framework that integrates expert-driven domain knowledge with explainable artificial intelligence techniques, directing the model toward clinically relevant anatomical regions and improving both interpretability and trustworthiness. Our approach employs a gradual multi-view strategy, progressively refining the model's focus from broad contextual features to finer, lesion-specific details. By incorporating domain insights at every stage, we enhance predictive accuracy while ensuring that the model's decision-making process aligns more closely with clinical reasoning. Evaluated on a dataset of NSCLC patients, Doctor-in-the-Loop delivers promising predictive performance and provides transparent, justifiable outputs, representing a significant step toward clinically explainable artificial intelligence in oncology.


Improving Value-based Process Verifier via Structural Prior Injection

arXiv.org Artificial Intelligence

In the Large Language Model(LLM) reasoning scenario, people often estimate state value via Monte Carlo sampling. Though Monte Carlo estimation is an elegant method with less inductive bias, noise and errors are inevitably introduced due to the limited sampling. To handle the problem, we inject the structural prior into the value representation and transfer the scalar value into the expectation of a pre-defined categorical distribution, representing the noise and errors from a distribution perspective. Specifically, by treating the result of Monte Carlo sampling as a single sample from the prior ground-truth Binomial distribution, we quantify the sampling error as the mismatch between posterior estimated distribution and ground-truth distribution, which is thus optimized via distribution selection optimization. We test the performance of value-based process verifiers on Best-of-N task and Beam search task. Compared with the scalar value representation, we show that reasonable structural prior injection induced by different objective functions or optimization methods can improve the performance of value-based process verifiers for about 1$\sim$2 points at little-to-no cost. We also show that under different structural prior, the verifiers' performances vary greatly despite having the same optimal solution, indicating the importance of reasonable structural prior injection.


The Esethu Framework: Reimagining Sustainable Dataset Governance and Curation for Low-Resource Languages

arXiv.org Artificial Intelligence

This paper presents the Esethu Framework, a sustainable data curation framework specifically designed to empower local communities and ensure equitable benefit-sharing from their linguistic resources. This framework is supported by the Esethu license, a novel community-centric data license. As a proof of concept, we introduce the Vuk'uzenzele isiXhosa Speech Dataset (ViXSD), an open-source corpus developed under the Esethu Framework and License. The dataset, containing read speech from native isiXhosa speakers enriched with demographic and linguistic metadata, demonstrates how community-driven licensing and curation principles can bridge resource gaps in automatic speech recognition (ASR) for African languages while safeguarding the interests of data creators. We describe the framework guiding dataset development, outline the Esethu license provisions, present the methodology for ViXSD, and present ASR experiments validating ViXSD's usability in building and refining voice-driven applications for isiXhosa.


Graph Attention Convolutional U-NET: A Semantic Segmentation Model for Identifying Flooded Areas

arXiv.org Artificial Intelligence

The increasing impact of human-induced climate change and unplanned urban constructions has increased flooding incidents in recent years. Accurate identification of flooded areas is crucial for effective disaster management and urban planning. While few works have utilized convolutional neural networks and transformer-based semantic segmentation techniques for identifying flooded areas from aerial footage, recent developments in graph neural networks have created improvement opportunities. This paper proposes an innovative approach, the Graph Attention Convolutional U-NET (GAC-UNET) model, based on graph neural networks for automated identification of flooded areas. The model incorporates a graph attention mechanism and Chebyshev layers into the U-Net architecture. Furthermore, this paper explores the applicability of transfer learning and model reprogramming to enhance the accuracy of flood area segmentation models. Empirical results demonstrate that the proposed GAC-UNET model, outperforms other approaches with 91\% mAP, 94\% dice score, and 89\% IoU, providing valuable insights for informed decision-making and better planning of future infrastructures in flood-prone areas.


Privacy Ripple Effects from Adding or Removing Personal Information in Language Model Training

arXiv.org Artificial Intelligence

Due to the sensitive nature of personally identifiable information (PII), its owners may have the authority to control its inclusion or request its removal from large-language model (LLM) training. Beyond this, PII may be added or removed from training datasets due to evolving dataset curation techniques, because they were newly scraped for retraining, or because they were included in a new downstream fine-tuning stage. We find that the amount and ease of PII memorization is a dynamic property of a model that evolves throughout training pipelines and depends on commonly altered design choices. We characterize three such novel phenomena: (1) similar-appearing PII seen later in training can elicit memorization of earlier-seen sequences in what we call assisted memorization, and this is a significant factor (in our settings, up to 1/3); (2) adding PII can increase memorization of other PII significantly (in our settings, as much as $\approx\!7.5\times$); and (3) removing PII can lead to other PII being memorized. Model creators should consider these first- and second-order privacy risks when training models to avoid the risk of new PII regurgitation.


