Identifying subtypes of complex conditions, such as Inflammatory Bowel Disease (IBD), often requires capturing latent patterns in longitudinal omics data. However, these data are typically high-dimensional, sparsely sampled, and irregularly observed over time, posing substantial challenges for conventional (bi)clustering and functional data analysis methods. We propose Tri-SfSVD, a unified sparse functional Singular Value Decomposition framework for discovering biclusters and triclusters in longitudinal data. Unlike existing functional biclustering methods that rely on ad hoc imputation or enforce restrictive shape-homogeneity assumptions, Tri-SfSVD integrates continuous trajectory estimation with simultaneous subject, feature, and temporal selection within a single optimization framework. By imposing sparse penalties across subjects, variables, and temporal subregions, the proposed method works directly on observed data to uncover localized structures at the subject, subject-feature, and subject-feature-time levels. Extensive simulations demonstrate that Tri-SfSVD outperforms existing approaches in high-dimensional settings. Applied to IBD multi-omics data, the method identified three biclusters linking sample clusters with distinct IBD-related clinical characteristics to microbial pathway groups associated with specific bacterial taxa, providing interpretable subject-pathway associations for characterizing disease heterogeneity. Applied to multi-channel EEG data, the method identified three triclusters linking sample clusters with distinct alcohol-related phenotypes to localized brain activity patterns, including subgroup differences separated by temporal subregions within the same spatial region.

Boltzmann machines are powerful distributions that have been shown to be an effective prior over binary latent variables in variational autoencoders (VAEs).

The work presented in this report introduces a framework aimed towards learning to imitate human gaits. Humans exhibit movements like walking, running, and jumping in the most efficient manner, which served as the source of motivation for this project. Skeletal and Musculoskeletal human models were considered for motions in the sagittal plane, and results from both were compared exhaustively. While skeletal models are driven with motor actuation, musculoskeletal models perform through muscle-tendon actuation. Model-free reinforcement learning algorithms were used to optimize inverse dynamics control actions to satisfy the objective of imitating a reference motion along with secondary objectives of minimizing effort in terms of power spent by motors and metabolic energy consumed by the muscles. On the one hand, the control actions for the motor actuated model is the target joint angles converted into joint torques through a Proportional-Differential controller. While on the other hand, the control actions for the muscle-tendon actuated model is the muscle excitations converted implicitly to muscle activations and then to muscle forces which apply moments on joints. Muscle-tendon actuated models were found to have superiority over motor actuation as they are inherently smooth due to muscle activation dynamics and don't need any external regularizers. Finally, a strategy that was used to obtain an optimal configuration of the significant decision variables in the framework was discussed. All the results and analysis are presented in an illustrative, qualitative, and quantitative manner. Supporting video links are provided in the Appendix.