FLEKE: Federated Locate-then-Edit Knowledge Editing

arXiv.org Artificial Intelligence

Locate-then-Edit Knowledge Editing (LEKE) is a key technique for updating large language models (LLMs) without full retraining. However, existing methods assume a single-user setting and become inefficient in real-world multi-client scenarios, where decentralized organizations (e.g., hospitals, financial institutions) independently update overlapping knowledge, leading to redundant mediator knowledge vector (MKV) computations and privacy concerns. To address these challenges, we introduce Federated Locate-then-Edit Knowledge Editing (FLEKE), a novel task that enables multiple clients to collaboratively perform LEKE while preserving privacy and reducing computational overhead. To achieve this, we propose FedEdit, a two-stage framework that optimizes MKV selection and reuse. In the first stage, clients locally apply LEKE and upload the computed MKVs. In the second stage, rather than relying solely on server-based MKV sharing, FLEKE allows clients retrieve relevant MKVs based on cosine similarity, enabling knowledge re-edit and minimizing redundant computations. Experimental results on two benchmark datasets demonstrate that FedEdit retains over 96% of the performance of non-federated LEKE while significantly outperforming a FedAvg-based baseline by approximately twofold. Besides, we find that MEMIT performs more consistently than PMET in the FLEKE task with our FedEdit framework. Our code is available at https://github.com/zongkaiz/FLEKE.


Paradigms of AI Evaluation: Mapping Goals, Methodologies and Culture

arXiv.org Artificial Intelligence

Research in AI evaluation has grown increasingly complex and multidisciplinary, attracting researchers with diverse backgrounds and objectives. As a result, divergent evaluation paradigms have emerged, often developing in isolation, adopting conflicting terminologies, and overlooking each other's contributions. This fragmentation has led to insular research trajectories and communication barriers both among different paradigms and with the general public, contributing to unmet expectations for deployed AI systems. To help bridge this insularity, in this paper we survey recent work in the AI evaluation landscape and identify six main paradigms. We characterise major recent contributions within each paradigm across key dimensions related to their goals, methodologies and research cultures. By clarifying the unique combination of questions and approaches associated with each paradigm, we aim to increase awareness of the breadth of current evaluation approaches and foster cross-pollination between different paradigms. We also identify potential gaps in the field to inspire future research directions.


Robust Bias Detection in MLMs and its Application to Human Trait Ratings

arXiv.org Artificial Intelligence

There has been significant prior work using templates to study bias against demographic attributes in MLMs. However, these have limitations: they overlook random variability of templates and target concepts analyzed, assume equality amongst templates, and overlook bias quantification. Addressing these, we propose a systematic statistical approach to assess bias in MLMs, using mixed models to account for random effects, pseudo-perplexity weights for sentences derived from templates and quantify bias using statistical effect sizes. Replicating prior studies, we match on bias scores in magnitude and direction with small to medium effect sizes. Next, we explore the novel problem of gender bias in the context of $\textit{personality}$ and $\textit{character}$ traits, across seven MLMs (base and large). We find that MLMs vary; ALBERT is unbiased for binary gender but the most biased for non-binary $\textit{neo}$, while RoBERTa-large is the most biased for binary gender but shows small to no bias for $\textit{neo}$. There is some alignment of MLM bias and findings in psychology (human perspective) - in $\textit{agreeableness}$ with RoBERTa-large and $\textit{emotional stability}$ with BERT-large. There is general agreement for the remaining 3 personality dimensions: both sides observe at most small differences across gender. For character traits, human studies on gender bias are limited thus comparisons are not feasible.


PIP-KAG: Mitigating Knowledge Conflicts in Knowledge-Augmented Generation via Parametric Pruning

arXiv.org Artificial Intelligence

Knowledge-Augmented Generation (KAG) has shown great promise in updating the internal memory of Large Language Models (LLMs) by integrating external knowledge. However, KAG inevitably faces knowledge conflicts when the internal memory contradicts external information. Current approaches to mitigating these conflicts mainly focus on improving external knowledge utilization. However, these methods have shown only limited effectiveness in mitigating the knowledge conflict problem, as internal knowledge continues to influence the generation process of LLMs. In this paper, we propose a ParametrIc Pruning-based Knowledge-Augmented Generation (PIP-KAG) approach, which prunes internal knowledge of LLMs and incorporates a plug-and-play adaptation module to help LLMs better leverage external sources. Additionally, we construct the CoConflictQA benchmark based on the hallucination of LLMs to better evaluate contextual faithfulness during answering questions. Experimental results on CoConflictQA demonstrate that PIP-KAG significantly reduces knowledge conflicts and improves context fidelity. Notably, PIP-KAG reduces LLM's parameters by 13%, enhancing parameter efficiency in LLMs within the KAG framework. All codes are available at https://github.com/OpenBMB/PIP-KAG.


Textual-to-Visual Iterative Self-Verification for Slide Generation

arXiv.org Artificial Intelligence

Generating presentation slides is a time-consuming task that urgently requires automation. Due to their limited flexibility and lack of automated refinement mechanisms, existing autonomous LLM-based agents face constraints in real-world applicability. We decompose the task of generating missing presentation slides into two key components: content generation and layout generation, aligning with the typical process of creating academic slides. First, we introduce a content generation approach that enhances coherence and relevance by incorporating context from surrounding slides and leveraging section retrieval strategies. For layout generation, we propose a textual-to-visual self-verification process using a LLM-based Reviewer + Refiner workflow, transforming complex textual layouts into intuitive visual formats. This modality transformation simplifies the task, enabling accurate and human-like review and refinement. Experiments show that our approach significantly outperforms baseline methods in terms of alignment, logical flow, visual appeal, and readability.